computer aided applications in pharmaceutical technology woodhead publishing series in biomedicine

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Computer Aided Applications In Pharmaceutical Technology

Author : Jelena Djuris
ISBN : 9781908818324
Genre : Medical
File Size : 28. 37 MB
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Research and development in the pharmaceutical industry is a time-consuming and expensive process, making it difficult for newly developed drugs to be formulated into commercially available products. Both formulation and process development can be optimized by means of statistically organized experiments, artificial intelligence and other computational methods. Simultaneous development and investigation of pharmaceutical products and processes enables application of quality by design concept that is being promoted by the regulatory authorities worldwide. Computer-aided applications in pharmaceutical technology covers the fundamentals of experimental design application and interpretation in pharmaceutical technology, chemometric methods with emphasis of their application in process control, neural computing (artificial neural networks, fuzzy logic and decision trees, evolutionary computing and genetic algorithms, self-organizing maps), computer-aided biopharmaceutical characterization as well as application of computational fluid dynamics in pharmaceutical technology. All of these techniques are essential tools for successful building of quality into pharmaceutical products and processes from the early stage of their development to selection of the optimal ones. In addition to theoretical aspects of various methods, the book provides numerous examples of their application in the field of pharmaceutical technology. A comprehensive review of the current state of the art on various computer aided applications in pharmaceutical technology Case studies are presented in order to facilitate understanding of various concepts in computer-aided applications

Computer Aided Applications In Pharmaceutical Technology

Author : Ljiljana Djekic
ISBN : 9780128091883
Genre : Technology & Engineering
File Size : 71. 32 MB
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This chapter introduces the concept of formulation development assisted by computer applications. Development and optimization of various types of pharmaceutical emulsions microemulsions, self-microemulsifying systems, and double emulsions are presented. Illustrative examples are presented to demonstrate the ability of computer-aided tools to facilitate formulation development. Various techniques, such as design of experiments and artificial neural networks, are implemented for optimization of the formulation and/or processing parameters. Furthermore, some of the critical quality attributes and processing parameters are optimized simultaneously. The examples presented should serve as the foundation for the future quality-by-design development of pharmaceutical emulsion and (self) microemulsion formulations.

Computer Aided Applications In Pharmaceutical Technology

Author : Sandra Grbic
ISBN : 9780128091920
Genre : Technology & Engineering
File Size : 51. 14 MB
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This chapter introduces the concept of gastrointestinal absorption simulation using in silico methodology. Parameters used for model construction and the sensitivity predicted pharmacokinetic responses to various input parameters are described. Virtual trials for in silico modeling of drug absorption are presented. The influence of food on drug absorption, as well as correlation between the in vitro and in vivo results, are also addressed, followed by biowaiver considerations. Numerous examples are provided throughout the chapter.

Computer Aided Applications In Pharmaceutical Technology

Author : Ivana Masic
ISBN : 9780128091937
Genre : Technology & Engineering
File Size : 60. 17 MB
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This chapter introduces the concept of computational fluid dynamics (CFD) and its applications in pharmaceutical technology. Basic theoretical explanations on the mathematics of fluid flow and numerical grids are provided. CFD is a versatile tool that is mainly used in complex dynamical process characterization. Examples of CFD applications in development of inhalers, analysis of dissolution apparatus hydrodynamics, and fluidized bed process simulations are presented.

Computer Aided Vaccine Design

Author : Joo Chuan Tong
ISBN : 9781908818416
Genre : Medical
File Size : 33. 35 MB
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Computational pre-screening of antigens is now routinely applied to the discovery of vaccine candidates. Computer-aided vaccine design is a comprehensive introduction to this exciting field of study. The book is intended to be a textbook for researchers and for courses in bioinformatics, as well as a laboratory reference guide. It is written mainly for biologists who want to understand the current methods of computer-aided vaccine design. The contents are designed to help biologists appreciate the underlying concepts and algorithms used, as well as limitations of the methods and strategies for their use. Chapters include: MHC and T cell responses; Immunoglobulins and B cell responses; Scientific publications and databases; Database design; Computational T cell vaccine design; Computational B cell vaccine design; infectious disease informatics; Vaccine safety and quality assessments; and Vaccine adjuvant informatics. Essential reading for any biologist who wants to understand methods of computer-aided vaccine design Description of available data sources and publicly available software, with detailed analysis of strengths and weaknesses Theoretical concepts and practical examples of database design and development for a virtual screening campaign

Open Source Software In Life Science Research

Author : Lee Harland
ISBN : 9781908818249
Genre : Science
File Size : 52. 29 MB
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The free/open source approach has grown from a minor activity to become a significant producer of robust, task-orientated software for a wide variety of situations and applications. To life science informatics groups, these systems present an appealing proposition - high quality software at a very attractive price. Open source software in life science research considers how industry and applied research groups have embraced these resources, discussing practical implementations that address real-world business problems. The book is divided into four parts. Part one looks at laboratory data management and chemical informatics, covering software such as Bioclipse, OpenTox, ImageJ and KNIME. In part two, the focus turns to genomics and bioinformatics tools, with chapters examining GenomicsTools and EBI Atlas software, as well as the practicalities of setting up an ‘omics’ platform and managing large volumes of data. Chapters in part three examine information and knowledge management, covering a range of topics including software for web-based collaboration, open source search and visualisation technologies for scientific business applications, and specific software such as DesignTracker and Utopia Documents. Part four looks at semantic technologies such as Semantic MediaWiki, TripleMap and Chem2Bio2RDF, before part five examines clinical analytics, and validation and regulatory compliance of free/open source software. Finally, the book concludes by looking at future perspectives and the economics and free/open source software in industry. Discusses a broad range of applications from a variety of sectors Provides a unique perspective on work normally performed behind closed doors Highlights the criteria used to compare and assess different approaches to solving problems

Bioelectronics And Medical Devices

Author : Kunal Pal
ISBN : 0081024207
Genre :
File Size : 70. 36 MB
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Bioelectronics and Medical Devices reviews the latest research on electronic devices used in the healthcare sector from materials to applications including biosensors, rehabilitation devices, drug delivery devices, and devices based on wireless technology. This information is presented from the unique interdisciplinary perspective of the editors and contributors with materials science, biomedical engineering, physics, and chemistry backgrounds. Each applicable chapter includes a discussion of these devices from materials and fabrication to reliability and technology applications. Each chapter includes case studies, future research directions and recommendations for additional readings. Bioelectronics and Medical Devices addresses hot topics such as the latest state-of the-art biosensing devices which have the ability for early detection of life-threatening diseases such as tuberculosis, HIV, and cancer. It covers rehabilitiation devices and advancements such as the devices that could be utilized by advanced-stage ALS patients to improve their interactions with the environment. Electronic controlled delivery systems are reviewed, including those that are based on artificial intelligences. The advancements in the field of MEMS-based technologies are also included. The current book will provide a materials perspective insight to electronics and instrumentation engineers and at the same time will allow materials scientists to have an insight on the manipulation of the signal acquired from the materials interface. Includes hot topics including MEMS-based fabrication of biomedical sensors, internet of things, certification of medical devices and drug delivery devices, and electrical safety considerations Presents the interdisciplinary perspective of materials scientists, biomedical engineers, physicists and chemists on biomedical electronic devices resulting in a unique comprehensive scope Features systematic coverage in each chapter including the recent advancements in the field, case studies, future research directions, and recommendations for additional readings

Science And Principles Of Biodegradable And Bioresorbable Medical Polymers

Author : Xiang Cheng Zhang
ISBN : 9780081003930
Genre : Medical
File Size : 68. 15 MB
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Science and Principles of Biodegradable and Bioresorbable Medical Polymers: Materials and Properties provides a practical guide to the use of biodegradable and bioresorbable polymers for study, research, and applications within medicine. Fundamentals of the basic principles and science behind the use of biodegradable polymers in advanced research and in medical and pharmaceutical applications are presented, as are important new concepts and principles covering materials, properties, and computer modeling, providing the reader with useful tools that will aid their own research, product design, and development. Supported by practical application examples, the scope and contents of the book provide researchers with an important reference and knowledge-based educational and training aid on the basics and fundamentals of these important medical polymers. Provides a practical guide to the fundamentals, synthesis, and processing of bioresorbable polymers in medicine Contains comprehensive coverage of material properties, including unique insights into modeling degradation Written by an eclectic mix of international authors with experience in academia and industry

National Library Of Medicine Current Catalog

Author : National Library of Medicine (U.S.).
ISBN : MINN:31951D00419854T
Genre : Medicine
File Size : 66. 34 MB
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Current Catalog

Author :
ISBN : UOM:39015074107601
Genre : Medicine
File Size : 75. 92 MB
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First multi-year cumulation covers six years: 1965-70.

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