chemistry of bioconjugates synthesis characterization and biomedical applications

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Chemistry Of Bioconjugates

Author : Ravin Narain
ISBN : 9781118776377
Genre : Science
File Size : 88. 79 MB
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Explores bioconjugate properties and applications of polymers, dendrimers, lipids, nanoparticles, and nanotubes Bioconjugation has enabled breakthroughs across many areas of industry and biomedicine. With its emphasis on synthesis, properties and applications, this book enables readers to understand the connection between chemistry and the biological application of bioconjugated materials. Its detailed descriptions of methods make it possible for researchers to fabricate and take full advantage of bioconjugates for a broad range of applications. Moreover, the book sets the foundation for the development of new applications, including assays, imaging, biosensors, drug delivery, and diagnostics. Chemistry of Bioconjugates features contributions from an international team of leading experts and pioneers in the field. These contributions reflect the authors’ firsthand laboratory experience as well as a thorough review of the current literature. The book’s six sections examine: General methods of bioconjugation Polymer bioconjugates Organic nanoparticle-based bioconjugates Inorganic nanomaterial bioconjugates, including metals and metal oxides Cell-based, hydrogel/microgel, and glyco-bioconjugates Characterization, physico-(bio)chemical properties, and applications of bioconjugates This comprehensive exploration of bioconjugates includes discussions of polymers, dendrimers, lipids, nanoparticles, and nanotubes. References at the end of each chapter serve as a gateway to the most important original research findings and reviews in the field. By drawing together and analyzing all the latest chemical methods and research findings on the physico-chemical and biochemical properties of bioconjugates, Chemistry of Bioconjugates sheds new light on the significance and potential of bioconjugation. The book is recommended for organic and polymer chemists, biochemists, biomaterial scientists, carbohydrate chemists, biophysicists, bioengineers, and drug and gene delivery scientists.

Bioconjugate Techniques

Author : Greg T. Hermanson
ISBN : 9780123822406
Genre : Science
File Size : 34. 13 MB
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Bioconjugate Techniques, 3rd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions, with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. Offers a one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Provides step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates Features full color illustrations Includes a more extensive introduction into the vast field of bioconjugation and one of the most thorough overviews of immobilization chemistry ever presented

Biomedical Applications Of Polymeric Materials And Composites

Author : Raju Francis
ISBN : 9783527690947
Genre : Technology & Engineering
File Size : 23. 99 MB
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With its content taken from only the very latest results, this is an extensive summary of the various polymeric materials used for biomedical applications. Following an introduction listing various functional polymers, including conductive, biocompatible and conjugated polymers, the book goes on to discuss different synthetic polymers that can be used, for example, as hydrogels, biochemical sensors, functional surfaces, and natural degradable materials. Throughout, the focus is on applications, with worked examples for training purposes as well as case studies included. The whole is rounded off with a look at future trends.

Engineered Carbohydrate Based Materials For Biomedical Applications

Author : Ravin Narain
ISBN : 9781118002247
Genre : Technology & Engineering
File Size : 56. 34 MB
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This book addresses the need for a comprehensive book on the design, synthesis, and characterization of synthetic carbohydrate-based polymeric materials along with their biological applications. The first two chapters cover the synthesis and self-assembly of glycopolymers and different techniques for creating these synthetic polymers. Subsequent chapters account for the preparation of block copolymers, branched glycopolymers, glycosurfaces, glycodendrimers, cationic glycopolymers, bioconjugates, glyconanoparticles and hydrogels. While these chapters comprehensively review the synthetic and characterization methods of those carbohydrate-based materials, their biological applications are discussed in detail.

Chemoselective And Bioorthogonal Ligation Reactions

Author : W. Russ Algar
ISBN : 9783527683475
Genre : Technology & Engineering
File Size : 73. 51 MB
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This timely, one-stop reference is the first on an emerging and interdisciplinary topic. Covering both established and recently developed ligation chemistries, the book is divided into two didactic parts: a section that focuses on the details of bioorthogonal and chemoselective ligation reactions at the level of fundamental organic chemistry, and a section that focuses on applications, particularly in the areas of chemical biology, biomaterials, and bioanalysis, highlighting the capabilities and benefits of the ligation reactions. With chapters authored by outstanding scientists who range from trailblazers in the field to young and emerging leaders, this book on a highly interdisciplinary topic will be of great interest for biochemists, biologists, materials scientists, pharmaceutical chemists, organic chemists, and many others.

Biomedical Applications Of Functionalized Nanomaterials

Author : Bruno Sarmento
ISBN : 9780323508797
Genre : Science
File Size : 61. 97 MB
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Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine. This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies. Provides an overview of the methodologies for biological target identification and ligand screening Includes case studies showing the development of functionalized nanomaterials and their biomedical applications Highlights the importance of functionalized nanomaterials for drug delivery, diagnostics and regenerative medicine applications

Emerging Applications Of Nanoparticles And Architectural Nanostructures

Author : Abdel Salam Hamdy Makhlouf
ISBN : 9780128135167
Genre : Science
File Size : 30. 67 MB
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Emerging Applications of Nanoparticles and Architecture Nanostructures: Current Prospects and Future Trends discusses the most important current applications of nanoparticles and architecture nanostructures in a comprehensive, detailed manner. The book covers major applications of nanoparticles and architecture nanostructures, taking into account their unusual shapes and high surface areas. In particular, coverage is given to applications in aerospace, automotive, batteries, sensors, smart textile design, energy conversion, color imaging, printing, computer chips, medical implants, pharmacy, cosmetics, and more. In addition, the book discusses the future of research in these areas. This is a valuable reference for both materials scientists, chemical and mechanical engineers working both in R&D and academia who want to learn more on how nanoparticles and nanomaterials are commercially applied. Provides an in-depth look at the properties of nanoparticles and architecture nanostructures in terms of their applicability for industrial uses Analyzes the most recent advances and industrial applications of different types of nanoparticles and architecture nanostructures, taking into account their unusual structures and compositions Identifies novel nanometric particles and architectures that are of particular value for applications and the techniques required to use them effectively

Bio Synthetic Hybrid Materials And Bionanoparticles

Author : Patrick van Rijn
ISBN : 9781782622109
Genre : Technology & Engineering
File Size : 43. 32 MB
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There is much interest in using biological structures for the fabrication of new functional materials. Recent developments in the particle character and behaviour of proteins and viral particles have had a major impact on the development of novel nanoparticle systems with new functions and possibilities. Bio-Synthetic Hybrid Materials and Bionanoparticles approaches the subject by covering the basics of disciplines involved as well as recent advances in new materials. The first section of the book focusses on the design and synthesis of different bionanoparticles and hybrid structures including the use of genetic modification as well as by organic synthesis. The second section of the book looks at the self-assembling behaviour of bionanoparticles to form new materials. The final section looks at bionanoparticle-based functional systems and materials including chapters on biomedical applications and electronic systems and devices. Edited by leading scientists in bionanoparticles, the book is a collaboration between scientists with different backgrounds and perspectives which will initiate the next generation of bio-based structures, materials and devices.

From Bioimaging To Biosensors

Author : Chau Lai-Kwan
ISBN : 9789814267243
Genre : Medical
File Size : 62. 6 MB
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This book provides a comprehensive overview of the use of noble metal nanoparticles for bioimaging and biosensing. It starts with a review on the synthesis, characterization, optical properties, and bioconjugation of noble metal nanoparticles, followed by introduction of various biodetection techniques based on noble metal nanoparticles. In between these topics, microfabrication of biosensing chips and the use of microfluidics to enhance biosensing performance are discussed.

Bioconjugation Protocols

Author : Christof M. Niemeyer
ISBN : 9781592598137
Genre : Medical
File Size : 70. 49 MB
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Expert laboratorians update the classic bioconjugation methods and introduce valuable new techniques that go beyond pure biomedical applications to include elements from advanced organic synthesis, molecular biology, and materials science. These readily reproducible methods cover the preparation of protein conjugates using covalent and noncovalent conjugation, the synthesis of nucleic acid conjugates using a variety of labeling techniques, and approaches to semisynthetic conjugates of proteins. Additional chapters address the biofunctionalization of inorganic surfaces, including the on-chip synthesis of peptide nucleic acids to generate microarrays for the high-throughput analysis of RNA and DNA, gold nanaoparticles, and carbon nanotube probes for atomic force microscopy.

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