dynamic regression models for survival data statistics for biology and health

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Dynamic Regression Models For Survival Data

Author : Torben Martinussen
ISBN : 0387202749
Genre : Mathematics
File Size : 85. 52 MB
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In survival analysis there has long been a need for models that goes beyond the Cox model as the proportional hazards assumption often fails in practice. This book studies and applies modern flexible regression models for survival data with a special focus on extensions of the Cox model and alternative models with the specific aim of describing time-varying effects of explanatory variables. One model that receives special attention is Aalen’s additive hazards model that is particularly well suited for dealing with time-varying effects. The book covers the use of residuals and resampling techniques to assess the fit of the models and also points out how the suggested models can be utilised for clustered survival data. The authors demonstrate the practically important aspect of how to do hypothesis testing of time-varying effects making backwards model selection strategies possible for the flexible models considered. The use of the suggested models and methods is illustrated on real data examples. The methods are available in the R-package timereg developed by the authors, which is applied throughout the book with worked examples for the data sets. This gives the reader a unique chance of obtaining hands-on experience. This book is well suited for statistical consultants as well as for those who would like to see more about the theoretical justification of the suggested procedures. It can be used as a textbook for a graduate/master course in survival analysis, and students will appreciate the exercises included after each chapter. The applied side of the book with many worked examples accompanied with R-code shows in detail how one can analyse real data and at the same time gives a deeper understanding of the underlying theory. Torben Martinussen is at the Department of Natural Sciences at the Royal Veterinary and Agricultural University. He has a Ph.D. from University of Copenhagen and is associate editor of the Scandinavian Journal of Statistics. Thomas Scheike is at the Department of Biostatistics at University of Copenhagen. He has a Ph.D. from University of California at Berkeley and is Doctor of Science at the University of Copenhagen. He is the editor of the Scandinavian Journal of Statistics and associate editor of several other journals.

Dynamic Regression Models For Survival Data

Author : Torben Martinussen
ISBN : 9780387339603
Genre : Medical
File Size : 25. 3 MB
Format : PDF, ePub
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This book studies and applies modern flexible regression models for survival data with a special focus on extensions of the Cox model and alternative models with the aim of describing time-varying effects of explanatory variables. Use of the suggested models and methods is illustrated on real data examples, using the R-package timereg developed by the authors, which is applied throughout the book with worked examples for the data sets.

Analyzing Ecological Data

Author : Alain Zuur
ISBN : 9780387459721
Genre : Science
File Size : 38. 26 MB
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This book provides a practical introduction to analyzing ecological data using real data sets. The first part gives a largely non-mathematical introduction to data exploration, univariate methods (including GAM and mixed modeling techniques), multivariate analysis, time series analysis, and spatial statistics. The second part provides 17 case studies. The case studies include topics ranging from terrestrial ecology to marine biology and can be used as a template for a reader’s own data analysis. Data from all case studies are available from www.highstat.com. Guidance on software is provided in the book.

Survival And Event History Analysis

Author : Odd Aalen
ISBN : 9780387685601
Genre : Mathematics
File Size : 90. 40 MB
Format : PDF
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The aim of this book is to bridge the gap between standard textbook models and a range of models where the dynamic structure of the data manifests itself fully. The common denominator of such models is stochastic processes. The authors show how counting processes, martingales, and stochastic integrals fit very nicely with censored data. Beginning with standard analyses such as Kaplan-Meier plots and Cox regression, the presentation progresses to the additive hazard model and recurrent event data. Stochastic processes are also used as natural models for individual frailty; they allow sensible interpretations of a number of surprising artifacts seen in population data. The stochastic process framework is naturally connected to causality. The authors show how dynamic path analyses can incorporate many modern causality ideas in a framework that takes the time aspect seriously. To make the material accessible to the reader, a large number of practical examples, mainly from medicine, are developed in detail. Stochastic processes are introduced in an intuitive and non-technical manner. The book is aimed at investigators who use event history methods and want a better understanding of the statistical concepts. It is suitable as a textbook for graduate courses in statistics and biostatistics.

Handbook Of Survival Analysis

Author : John P. Klein
ISBN : 9781466555679
Genre : Mathematics
File Size : 37. 77 MB
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Handbook of Survival Analysis presents modern techniques and research problems in lifetime data analysis. This area of statistics deals with time-to-event data that is complicated by censoring and the dynamic nature of events occurring in time. With chapters written by leading researchers in the field, the handbook focuses on advances in survival analysis techniques, covering classical and Bayesian approaches. It gives a complete overview of the current status of survival analysis and should inspire further research in the field. Accessible to a wide range of readers, the book provides: An introduction to various areas in survival analysis for graduate students and novices A reference to modern investigations into survival analysis for more established researchers A text or supplement for a second or advanced course in survival analysis A useful guide to statistical methods for analyzing survival data experiments for practicing statisticians

Survival Analysis

Author : John P. Klein
ISBN : 9781475727289
Genre : Medical
File Size : 42. 57 MB
Format : PDF
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Making complex methods more accessible to applied researchers without an advanced mathematical background, the authors present the essence of new techniques available, as well as classical techniques, and apply them to data. Practical suggestions for implementing the various methods are set off in a series of practical notes at the end of each section, while technical details of the derivation of the techniques are sketched in the technical notes. This book will thus be useful for investigators who need to analyse censored or truncated life time data, and as a textbook for a graduate course in survival analysis, the only prerequisite being a standard course in statistical methodology.

Mathematical Reviews

Author :
ISBN : UOM:39015076649915
Genre : Mathematics
File Size : 57. 18 MB
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The Statistical Analysis Of Functional Mri Data

Author : Nicole Lazar
ISBN : 9780387781914
Genre : Medical
File Size : 53. 60 MB
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The study of brain function is one of the most fascinating pursuits of m- ern science. Functional neuroimaging is an important component of much of the current research in cognitive, clinical, and social psychology. The exci- ment of studying the brain is recognized in both the popular press and the scienti?c community. In the pages of mainstream publications, including The New York Times and Wired, readers can learn about cutting-edge research into topics such as understanding how customers react to products and - vertisements (“If your brain has a ‘buy button,’ what pushes it?”, The New York Times,October19,2004),howviewersrespondtocampaignads(“Using M. R. I. ’s to see politics on the brain,” The New York Times, April 20, 2004; “This is your brain on Hillary: Political neuroscience hits new low,” Wired, November 12,2007),howmen and womenreactto sexualstimulation (“Brain scans arouse researchers,”Wired, April 19, 2004), distinguishing lies from the truth (“Duped,” The New Yorker, July 2, 2007; “Woman convicted of child abuse hopes fMRI can prove her innocence,” Wired, November 5, 2007), and even what separates “cool” people from “nerds” (“If you secretly like Michael Bolton, we’ll know,” Wired, October 2004). Reports on pathologies such as autism, in which neuroimaging plays a large role, are also common (for - stance, a Time magazine cover story from May 6, 2002, entitled “Inside the world of autism”).

The Statistical Analysis Of Recurrent Events

Author : Richard J. Cook
ISBN : 9780387698106
Genre : Medical
File Size : 45. 40 MB
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This book presents models and statistical methods for the analysis of recurrent event data. The authors provide broad, detailed coverage of the major approaches to analysis, while emphasizing the modeling assumptions that they are based on. More general intensity-based models are also considered, as well as simpler models that focus on rate or mean functions. Parametric, nonparametric and semiparametric methodologies are all covered, with procedures for estimation, testing and model checking.

Survival And Event History Analysis

Author : Odd Aalen
ISBN : 9780387685601
Genre : Mathematics
File Size : 40. 68 MB
Format : PDF, ePub, Docs
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The aim of this book is to bridge the gap between standard textbook models and a range of models where the dynamic structure of the data manifests itself fully. The common denominator of such models is stochastic processes. The authors show how counting processes, martingales, and stochastic integrals fit very nicely with censored data. Beginning with standard analyses such as Kaplan-Meier plots and Cox regression, the presentation progresses to the additive hazard model and recurrent event data. Stochastic processes are also used as natural models for individual frailty; they allow sensible interpretations of a number of surprising artifacts seen in population data. The stochastic process framework is naturally connected to causality. The authors show how dynamic path analyses can incorporate many modern causality ideas in a framework that takes the time aspect seriously. To make the material accessible to the reader, a large number of practical examples, mainly from medicine, are developed in detail. Stochastic processes are introduced in an intuitive and non-technical manner. The book is aimed at investigators who use event history methods and want a better understanding of the statistical concepts. It is suitable as a textbook for graduate courses in statistics and biostatistics.

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