combinatorial chemistry and technology principles methods and applications

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Combinatorial Chemistry And Technologies

Author : Stanislav Miertus
ISBN : 0824758374
Genre : Medical
File Size : 48. 82 MB
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Several books on the market cover combinatorial techniques, but they offer just a limited perspective of the field, focusing on selected aspects without examining all approaches and integrated technologies. Combinatorial Chemistry and Technologies: Methods and Applications answers the demand for a complete overview of the field, covering all of the methodologies used in the design, synthesis, and screening of molecular libraries. Now in its second edition, this volume updates prior content and explores new areas such as catalysis, applications in biotechnology, and current ICS-UNIDO activities. Topics include the generation of molecular diversity by chemical methods using solution- and solid-phase chemistries, biological approaches for the production and screening of peptides, antibody and oligonucleotide libraries, and the application of computer-assisted approaches to guide library synthesis. The book establishes the link between combinatorial chemistry and molecular modeling and illustrates the importance of economics and patenting in combinatorial technologies. Valuable to technologists and researchers as an introductory survey on the many aspects of combinatorial chemistry and combinatorial technology, Combinatorial Chemistry and Technologies: Methods and Applications offers an overview of a field that promises broad applicability in the identification of new drugs, as well as in diagnostics, new materials, and catalysis.

Solid Phase Synthesis And Combinatorial Technologies

Author : Pierfausto Seneci
ISBN : 9780471460732
Genre : Science
File Size : 29. 55 MB
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A unique, integrated look at solid-phase synthesis and advances in combinatorial chemistry and technologies The last decade has seen a rapid expansion in combinatorial technologies, a field where chemistry disciplines intersect with automation, statistics, and information science, as well as certain biological disciplines. Reflecting these multidisciplinary trends, this new work provides a comprehensive overview of the most important aspects of solid-phase synthesis (SPS), combinatorial chemistry, and related combinatorial technologies. It clearly demonstrates how SPS and combinatorial chemistry have extended their application from the pharmaceutical arena to new areas, including biotechnology, material sciences, catalysis, and agrochemical industries, and explores in detail strategies for planning, designing, preparing, and testing of combinatorial libraries in various disciplines. Designed to meet the needs of both experienced combinatorial chemists and newcomers to the field, Solid-Phase Synthesis and Combinatorial Technologies: Surveys the most recent developments in SPS and combinatorial chemistry Explains the entire process, from determining the need for a library to the details necessary for synthesis of the library Discusses choice of format, size, and the rationale behind the design of each synthetic step Surveys the analytical techniques and the purification methods used to characterize and purify combinatorial libraries Employs a large number of examples to illustrate important concepts Includes problems geared toward applying acquired knowledge and designing the steps to SPS/library synthesis Describes the quality control and activity screening of combinatorial libraries for various applications Features a detailed bibliography of more than 1,700 relevant sources

Molecular Diversity And Combinatorial Chemistry

Author : Michael C. Pirrung
ISBN : 0080444938
Genre : Medical
File Size : 36. 44 MB
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Written for advanced undergraduate and graduate students, this textbook makes the main concepts of combinatorial chemistry accessible to the non-specialist.

Integrated Drug Discovery Technologies

Author : Houng-Yau Mei
ISBN : 0203910699
Genre : Science
File Size : 63. 17 MB
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Integrated Drug Discovery Technologies provides a global overview of emerging drug development technologies by presenting and integrating new techniques from the disciplines of chemistry, biology, and computational sciences. It combines integration of contemporary mechanization with strategies in drug delivery. Topics include: functional genomics, microfabrication techniqes, integrated proteomics technologies, high throughput screening, and fluorescence correlation spectroscopy methods.

Combinatorial Chemistry

Author : Willi Bannwarth
ISBN : 9783527607389
Genre : Science
File Size : 49. 4 MB
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The new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis. A new chapter on screening complements the overview of combinatorial strategy and synthetic methods. "Experimental details and complete reaction data [...] are a constant theme running through this work" (Angewandte Chemie) "Recommended to newcomers in the field of combinatorial chemical synthesis because of its broad scope" (Journal of the American Chemical Society)

Burger S Medicinal Chemistry And Drug Discovery Drug Discovery And Drug Development

Author : Alfred Burger
ISBN : UOM:39015056276937
Genre : Medical
File Size : 70. 74 MB
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Offers access via basic and advanced search engines to broad coverage of the field of medicinal chemistry and drug discovery for medicinal chemists, biologists, pharmacologists and molecular biologists.

The Characterization Of Chemical Purity

Author : L. A. K. Staveley
ISBN : 0408701455
Genre : Science
File Size : 28. 65 MB
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The Cumulative Book Index

Author :
ISBN : STANFORD:36105124517769
Genre : American literature
File Size : 61. 59 MB
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High Throughput Screening In Drug Discovery

Author : Jörg Hüser
ISBN : 9783527609369
Genre : Science
File Size : 42. 81 MB
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Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results. For both academics and professionals in the pharma and biotech industries working on small molecule screening.

Synthetic Strategies For Solid Phase Synthesis

Author : Joseph Charles Kappel
ISBN : MINN:31951P00831839D
Genre :
File Size : 21. 49 MB
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