applications in high resolution mass spectrometry

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Applications In High Resolution Mass Spectrometry

Author : Roberto Romero-González
ISBN : 9780128096482
Genre : Science
File Size : 89. 47 MB
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Applications of High Resolution Mass Spectrometry: Food Safety and Pesticide Residue Analysis is the first book to offer complete coverage of all aspects of high resolution mass spectrometry (HRMS) used for the analysis of pesticide residue in food. Aimed at researchers and graduate students in food safety, toxicology, and analytical chemistry, the book equips readers with foundational knowledge of HRMS, including established and state-of-the-art principles and analysis strategies. Additionally, it provides a roadmap for implementation, including discussions of the latest instrumentation and software available. Detailed coverage is given to the application of HRMS coupled to ultra high-performance liquid chromatography (UHPLC-HRMS) in the analysis of pesticide residue in fruits and vegetables and food from animal origin. The book also discusses extraction procedures and the challenges of sample preparation, gas chromatography coupled to high resolution mass spectrometry, flow injection-HRMS, ambient ionization, and identification of pesticide transformation products in food. Responding to the fast development and application of these new procedures, this book is an essential resource in the food safety field. Arms researchers with an in-depth resource devoted to the rapid advances in HRMS tools and strategies for pesticide residue analysis in food Provides a complete overview of analytical methodologies and applications of HRMS, including UHPLC-HRMS, HRMS coupled with time of flight (TOF) and/or GC-Orbitrap, and flow injection-HRMS Discusses the current international regulations and legislation related to the use of HRMS in pesticide residue analysis Features a chapter on the hardware and software available for HRMS implementation Offers separate chapters on HRMS applied to pesticide residue analysis in fruits and vegetables and in food from animal origin

Special Issue Applications Of High Resolution Mass Spectrometry In Food Safety And Food Authenticity

Author : John Gilbert
ISBN : OCLC:1075744829
Genre :
File Size : 77. 99 MB
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Development And Application Of A High Resolution Mass Spectrometer Computer System

Author : Richard Joseph Klimowski
ISBN : CORNELL:31924022302396
Genre : Science
File Size : 59. 26 MB
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Mass Spectrometry

Author : D. H. Williams
ISBN : 9780851862682
Genre : Reference
File Size : 66. 63 MB
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Reflecting the growing volume of published work in this field, researchers will find this book an invaluable source of information on current methods and applications.

Mass Spectrometry In Drug Metabolism And Disposition

Author : Mike S. Lee
ISBN : 0470934697
Genre : Science
File Size : 45. 93 MB
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This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.

Time Of Flight Mass Spectrometry And Its Applications

Author : E.W. Schlag
ISBN : 9780444596185
Genre : Science
File Size : 22. 20 MB
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The resurgence of time-of-flight mass spectrometry (TOF-MS) has had its origin in the simplicity of construction and application of such instruments together with the high transmission and the great increase in resolution that has been achieved. The instrument lends itself naturally to a coupling with pulsed laser sources, though this is not a prerequisite. It also affords a time resolution far beyond that traditionally achieved with mass spectrometric rapid scan techniques - a recent example being the real-time analysis of a multi-component mixture from an automobile exhaust. Furthermore, the mass range appears to be extremely large: mass up to 500 kDa and beyond what is being readily measured in the laboratory today. The present set of contributions attempts to give a survey of current applications from many of the active groups in the field. A variety of new applications are considered which are no doubt just the beginning of large new areas of application. By presenting this work in book form it is hoped that it will be of help to the many groups intending to initiate work in this rapidly expanding new area of mass spectrometry.

Mass Spectrometry For Drug Discovery And Drug Development

Author : Walter A. Korfmacher
ISBN : 9781118516140
Genre : Science
File Size : 51. 27 MB
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Facilitates the discovery and development of new, effectivetherapeutics With coverage of the latest mass spectrometry technology, thisbook explains how mass spectrometry can be used to enhance almostall phases of drug discovery and drug development, including newand emerging applications. The book's fifteen chapters have beenwritten by leading pharmaceutical and analytical scientists. Theircontributions are based on a thorough review of the currentliterature as well as their own experience developing new massspectrometry techniques to improve the ability to discover anddevelop new and effective therapeutics. Mass Spectrometry for Drug Discovery and Drug Developmentbegins with an overview of the types of mass spectrometers thatfacilitate drug discovery and development. Next it covers: HPLC–high-resolution mass spectrometry for quantitativeassays Mass spectrometry for siRNA Quantitative analysis of peptides Mass spectrometry analysis of biological drugs Applications that support medicinal chemistryinvestigations Mass spectrometry imaging and profiling Throughout the book, detailed examples underscore the growingrole of mass spectrometry throughout the drug discovery anddevelopment process. In addition, images of mass spectra areprovided to explain how results are interpreted. Extensivereferences at the end of each chapter guide readers to the primaryliterature in the field. Mass Spectrometry for Drug Discovery and Drug Developmentis recommended for readers in pharmaceutics, including medicinalchemists, analytical chemists, and drug metabolism scientists. Allreaders will discover how mass spectrometry can streamline andadvance new drug discovery and development efforts.

Contemporary Practice Of Chromatography

Author : C.F. Poole
ISBN : 9780444596260
Genre : Science
File Size : 47. 80 MB
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Written for all those who use chromatography as an analytical tool, this book covers all areas of gas, liquid, and thin-layer chromatography; no other book offers the same scope. The authors have had considerable experience in teaching graduate-level courses and the material presented here has been tried and tested, having formed the basis for short courses taught to groups of industrial chemists. Emphasis is on the practice of chromatographic methods, including ``how to'' sections and numerous examples of calculation methods. Extensively illustrated, the book contains numerous tables of all useful constants, materials and formulas frequently used by chromatographers. Valuable features are the chapters on sample preparation for chromatographic analysis, on instrumental methods for sample identification, and the comprehensive literature review.

Liquid Chromatography Time Of Flight Mass Spectrometry

Author : Imma Ferrer
ISBN : 047042995X
Genre : Science
File Size : 32. 20 MB
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Time of flight mass spectrometry identifies the elements of a compound by subjecting a sample of ions to a strong electrical field. Illuminating emerging analytical techniques in high-resolution mass spectrometry, Liquid Chromatography Time-of-Flight Mass Spectrometry shows readers how to analyze unknown and emerging contaminants—such as antibiotics, steroids, analgesics—using advanced mass spectrometry techniques. The text combines theoretical discussion with concrete examples, making it suitable for analytical chemists, environmental chemists, organic chemists, medicinal chemists, university research chemists, and graduate and post-doctorate students.

Plasma Source Mass Spectrometry

Author : Scott D Tanner
ISBN : 9781847551696
Genre : Science
File Size : 42. 47 MB
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The understanding of the principles of ICP-MS and its application as an analytical technique is continually evolving and this book provides a unique snapshot of the current state-of-the-art. Plasma Source Mass Spectrometry: The New Millennium covers a diverse range of topics including the fate of the sample as it passes through the sample introduction system, chemical resolution using reaction and collision cells, various methods of mass analysis, approaches to account for spectral interferences, hyphenation methods to enable speciation, and the results of analyses ranging from natural waters and archaeological isotope ratios to organometallic speciation in biological materials. Describing explicitly the analytical methods that deal with current analytical challenges, and offering a current perspective on elemental analysis by plasma source mass spectrometry that is not to be found elsewhere, this book will be welcomed by both academics and industrialists as containing the most up-to-date information available on this burgeoning topic.

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