chemistry of peptide synthesis

Download Book Chemistry Of Peptide Synthesis in PDF format. You can Read Online Chemistry Of Peptide Synthesis here in PDF, EPUB, Mobi or Docx formats.

Chemistry Of Peptide Synthesis

Author : N. Leo Benoiton
ISBN : 1574444549
Genre : Science
File Size : 63. 13 MB
Format : PDF
Download : 925
Read : 280

Get This Book


Chemistry of Peptide Synthesis is a complete overview of how peptides are synthesized and what techniques are likely to generate the most desirable reactions. Incorporating elements from the author’s role of Career Investigator of the Medical Research Council of Canada and his extensive teaching career, the book emphasizes learning rather than memorization. The text uses clear language and schematics to present concepts progressively, carefully excluding unnecessary details and providing a historical context in which to appreciate the development of the field. The author first outlines the fundamentals of peptide synthesis, focusing on the intermediates in aminolysis reactions. Gradually the text builds into discussions of the applicability of coupling reactions, stereomutation, methods of deprotection, solid-phase synthesis, side-chain protection and side reactions, and amplification on coupling methods. The book clarifies the differences between oxazolones from amino-acid derivatives and segments and the implications of their formation on the chiral integrity of products. The author offers a critical analysis of the mechanisms of coupling reactions and the desirability of preactivation. The text explains hindrance and the nucleophilicity of tertiary amines and rationalizes their use. The book also explores mechanisms of acidolysis and the dual role of nucleophiles as reactants and scavengers. Chemistry of Peptide Synthesis supplies a broad, yet straightforward approach that appeals to those with limited knowledge of organic chemistry or chemists from other fields as well as in-depth coverage that can be appreciated by experienced peptidologists.

Peptides

Author : Bernd Gutte
ISBN : 0080538592
Genre : Science
File Size : 71. 15 MB
Format : PDF, Mobi
Download : 177
Read : 748

Get This Book


In recent years, research has shown the importance of peptides in neuroscience, immunology, and cell biology. Active research programs worldwide are now engaged in developing peptide-based drugs and vaccines using modification of natural peptides and proteins, design of artificial peptides and peptide mimetics, and screening of peptide and phage libraries. In this comprehensive book, the authors discuss peptide synthesis and application within the context of their increasing importance to the pharmaceutical industry. Peptides: Synthesis, Structures, and Applications explores the broad growth of information in modern peptide synthetic methods and the structure-activity relationships of synthetic polypeptides. The history of peptide chemistry Amide formation, deprotection, and disulfide formation in peptide synthesis Solid-phase peptide synthesis a-helix formation by peptides in water Stability and dynamics of peptide conformation An overview of structure-function studies of peptide hormones Neuropeptides:peptide and nonpeptide analogs Reversible inhibitors of serine proteinases Design of polypeptides Current capabilities and future possibilities of soluble chemical combinatorial libraries Epitope mapping with peptides Synthesis and applications of branched peptides in immunological methods and vaccines

Principles Of Peptide Synthesis

Author : M. Bodanszky
ISBN : 9783642967634
Genre : Science
File Size : 72. 76 MB
Format : PDF, Docs
Download : 526
Read : 305

Get This Book


A look at the shelves of a major library awakens doubts in the author of this small volume about the importance of writing a new introduction to peptide synthesis. This rather narrow area of bio-organic chemistry already has received considerable attention. A whole series of books deals with the synthesis of peptides. Some of these are textbooks written to support lecture courses on peptide synthesis. Others try to help the beginner, otherwise well versed in organic chemistry, to embark on some experimental project that requires the construction of peptide chains. Not less useful are the monographs which were compiled to aid the adept practitioner and to provide him with references to the growing literature of a very active field. Is there any need for a new book on peptide synthesis? Should we add a new volume to an already impressive and certainly useful series? The answer is not obvious. The author has already participated in two similar en deavors. The first edition! of "Peptide Synthesis", with M. A. Ondetti as coauthor, was meant to serve as an introduction for the beginner. It was rather well received by researchers who joined the field of peptide chemistry and were looking for initiation. While working on the 2 second edition with Drs. Klausner and Ondetti, we became painfully aware of the impossibility of the task.

Chemistry Of Peptides And Proteins Volumes 5 6

Author :
ISBN : CORNELL:31924068834484
Genre : Peptides
File Size : 90. 86 MB
Format : PDF, ePub, Mobi
Download : 281
Read : 1195

Get This Book



Life During A Golden Age Of Peptide Chemistry

Author : Bruce Merrifield
ISBN : STANFORD:36105003439804
Genre : Science
File Size : 22. 72 MB
Format : PDF, ePub, Docs
Download : 847
Read : 1240

Get This Book


Bruce Merrifield, eminent American scientist, 1984 Nobel Prize winner and professor at The Rockefeller University, is noted for his single-handed development of solid phase peptide synthesis. The progress of biochemistry and related fields is closely correlated with the availability of pure peptides, and in this volume, Merrifield describes nearly 40 years of progress. The warmth and kindness of this sincere gentleman is described by his personal experiences. Many photographs depict both the professional as well as the personal side of Bruce Merrifield.

Amino Acid And Peptide Synthesis

Author : John Jones
ISBN : UOM:39015029145375
Genre : Science
File Size : 73. 24 MB
Format : PDF, Mobi
Download : 105
Read : 710

Get This Book


The principal methods for the synthesis of amino acids and peptides are outlined in this concise introduction. With its emphasis on chemical principles and strategies, the book should be of value to all undergraduate chemistry students.

Solid Phase Synthesis

Author : Fernando Albericio
ISBN : 0824703596
Genre : Science
File Size : 62. 43 MB
Format : PDF, ePub, Mobi
Download : 609
Read : 1222

Get This Book


This volume provides the information needed to synthesize peptides by solid-phase synthesis (SPS) - employing polymeric support (resins), anchoring linkages (handles), coupling reagents (activators), and protection schemes. It presents strategies for creating a wide variety of compounds for drug discovery and analyzes peptides, DNA, carbohydrates, conjugates of biomolecules, and small molecules.

Amino Acids Peptides And Proteins In Organic Chemistry Building Blocks Catalysis And Coupling Chemistry

Author : Andrew B. Hughes
ISBN : 9783527633050
Genre : Science
File Size : 44. 69 MB
Format : PDF, ePub
Download : 635
Read : 282

Get This Book


This is the third of five books in the Amino Acids, Peptides and Proteins in Organic Synthesis series. Closing a gap in the literature, this is the only series to cover this important topic in organic and biochemistry. Drawing upon the combined expertise of the international "who's who" in amino acid research, these volumes represent a real benchmark for amino acid chemistry, providing a comprehensive discussion of the occurrence, uses and applications of amino acids and, by extension, their polymeric forms, peptides and proteins. The practical value of each volume is heightened by the inclusion of experimental procedures. The 5 volumes cover the following topics: Volume 1: Origins and Synthesis of Amino Acids Volume 2: Modified Amino Acids, Organocatalysis and Enzymes Volume 3: Building Blocks, Catalysis and Coupling Chemistry Volume 4: Protection Reactions, Medicinal Chemistry, Combinatorial Synthesis Volume 5: Analysis and Function of Amino Acids and Peptides This third volume in the series presents an in depth account of recent developments in the (bio-)synthesis of amino acids and peptides. Divided into two parts, the first section deals with amino acids as building blocks, including the generation of alpha-amino acids, beta-lactams, and heterocycles. The second section is devoted to the synthesis of peptides, with the focus on solid phase synthesis. However, solution phase peptide synthesis is covered as well, as are topics such as coupling reagents, chemical ligation, peptide purification and automation. Originally planned as a six volume series, Amino Acids, Peptides and Proteins in Organic Chemistry now completes with five volumes but remains comprehensive in both scope and coverage. Further information about the 5 Volume Set and purchasing details can be viewed here.

Solid Phase Peptide Synthesis

Author : John Morrow Stewart
ISBN : UOM:39015016062195
Genre : Science
File Size : 59. 3 MB
Format : PDF, ePub
Download : 538
Read : 1312

Get This Book



Fmoc Solid Phase Peptide Synthesis

Author : W. Chan
ISBN : 0199637245
Genre : Medical
File Size : 23. 28 MB
Format : PDF, Docs
Download : 696
Read : 482

Get This Book


In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems at the time of publication of this earlier work have now for the most part, been solved. As a result, innovators in the field have focussed their efforts to develop methodologies and chemistry for the synthesis of more complex structures. The focus of this new volume is much broader, and covers the essential procedures for the production of linear peptides and more advanced techniques for preparing cyclic, side-chain modified, phospho- and glycopeptides. Many other methods also deserving attention have been included: convergent peptide synthesis; peptide-protein conjugation; chemoselective ligation; and chemoselective purification. The difficult preparation of cysteine and methionine-containing peptides is also covered, as well as methods for overcoming aggregation during peptide chain assembly. Many of the techniques developed for the production of large arrays of peptides by parallel synthesis, such as t-bag, SPOT and PIN synthesis, have naturally been included. Finally, a survey of available automated instrumentation has also been provided.

Top Download:

Best Books