bio assays for oxidative stress status

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Bio Assays For Oxidative Stress Status

Author : W.A. Pryor
ISBN : 9780080929927
Genre : Science
File Size : 31. 79 MB
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This work contains over thirty chapters by leading researchers in the field of oxidative biology, originally presented as articles in an extended Forum in the highly-cited journal, Free Radical Biology & Medicine. The papers in this Forum (or Symposium-in-print) spanned seven issues of the journal, over many months. This is the first time that all of these expert contributions are presented in one place. Reliable methods for measuring OSS in organisms are essential. These would, amongst other things, offer applications as early warning signals for cancer and heart disease - eventually giving a range of measurable oxidation products best related to any given disease state. Additional observations relevant to OSS include: how much do measures of OSS vary in a group of humans? Does OSS decrease as a result of life-change factors and does it increase with age? With disease? With stress? Can a non-invasive, reliable, reputable measure of OSS be identified? This informative book provides the reader with the latest status of studies into OSS, currently used examples of BOSS, and answers to at least some of the questions posed above.

Oxidative Stress And Biomaterials

Author : Thomas Dziubla
ISBN : 9780128032701
Genre : Technology & Engineering
File Size : 44. 57 MB
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Oxidative Stress and Biomaterials provides readers with the latest information on biomaterials and the oxidative stress that can pose an especially troubling challenge to their biocompatibility, especially given the fact that, at the cellular level, the tissue environment is a harsh landscape of precipitating proteins, infiltrating leukocytes, released oxidants, and fluctuations of pH which, even with the slightest shift in stasis, can induce a perpetual state of chronic inflammation. No material is 100% non-inflammatory, non-toxic, non-teratogenic, non-carcinogenic, non-thrombogenic, and non-immunogenic in all biological settings and situations. In this embattled terrain, the most we can hope for from the biomaterials we design is a type of “meso-compatibility, a material which can remain functional and benign for as long as required without succumbing to this cellular onslaught and inducing a local inflammatory reaction. Explores the challenges of designing and using biomaterials in order to minimize oxidative stress, reducing patterns of chronic inflammation and cell death Brings together the two fields of biomaterials and the biology of oxidative stress Provides approaches for the design of biomaterials with improved biocompatibility

Redox Proteomics

Author : Isabella Dalle-Donne
ISBN : 9780471973119
Genre : Science
File Size : 58. 97 MB
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Methodology and applications of redox proteomics The relatively new and rapidly changing field of redox proteomics has the potential to revolutionize how we diagnose disease, assess risks, determine prognoses, and target therapeutic strategies for people with inflammatory and aging-associated diseases. This collection brings together, in one comprehensive volume, a broad array of information and insights into normal and altered physiology, molecular mechanisms of disease states, and new applications of the rapidly evolving techniques of proteomics. Written by some of the finest investigators in this area, Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases examines the key topics of redox proteomics and redox control of cellular function, including: * The role of oxidized proteins in various disorders * Pioneering studies on the development of redox proteomics * Analytical methodologies for identification and structural characterization of proteins affected by oxidative/nitrosative modifications * The response and regulation of protein oxidation in different cell types * The pathological implications of protein oxidation for conditions, including asthma, cardiovascular disease, diabetes, preeclampsia, and Alzheimer's disease Distinguished by its in-depth discussions, balanced methodological approach, and emphasis on medical applications and diagnosis development, Redox Proteomics is a rich resource for all professionals with an interest in proteomics, cellular physiology and its alterations in disease states, and related fields.

Impacts Of Oil Spill Disasters On Marine Habitats And Fisheries In North America

Author : J. Brian Alford
ISBN : 9781466557208
Genre : Science
File Size : 71. 50 MB
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At an increasingly global scale, aquatic scientists are heavily entrenched in understanding the fate of marine ecosystems in the face of human-altered environments. Oil spill disasters, especially large-scale ones like the 2010 Deepwater Horizon tragedy, have left uncertain and indelible marks on marine ecosystems. Impacts of Oil Spill Disasters on Marine Habitats and Fisheries in North America contains independent scientific findings and critical reviews from experts researching the impacts of the Exxon Valdez, Ixtoc I, and Deepwater Horizon oil spills on coastal fishery resources. Comprised of three sections, this seminal work: Details the physiological effects of oil-derived compounds on fishes, presenting results from field and laboratory investigations Addresses the science of assessing the impacts of oil spills and oil response measures on coastal habitats, with an emphasis on salt-marsh ecosystems in the Gulf of Mexico Explores the quantified and potential impacts of oil spills on population and community dynamics of commercial and recreational fishery species Provides newly released results from the 25-year recovery of marine mammals, birds, and fishes following the Exxon Valdez spill Chapters discuss new techniques for collecting and processing blood samples for toxicity testing, new aerial radar techniques for detecting unseen oil on marshes, consequences of oil prevention measures (such as diverting fresh water to estuaries or building sand berms to stop oil) on coastal fishery resources, and non-traditional methods for assessing the herring stock in Prince William Sound, Alaska, USA following the Exxon Valdez disaster.

Critical Reviews Of Oxidative Stress And Aging

Author : Richard G. Cutler
ISBN : 9789812775733
Genre : FAMILY & RELATIONSHIPS
File Size : 27. 88 MB
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This two-volume reference examines the translational research field of oxidative stress and ageing. It focuses on understanding the molecular basis of oxidative stress and its associated age-related diseases, with the goal of developing new methods for treating the human ageing processes.

Pharmaceutical Bioassays

Author : Shiqi Peng
ISBN : 0470522194
Genre : Medical
File Size : 79. 89 MB
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The definitive compendium of bioassay procedures and applications A virtual encyclopedia of key bioassay protocols, this up-to-date, essential resource reviews the methods and applications of bioassays that quantify drug activity and evaluate the validity of pharmacological models. Demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules, the book covers the evaluation and screening of drug compounds in a wide spectrum of therapeutic categories. Throughout, the authors use various models to link experimental observations with findings that clarify the effect of drug compounds on cellular biology and measure the pharmacological activity of chemical substances. This provides an important technological platform for successful drug research and clinical therapy, making Pharmaceutical Bioassays an ideal sourcebook for pharmacologists, pharmaceutical and medical researchers, analytical chemists, toxicologists, and students. Just as a fundamental knowledge of pharmaceutical bioassays is vital to understanding how bioactive agents and new drugs are defined, discovered, and developed, so too is this indispensable reference, which: Offers a complete reference on pharmaceutical bioassays and their specific applications in the assessment of therapies for cancer, Alzheimer's, diabetes, epilepsy, inflammation, antimalarials, pharmacogenomics, and other major therapeutic areas Covers bioassays that measure toxicity, including those for chemical toxicity and hepatoxicity—a particularly significant consideration in the development of safe and tolerable medications Highlights clinically relevant methods, ideas, and techniques to support any pharmaceutical researcher Suggests guidelines and systems to enhance communication between pharmacologists, chemists, and biologists Provides an informative analysis of pharmaceutical bioassay technologies and lab applications

American Book Publishing Record

Author :
ISBN : STANFORD:36105111052903
Genre : Books
File Size : 25. 10 MB
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Advances In Plant Ecophysiology Techniques

Author : Adela M. Sánchez-Moreiras
ISBN : 9783319932330
Genre : Science
File Size : 25. 34 MB
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This handbook covers the most commonly used techniques for measuring plant response to biotic and abiotic stressing factors, including: in vitro and in vivo bioassays; the study of root morphology, photosynthesis (pigment content, net photosynthesis, respiration, fluorescence and thermoluminiscence) and water status; thermal imaging; the measurement of oxidative stress markers; flow cytometry for measuring cell cycle and other physiological parameters; the use of microscope techniques for studying plant microtubules; programmed-cell-death; last-generation techniques (metabolomics, proteomics, SAR/QSAR); hybridization methods; isotope techniques for plant and soil studies; and the measurement of detoxification pathways, volatiles, soil microorganisms, and computational biology.

Oxidative Stress Diagnostic Methods And Applications In Medical Science

Author : Pawan Kumar Maurya
ISBN : 9789811047114
Genre : Science
File Size : 30. 20 MB
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This book discusses the importance of oxidative stress, related biomarkers, and its diagnostic methods including bio-analytical and advanced detection systems. Oxidative stress is associated with diminished capacity of a biological system to overcome the overproduction of reactive oxygen species. Since oxidative stress has been suggested as a causative factor in many diseases, its prevention is vital, and there is an urgent need for oxidative stress monitoring using in vitro and in vivo models. Interdisciplinary approaches have lead to the development of various oxidative stress monitoring models for real-world clinical and biomedical applications. The development of such methods requires a broad understanding of biology, chemistry, molecular biology, immunology and microbiology. As such, the book is a valuable resource for students, researchers and clinicians interested in the fundamental as well as applied aspects of oxidative stress associated diseases.

Antioxidants In Sport Nutrition

Author : Manfred Lamprecht
ISBN : 9781466567573
Genre : Medical
File Size : 77. 78 MB
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The use of antioxidants in sports is controversial due to existing evidence that they both support and hinder athletic performance. Antioxidants in Sport Nutrition covers antioxidant use in the athlete ́s basic nutrition and discusses the controversies surrounding the usefulness of antioxidant supplementation. The book also stresses how antioxidants may affect immunity, health, and exercise performance. The book contains scientifically based chapters explaining the basic mechanisms of exercise-induced oxidative damage. Also covered are methodological approaches to assess the effectiveness of antioxidant treatment. Biomarkers are discussed as a method to estimate the bioefficacy of dietary/supplemental antioxidants in sports. This book is useful for sport nutrition scientists, physicians, exercise physiologists, product developers, sport practitioners, coaches, top athletes, and recreational athletes. In it, they will find objective information and practical guidance.

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