diabetes oxidative stress and dietary antioxidants

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Diabetes

Author : Victor R. Preedy
ISBN : 9780124055223
Genre : Medical
File Size : 81. 96 MB
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Diabetes: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide among diabetologists, endocrinologists, and nutritionists in understanding and treating diabetes. The book covers, in a single volume, the science of oxidative stress in diabetes and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes such as apoptosis, cell signaling, receptor-mediated responses and more. This approach recognizes that diseases are usually multifactorial and that oxidative stress is a single component of this. Pharmacological treatments for diabetes are commonly marked by unwanted side effects, leading to treatment efforts using naturally occurring substances. But a plant-based approach alone is not sufficient; understanding the processes inherent in the oxidative stress of diabetes is vital for clinical workers, dietitians, and nutritionists. This translational work provides that understanding. The book begins by covering the basic biology of oxidative stress from molecular biology to imaging in relation to diabetes. There are chapters on neuropathy, nephropathy, atherosclerosis, cardiomyopathy, and retinopathy. The book then moves on to antioxidants in foods, including plants, components of the diet, and their relevance to diabetes. Nutritionists will use the information related to mitochondrial oxidative stress in one disease and propose new diet-related strategies to prevent such conditions arising in another unrelated disease. Dietitians will prescribe new foods or diets containing antioxidants for conditions that are refractory by conventional pharmacological treatments. Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teams. Nutritionists and dietitians will learn about cell signaling and will be able to suggest preventive or therapeutic strategies with antioxidant-rich foods to reduce damage done by diseases involving abnormal cell signaling.

Aging

Author : Victor R. Preedy
ISBN : 9780124055230
Genre : Technology & Engineering
File Size : 51. 33 MB
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Aging: Oxidative Stress and Dietary Antioxidants bridges the trans-disciplinary divide and covers in a single volume the science of oxidative stress in aging and the potentially therapeutic use of natural antioxidants in the diet or food matrix. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial, and oxidative stress is a single component of this. Gerontologists, geriatricians, nutritionists, and dieticians are separated by divergent skills and professional disciplines that need to be bridged in order to advance preventative as well as treatment strategies. While gerontologists and geriatricians may study the underlying processes of aging, they are less likely to be conversant in the science of nutrition and dietetics. On the other hand, nutritionists and dietitians are less conversant with the detailed clinical background and science of gerontology. This book addresses this gap and brings each of these disciplines to bear on the processes inherent in the oxidative stress of aging. Nutritionists can apply information related to mitochondrial oxidative stress in one disease to diet-related strategies in another unrelated disease Dietitians can prescribe new foods or diets containing anti-oxidants for conditions resistant to conventional pharmacological treatments Dietitians, after learning about the basic biology of oxidative stress, will be able to suggest new treatments to their multidisciplinary teams Nutritionists and dietitians will gain an understanding of cell signaling and be able to suggest new preventative or therapeutic strategies with anti-oxidant rich foods

The Liver

Author : Vinood Patel
ISBN : 9780128039786
Genre : Medical
File Size : 33. 30 MB
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The Liver: Oxidative Stress and Dietary Antioxidants takes a novel approach to the science of oxidative stress in liver disease by recognizing that diseases are multifactorial and oxidative stress is a single component. It highlights oxidative stress in relation to other processes, such as apoptosis, cell signaling and receptor mediated responses, and includes the therapeutic usage of natural antioxidants in the diet and food matrix, along with coverage of pharmacological and natural agents designed to counteract oxidative stress. Written for research scientists, gastroenterologists, food scientists, hepatologists and physicians, this trans-disciplinary guide will help advance medical sciences and enable new preventative and treatment strategies. Provides a framework for in-depth analysis of the basic processes of oxidative stress, from molecular biology, to whole organs in relation to the liver Bridges the trans-disciplinary divide between the basic science and mechanisms of liver disease and oxidative stress to advance medical sciences and enable preventative and treatment strategies Contains contributions from leading national and international experts, including those from world renowned institutions

Gastrointestinal Tissue

Author : Jordi Gracia-Sancho
ISBN : 9780128093009
Genre : Medical
File Size : 27. 71 MB
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Gastrointestinal Tissue: Oxidative Stress and Dietary Antioxidants brings together leading experts from world renowned institutions, combining the basic mechanisms of gastrointestinal diseases with information regarding new and alternative treatments. The processes within the science of oxidative stress are described in concert with other processes, including apoptosis, cell signaling and receptor mediated responses, further recognizing that diseases are often multifactorial with oxidative stress as a component. By combining the critical molecular processes underlying free radical mediated pathologies and the role of dietary antioxidant molecules, a connection is made that helps advance therapies and the prevention of gastrointestinal pathological processes. This important reference is well designed with two complementary sections. Section One, Oxidative Stress and Gastroenterology, covers the basic processes of oxidative stress from molecular biology to whole organs, the gastrointestinal anatomy and sources of oxidative stress and free radicals and their products in gastrointestinal diseases. Section Two, Antioxidants and Gastroenterology covers antioxidants in foods, including plants and components. Covers the science of oxidative stress in gastrointestinal tissue and associated conditions and scenarios Provides information on optimal levels for human consumption of antioxidants, suggested requirements per day, recommended dietary allowances and curative/preventive effects of dietary antioxidants Presents an easy to reference guide with two complementary sections that discuss the pathophysiology of gastrointestinal diseases in relation to oxidative stress and antioxidant therapies

Antioxidants In Food Vitamins And Supplements

Author : Amitava Dasgupta
ISBN : 9780124059177
Genre : Science
File Size : 44. 9 MB
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Antioxidants in Food, Vitamins and Supplements bridges the gap between books aimed at consumers and technical volumes written for investigators in antioxidant research. It explores the role of oxidative stress in the pathophysiology of various diseases as well as antioxidant foods, vitamins, and all antioxidant supplements, including herbal supplements. It offers healthcare professionals a rich resource of key clinical information and basic scientific explanations relevant to the development and prevention of specific diseases. The book is written at an intermediate level, and can be easily understood by readers with a college level chemistry and biology background. Covers both oxidative stress-induced diseases as well as antioxidant-rich foods (not the chemistry of antioxidants) Contains easy-to-read tables and figures for quick reference information on antioxidant foods and vitamins Includes a glycemic index and a table of ORAC values of various fruits and vegetables for clinicians to easily make recommendations to patients

Natural Antioxidants And Anticarcinogens In Nutrition Health And Disease

Author : J T Kumpulainen
ISBN : 9781845698409
Genre : Technology & Engineering
File Size : 32. 76 MB
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Natural antioxidants and anticarcinogens in nutrition, health and disease represents the most recent information and state-of-the-art knowledge on the role of antioxidative vitamins, carotenoids and flavonoids in ageing, atherosclerosis, and diabetes, as well as the role of natural anticarcinogenic compounds, particularly lignans and isoflavonoids, and cancer prevention. It is highly interdisciplinary, and will be of importance to all scientists working in the medical, biomedical, nutritional and food sciences as well as the academics.

Diabetes

Author : Victor M. Victor
ISBN : 9780128069660
Genre : Medical
File Size : 81. 9 MB
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Diabetes is a multifactorial disease associated with serious comorbidities. This condition has been related to oxidative stress and, as a consequence, to overproduction of reactive oxygen species (ROS), which are known to be produced by different sources in diabetes. Excessive production of ROS can be harmful, making antioxidant defenses of vital importance. Dietary antioxidants, such as vitamin E or vitamin C, polyphenols and flavonoids have been used to modulate the oxidative stress created in diabetes, producing contradictory results in clinical trials, perhaps as a consequence of the targets selected and/or the design of the studies in question. This chapter considers the process of diabetes with respect to oxidative stress and reviews the different antioxidant strategies employed to treat the disease.

Diabetes

Author : Sara Rani Marcus
ISBN : 9780128069677
Genre : Medical
File Size : 41. 24 MB
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Iron is a micronutrient which exists in the redox states Fe2+ and Fe3+. The easy transition between the two contributes to its metabolic functions and toxic effects. Iron is normally sequestered by binding to proteins – hemoproteins and non-heme iron proteins. Iron homeostasis is maintained by regulation at the levels of dietary uptake and gene expression of iron binding proteins – transferrin receptor and ferritin, to prevent the release of catalytically active Fe2+ ions. Free iron promotes oxidative stress by generating highly reactive hydroxyl radicals through the Fenton/Haber Weiss reactions, which react with cellular biomolecules, resulting in tissue damage. Diabetes is a metabolic disorder characterized by hyperglycemia and oxidative stress. The elevated iron levels in diabetes also elicit oxidative stress and probably mediate insulin deficiency, insulin resistance, hepatic dysfunction and decreased antioxidant defense systems. Both iron overload and deficiency enhance oxidative stress and promote the prognosis of diabetes and its complications.

Handbook Of Oxidants And Antioxidants In Exercise

Author : C. Sen
ISBN : 0080538290
Genre : Science
File Size : 36. 32 MB
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Interest in the science of exercise dates back to the time of ancient Greece. Today exercise is viewed not only as a leisurely activity but also as an effective preventive and therapeutic tool in medicine. Further biomedical studies in exercise physiology and biochemistry reports that strenuous physical exercise might cause oxidative lipid damage in various tissues. The generation of reactive oxygen species is elevated to a level that overwhelms the tissue antioxidant defense systems resulting in oxidative stress. The Handbook of Oxidants and Antioxidants in Exercise examines the different aspects of exercise-induced oxidative stress, its management, and how reactive oxygen may affect the functional capacity of various vital organs and tissues. It includes key related issues such as analytical methods, environmental factors, nutrition, aging, organ function and several pathophysiological processes. This timely publication will be of relevance to those in biomedical science and was designed to be readily understood by the general scientific audience.

Diabetes

Author : Jose Javier Garcia-Medina
ISBN : 9780128069837
Genre : Medical
File Size : 87. 9 MB
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Conventional treatments for diabetic retinopathy (DR) includes glycemic control, laser photocoagulation, vitrectomy, intravitreal triamcinolone, and intravitreal anti-vascular endothelial growth factor agents. However these strategies have not proved capable of halting the progression of this disease in all cases. The mechanisms leading to DR are not fully understood, but there is a growing body of evidence showing that oxidative stress plays a pivotal role in the development of this diabetic complication. In fact it has been proposed that oxidative stress is the initial and maintaining event that triggers and provides feedback to the other pathophysiological pathways related to DR. The experimental data discussed in this review show that different antioxidant agents may prevent various biochemical and structural alterations in retinal cells cultured under hyperglycemic conditions, and also in experimental diabetic animals. Although the results of human trials are somewhat variable, some clinical studies have provided promising results.

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