a beginner s guide to microarrays

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Microarray Gene Expression Data Analysis

Author : Helen Causton
ISBN : 9781444311563
Genre : Science
File Size : 73. 22 MB
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This guide covers aspects of designing microarray experiments and analysing the data generated, including information on some of the tools that are available from non-commercial sources. Concepts and principles underpinning gene expression analysis are emphasised and wherever possible, the mathematics has been simplified. The guide is intended for use by graduates and researchers in bioinformatics and the life sciences and is also suitable for statisticians who are interested in the approaches currently used to study gene expression. Microarrays are an automated way of carrying out thousands of experiments at once, and allows scientists to obtain huge amounts of information very quickly Short, concise text on this difficult topic area Clear illustrations throughout Written by well-known teachers in the subject Provides insight into how to analyse the data produced from microarrays

A Beginner S Guide To Microarrays

Author : Eric M. Blalock
ISBN : 9781441987600
Genre : Science
File Size : 47. 89 MB
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A Beginner's Guide to Microarrays addresses two audiences - the core facility manager who produces, hybridizes, and scans arrays, and the basic research scientist who will be performing the analysis and interpreting the results. User friendly coverage and detailed protocols are provided for the technical steps and procedures involved in many facets of microarray technology, including: -Cleaning and coating glass slides, -Designing oligonucleotide probes, -Constructing arrays for the detection and quantification of different bacterial species, -Preparing spotting solutions, -Troubleshooting spotting problems, -Setting up and running a core facility, -Normalizing background signal and controlling for systematic variance, -Designing experiments for maximum effect, -Analyzing data with statistical procedures, -Clustering data with machine-learning protocols.

Microbial Functional Genomics

Author : Jizhong Zhou
ISBN : 0471071900
Genre : Medical
File Size : 76. 95 MB
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Genomics: toward a genome-level understanding of the structure, functions, and evolution of bioloical systems; Microbial diversity and genomics. Computational genome annotation. Microbial evolution from a genomics perspective. Computational methods for functional prediction of genes. DNA microarray technology. Microarray gene expression data analysis. Mutagenesis as a genomic tool for studying gene function. Mass spectrometry. Identification of protein-ligand interactions. The functional genomics of model organisms: addressing old questions from a new perspective. Functional genomic analysis of bacterial pathogens and environmentally significant microorganisms. The impact of genomics on antimicrobial drug discovery and toxicology. Application of microarray-based genomic technology to mutation analysis and microbial detection. Future perspectives: genomics beyond single cells.

Microarray Technology In Practice

Author : Steve Russell
ISBN : 0080919766
Genre : Science
File Size : 49. 52 MB
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Using chips composed of thousands of spots, each with the capability of holding DNA molecules corresponding to a given gene, DNA microarray technology has enabled researchers to measure simultaneously gene expression across the genome. As with other large-scale genomics approaches, microarray technologies are broadly applicable across disciplines of life and biomedical sciences, but remain daunting to many researchers. This guide is designed to demystify the technology and inform more biologists about this critically important experimental technique. Cohesive overview of the technology and available platforms, followed by detailed discussion of experimental design and analysis of microarray experiments Up-to-date description of normalization methods and current methods for sample amplification and labeling Deep focus on oligonucleotide design, printing, labeling and hybridization, data acquisition, normalization, and meta-analysis Additional uses of microarray technology such as ChIP (chromatin immunoprecipitation) with hybridization to DNA arrays, microarray-based comparative genomic hybridization (CGH), and cell and tissue arrays

Leading Edge Environmental Biodegradation Research

Author : Lyman E. Pawley
ISBN : 1600219039
Genre : Science
File Size : 39. 87 MB
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This volume presents new leading-edge research on environmental biodegradation which is the destruction of organic compounds by micro-organisms. Micro-organisms, particularly bacteria, are responsible for the decomposition of both natural and synthetic organic compounds in nature. Mineralisation results in complete conversion of a compound to its inorganic mineral constituents (for example, carbon dioxide from carbon, sulphate or sulphide from organic sulfur, nitrate or ammonium from organic nitrogen, phosphate from organophosphates, or chloride from organochlorine). Since carbon comprises the greatest mass of organic compounds, mineralisation can be considered in terms of CO2 evolution. Radioactive carbon-14 (14C) isotopes enable scientists to distinguish between mineralisation arising from contaminants and soil organic matter. However, mineralisation of any compound is never 100% because some of it (10Chr(45)40% of the total amount degraded) is incorporated into the cell mass or products that become part of the amorphous soil organic matter, commonly referred to as humus. Thus, biodegradation comprises mineralisation and conversion to innocuous products, namely biomass and humus. Primary biodegradation is more limited in scope and refers to the disappearance of the compound as a result of its biotransformation to another product. Compounds that are readily biodegradable are generally utilised as growth substrates by single micro-organisms. Many of the components of petroleum products (and frequent ground-water contaminants), such as benzene, toluene, ethylbenzene, and xylene, are utilised by many genera of bacteria as sole carbon sources for growth and energy.

Encyclopedic Reference Of Genomics And Proteomics In Molecular Medicine

Author : Detlev Ganten
ISBN : 3540442448
Genre : Medical
File Size : 74. 14 MB
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Applications Of Cold Plasma Chemistry To Surface Functionalization For Biomolecualar Attachment And Disinfection Of Teat Cup Liners

Author : Jason Michael Helgren
ISBN : WISC:89090642208
Genre :
File Size : 84. 81 MB
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Genomics And Proteomics Engineering In Medicine And Biology

Author : Metin Akay
ISBN : UOM:39015067674971
Genre : Medical
File Size : 68. 55 MB
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Current applications and recent advances in genomics and proteomics Genomics and Proteomics Engineering in Medicine and Biology presents a well-rounded, interdisciplinary discussion of a topic that is at the cutting edge of both molecular biology and bioengineering. Compiling contributions by established experts, this book highlights up-to-date applications of biomedical informatics, as well as advancements in genomics-proteomics areas. Structures and algorithms are used to analyze genomic data and develop computational solutions for pathological understanding. Topics discussed include: Qualitative knowledge models Interpreting micro-array data Gene regulation bioinformatics Methods to analyze micro-array Cancer behavior and radiation therapy Error-control codes and the genome Complex life science multi-database queries Computational protein analysis Tumor and tumor suppressor proteins interactions

Python 2 6 Text Processing

Author : Jeff McNeil
ISBN : 9781849512138
Genre : Computers
File Size : 60. 54 MB
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The easiest way to learn how to manipulate text with Python.

Introduction To Genomic Signal Processing With Control

Author : Aniruddha Datta
ISBN : 0849371988
Genre : Science
File Size : 46. 32 MB
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Studying large sets of genes and their collective function requires tools that can easily handle huge amounts of information. Recent research indicates that engineering approaches for prediction, signal processing, and control are well suited for studying multivariate interactions. A tutorial guide to the current engineering research in genomics, Introduction to Genomic Signal Processing with Control provides a state-of-the-art account of the use of control theory to obtain intervention strategies for gene regulatory networks. The book builds up the necessary molecular biology background with a basic review of organic chemistry and an introduction of DNA, RNA, and proteins, followed by a description of the processes of transcription and translation and the genetic code that is used to carry out the latter. It discusses control of gene expression, introduces genetic engineering tools such as microarrays and PCR, and covers cell cycle control and tissue renewal in multi-cellular organisms. The authors then delineate how the engineering approaches of classification and clustering are appropriate for carrying out gene-based disease classification. This leads naturally to expression prediction, which in turn leads to genetic regulatory networks. The book concludes with a discussion of control approaches that can be used to alter the behavior of such networks in the hope that this alteration will move the network from a diseased state to a disease-free state. Written by recognized leaders in this emerging field, the book provides the exact amount of molecular biology required to understand the engineering applications. It is a self-contained resource that spans the diverse disciplines of molecular biology and electrical engineering.

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