coumarins biology applications and mode of action

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Author : Richard O'Kennedy
ISBN : 0471969974
Genre : Science
File Size : 39. 62 MB
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Coumarins: Biology, Applications and Mode of Action predominantly focuses on the parent compound, coumarin, and its main metabolite in humans, 7-hydroxycoumarin. It describes in detail every facet of these compounds including history, toxicology, chemistry, metabolism, analysis, clinical, veterinary and other applications, their roles as immunomodulatory agents and speculates on their mode of action.


Author : Markward Marshall
ISBN : 9783642557255
Genre : Medical
File Size : 41. 78 MB
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Dieser kompetente Praxisleitfaden enthält alles, was man über die Arzneimitteltherapie von Venenerkrankungen wissen muss. Dabei wird nicht nur auf die Wirkstoffe, sondern auch auf die Grundlagen eingegangen. Anerkannte Indikationen werden ebenso dargestellt wie die unerwünschten Wirkungen. Nutzen-Risiko-Relation und Aufwand-Nutzen-Relation sind die zentralen Parameter für die Arzneimittelauswahl. Hinweise für die Betreuung von Patienten und Patiententipps runden das Werk ab.

Coumarin Anticoagulant Research Progress

Author : Joseph P. Edardes
ISBN : 160021990X
Genre : Anticoagulants (Medicine)
File Size : 42. 16 MB
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Warfarin (also known under the brand names of Coumadin, Jantoven, Marevan, and Waran) is an anticoagulant medication that is administered orally or, very rarely, by injection. It is used for the prophylaxis of thrombosis and embolism in many disorders. Its activity has to be monitored by frequent blood testing for the international normalized ratio (INR). It is named for the Wisconsin Alumni Research Foundation. Warfarin is a synthetic derivative of coumarin, a chemical found naturally in many plants, notably woodruff (Galium odoratum, Rubiaceae), and at lower levels in licorice, lavender and various other species. Warfarin was originally developed as a rat poison; however, more modern poisons are much more potent and toxic (e.g., brodifacoum). Warfarin and contemporary rodenticides belong to the same class of drugs (coumarins) and both decrease blood coagulation by interfering with vitamin K metabolism. For this reason, drugs in this class are also referred to as vitamin K antagonists.


Author : Karen Jenns
ISBN : 1857753771
Genre : Medical
File Size : 37. 6 MB
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This practical reference draws together the combined expertise of a wide range of health professionals in managing this condition. Their work is soundly based on recent research into its pathology, manifestations and treatment to develop appropriate management strategies. Part of the value in this book lies in its reference to patient perspectives and how they can contribute to the most effective care.

Fundamentals Of Herbal Medicine

Author : Kofi Busia
ISBN : 9781514447352
Genre : Health & Fitness
File Size : 65. 93 MB
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This book consists of cutting-edge materials drawn from diverse, authoritative sources, which are sequentially arranged into a multipurpose, one-stop-shop, user-friendly text. It is divided into four parts as follows: Part 1: Historical overview of some indigenous medical systems; an outline of the basic concepts of pharmacognosy, ethnopharmacology; common analytical methods for isolating and characterising phytochemicals; and the different methods for evaluating the quality, purity, biological and pharmacological activities of plant extracts. Part 2: Phytochemistry and mode of action of major plant metabolites. Part 3: Systems-based phytotherapeutics; discusses how dysfunctioning of the main systems of the human body can be treated with herbal remedies. Part 4: Provides 153 monographs of some medicinal plants commonly used around the world, including 63 on African medicinal plants. This book therefore demonstrates the scrupulous intellectual nature of herbalism, depicting it as a scientific discipline in its own right.

Remediation Engineering Of Contaminated Soils

Author : Donald L. Wise
ISBN : 0824703324
Genre : Science
File Size : 58. 70 MB
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"Offers thorough coverage of the remediation of soils contaminated by hazardous wastes, including materials, analytical techniques, cleanup design and methodology, characterization of geomedia, monitoring of contaminants in the subsurface, and waste containment. Cites specific case studies in hydrocarbon remediation that offer a concise overview of possible technological approaches."


Author : H. Leon Bradlow
ISBN : 1573311146
Genre : Medical
File Size : 39. 87 MB
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This volume contains papers presented at a conference on Genetics and the Environment which was held by the Strang International Cancer Prevention Center on November 15th and 16th, 1996 in New York. The text seeks to describe the evolution and current status of human cancer genetics and the current role of molecular diagnosis. It elucidates the significance of mutations in specific cancer-related genes and the ethical implications of genetic testing. Environmental factors such as tobacco and toxic chemicals that have an important impact on cancer risk are also discussed.

Nova Acta Leopoldina

Author :
ISBN : UCLA:L0078658994
Genre : Biology
File Size : 39. 21 MB
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Benzo C Quinolizine Coumarin And Spiroisoxazolinoproline

Author : Yannan Liu
ISBN : UCAL:X64610
Genre :
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Some Industrial Chemicals

Author : IARC Working Group on the Evaluation of Carcinogenic Risks to Humans
ISBN : UOM:39015054440204
Genre : Medical
File Size : 45. 60 MB
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Evaluates or re-evaluates the carcinogenic risks to humans posed by exposure to sixteen organic industrial chemicals. These included some aromatic amines (ortho-toluidine, 4-chloro-ortho-toluidine, and 5-chloro-ortho-toluidine), some ethanolamines (di- and triethanolamine and N-nitrosodiethanolamine), and three esters [di(2-ethylhexyl) phthalate (DEHP), di(2-ethylhexyl) adipate, and cinnamyl anthranilate]. Seven of the sixteen compounds were evaluated in previous IARC Monographs and are reconsidered here in the light of new evidence. Three chemicals were classified or reclassified as probably carcinogenic to humans: ortho-toluidine, 4-chloro-ortho-toluidine, and glycidol. Four compounds, evaluated here for the first time, namely 2,2-bis(bromomethyl)propane-1,3-diol, 2,3-dibromopropan-1-ol, ethylbenzene, and nitromethane, were classified as possibly carcinogenic to humans. N-Nitrosodiethanolamine, which can readily be formed from either di- or triethanolamine in the presence of inorganic nitrite, remained classified as possibly carcinogenic to humans. For eight compounds, including 5-chloro-ortho-toluidine, coumarin, pyridine, diethanolamine, triethanolamine, di(2-ethylhexyl) adipate, and cinnamyl anthranilate, evidence was judged inadequate to classify these compounds according to their carcinogenicity in humans. The most extensive monograph is devoted to an evaluation of di(2-ethylhexyl) phthalate (DEHP), which had previously been classified as possibly carcinogenic to humans. Using assessment criteria recently established for compounds that induce peroxisome proliferation in the liver, the evaluation downgraded DEHP to the group of compounds that cannot be classified. Two other compounds that cause peroxisome proliferation, di(2-ethylhexyl) adipate and cinnamyl anthranilate, were also evaluated as not classifiable as to carcinogenicity to humans.

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