apoptosis in normal development and cancer

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Apoptosis In Normal Development And Cancer

Author : M Sluyser
ISBN : 9781482295276
Genre : Medical
File Size : 36. 34 MB
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In apoptosis in the mammalian system, cells have a finite life - they develop, are used and then die. Cancer cells escape this programmed routine but, from an understanding of apoptosis, they can be programmed to die. This book addresses the

Molecular Biology Of The Cell

Author : Bruce Alberts
ISBN : 9781317563747
Genre : Science
File Size : 74. 48 MB
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As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.

Mammary Tumor Cell Cycle Differentiation And Metastasis

Author : Robert B. Dickson
ISBN : 9781461312598
Genre : Medical
File Size : 50. 19 MB
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Mammary Tumor Cell Cycle, Differentiation and Metastasis is the fifth volume since 1988 in a series designed to broadly examine current advances in the cellular and molecular biology of breast cancer. As in previous volumes, the editors have invited recognized experts in cutting-edge topics to provide a chapter focused on their area of research. The editors have turned to the researchers who study rodent models of the disease and to those who study the cellular and molecular basis of human breast cancer. The first section of the book is devoted to new mouse models of mammary development and tumorigenesis. The second section moves to studies of human breast cancer and focuses on receptors, signalling, and the cell cycle. The final section deals with defective tissue interactions in human breast cancer. We are now in a period of extremely rapid accumulation of data on the molecular and cellular biology of breast cancer. These findings are highlighted in chapters from Mammary Tumor Cell Cycle, Differentiation and Metastasis: Advances in Cellular and Molecular Biology of Breast Cancer.

Apoptosis And Development

Author :
ISBN : 9780124095984
Genre : Medical
File Size : 69. 85 MB
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Apoptosis and Development, the latest volume of Current Topics in Developmental Biology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis and development, and includes sections on such topics as the non-lethal role of apoptotic proteins and germ line cell death in Drosophila. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Includes descriptions of the most recent advances in the field Covers research methods in apoptosis and development, and includes sections on such topics as the non-lethal role of apoptotic proteins and germ line cell death in Drosophila

Breast Cancer Management And Molecular Medicine

Author : Martine Piccart
ISBN : 9783540282662
Genre : Medical
File Size : 49. 29 MB
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Tailoring treatment for individual breast cancers is no longer a dream and is now the main goal for current research. This book gives an overview of the most recent techniques, agents and approaches for breast cancer and the individualization of treatment. Particular attention is given to organ-specific tailored approaches, specific populations, patients’ preferences and rehabilitation. Contributions from experts focus on the biomedical research behind the transfer of molecular biology knowledge into the clinical management of patients. This has led to increased survival as well as improved quality of life. The book gives an overview of the latest achievements in breast cancer and their use in clinical practice.

Growth Factors And Their Receptors In Cell Differentiation Cancer And Cancer Therapy

Author : G V Sherbet
ISBN : 9780123878205
Genre : Science
File Size : 78. 88 MB
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Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes Aids the development of therapeutic treatments for cancer Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research

Autophagy Cancer Other Pathologies Inflammation Immunity Infection And Aging

Author : M. A. Hayat
ISBN : 9780128094280
Genre : Medical
File Size : 53. 15 MB
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Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging, Volume 10 offer a valuable guide to both cellular processes, while encouraging researchers to explore their potentially important connections. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. This is the tenth volume of the multivolume series that discusses, in detail, almost all aspects of the autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. Volume 10 of the Autophagy series discusses the role of a novel binuclear palladacycle complex that inhibits melanoma growth through apoptosis and autophagy. Presents the most advanced information regarding the role of the autophagic system in life and death Contains a direct focus on the role of a novel binuclear palladacycle complex that inhibits melanoma growth Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation States recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities Edited work with chapters authored by leaders in the field from around the globe—the broadest, most expert coverage available

Apoptosis And Cancer

Author : Seamus J. Martin
ISBN : 3805565798
Genre : Health & Fitness
File Size : 69. 82 MB
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Apoptosis and Cancer is an up-to-date overview of our understanding of apoptosis and how it effects cancer development and cancer treatment. Written by leading researchers in the field of apoptosis, this book provides an extremely valuable reference for those already familiar with apoptosis as well as a jumping-off point for those new to the field. It will appeal to scientists interested in mechanisms of cell transformation that lead to cancer and to oncologists interested in investigating and understanding new cancer therapies.

The Role Of Apoptosis In Development Tissue Homeostasis And Malignancy

Author : R.M. Dexter
ISBN : 041263810X
Genre : Medical
File Size : 83. 48 MB
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The role of programmed cell death is recognised as being important in a number of key biological processes, particularly development and maintenance of a healthy organism. This volume, which arises from a Royal Society discussion meeting, provides an up-to-date overview of current research into programmed cell death from top international scientists. Key topics discussed include genetic control of programmed cell death in development, regulation of cell death in cancer cells, influence of signals, modulators and effectors on cell death and clinical applications. Each chapter provides good access to other relevant literature for those not familiar with the area.

Molecular Exploitation Of Apoptosis Pathways In Prostate Cancer

Author : Natasha Kyprianou
ISBN : 9781908978257
Genre : Science
File Size : 54. 98 MB
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This book focuses on the functional significance of targeting apoptosis for the treatment of prostate cancer. New concepts on the challenges relating to the development of resistance by androgen-independent tumors are introduced, in terms of the contribution of anoikis and cross-talk of androgens with key growth factor signaling pathways. This volume also provides insightful discussion on the exploitation of the apoptotic and angiogenic synergism towards complete eradication of prostate tumors. Last but not least, it includes reflections on the drug development challenge based on the analysis of data from existing clinical trials. Contents:Introduction: Prostate CancerThe Prostate Gland DynamicsApoptosis Pathways Signaling Execution of Cancer CellsAndrogen Receptor-Mediated Apoptosis: Significance in Development of Castration-Resistant Prostate CancerAnoikis in Prostate Cancer MetastasisEpithelial–Mesenchymal Transition (EMT) in Prostate Cancer MetastasisNovel Molecular Therapeutics for Targeting Castration-Resistant Prostate CancerApoptotic-Based Molecular Markers of Therapeutic ResponseRole of Apoptosis in Prostate Cancer PreventionSummary and Future Directions Readership: Practising clinicians including urologists, pathologists, medical oncologists and scientists with an interest in cancer, especially prostate cancer. Keywords:Apoptosis;Prostrate CancerKey Features:Discusses apoptosis with respect to prostate cancer that exhibits distinct signaling responsesProvides updated evidence on the understanding of the molecular pathways that lead to apoptosisCovers new mechanisms and therapeutic urology

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