computational approaches for studying enzyme mechanism part a 577 methods in enzymology

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Computational Approaches For Studying Enzyme Mechanism

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ISBN : 9780128053638
Genre : Medical
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Computational Approaches for Studying Enzyme Mechanism Part A, is the first of two volumes in the Methods in Enzymology series, focusses on computational approaches for studying enzyme mechanism. The serial achieves the critically acclaimed gold standard of laboratory practices and remains one of the most highly respected publications in the molecular biosciences. Each volume is eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 550 volumes, the series remains a prominent and essential publication for researchers in all fields of life sciences and biotechnology, including biochemistry, chemical biology, microbiology, synthetic biology, cancer research, and genetics to name a few. Focuses on computational approaches for studying enzyme mechanism Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in intermediate filament associated proteins, and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers

Computational Methods For Understanding Riboswitches

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ISBN : 9780128016183
Genre : Science
File Size : 21. 34 MB
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This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers computational prediction RNA structure and dynamics, including such topics as computational modeling of RNA secondary and tertiary structures, riboswitch dynamics, and ion-RNA, ligand-RNA and DNA-RNA interactions. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers computational methods and applications in RNA structure and dynamics Contains chapters with emerging topics such as RNA structure prediction, riboswitch dynamics and thermodynamics, and effects of ions and ligands.

Dynamics In Enzyme Catalysis

Author : Judith Klinman
ISBN : 9783642389627
Genre : Science
File Size : 46. 2 MB
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Christopher M. Cheatum and Amnon Kohen, Relationship of Femtosecond–Picosecond Dynamics to Enzyme-Catalyzed H-Transfer. Cindy Schulenburg and Donald Hilvert, Protein Conformational Disorder and Enzyme Catalysis. A. Joshua Wand, Veronica R. Moorman and Kyle W. Harpole, A Surprising Role for Conformational Entropy in Protein Function. Travis P. Schrank, James O. Wrabl and Vincent J. Hilser, Conformational Heterogeneity Within the LID Domain Mediates Substrate Binding to Escherichia coli Adenylate Kinase: Function Follows Fluctuations. Buyong Ma and Ruth Nussinov, Structured Crowding and Its Effects on Enzyme Catalysis. Michael D. Daily, Haibo Yu, George N. Phillips Jr and Qiang Cui, Allosteric Activation Transitions in Enzymes and Biomolecular Motors: Insights from Atomistic and Coarse-Grained Simulations. Karunesh Arora and Charles L. Brooks III, Multiple Intermediates, Diverse Conformations, and Cooperative Conformational Changes Underlie the Catalytic Hydride Transfer Reaction of Dihydrofolate Reductase. Steven D. Schwartz, Protein Dynamics and the Enzymatic Reaction Coordinate.

Nanozymes Next Wave Of Artificial Enzymes

Author : Xiaoyu Wang
ISBN : 9783662530689
Genre : Technology & Engineering
File Size : 80. 74 MB
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This book describes the fundamental concepts, the latest developments and the outlook of the field of nanozymes (i.e., the catalytic nanomaterials with enzymatic characteristics). As one of today’s most exciting fields, nanozyme research lies at the interface of chemistry, biology, materials science and nanotechnology. Each of the book’s six chapters explores advances in nanozymes. Following an introduction to the rise of nanozymes research in the course of research on natural enzymes and artificial enzymes in Chapter 1, Chapters 2 through 5 discuss different nanomaterials used to mimic various natural enzymes, from carbon-based and metal-based nanomaterials to metal oxide-based nanomaterials and other nanomaterials. In each of these chapters, the nanomaterials’ enzyme mimetic activities, catalytic mechanisms and key applications are covered. In closing, Chapter 6 addresses the current challenges and outlines further directions for nanozymes. Presenting extensive information on nanozymes and supplemented with a wealth of color illustrations and tables, the book offers an ideal guide for readers from disparate areas, including analytical chemistry, materials science, nanoscience and nanotechnology, biomedical and clinical engineering, environmental science and engineering, green chemistry, and novel catalysis.

Protein Engineering Handbook

Author : Stefan Lutz
ISBN : 9783527667017
Genre : Science
File Size : 56. 32 MB
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Unparalleled in size and scope, this new major reference integrates academic and industrial knowledge into a single resource, allowing for a unique overview of the entire field. Adopting a systematic and practice-oriented approach, and including a wide range of technical and methodological information, this highly accessible handbook is an invaluable 'toolbox' for any bioengineer. In two massive volumes, it covers the full spectrum of current concepts, methods and application areas.

Enzyme Kinetics Catalysis And Control

Author : Daniel L. Purich
ISBN : 9780123809254
Genre : Science
File Size : 27. 38 MB
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Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also focusing on the persuasive power of kinetic isotope effects, the design of high-potency drugs, and the behavior of regulatory enzymes. Historical analysis of kinetic principles including advanced enzyme science Provides both theoretical and practical measurements tools Coverage of single molecular kinetics Examination of force generation mechanisms Discussion of organic and inorganic enzyme reactions

Conn S Handbook Of Models For Human Aging

Author : Jeffrey L. Ram
ISBN : 9780128113547
Genre : Medical
File Size : 20. 69 MB
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Conn's Handbook of Models for Human Aging, Second Edition, presents key aspects of biology, nutrition, factors affecting lifespan, methods of age determination, use in research and the disadvantages/advantages of use. Using a multidisciplinary approach, this updated edition is designed as the only comprehensive, current work that covers the diversity in aging models. Chapters on comparative models explore age-related diseases, including Alzheimer's, joint disease, cataracts, cancer and obesity. Also included are new tricks and approaches not available in primary publications. This must-have handbook is an indispensable resource for researchers interested in the mechanisms of aging, gerontologists, health professionals, allied health practitioners and students. Combines both the methods of study for human aging and animal models Provides a historical overview and discussion of model availability, key methods and ethical issues Contains over 200 full color illustrations

Acupuncture In Pregnancy And Childbirth

Author : Zita West
ISBN : 9780443103711
Genre : Medical
File Size : 87. 71 MB
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ACUPUNCTURE IN PREGNANCY AND CHILDBIRTH is a concise highly illustrated and practical guide to using acupuncture to treat women throughout their pregnancy and labour. Drawing on an unparalleled wealth of experience as a midwife and an acupuncturist, the author has produced a book accessible to both acupuncture students and practitioners covering physiology related to pregnancy and childbirth, illuminating links between Western knowledge and acupuncture approaches and suggesting points and point combinations for particular stages and actions during pregnancy and labour. Highly illustrated with summary boxes and guidelines Covers nutritional aspects of pregnancy Gives practical advice and instruction on the use of acupuncture through the four trimesters of pregnancy and labour Uses case examples to further illustrate the text Covers recent advances in relation to the effects of aspirin and heparin to the immune system and pregnancy Includes IVF pregnancies Glossary and appendix of useful addresses Fully updated and revised throughout to include recent research Nutrition and its effect on the foetus (new and developing area of research)

Isotope Effects In Chemistry And Biology

Author : Amnon Kohen
ISBN : 1420028022
Genre : Science
File Size : 65. 7 MB
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The field of isotope effects has expanded exponentially in the last decade, and researchers are finding isotopes increasingly useful in their studies. Bringing literature on the subject up to date, Isotope Effects in Chemistry and Biology covers current principles, methods, and a broad range of applications of isotope effects in the physical, biological, and environmental sciences. The authors first explain how kinetic, equilibrium, and anharmonic isotope effects are used to measure the ratio of reaction rates, the ratio between isotopes in thermodynamic equilibrium, and the geometric changes between molecules. The volume describes basic theories, including gas phase, simple condensed phase, small molecule studies, and applications of the Bigeleisen-Mayer theory before covering how isotopes affect molecular geometries, chemical bond breaking, formation and chemical dynamics, and hydrogen transfer. It explores novel, mass-independent isotope effects and problems encountered in hydrogen transfer, tunneling, and exchange. Authors also discuss isotope effects in organic and organometallic reactions and complex enzyme reactions and a unique chapter explores water isotope effects under pressure. Written by internationally recognized researchers from 13 countries, some chapters summarize the perspective of a well-established subject while others review recent findings and on-going research that occasionally present controversial viewpoints using clear scientific arguments and discussion presented by all relevant authors. Isotope Effects in Chemistry and Biology brings together a wide scope of different perspectives and practical developments and applications into a comprehensive reference of isotope effects that reflect the most current state of the art.

The Organic Chemistry Of Biological Pathways

Author : John McMurry
ISBN : 0974707716
Genre : Science
File Size : 84. 88 MB
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Intended for advanced undergraduates and graduate students in all areas of biochemistry, The Organic Chemistry of Biological Pathways provides an accurate treatment of the major biochemical pathways from the perspective of mechanistic organic chemistry.

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