atp and the heart basic science for the cardiologist

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Atp And The Heart

Author : Joanne S. Ingwall
ISBN : 9781461510932
Genre : Medical
File Size : 77. 65 MB
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ATP plays a central role in the two leading causes of cardiac morbidity and mortality in the western world: ischemia and heart failure. We are in our infancy applying what is known about biology and chemistry of ATP toward developing effective therapies for these diseases. In this volume, the current understanding of the chemistry and biology of ATP specifically in the cardiomyocyte is presented. New insights into ATP have been gleaned using biophysical techniques allowing dynamic measurement of chemical events in the intact beating heart and using new animal models in which cardiac proteins are either over expressed, deleted or harbor specific mutations. This book provides a summary of the basic understanding and includes illustrations of why ATP and the Heart is important to both the clinician and scientist.

Translational Cardiology

Author : Cam Patterson
ISBN : 9781617798917
Genre : Medical
File Size : 56. 63 MB
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Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques provides an up-to-date introduction to the role circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart, while at the same time introducing new developments in cellular, viral, and non-biologic therapies that are in the process of being developed. Importantly, the focus of this book is on topics that, due to their novelty, are largely not covered in the other major textbooks. A special emphasis is placed on the molecular basis of cardiac metabolism, new concepts in cardiac remodeling, and translational therapies and imaging techniques currently under development for clinical use. The chapters are written by experts from diverse clinical and biomedical research backgrounds. Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques simplifies the complexity of the molecular basis of disease by focusing on patient-oriented disease mechanisms and therapies and is of great value to a broad audience including physicians (e.g. cardiologists, cardiovascular surgeons, pathologists) as well as translational biomedical researchers in a wide range of disciplines.

Sports Cardiology An Issue Of Cardiology Clinics

Author : Aaron Baggish
ISBN : 9780323476997
Genre : Medical
File Size : 60. 12 MB
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This issue of Cardiology Clinics on Sports Cardiology, edited by Drs. Aaron Baggish and Andre La Gerche, will cover a variety of aspects related to cardiovascular health and complications related to athletic activity. Topics covered in this issue include, but are not limited to, molecular aspects of exercise-induced cardiac remodeling; sudden cardiac death; atrial fibrillation in endurance athletes; congenital heart disease in athletes; exercise prescription for the athlete with cardiomyopathy; and advanced exercise testing for the sports cardiologist.

Clinical Nuclear Cardiology State Of The Art And Future Directions E Book

Author : Barry L. Zaret
ISBN : 9780323085724
Genre : Medical
File Size : 35. 17 MB
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Clinical Nuclear Cardiology—now in its fourth edition—covers the tremendous clinical growth in this field, focusing on new instrumentation and techniques. Drs. Barry L. Zaret and George A Beller address the latest developments in technology, radiopharmaceuticals, molecular imaging, and perfusion imaging. Thoroughly revised to include 20 new chapters—Digital/Fast SPECT, Imaging in Revascularized Patients, and more—this new edition provides state-of-the-art guidance on key areas and hot topics with stunning visuals. Online access to the fully searchable text at expertconsult.com includes highly illustrated case studies that let you see the problem using a variety of imaging modalities. In other words, this is an invaluable resource no clinician or researcher in nuclear cardiology should be without. Features an editorial and contributing team of worldwide leaders in nuclear cardiology to provide you with current and authoritative guidance. Includes a section focusing on acute coronary syndromes to provide you with practical management tools for these conditions. Presents a full-color design that allows color images to be integrated throughout the text. Includes access to the fully searchable contents of the book online at expertconsult.com, along with highly illustrated case studies that let you see the problem using a variety of imaging modalities. Features 20 new chapters including Cellular Mechanisms of Tracer Uptake and Clearance; Attenuation/Scatter Corrections: Clinical Aspects; Hybrid Imaging; Digital/Fast SPECT; Imaging in Revascularized Patients; and more. Focuses on perfusion imaging in a section dedicated to this hot topic so you get all the information you need to stay current.

Post Genomic Cardiology

Author : José Marín-García
ISBN : 9780124046429
Genre : Science
File Size : 70. 88 MB
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In this second edition of Post-Genomic Cardiology, developing and new technologies such as translational genomics, next generation sequencing (NGS), bioinformatics, and systems biology in molecular cardiology are assessed in light of their therapeutic potential. As new methods of mutation screening emerge, both for the genome and for the “epigenome,” comprehensive understanding of the many mutations that underlie cardiovascular diseases and adverse drug reactions is within our reach. This book, written by respected cardiologist José Marín-García, features discussion on the Hap-Map: the largest international effort to date aiming to define the differences between our individual genomes. This unique reference further reviews and investigates genome sequences from our evolutionary relatives that could help us decipher the signals of genes, and offers a comprehensive and critical evaluation of regulatory elements from the complicated network of the background DNA. Offers updated discussion of cutting-edge molecular techniques including new genomic sequencing / NGS / Hap-Map / bioinformatics / systems biology approaches Analyzes mitochondria dynamics and their role in cardiac dysfunction, up-to-date analysis of cardio-protection, and cardio-metabolic syndrome Presents recent translational studies, gene therapy, transplantation of stem cells, and pharmacological treatments in CVDs

Cardiac Energy Metabolism In Health And Disease

Author : Gary D. Lopaschuk
ISBN : 9781493912278
Genre : Science
File Size : 83. 52 MB
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The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.

Atlas Of Nuclear Cardiology

Author : Vasken Dilsizian
ISBN : 9781461455516
Genre : Medical
File Size : 33. 38 MB
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The aim of the 4th edition of the Atlas of Nuclear Cardiology is to provide physicians and students in cardiology, radiology, and nuclear medicine who want the latest information in the field of cardiovascular nuclear medicine up-to-date and comprehensive information on advances in instrumentation, radiotracers, protocols, and clinical studies. Unlike other books that are narrow in their scope of either technology and technique or clinical studies, the 4th edition of the Atlas will present diagnostic algorithms and schematic diagrams integrated with nuclear cardiology procedures generously interspersed with color illustrations to emphasize key concepts in cardiovascular physiology, pathology, and metabolism relevant for the clinical practice of cardiology. The atlas emphasizes today’s most current information, meeting the requirements for those who will be using the book as a reference source for certifying or re-certifying in cardiology, nuclear cardiology, nuclear medicine or radiology. Hybrid PET/CT and SPECT/CT represent new technologies that were introduced recently in clinical medicine and are evolving rapidly with several improvements in instrumentation, imaging procedures as well as in clinical trials that support the expanded role of these technologies in clinical practice. As such, an updated 4th edition of the Atlas is critical in order for the clinicians remain current with the imaging field and maintain their skills. Imaging protocols with the se technologies have to be updated and/or expanded in order to acquire high quality images at a reduced radiation burden to the patient while advancing the application of these techniques for more advanced disease detection. Accordingly, beyond significantly updating the chapters from the 3rd edition, 2 new chapters will be introduced in the 4th edition, which reflects the expanded clinical applications of the technologies in the past 3 years. The new chapters are as follows: "Hybrid SPECT/CT and PET/CT Imaging" and a dedicated chapter on "Radiation Safety and Exposure: Clinical Decision-Making and the Risk-Benefit Ratio". Chapter 7 from the 3rd edition will be deleted. The updated Atlas will serve as a reference source for all cardiologists, radiologists, and nuclear medicine physicians interested in the most up-to-date approaches to noninvasive diagnostic cardiovascular nuclear imaging techniques for the evaluation of patients with known or suspected coronary artery disease as well as non-coronary heart disease. It will also serve as a ready reference textbook for medical students and residents interested in the practice of cardiovascular medicine.

Preventive Cardiology A Companion To Braunwald S Heart Disease E Book

Author : Roger Blumenthal
ISBN : 9781437737851
Genre : Medical
File Size : 53. 88 MB
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Endorsed by the American Society for Preventive Cardiology! Preventive Cardiology - a new Companion to Braunwald’s Heart Disease - addresses the prevention and risk stratification of cardiovascular disease so that you can delay the onset of disease and moderate the effects and complications. Drs. Roger Blumenthal, JoAnne Foody, and Nathan Wong discuss the full range of relevant considerations, including the epidemiology of heart disease, risk assessment, risk factors, multiple risk factor-based prevention strategies, and developments in genetics and personalized medicine. This authoritative reference gives you the clinically relevant information you need for the effective prevention of cardiovascular disease. Recognize the factors for prevention and risk stratification around cardiovascular disease and effectively delay the onset of disease and moderate the effects and complications, even for individual who are genetically predisposed. Effectively navigate full range of considerations in prevention from epidemiology of heart disease, biology of atherosclerosis and myocardial infraction, risk assessment—established risk factors and emerging risk factors, multiple risk factor-based prevention strategies, and future directions—through genetics, personalized medicine, and much more. Tap into the expertise of prominent leaders in cardiovascular disease prevention with guidance from Drs. Roger Blumenthal—longtime director of the Framingham Heart Study—JoAnne Foody, and Nathan Wong. Gain a deeper understanding of the pathogenesis of disease and the rationale for management through discussions of basic science. Apply current clinical practice guidelines to ensure optimal outcomes in both primary and secondary prevention.

Heart Failure An Issue Of Cardiology Clinics

Author : Howard J Eisen
ISBN : 9780323277839
Genre : Medical
File Size : 45. 48 MB
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Over 5.7 million people in America carry a diagnosis of heart failure, the incidence of which approaches 1 in 100 people over the age of 65. The cost to society is estimated at $29 billion annually and over 1.1 million hospital admissions. For hospitalized heart failure patients, the 30-day readmission rate approaches 25%. As our population ages these numbers are expected to grow. This issue of Cardiology Clinics helps practitioners to manage patients at all ACC/AHA stages of heart failure and addresses key issues that include sudden cardiac death, arrhythmias, acute decompensated heart failure, and heart failure with preserved ejection fraction.

Molecular Cardiology For The Cardiologists

Author : Bernard Swynghedauw
ISBN : 9781461520191
Genre : Medical
File Size : 68. 36 MB
Format : PDF
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Molecular Cardiology for the Cardiologist provides a short, easily readable summary of what the new biology brings to cardiology. With this in mind, special efforts have been made to present many comprehensive schemes and drawings, as well as teaching tables. The five parts of the book provide a general introduction to the new language of biology; the normal structure of the heart and blood vessels; the physiopathology and the new therapeutic avenues that have been opened up by the new biology. A concise summary of the keys that assist the cardiologist or student who seeks to learn and read more about this field. Provides practical examples to illustrate the clinical interest of the new approach.

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