biocatalysts and enzyme technology

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Biocatalysts And Enzyme Technology

Author : Klaus Buchholz
ISBN : 9783527672004
Genre : Science
File Size : 81. 70 MB
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This second edition of a bestselling textbook offers an instructive and comprehensive overview of our current knowledge of biocatalysis and enzyme technology. The book now contains about 40% more printed content. Three chapters are completely new, while the others have been thoroughly updated, and a section with problems and solutions as well as new case studies have been added. Following an introduction to the history of enzyme applications, the text goes on to cover in depth enzyme mechanisms and kinetics, production, recovery, characterization and design by protein engineering. The authors treat a broad range of applications of soluble and immobilized biocatalysts, including wholecell systems, the use of non-aqueous reaction systems, applications in organic synthesis, bioreactor design and reaction engineering. Methods to estimate the sustainability, important internet resources and their evaluation, and legislation concerning the use of biocatalysts are also covered.

Technological Applications Of Biocatalysts

Author :
ISBN : UOM:39015032910690
Genre : Technology & Engineering
File Size : 72. 82 MB
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This book builds upon a knowledge of the properties of enzymes and shows how these important catalysts can be used in industry. The central theme demonstrates how proteins, especially enzymes and immunoglobins can be isolated, characterised and produced on a large scale. Specific examples are given and both practical and theoretical aspects are examined. Applications for a wide range of metabolites are described with particular emphasis on the design, performance and production of biosensors. * Step-by-step logical development * Student centered learning style * Texts planned by both industry and academia The need for a cost effective training scheme for new and existing staff at all levels has been met by the University of Greenwich (formerly Thames Polytechnic) and the Open University of the Netherlands. As part of the European Community Education and Technology Training initiative (COMETT) and in conjunction with a number of other leading UK and European universities, they are developing BIOTOL, a training scheme in biotechnology using open learning materials, which will provide tailor-made courses, flexible in content, pace and place. 'This is a particularly useful learning resource for people wanting to broaden their knowledge in biotechnology either informally or by extending their formal education in MScs and similar courses.' - Journal of Chemical Tech & Biotechnology, July 1995

Enzyme Biocatalysis

Author : Andrés Illanes
ISBN : 9781402083617
Genre : Technology & Engineering
File Size : 67. 50 MB
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This book was written with the purpose of providing a sound basis for the design of enzymatic reactions based on kinetic principles, but also to give an updated vision of the potentials and limitations of biocatalysis, especially with respect to recent app- cations in processes of organic synthesis. The ?rst ?ve chapters are structured in the form of a textbook, going from the basic principles of enzyme structure and fu- tion to reactor design for homogeneous systems with soluble enzymes and hete- geneous systems with immobilized enzymes. The last chapter of the book is divided into six sections that represent illustrative case studies of biocatalytic processes of industrial relevance or potential, written by experts in the respective ?elds. We sincerely hope that this book will represent an element in the toolbox of gr- uate students in applied biology and chemical and biochemical engineering and also of undergraduate students with formal training in organic chemistry, biochemistry, thermodynamics and chemical reaction kinetics. Beyond that, the book pretends also to illustrate the potential of biocatalytic processes with case studies in the ?eld of organic synthesis, which we hope will be of interest for the academia and prof- sionals involved in R&D&I. If some of our young readers are encouraged to engage or persevere in their work in biocatalysis this will certainly be our more precious reward.

Enzyme Technology

Author : Ashok Pandey
ISBN : 0387292942
Genre : Medical
File Size : 76. 58 MB
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This book is a unique resource for state-of-the-art research findings on biotechnological enzyme innovations. It provides a great deal of information on the potential of enzymes for commercial exploitation. The book includes photographs, figures, and tables.

Enzyme Technologies

Author : Wu-Kuang Yeh
ISBN : 9781118125038
Genre : Science
File Size : 57. 43 MB
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An authoritative review of the latest developments in thechemical biology of enzymes In the first decade of the twenty-first century, enzymes andtheir multiple applications have played a critical role in thediscovery and development of many new therapeutic agents.This bookis a coordinated compilation of research expertise and currentopinion uniquely focused on enzymes and their properties andapplications. Compiled by editors with a combined pharmaceutical experience ofover sixty years, the text provides in-depth reviews of recentdevelopments in selective topics on biosynthesis, biocatalysis, andchemical biology of enzymes as it applies to drug discovery,development, and manufacture. The first in a multi-part series on enzymes, this volumefeatures three sections: New Approaches to Find and Modify Enzymes describes the emergingfield of metagenomics, presents the practical applications ofdirected evolution to enzymes and pathways, and explores approachesfor the discovery and design of biocatalysts Biocatalytic Applications reviews specific applications ofdifferent reactions in producing active pharmaceutical ingredientsand surveys recent developments employing enzymes in organicsynthesis Biosynthetic Applications goes over successful drug discoveriesand developments by combinatorial biosynthesis and reviews theapplication of combinatorial biosynthesis among multiple compatiblehosts These timely discussions, which cover everything from chemicalbiology of enzymes, to the redesign of binding and catalyticspecificities of enzymes, make this volume a valuable tool forkeeping up to date. As such, it is an important read forresearchers, students, and professors in the study ofbiotechnology, life sciences, biochemistry, enzymology, medicinalchemistry, and natural products.

Microbial Enzyme Technology In Food Applications

Author : Ramesh C. Ray
ISBN : 9781498749848
Genre : Technology & Engineering
File Size : 48. 14 MB
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The aim of food processing is to produce food that is palatable and tastes good, extend its shelf-life, increase the variety, and maintain the nutritional and healthcare quality of food. To achieve favorable processing conditions and for the safety of the food to be consumed, use of food grade microbial enzymes or microbes (being the natural biocatalysts) is imperative. This book discusses the uses of enzymes in conventional and non-conventional food and beverage processing as well as in dairy processing, brewing, bakery and wine making. Apart from conventional uses, the development of bioprocessing tools and techniques have significantly expanded the potential for extensive application of enzymes such as in production of bioactive peptides, oligosaccharides and lipids, flavor and colorants. Some of these developments include extended use of the biocatalysts (as immobilized/encapsulated enzymes), microbes (both natural and genetically modified) as sources for bulk enzymes, solid state fermentation technology for enzyme production. Extremophiles and marine microorganisms are another source of food grade enzymes. The book throws light on potential applications of microbial enzymes to expand the base of food processing industries.

Biocatalysis For The Pharmaceutical Industry

Author : Junhua (Alex) Tao
ISBN : 9780470823156
Genre : Science
File Size : 22. 12 MB
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Biocatalysis is rapidly evolving into a key technology for the discovery and production of chemicals, especially in the pharmaceutical industry, where high yielding chemo-, regio-, and enantioselective reactions are critical. Taking the latest breakthroughs in genomics and proteomics into consideration, Biocatalysis for the Pharmaceutical Industry concisely yet comprehensively discusses the modern application of biocatalysis to drug discovery, development, and manufacturing. Written by a team of leading experts, the book offers deep insight into this cutting edge field. Covers a wide range of topics in a systematic manner with an emphasis on industrial applications Provides a thorough introduction to the latest biocatalysts, modern expression hosts, state-of-the-art directed evolution, high throughput screening, and bioprocess engineering Addresses frontier subjects such as emerging enzymes, metabolite profiling, combinatorial biosynthesis, metabolic engineering, and autonomous enzymes for the synthesis and development of chiral molecules, drug metabolites, and semi-synthetic medicinal compounds and natural product analogs Highlights the impact of biocatalysis on green chemistry Contains numerous graphics to illustrate concepts and techniques Biocatalysis for the Pharmaceutical Industry is an essential resource for scientists, engineers, and R&D policy makers in the fine chemical, pharmaceutical, and biotech industries. It is also an invaluable tool for academic researchers and advanced students of organic and materials synthesis, chemical biology, and medicinal chemistry.

Biocatalysis Based On Heme Peroxidases

Author : Eduardo Torres
ISBN : 3642126278
Genre : Science
File Size : 77. 3 MB
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The last systematic description of heme peroxidases was published in 1999 by Brian Dunford, from the University of Alberta in Canada. The book Heme per- idases covers discussion on three-dimensional structure, reaction mechanism, kinetics, and spectral properties of representative enzymes from bacterial, plant, fungal, and animal origin. Since 1999, vast information on basic but also applied aspects of heme peroxidases has been generated. We believe fusion of these two aspects will bene?t research of those dedicated to development of biocatalytic process. The aim of this book is to present recent advances on basic aspects such as evolution, structure–function relation, and catalytic mechanism, as well as applied aspects, such as bioreactor and protein engineering, in order to provide the tools for rational design of enhanced biocatalysts and biocatalytic processes. The book does not include an exhaustive listing of references but rather a selected collection to enrich discussion and to allow envisioning future directions for research. This book is organized in three parts. In Part I, current knowledge of structure and mechanism of peroxidases is covered. From the molecular phylogeny, going through the in?uence of structural factors over oxidative ability to the molecular mechanism of catalysis, the authors intend to provide an understanding of per- idases at the molecular level. The understanding of the fundamental behavior of peroxidases will allow further adequation, design, and/or optimization of pero- dase-based catalysis to a particular process. In Part II, research on potential applications of peroxidases in several ?elds is presented and discussed.

Enzyme Technologies

Author : Hsiu-Chiung Yang
ISBN : 9781118739891
Genre : Science
File Size : 50. 79 MB
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Sets the stage for advances in drug discovery using thelatest enzyme technology Reviewing new and emerging applications of enzyme technology indrug discovery, this book highlights some of the most promisingareas of pharmaceutical and biotechnology research. It coversenzyme assay technology, utilization of enzymology for prodrugdesign, and the application of enzymes as therapeutic agents.Expert reviews highlight how our latest understanding of enzymologyis used to develop new practical applications in drug discovery anddesign. Filled with case studies, Enzyme Technologies: PluripotentPlayers in Discovering Therapeutic Agents enables readers tobetter understand the diverse functions of enzymes and masterspecific applications in drug discovery research. In addition tosmall molecule drug discovery, the book explores new developmentsin enzymes as therapeutic agents for genetic disorders. Section A, Enzymes – Essential Workhorses inPharmaceutical Research, offers support in selecting the bestenzyme targets for drug discovery, designing enzyme inhibitors fortherapeutic agents, and evaluating selective enzymeinhibitors. Section B, Enzymes – Indispensable Tools for ImprovingDruggability, sets forth the principles alongside real-worldexamples of exploiting specific properties of enzymes to designsuccessful prodrugs. Section C, Enzymes – Powerful Weapons for CorrectingNature's Errors, provides new insights on applying enzymes astherapeutic agents or diagnostic tools to treat geneticdisorders. Chapters are contributed by leading experts from around theworld. Their contributions are based on a thorough review of thecurrent literature as well as their own research. Reviewing our latest understanding of the nature of enzymes andtheir role in drug discovery, this book is recommended forresearchers in pharmaceuticals and biotechnology as well as forresearchers in enzymology, biochemistry, molecular biology, andmedicinal chemistry.

Biotechnology Of Microbial Enzymes

Author : Goutam Brahmachari
ISBN : 9780128037461
Genre : Medical
File Size : 64. 44 MB
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Biotechnology of Microbial Enzymes: Production, Biocatalysis and Industrial Applications provides a complete survey of the latest innovations on microbial enzymes, highlighting biotechnological advances in their production and purification along with information on successful applications as biocatalysts in several chemical and industrial processes under mild and green conditions. Applications of microbial enzymes in food, feed, and pharmaceutical industries are given particular emphasis. The application of recombinant DNA technology within industrial fermentation and the production of enzymes over the last 20 years have produced a host of useful chemical and biochemical substances. The power of these technologies results in novel transformations, better enzymes, a wide variety of applications, and the unprecedented development of biocatalysts through the ongoing integration of molecular biology methodology, all of which is covered insightfully and in-depth within the book. Features research on microbial enzymes from basic science through application in multiple industry sectors for a comprehensive approach Includes information on metabolic pathway engineering, metagenomic screening, microbial genomes, extremophiles, rational design, directed evolution, and more Provides a holistic approach to the research of microbial enzymes

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