bisphosphonates in bone disease from the laboratory to the patient

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Bisphosphonates In Bone Disease

Author : Herbert Fleisch
ISBN : 0080528112
Genre : Medical
File Size : 56. 59 MB
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This book is an essential handbook on bisphosphonates, the most widely used new class of drugs for osteoporosis therapy. It reviews basic physiology in addition to the indications and adverse reactions of these drugs. Bisphosphonates in Bone Disease, 4E, discusses the compounds' chemistry, mechanisms of action, and animal toxicology before presenting a clinical picture of the diseases treated by bisphosphonates. The book provides a table listing the trade names of the commercially available bisphosphonates, registered indications, and the available forms for various countries. The revised Fourth Edition contains approximately 50% new material, including information on all of the latest drugs. * The revised fourth edition contains approximately 50% new material * Includes information on all the latest drugs

Osteogenesis Imperfecta

Author : Peter H. Byers
ISBN : 9780123977892
Genre : Medical
File Size : 48. 65 MB
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Osteogenesis Imperfecta is the first translational reference professionals can turn to for a source of comprehensive information on this disorder. Although several reviews of the field have been published in various journals, there is no other single source for a compendium of current information. Separate chapters discuss each of the several clinical features of OI. Ethical issues related to OI are discussed, as is the importance of nutrition in managing the OI child and the OI adult. The role of physical medicine and rehabilitation for OI patients is also presented, along with the current status of OI medical treatment and the prospects for genetic engineering in the future. The text also provides the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI. Incorporates chapters and information on the ethical issues related to osteogenesis imperfecta (OI) as will the importance of nutrition in managing the OI child and the OI adult Offers new insights into the underlying mechanisms of collagen biochemistry as related to OI as well as a presentation of intracellular collagen processing and the expanded role of protein chaperones in OI Discusses the role of physical medicine and rehabilitation for OI patients and the current status of OI medical treatment as well as prospects for genetic engineering in the future Provides a unique overview for the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI

Bone Cancer

Author : Dominique Heymann
ISBN : 0080953883
Genre : Medical
File Size : 71. 97 MB
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The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research. This period of time has been marked by a number of key discoveries that have led to the opening up of entirely new areas for investigation as well as new therapies which combine surgery and biological therapeutic approaches. Bone is a common site of cancer metastases - cancer cells commonly develop in bone and spread to other organ systems through the bloodstream. For example, the incidence of bone metastases in breast and prostate cancers is 70%, whereas it is only 30 to 40% in metastatic lung cancer. In clinical terms, bone metastases have substantial negative effects on a patient's quality of life and are a main cause of patient mortality. Given the global prevalence of breast and prostate cancers, knowledge of bone biology has become essential for the medical and cancer research communities. This book provides, all in one resource, the most recent data on bone cancer development (cellular and molecular mechanisms), genomic and proteomic analyses, clinical analyses (histopathology, imaging, pain monitoring), as well as new therapeutic approaches and clinical trials for primary bone tumors and bone metastases. Feature Presents a comprehensive, translational source for all aspects of bone cancer in one reference work Bone cancer experts (from all areas of research and practice) take readers from the bench research (cellular and molecular mechanism), through genomic and proteomic analysis, all the way to clinical analysis (histopathology and imaging) and new therapeutic approaches. Clear presentation by bone biologists of the cellular and molecular mechanisms underlying bone tumors and bone cancer metastasis as well as the genomic and proteomic assays used in detecting cancer within given organ systems Clear presentation by oncologists and radiologists of how histopathology, imaging, and pain monitoring can lead to new therapeutic approaches Benefit Saves researchers and clinicians time in quickly accessing the very latest details on a broad range of bone cancer issues, as opposed to searching through thousands of journal articles. Provides a common language for cancer researchers, bone biologists, oncologists, and radiologists to discuss bone tumors and how bone cancer metastases affects each major organ system Correct diagnosis (and therefore correct treatment) of cancer depends on a strong understanding of the molecular basis for the disease – both oncologists and radiologists will benefit Bone biologists will gain insight into how clinical observations and practices can feed back into the research cycle and will, therefore, be able to develop more targeted genomic and proteomic assays

Bone Disease In Rheumatology

Author : Michael J. Maricic
ISBN : 0781753015
Genre : Medical
File Size : 88. 46 MB
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Geared toward rheumatologists, this book examines the diagnosis, prevention, and treatment of bone loss in patients with inflammatory diseases. Drs. Maricic and Gluck—along with contributors from bone biology, diagnosis, imaging, biomarkers, and treatment—have developed a comprehensive, practical text on this specific aspect of rheumatology. Bone Disease in Rheumatology provides cutting-edge information on the pathophysiology of systemic and focal bone loss (erosions) in inflammatory disorders, the tools used to assess and measure bone loss, and the medications used in management of bone loss associated with rheumatic diseases. The book also discusses common and uncommon metabolic bone disorders, emphasizing state-of-the-art management techniques.

Osteoporosis An Issue Of Endocrinology And Metabolism Clinics E Book

Author : Sol Epstein
ISBN : 9781455748440
Genre : Medical
File Size : 71. 63 MB
Format : PDF
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This issue of Endocrinology and Metabolism Clinics provides a comprehensive review of osteoporosis written by the world's leading experts. Topics include new mechanistic insights into pathophysiology; bisphosphonates; combination therapy; atypical fractures; non-BP anti resorbers; anabolic therapies; calcium; the impact of Vitamin D on bones; extraskeletal effects of Vitamin D; glucocorticoid osteoporosis; relation to anorexia nervosa, coeliac disease, and diabetes; and male osteoporosis.

Dental Management Of The Medically Compromised Patient E Book

Author : James W. Little
ISBN : 9780323088015
Genre : Medical
File Size : 89. 96 MB
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Learn how common medical conditions can affect the course of the dental treatment a patient receives. This updated, concise reference provides the information you need to provide appropriate dental care to any patient, regardless of existing medical conditions. Featuring vivid illustrations and well-organized tables in each chapter, this text gives you the in-depth details and the overall summaries you need to get to the root of your patients’ needs. Organization of medical conditions provides a brief overview of the basic disease process, epidemiology, pathophysiology, signs and symptoms, laboratory findings, and currently accepted medical therapy of each disorder. This is followed by a detailed explanation and recommendations for specific dental management. Coverage of dosages, side effects, and drug interactions with medications used in dentistry, including those used during pregnancy. Chapters focusing on major health problems in the US and other nations include, ischemic hearth disease, smoking and tobacco use cessation, sleep-related breathing disorders, sexually transmitted diseases, diabetes mellitus, and psychiatric disorders. Dental management summary table summarizes important factors for consideration in the dental management of medically compromised patients. Appendix on the therapeutic management of common oral lesions provides a quick reference to the causative factors, clinical description, currently accepted therapeutic management, and patient education regarding common oral conditions. Appendix on alternative and complementary drugs looks at herbal remedies, specifically efficacy, adverse effects/reactions, medical problems, drug interactions, and dental implications. NEW! Chapter on drug and alcohol abuse discusses the effects of marijuana, cocaine, amphetamines/methamphetamine, and alcohol, along with considerations for both medical and dental management. NEW! 2009 AAOS statement on Antibiotic Prophylaxis for Bacteremia in Patients with Joint Replacements provides recommendations to supplement practitioners in their clinical judgment regarding antibiotic prophylaxis for patients with a joint prosthesis.

The Bone And Mineral Manual

Author : Michael Kleerekoper
ISBN : 0080470742
Genre : Medical
File Size : 76. 24 MB
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*Brings together up-to-date bone and mineral metabolism methods in one easily, accessible volume *Provides a quick reference for bone and mineral disorders *Addresses problems likely to be seen at all ages, from the pre-term infant to the centenarian *Ideal for practicing physicians, residents, medical students, and researchers

Myeloma Bone Disease

Author : G. David Roodman
ISBN : 1607615541
Genre : Medical
File Size : 24. 69 MB
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This book presents the forefront in the science and clinical management of myeloma bone disease. Coverage begins with sections on clinical presentation, imaging, and biochemical markers and goes on to discuss radiation, surgical, and medical therapies.

Abstracts From The Eight Workshop On Cell Biology Of Bone And Cartilage In Health And Disease

Author :
ISBN : OCLC:67754395
Genre :
File Size : 34. 3 MB
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Bone Metastases

Author : Vassilios Vassiliou
ISBN : 9789400775695
Genre : Medical
File Size : 90. 80 MB
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The second edition of this book serves both as an introductory and reference book focusing on the field of metastatic bone disease. Featuring contributions from experts in the field, this volume describes the molecular and cellular mechanisms involved in the formation of bone metastases, presents the newer advances made in the understanding of the clinical picture and symptoms of patients, analyses the role of bone markers in research and clinical practice and deals with all aspects of imaging modalities applied for the detection and evaluation of bone metastases. Moreover, the use of all available treatment methods, such as radiotherapy, surgery and systemic treatments for the management of patients with metastatic bone disease is discussed in detail. Overall this volume presents a thorough overview of all aspects of metastatic bone disease and provides a comprehensive and concise information resource for researchers, oncologists, orthopaedic surgeons and clinicians dealing with patients with metastatic bone disease.

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