comprehensive analysis of parasite biology from metabolism to drug discovery drug discovery in infectious diseases

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Comprehensive Analysis Of Parasite Biology

Author : Sylke M?ller
ISBN : 9783527339044
Genre : Medical
File Size : 63. 47 MB
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Written and edited by experts in the field, this book brings together the current state of the art in phenotypic and rational, target-based approaches to drug discovery against pathogenic protozoa. The chapters focus particularly on virtual compounds and high throughput screening, natural products, computer-assisted drug design, structure-based drug design, mechanism of action identification, and pathway modelling. Furthermore, state-of the art "omics" technologies are described and currently studied enzymatic drug targets are discussed. Mathematical, systems biology-based approaches are introduced as new methodologies for dissecting complex aspects of pathogen survival mechanisms and for target identification. In addition, recently developed anti-parasitic agents targeting particular pathways, which serve as lead compounds for further drug development, are presented.


Author : Charles Q. Meng
ISBN : 9783527802906
Genre : Medical
File Size : 31. 51 MB
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This first book specifically dedicated to ectoparasite drug discovery is unique in providing insights from the veterinary as well as the medical perspective, covering research from both industry and academia while paving the way for new synergies between the two research communities. Edited by a team combining 80 years of experience in academic research and industrial antiparasitic drug discovery, this volume of Drug Discovery in Infectious Diseases summarizes current knowledge in this rapidly expanding field. Comprehensive yet concise, this ready reference blends solid background information on ectoparasite biology with the very latest methods in ectoparasite drug discovery. Three major parts cover current ectoparasite control strategies and the threat of drug resistance, screening and drug evaluation, and the new isoxazoline class of ectoparasiticides. The future potential of mechanism-based approaches for repellents and parasiticides is thoroughly discussed, as are strategies for vaccines against ectoparasites, making the book ideal for parasitologists in academia as well as researchers working in the pharmaceutical industry.

Host Pathogen Interaction

Author : Gottfried Unden
ISBN : 9783527682393
Genre : Science
File Size : 52. 44 MB
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In light of the rapidity increasing incidence rate of bacterial and fungal infections with multi-resistant pathogens, the metabolic changes associated with host-pathogen interactions offer one of the most promising starting points for developing novel antibiotics. . Part one of this comprehensive guide describes the metabolic adaptation of pathogenic microbes in humans, while part two points to routes for the development of novel antibiotics. This is volume six of the book series on drug discovery in infectious diseases by Paul Selzer.

Protein Phosphorylation In Parasites

Author : Christian Doerig
ISBN : 9783527675371
Genre : Medical
File Size : 45. 59 MB
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This is the first book to collect and summarize in one publication the efforts to use kinases or phosphatases for drug development against parasite infections. The editors and contributors comprise the Who is Who in the field, and they are comprehensive in covering every aspect of the topic, from basic research findings to translational approaches in drug development The result will be welcomed by everyone in academia and industry participating in the global effort to finally combat the major diseases caused by eukaryotic parasites. This is volume one of a two-volume treatise, the second being exclusively dedicated to efforts to combat malaria using the same approach.

The Application Of Functional Genomics Systems Biology And Drug Development To The Study Of Infectious Diseases

Author : Jingchun Zhu
ISBN : UCAL:X85693
Genre :
File Size : 70. 94 MB
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Genomics is creating a paradigm shift in the research of infectious diseases, transforming it from studying a few targets at a time to a genomic scale. We applied three genomic approaches to the study of malaria and its causative agents, a type of intracellular parasites belonging to the genus Plasmodium.

Antimalarial Chemotherapy

Author : Philip J. Rosenthal
ISBN : 9781592591114
Genre : Medical
File Size : 55. 9 MB
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Philip Rosenthal, MD, and a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. Their survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, new chemical approaches to chemotherapy, and possible new targets for chemotherapy. Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.

Philosophical Transactions Of The Royal Society Of London

Author :
ISBN : IND:30000121555647
Genre : Biology
File Size : 47. 11 MB
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Philosophical Transactions

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ISBN : CORNELL:31924089609915
Genre : Biology
File Size : 68. 53 MB
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Each issue of Transactions B is devoted to a specific area of the biological sciences, including clinical science. All papers are peer reviewed and edited to the highest standards. Published on the 29th of each month, Transactions B is essential reading for all biologists.

Tropical Disease Research

Author :
ISBN : CHI:49673096
Genre : Tropical medicine
File Size : 90. 59 MB
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Antiparasitic And Antibacterial Drug Discovery

Author : Paul M. Selzer
ISBN : 9783527323272
Genre : Medical
File Size : 56. 33 MB
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Mainly addressing parasitic diseases but also focusing on diseases caused by bacteria, this much-needed reference and handbook provides a unique insight into the approach adopted by commercial science towards infectious diseases, including the work of medicinal chemists. Many of the authors are scientists with hands-on experience of drug discovery units within the pharmaceutical industry. In addition, the text covers efforts towards drug development in infectious diseases from academic groups and non profit organizations.

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