cadmium from toxicity to essentiality 11 metal ions in life sciences

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Metal Ions In Biological Systems

Author : Helmut Sigel
ISBN : 0824775406
Genre : Science
File Size : 35. 23 MB
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Metal Ions in Biological Systems is devoted to increasing our understanding of the relationship between the chemistry of metals and life processes. The volumes reflect the interdisciplinary nature of bioinorganic chemistry and coordinate the efforts of researchers in the fields of biochemistry, inorganic chemistry, coordination chemistry, environmental chemistry, biophysics, pharmacy, and medicine. Volumes deal with such topics as the formation, stability, structure, and reactivity of biological compounds of low and high molecular weight containing metal ions; the metabolism and transport of metal ions and their complexes; and new models of complicated natural structures and processes. Volume 20: Concepts on Metal Ion Toxicity is a logical consequence of the previous Volume 18: Circulation of Metals in the Environment. It focuses on the interrelationship between the chemistry of metal ions and their toxicologic properties. In 11 stimulating chapters by leading international experts, this authoritative volume examines the distribution of potentially hazardous metal ions, their bioinorganic chemistry, and their speciation, as well as metal ion toxicity to aquatic ecosystems, to agricultural crops, to man and animals, including nutritional aspects. Chromosome damage and carcinogenesis by metal ions are considered, and methods are summarized for the in vitro assessment of metal ion toxicity and the analysis of biological materials for toxic trace elements. With nearly 1000 references to assist further research, Concepts on Metal Ion Toxicity is an essential resource for scientists and students working in environmental chemistry; toxicology and nutrition; pharmacology; clinical chemistry; gerontology; enzymology; bioinorganic, inorganic, and coordination chemistry; and molecular biology. Book jacket.

Cadmium From Toxicity To Essentiality

Author : Astrid Sigel
ISBN : 9789400751798
Genre : Science
File Size : 85. 92 MB
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Volume 11 provides in an authoritative and timely manner in 16 stimulating chapters, written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research area. MILS-11 covers the bioinorganic chemistry of Cd(II), its biogeochemistry, anthropogenic release into the environment, and speciation in the atmosphere, waters, soils, and sediments. The analytical tools for Cd determination, its imaging in cells, and the use of 113Cd NMR to probe Zn(II) and Ca(II) proteins are summarized, as are Cd(II) interactions with nucleotides, nucleic acids, amino acids, and proteins including metallothioneins. The phytoremediation by Cd(II)-accumulating plants, etc., the toxicology of Cd(II), its damage to mammalian organs, and its role as a carcinogen for humans, are highlighted.

Cadmium From Toxicity To Essentiality

Author : Astrid Sigel
ISBN : 9789400751798
Genre : Science
File Size : 46. 10 MB
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Volume 11 provides in an authoritative and timely manner in 16 stimulating chapters, written by 40 internationally recognized experts from 11 nations, and supported by more than 2600 references, 35 tables, and over 100 illustrations, many in color, a most up-to-date view on the role of cadmium for life, presently a vibrant research area. MILS-11 covers the bioinorganic chemistry of Cd(II), its biogeochemistry, anthropogenic release into the environment, and speciation in the atmosphere, waters, soils, and sediments. The analytical tools for Cd determination, its imaging in cells, and the use of 113Cd NMR to probe Zn(II) and Ca(II) proteins are summarized, as are Cd(II) interactions with nucleotides, nucleic acids, amino acids, and proteins including metallothioneins. The phytoremediation by Cd(II)-accumulating plants, etc., the toxicology of Cd(II), its damage to mammalian organs, and its role as a carcinogen for humans, are highlighted.

Interrelations Between Essential Metal Ions And Human Diseases

Author : Astrid Sigel
ISBN : 9789400775008
Genre : Science
File Size : 43. 12 MB
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MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.

The Alkali Metal Ions Their Role For Life

Author : Astrid Sigel
ISBN : 9783319217567
Genre : Science
File Size : 69. 28 MB
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MILS-16 provides an up-to-date review of the impact of alkali metal ions on life. Their bioinorganic chemistry and analytical determination, the solid state structures of bio-ligand complexes and the properties of alkali metal ions in solution in the context of all kinds of biologically relevant ligands are covered, this includes proteins (enzymes) and nucleic acids (G-quadruplexes). Minerals containing sodium (Na+) and potassium (K+) are abundant in the Earth's crust, making Na+ and K+ easily available. In contrast, the alkali elements lithium (Li+), rubidium, and cesium are rare and the radioactive francium occurs only in traces. Since the intra- and extracellular, as well as the compartmental concentrations of Na+ and K+ differ significantly, homeostasis and active transport of these ions are important; this involves transporters/carriers and pore-forming ion channel proteins. Systems like Na+/K+-ATPases, H+/K+-ATPases or Na+/H+ antiporters are thoroughly discussed. The role of K+ in photosynthesis and the role of Na+ in charging the "battery of life" are pointed out. Also, the relationships between alkali metal ions and diseases (e.g., Parkinson or traumatic brain injury) are covered and the relevance of Li+ salts in medicine (pharmacology and mechanism) is reviewed. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 16, The Alkali Metal Ions: Their Role for Life, which are written by 44 internationally recognized experts from 12 nations. The impact of this vibrant research area is manifested in nearly 3000 references, over 30 tables and more than 150 illustrations (two thirds in color). MILS-16 also provides excellent information for teaching. Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems.

Metallomics

Author : Marco Aurélio Zezzi Arruda
ISBN : 9783319901435
Genre : Science
File Size : 39. 98 MB
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This book covers the new Omics area, Metallomics. As Metallomics is intrinsically a transdisciplinary area, this book is authored by experts in the field on such diverse topics as Environmental, Nuclear, and Human Metallomics. Within these topics metals play important role, as being part of biomolecules, controlling different biochemical process, being signaling agents, being catalyst of biochemical reactions, among others. This volume demonstrates the importance of more investigation about metals and their interactions with biomolecules. As the knowledge in this field is growing and growing daily, then new challenges concerning studies involving Metallomics is appearing, such as comparative metallomics, speciation metallomics, real-time metallomics, new predictions of metals in biomolecules, metalloprotein databank expansion, interactions between metalloprotein-metalloprotein, among others.

The Metal Driven Biogeochemistry Of Gaseous Compounds In The Environment

Author : Peter M. H. Kroneck
ISBN : 9789401792691
Genre : Science
File Size : 39. 93 MB
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MILS-14 provides a most up-to-date view of the exciting biogeochemistry of gases in our environment as driven mostly by microorganisms. These employ a machinery of sophisticated metalloenzymes, where especially transition metals (such as Fe, Ni, Cu, Mo, W) play a fundamental role, that is, in the activation, transformation and syntheses of gases like dihydrogen, methane, carbon monoxide, acetylene and those of the biological nitrogen and sulfur cycles. The Metal-Driven Biogeochemistry of Gaseous Compounds in the Environment is a vibrant research area based mainly on structural and microbial biology, inorganic biological chemistry and environmental biochemistry. All this is covered in an authoritative manner in 11 stimulating chapters, written by 26 internationally recognized experts and supported by nearly 1200 references, informative tables and about 100 illustrations (two thirds in color). MILS-14 also provides excellent information for teaching. Peter M. H. Kroneck is a bioinorganic chemist who is exploring the role of transition metals in biology, with a focus on functional and structural aspects of microbial iron, copper and molybdenum enzymes and their impact on the biogeochemical cycles of nitrogen and sulfur. Martha E. Sosa Torres is an inorganic chemist, with special interests in magnetic properties of newly synthesized transition metal complexes and their reactivity towards molecular oxygen, applying kinetic, electrochemical and spectroscopic techniques.

Handbook On The Toxicology Of Metals

Author : Gunnar F. Nordberg
ISBN : 9780123973399
Genre : Medical
File Size : 73. 63 MB
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Handbook on the Toxicology of Metals, Fourth Edition bridges the gap between established knowledgebase and new advances in metal toxicology to provide one essential reference for all those involved in the field. This book provides comprehensive coverage of basic toxicological data, emphasizing toxic effects primarily in humans, but also those of animals and biological systems in vitro. The fourth edition also contains several new chapters on important topics such as nanotoxicology, metals in prosthetics and dental implants, gene-environment interaction, neurotoxicology, metals in food, renal, cardiovascular, and diabetes effects of metal exposures and more. Volume I covers “General Considerations and Volume II is devoted to “Specific Metals. A multidisciplinary resource with contributions from internationally-recognized experts, the fourth edition of the Handbook on the Toxicology of Metals is a prominent and indispensable reference for toxicologists, physicians, pharmacologists, engineers, and all those involved in the toxicity of metals. Contains 61 peer reviewed chapters dealing with the effects of metallic elements and their compounds on biological systems Includes information on sources, transport and transformation of metals in the environment and on certain aspects of the ecological effects of metals to provide a basis for better understanding of the potential for adverse effects on human health Covers the toxicology of metallic nanomaterials in a new comprehensive chapter Metal toxicology in developing countries is dealt with in another new chapter emphasizing the adverse effects on human health by the inadequate handling of "ewaste Other new chapters in the 4th edition include: Toxic metals in food; Toxicity of metals released from medical devices; Gene-environment interactions; Neurotoxicology of metals; Cardiovascular disease; Renal effects of exposure to metals; Gold and gold mining; Iridium; Lanthanum; Lithium and Rhodium

Metal Ions In Life Sciences Set

Author : Astrid Sigel
ISBN : 1849731179
Genre : Medical
File Size : 69. 38 MB
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Complete your toxicology information and plan for the future by getting familiar with metal/RNA systems including ribozymes

Metallothioneins And Related Chelators

Author : Astrid Sigel
ISBN : 9781847558992
Genre : Science
File Size : 29. 73 MB
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Chapters 3 to 5 give an account of bacterial MTs, MTs in yeast and fungi, and MTs in plants. Most astonishingly, the MTs of bacteria and plants contain next to cysteine also histidine residues and thus, metal ions are not only sulfur- but also imidazole-coordinated which gives rise to zinc finger-like structures. Remarkably, yeast and fungal MTs are Cu(I) rather than Zn(II) or Cd(II) binding proteins. Next, Chapters 6 through 9 discuss the MTs of dipteran insects, including the model organism Drosophila melanogaster, earthworms and nematodes, as well as echinoderms, crustaceans, molluscs, and fish. Actually, aquatic animals, both vertebrates and invertebrates, have the potential to be used for monitoring metal contamination in aquatic ecosystems. Interestingly, in Chapter 9 the remarkable speculation is presented that under chronic natural exposure conditions the animals establish a trade-off between the "cost" of detoxifying non-essential metals and the "cost" of allowing some of these metals to spill over onto metal-sensitive sites. This contrasts with laboratory experiments involving aquatic animals, where the toxicity of non-essential metals normally exhibits a threshold response: at low exposure concentrations the organisms can detoxify the incoming metal and thus, tolerate the exposure, whereas at concentrations above the threshold, the detoxification mechanism is no longer able to protect the organism completely.

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