a crack in creation gene editing and the unthinkable power to control evolution

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A Crack In Creation

Author : Jennifer Doudna
ISBN : 1784702765
Genre :
File Size : 65. 3 MB
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A handful of discoveries have changed the course of human history. This book is about the most recent and potentially the most powerful and dangerous of them all. It is an invention that allows us to rewrite the genetic code that shapes and controls all living beings with astonishing accuracy and ease. Thanks to it, the dreams of genetic manipulation have become a stark reality: the power to cure disease and alleviate suffering, to create new sources of food and energy, as well as to re-design any species, including humans, for our own ends. Jennifer Doudna is the co-inventor of this technology - known as CRISPR - and a scientist of worldwide renown. Writing with fellow researcher Samuel Sternberg, here she provides the definitive account of her discovery, explaining how this wondrous invention works and what it is capable of. She also asks us to consider what our new-found power means: how do we enjoy its unprecedented benefits while avoiding its equally unprecedented dangers? The future of humankind - and of all life on Earth - is at stake. This book is an essential guide to the path that now lies ahead.

A Crack In Creation

Author : Jennifer A. Doudna
ISBN : 9780544716964
Genre : Science
File Size : 69. 31 MB
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A trailblazing biologist grapples with her role in the biggest scientific discovery of our era: a cheap, easy way of rewriting genetic code, with nearly limitless promise and peril. Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers, and will help address the world’s hunger crisis. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences—to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Samuel Sternberg, Doudna shares the thrilling story of her discovery, and passionately argues that enormous responsibility comes with the ability to rewrite the code of life. With CRISPR, she shows, we have effectively taken control of evolution. What will we do with this unfathomable power?

Summary Study Guide A Crack In Creation

Author : Lee Tang
ISBN : 9780995943162
Genre : Science
File Size : 33. 1 MB
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The Power and Peril of Gene Editing CRISPR/Cas9 Technology The must-read summary of “A Crack in Creation: Gene Editing and the Unthinkable Power to Control Evolution” by Jennifer A. Doudna and Samuel H. Sternberg. This complete summary of Jennifer Doudna and Samuel Sternberg’s book tells the story of CRISPR and “gene-editing.” CRISPR is a cutting-edge gene-editing technology that mimics what happens naturally in bacteria. It enables scientists to “play god” with plant or animal DNA, with unlimited power and peril. The technology of gene editing is the most important advance in our era. The possibility of forever altering the genetic composition of humankind is frightening. Yet we can’t overlook the opportunities that may lead to inventions for cures of HIV, debilitating genetic diseases, and cancers, and end food shortages. The book will demystify this exciting area of science and inspire you to seek answers to tough moral and ethical questions on the use of this technology. This guide includes: Book Summary—The summary helps you understand the key ideas and recommendations. OnlineVideos—On-demand replay of public lectures, and seminars on the topics covered in the chapter. Value-added of this guide: Save time Understand key concepts Expand your knowledge Read this summary and get involved in the debate on the moral and ethical issues on the use of this technology.

Modern Prometheus

Author : Jim Kozubek
ISBN : 9781108454629
Genre : Law
File Size : 21. 78 MB
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This book tells the dramatic story of Crispr and the potential impact of this gene-editing technology.

Babies By Design

Author : Ronald M. Green
ISBN : 0300138571
Genre : SCIENCE
File Size : 66. 72 MB
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Product Description: We stand on the brink of unprecedented growth in our ability to understand and change the human genome. New reproductive technologies now enable parents to select some genetic traits for their children, and soon it will be possible to begin to shape ourselves as a species. Despite the loud cries of alarm that such a prospect inspires, Ronald Green argues that we will, and we should, undertake the direction of our own evolution. A leader in the bioethics community, Green offers a scientifically and ethically informed view of human genetic self-modification and the possibilities it opens up for a better future. Fears of a terrible Brave New World or a new eugenics movement are overblown, he maintains, and in the more likely future, genetic modifications may improve parents' ability to enhance children's lives and may even promote social justice. The author outlines the new capabilities of genomic science, addresses urgent questions of safety that genetic interventions pose, and explores questions of parenting and justice. He also examines the religious implications of gene modification. Babies by design are assuredly in the future, Green concludes, and by making responsible choices as we enter that future, we can incorporate gene technology in a new age of human adventure.

Crispr Cas

Author : University Jennifer Doudna
ISBN : 1621821307
Genre : RNA
File Size : 39. 4 MB
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The development of CRISPR-Cas technology is revolutionizing biology. Based on machinery bacteria use to target foreign nucleic acids, these powerful techniques allow investigators to edit nucleic acids and modulate gene expression more rapidly and accurately than ever before. Featuring contributions from leading figures in the CRISPR-Cas field, this laboratory manual presents a state-of-the-art guide to the technology. It includes step-by-step protocols for applying CRISPR-Cas-based techniques in various systems, including yeast, zebrafish, Drosophila, mice, and cultured cells (e.g., human pluripotent stem cells). The contributors cover web-based tools and approaches for designing guide RNAs that precisely target genes of interest, methods for preparing and delivering CRISPR-Cas reagents into cells, and ways to screen for cells that harbor the desired genetic changes. Strategies for optimizing CRISPR-Cas in each system--especially for minimizing off-target effects--are also provided. Authors also describe other applications of the CRISPR-Cas system, including its use for regulating genome activation and repression, and discuss the development of next-generation CRISPR-Cas tools. The book is thus an essential laboratory resource for all cell, molecular, and developmental biologists, as well as biochemists, geneticists, and all who seek to expand their biotechnology toolkits.

Gene Editing Epigenetic Cloning And Therapy

Author : Amin Elser
ISBN : 1524621994
Genre : Education
File Size : 88. 4 MB
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This book is really helpful for someone who wants to start learning about genes and DNA. It is a well-written book describing all the introductory materials one would need to become current with genomes and genomics topics. It begins with an introduction to DNA and genes in chapter 1 and goes on from there through epigenetic in chapter 2, including acetylation, methylation, ubiquitylation of protein, deimination, and proline isomerization. It goes through gene editing in chapter 3, which includes good description of TALENs, ZFNs, and CRISPR/Cas systems. Chapter 4 includes cloning using artificial embryo twinning, somatic cell nuclear transfer, and asexual reproduction. Chapter 5 is about the material on basic stem cells of embryonic stem cells and adult stem cells. Chapter 6 discusses techniques and technology of gene therapy and cloning therapy. Chapter 7 includes descriptions on cell division, mitosis, meiosis, biological life cycle, parthenogenesis, bacterial conjugation, DNA fingerprints, genetic relationship between individuals and surname studies. The book includes many diagrams and a glossary and an index. For a serious book on DNA and genes, this book is quite readable. It is a user-friendly textbook so that many readers will find it helpful to read some chapters more than once. The book is a valuable introduction to the extremely important field of genes and genomics.

Virolution

Author : Frank Ryan
ISBN : 9780007545278
Genre : Science
File Size : 26. 54 MB
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The extraordinary role of viruses in evolution and how this is revolutionising biology and medicine.

Redesigning Life

Author : John Parrington
ISBN : 9780198766827
Genre : Science
File Size : 28. 64 MB
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Since the birth of civilisation, human beings have manipulated other life-forms. We have selectively bred plants and animals for thousands of years to maximize agricultural production and cater to our tastes in pets. The observation of the creation of artificial animal and plant variants was a key stimulant for Charles Darwin's theory of evolution. The ability to directly engineer the genomes of organisms first became possible in the 1970s, when the gene for human insulin was introduced into bacteria to produce this protein for diabetics. At the same time, mice were modified to produce human growth hormone, and grew huge as a result. But these were only our first tottering steps into the possibilities of genetic engineering. In the past few years, the pace of progress has accelerated enormously. We can now cut and paste genes using molecular scissors with astonishing ease, and the new technology of genome editing can be applied to practically any species of plants or animals. 'Mutation chain reaction' can be used to alter the genes of a population of pests, such as flies; as the modified creatures breed, the mutation is spread through the population, so that within a few generations the organism is almost completely altered. At the same time, scientists are also beginning to synthesize new organisms from scratch. These new technologies hold much promise for improving lives. Genome editing has already been used clinically to treat AIDS patients, by genetically modifying their white blood cells to be resistant to HIV. In agriculture, genome editing could be used to engineer species with increased food output, and the ability to thrive in challenging climates. New bacterial forms may be used to generate energy. But these powerful new techniques also raise important ethical dilemmas and potential dangers, pressing issues that are already upon us given the speed of scientific developments. To what extent should parents be able to manipulate the genetics of their offspring - and would designer babies be limited to the rich? Can we effectively weigh up the risks from introducing synthetic lifeforms into complex ecosystems? John Parrington explains the nature and possibilities of these new scientific developments, which could usher in a brave, new world. We must rapidly come to understand its implications if we are to direct its huge potential to the good of humanity and the planet.

Junk Dna

Author : Nessa Carey
ISBN : 9781848318267
Genre : Science
File Size : 25. 37 MB
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From the author of the acclaimed The Epigenetics Revolution (‘A book that would have had Darwin swooning’ – Guardian) comes another thrilling exploration of the cutting edge of human science. For decades after the structure of DNA was identified, scientists focused purely on genes, the regions of the genome that contain codes for the production of proteins. Other regions – 98% of the human genome – were dismissed as ‘junk’. But in recent years researchers have discovered that variations in this ‘junk’ DNA underlie many previously intractable diseases, and they can now generate new approaches to tackling them. Nessa Carey explores, for the first time for a general audience, the incredible story behind a controversy that has generated unusually vituperative public exchanges between scientists. She shows how junk DNA plays an important role in areas as diverse as genetic diseases, viral infections, sex determination in mammals, human biological complexity, disease treatments, even evolution itself – and reveals how we are only now truly unlocking its secrets, more than half a century after Crick and Watson won their Nobel prize for the discovery of the structure of DNA in 1962.

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