diagnostic atlas of gastroesophageal reflux disease a new histology based method

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Diagnostic Atlas Of Gastroesophageal Reflux Disease

Author : Parakrama T. Chandrasoma
ISBN : 0080878032
Genre : Medical
File Size : 40. 11 MB
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Gastroesophageal reflux is one of the most common maladies of mankind. Approximately 40% of the adult population of the USA suffers from significant heartburn and the numerous antacids advertised incessantly on national television represents a $8 billion per year drug market. The ability to control acid secretion with the increasingly effective acid-suppressive agents such as the H2 blockers (pepcid, zantac) and proton pump inhibitors (nexium, prevacid) has given physicians an excellent method of treating the symptoms of acid reflux. Unfortunately, this has not eradicated reflux disease. It has just changed its nature. While heartburn, ulceration and strictures have become rare, reflux-induced adenocarcinoma of the esophagus is becoming increasingly common. Adenocarcinoma of the esophagus and gastric cardia is now the most rapidly increasing cancer type in the Western world. At present, there is no histologic test that has any practical value in the diagnosis of reflux disease. The only histologic diagnostic criteria are related to changes in the squamous epithelium which are too insensitive and nonspecific for effective patient management. It is widely recognized that columnar metaplasia of the esophagus (manifest histologically as cardiac, oxyntocardiac and intestinal epithelia) is caused by reflux. However, except for intestinal metaplasia, which is diagnostic for Barrett esophagus, these columnar epithelia are not used to diagnose reflux disease in biopsies. The reason for this is that these epithelial types are indistinguishable from "normal" "gastric" cardiac mucosa. In standard histology texts, this "normal gastric cardia" is 2-3 cm long. In the mid-1990s, Dr. Chandrasoma and his team at USC produced autopsy data suggesting that cardiac and oxyntocardiac mucosa is normally absent from this region and that their presence in biopsies was histologic evidence of reflux disease. From this data, they determined that the presence of cardiac mucosa was a pathologic entity caused by reflux and could therefore be used as a highly specific and sensitive diagnostic criterion for the histologic diagnosis of reflux disease. They call this entity "reflux carditis". In addition, the length of these metaplastic columnar epithelia in the esophagus was an accurate measure of the severity of reflux disease in a given patient. At present, there is some controversy over whether cardiac mucosa is totally absent or present normally to the extent of 0-4 mm. While this should not be a deterrent to changing criteria which are dependent on there normally being 20-30 cm of cardiac mucosa, there has been little mainstream attempt to change existing endoscopic and pathologic diagnostic criteria in the mainstream of either gastroenterology or pathology. The ATLAS will be the source of easily digestible practical information for pathologists faced with biopsies from this region. It will also guide gastroenterologists as they biopsy these patients. The American Gastroenterological Association claims there are 14,500 members worldwide who are practicing physicians and scientists who research, diagnose and treat disorders of the gastrointestinal tract and liver According to the American Society for Clinical Pathology, there are 12,000 board certified pathologists in the U.S. Adenocarcinoma of the esophagus and gastric cardia is now the most rapidly increasing cancer type in the Western world Approximately 40% of the adult population of the U.S. suffers from significant heartburn and the numerous antacids advertised on national television represents an $8 billion per year drug market

Shackelford S Surgery Of The Alimentary Tract E Book

Author : Charles J. Yeo
ISBN : 9781455738076
Genre : Medical
File Size : 47. 53 MB
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Comprehensive and complete, Shackelford’s Surgery of the Alimentary Tract delivers the definitive, clinically oriented, cutting-edge guidance you need to achieve optimal outcomes managing the entire spectrum of gastrointestinal disorders. Make effective use of the latest endoscopic, robotic, and minimally invasive procedures as well as medical therapies with unbeatable advice from a "who’s who" of international authorities! Find expert answers to any clinical question in gastrointestinal surgery, from the esophagus to the colon. See exactly what to look for and how to proceed from an abundance of beautifully detailed intraoperative and laparoscopic photographs.

Gerd

Author : Parakrama T. Chandrasoma
ISBN : 9780128098561
Genre : Medical
File Size : 54. 25 MB
Format : PDF, ePub
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GERD: A New Understanding of Pathology, Pathophysiology, and Treatment transforms the assessment of gastroesophageal reflux disease (GERD) from its present state, which is largely dependent on clinical definition and management, to a more objective scientific basis that depends on pathologic assessment. Sequential chapters in this single-author book describe the fetal development of the esophagus, the normal adult state, and the way exposure to gastric juice causes epithelial and lower esophageal sphincter damage at a cellular level. It allows recognition of the pathologic manifestations of lower esophageal sphincter damage and develops new histopathologic criteria for quantitating such damage. This understanding provides new pathologic criteria for definition and diagnosis of GERD from its earliest cellular stage. Algorithms based on measurement of sphincter damage can identify, even before the onset of clinical GERD, persons who will never develop GERD during life, those who develop GERD but remain with mild and easily controlled disease, and those who will progress to severe GERD with failure to control symptoms, Barrett esophagus and adenocarcinoma. Aggressive early intervention in the last group with the objective of preventing disease progression to its end points of uncontrolled symptoms and adenocarcinoma becomes feasible. Provides a new method of assessment of GERD that has never previously been presented, creating a pathway to control. Describes a new pathologic test based on standard histology that can define lower esophageal sphincter damage. Sequential chapters outline the way GERD progresses from the perspective of the amount of damage to the lower esophageal sphincter. Provides new avenues of clinical research and technologic innovations in pathology and treatment aimed at preventing esophageal adenocarcinoma.

Pediatric Gastrointestinal Disease

Author : W. Allan Walker
ISBN : 1550092405
Genre : Medical
File Size : 55. 22 MB
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This new edition of Pediatric Gastrointestinal Disease is dedicated to the maintenance of a comprehensive approach to the practice of Pediatric Gastroenterology. Considered to be the definitive reference work, this fourth edition has been extensively reviewed. As a result, the size and content of various sections have been modified and new ......

Atlas Of Gi Tract Biopsy A Pattern Based Approach

Author : Christina Arnold
ISBN : 9781496300997
Genre : Medical
File Size : 51. 49 MB
Format : PDF, Kindle
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Effectively evaluate challenging GI biopsies with Atlas of Gastrointestinal Pathology: A Pattern Based Approach to Non-Neoplastic Biopsies! Presented in a format that closely mirrors the daily sign-out process, this one-of-a-kind resource helps you interpret challenging cases by highlighting red flags in the clinical chart and locating hidden clues in the slides. You’ll be able to reach confident diagnoses efficiently with this patterns based “scope-side guide”.

Diagnostic Atlas Of Renal Pathology E Book

Author : Agnes B. Fogo
ISBN : 9780323462488
Genre : Medical
File Size : 30. 96 MB
Format : PDF
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Recognize and diagnose a wide range of renal pathologic entities with Diagnostic Atlas of Renal Pathology, 3rd Edition. In this edition, Drs. Agnes B. Fogo and Michael Kashgarian use hundreds of high-quality illustrations to clearly depict the pathologic features and clinical manifestations of both common and rare renal disorders. Extensive updates to the text keep you current with the knowledge you need for clinical practice or continuing education and certification. More than 700 images of light, immunofluorescence, and electron microscopy for each diagnostic entity with correlations to clinical presentation and pathogenesis. Focused, detailed discussions on key characteristic pathologic findings and prognostic, pathogenetic, and etiologic information. An in-depth examination of pathophysiology, clinical presentations, and the latest evidence-based practices. User-friendly format features tables and sidebars with key points and differential diagnoses, and chapters that include concise, templated discussions regarding the etiology and pathogenesis of the disorder. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. A new chapter describing a logical approach to differential diagnosis. New insights into pathogenesis and classification of diseases. New coverage of aging and the kidney, endemic diseases, transplant, lupus-related kidney diseases, Mesoamerican nephropathy, ApolL1-related nephropathies, C3 glomerulopathies, and thrombotic microangiopathies. Recent results of consensus conferences on vasculitides and renal neoplasia.

American Book Publishing Record

Author :
ISBN : UOM:39015066180400
Genre : American literature
File Size : 51. 31 MB
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Atlas Of Gastrointestinal Surgery

Author : John L. Cameron
ISBN : 1550092707
Genre : Medical
File Size : 51. 39 MB
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Volume 1: Hamilton: BC Decker Inc., c2007.

Color Atlas And Synopsis Gastrointestinal Pathology

Author : Shu-Yuan Xiao
ISBN : 9780071819138
Genre : Medical
File Size : 66. 80 MB
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The ONLY super-concise guide to gastrointestinal pathology In marked contrast to the standard heavy, dense pathology textbook, Dr. Shu-Yuan Xiao has created the first practical “field guide” for gastrointestinal pathology, expressly written to support fast, accurate diagnosis. Practical Gastrointestinal Pathology walks readers through differential diagnosis, whether it be following a pattern of tissue injury or asking the right questions to meet the clinical goal of a particular biopsy. This unique text will help readers differentiate diseases with overlapping histologic features, and render descriptive diagnoses to assist the clinician in providing the best possible patient care. Practical Gastrointestinal Pathology covers some of the most frequently encountered clinical queries faced by the pathologist, and includes algorithms in every chapter to lead readers through differential diagnosis. The book’s focused approach, affordable price, and image-packed presentation makes it appealing to pathology residents as well as the established practicing pathologist. Full-color presentation includes hundreds of high-quality pathology images Algorithms in every chapter lead readers through differential diagnosis

Surgery Of The Esophagus

Author : Jakob R. Izbicki
ISBN : 9783798517431
Genre : Medical
File Size : 90. 58 MB
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While a surgeon many decades agotreated diseases from headtotoe, this concept has evolved, and today some degree of specialization is the rule worldwide. In many countries various boards for sub-specializations are designed, and after a broad training in general surgery, many young surgeons move on further into a specific field. Knowledge of anatomy and precise surgical technique remain the foundation of high quality surgery. A knowledgeable surgeon, equipped with excellent theore- cal and clinical skills, will only be accomplished when he or she masters the - erative techniques of the practice of surgery. The legacy of an academic surgeon or a surgical teacher relies in great part onthe transmission of his or her surgical abilities. Significant influence on the development in esophageal surgery arises from the surgical understanding of the anatomical and functional structures of the esophagus as well as the ongoing developments in the multidisciplinary m- agement in this challenging field of surgery. In bringing forth this atlas, we were motivated by the desire to create a comp- hensive and educational atlas on esophageal diseases, emphasizing all details of pathophysiologies, diagnostic strategies, pre- and postoperative management, and operative techniques covering minimally invasive and open procedures ranging fromstraightforward tomore complex procedures.

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