dna replication

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Molecular Themes In Dna Replication

Author : Lynne Suzanne Cox
ISBN : 9780854041640
Genre : Science
File Size : 59. 61 MB
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DNA replication, the process of copying one double stranded DNA molecule to form two identical copies, is highly conserved at the mechanistic level across evolution. Interesting in its own right as a fascinating feat of biochemical regulation and coordination, DNA replication is at the heart of modern advances in molecular biology. An understanding of the process at both the biological and chemical level is essential to developing new techniques in molecular biology. Insights into the process at the molecular level provide opportunities to modulate and intervene in replication. Rapidly dividing cells need to replicate their DNA prior to division, and targeting components of the replication process is a potentially powerful strategy in cancer treatment. Conversely, ageing may be associated with loss of replication activity and restoring it to cells may moderate some of the diseases associated with old age. Replication is, therefore, fundamental to a huge range of molecular biological and biochemical applications, and provides many potential targets for drug design. The fast pace of replication research, particularly in providing new structural insights, has outdated the majority of available texts. This learned, yet accessible, book contains the latest research written by those conducting it. It examines conserved themes providing a biological background for biochemical, chemical and pharmaceutical studies of this huge and exciting field. Rather than simply "itemising" the replication steps and the proteins involved, replication is tackled from a novel perspective. The book provides logical groupings of processes based upon biochemical similarities. The emphasis on mechanisms and the relationship between structure and function targets the chapters towards biochemists and biological chemists as well as molecular and cell biologists. The book highlights new insights into the replication process, from the assembly of pre-replication complexes, through polymerisation mechanisms, to considering replication in the context of chromatin and chromosomes. It also covers mitochondrial DNA replication, and includes archaeal paradigms, which are proving increasingly relevant to the study of replication in higher eukaryotes. Exciting potential drug targets in DNA replication are discussed, particularly in the context of treating malaria and cancer.

Dna Replication

Author : Arthur Kornberg
ISBN : 1891389440
Genre : Science
File Size : 43. 14 MB
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Often imitated but never rivalled, DNA Replication, regarded around the world as a classic of modern science, is now back in print in a paperback edition. Tania Baker and Nobel Prize-winner Arthur Kornberg's insightful coverage of DNA replication and related cellular processes have made this 1992 edition the standard reference in the field.

Eukaryotic Dna Replication

Author : J. Julian Blow
ISBN : 0199635862
Genre : Medical
File Size : 67. 55 MB
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A cell's ability to control replication of its DNA is fundamental to its normal development or transformation into a cancerous state. DNA replication is also a crucial step in the cell cycle, and recent improvements in our understanding of cell cycle control have promoted a fresh surge ofinterest in the subject.This book begins with reviews of the molecular and genetic components of the replication machinery, and builds up a picture of how the replication process is regulated within the cell division cycle.

Dna Replication

Author : Hisao Masai
ISBN : 9789811069550
Genre : Science
File Size : 85. 31 MB
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This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.

Dna Replication In Eukaryotic Cells

Author : Melvin L. DePamphilis
ISBN : 0879694599
Genre : Science
File Size : 60. 53 MB
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National Institutes of Health. Cold Spring Harbor Monograph, Volume 31 Extensive text on the replication of DNA, specifically in eukaryotic cells, for researchers. 68 contributors, 54 U.S.

The Initiation Of Dna Replication In Eukaryotes

Author : Daniel L. Kaplan
ISBN : 9783319246963
Genre : Medical
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​Every time a cell divides, a copy of its genomic DNA has to be faithfully copied to generate new genomic DNA for the daughter cells. The process of DNA replication needs to be precisely regulated to ensure that replication of the genome is complete and accurate, but that re-replication does not occur. Errors in DNA replication can lead to genome instability and cancer. The process of replication initiation is of paramount importance, because once the cell is committed to replicate DNA, it must finish this process. A great deal of progress has been made in understanding how DNA replication is initiated in eukaryotic cells in the past ten years, but this is the first one-source book on these findings. The Initiation of DNA Replication in Eukaryotes will focus on how DNA replication is initiated in eukaryotic cells. While the concept of replication initiation is simple, its elaborate regulation and integration with other cell processes results in a high level of complexity. This book will cover how the position of replication initiation is chosen, how replication initiation is integrated with the phases of the cell cycle, and how it is regulated in the case of damage to DNA. It is the cellular protein machinery that enables replication initiation to be activated and regulated. We now have an in-depth understanding of how cellular proteins work together to start DNA replication, and this new resource will reveal a mechanistic description of DNA replication initiation as well.

Proteins Involved In Dna Replication

Author : Ulrich Huebscher
ISBN : 9781468487305
Genre : Science
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This book collects the Proceedings of a workshop sponsored by the European Molecular Biology Organization (EMBO) entitled "Pro teins Involved in DNA Replication" which was held September 19 to 23,1983 at Vitznau, near Lucerne, in Switzerland. The aim of this workshop was to review and discuss the status of our knowledge on the intricate array of enzymes and proteins that allow the replication of the DNA. Since the first discovery of a DNA polymerase in Escherichia coli by Arthur Kornberg twenty eight years ago, a great number of enzymes and other proteins were des cribed that are essential for this process: different DNA poly merases, DNA primases, DNA dependent ATPases, helicases, DNA liga ses, DNA topoisomerases, exo- and endonucleases, DNA binding pro teins and others. They are required for the initiation of a round of synthesis at each replication origin, for the progress of the growing fork, for the disentanglement of the replication product, or for assuring the fidelity of the replication process. The number, variety and ways in which these proteins inter act with DNA and with each other to the achievement of replication and to the maintenance of the physiological structure of the chromo somes is the subject of the contributions collected in this volume. The presentations and discussions during this workshop reinforced the view that DNA replication in vivo can only be achieved through the cooperation of a high number of enzymes, proteins and other cofactors.

Dna Replication The Regulatory Mechanisms

Author : Patrick Hughes
ISBN : 9783642769887
Genre : Science
File Size : 36. 52 MB
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DNA replication is a key event in the cell cycle. Although our knowledge is far from complete and many elusive regulatory mechanisms still remain beyondour grasp, many enzymes and a multiplicity of biochemical mechanisms involved have been discovered. Recent findings in E. coli have confirmed and yet surpassed the original hypothesis of F. Jacob. In yeast and higher eucaryotes, the apparent redundancy in putative origins and initiators has made an estimation of the importance of each identified element difficult to access. In spite of well established methodologies - which are also described in the book - the origin identification in mammalian chromosomes is still a controversial subject. On the other hand, considerable advances have been made in our understanding of virus DNA replication and this continues to deepen and broaden our understanding of the controls of cellular DNA replication.

Dna Replication

Author : Roger Lionel Poulter Adams
ISBN : UOM:39015031835427
Genre : Science
File Size : 90. 99 MB
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An understanding of the initiation of DNA replication holds the key to what controls cell division, growth and differentiation. This topic is central to studies in biochemistry, cell biology, genetics and molecular biology, but many textbooks have fallen behind the rapid developments in the field. This timely volume reviews most of the current understanding of replication in different organisms and provides details of exciting new findings. The book presents the general model for DNA replication, the various types of proteins involved, and the reactions occurring at the replication fork. Additional topics include alternative initiation mechanisms, replication control in organisms with single replicons, the significance of timing and direction of gene transcription, and various experimental approaches to studying eukaryotic origins. Termination signals and exciting new findings regarding telomere structure are investigated, followed by a consideration of how replicated DNA is packaged prior to cell division and how epigenetic information is conserved.

Dna Replication And Human Disease

Author : Melvin L. DePamphilis
ISBN : 9780879697662
Genre : Medical
File Size : 79. 7 MB
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This is a second edition of DNA Replication in Eukaryotic Cells, published in 1996. This up-to-date monograph provides a broad account of DNA replication and related functions such as DNA repair and protein phosphorylation, as well as a review of recent advances in understanding the complex gene and protein interactions that underpin this essential cellular function. The new edition not only summarizes the many advances in our understanding of DNA replication in eukaryotic cells that have occurred during the past decade, but also will stimulate thinking about the relationships between DNA replication, human disease, and targeted therapeutics.

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