evolutionary biology of aging

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Evolutionary Biology Of Aging

Author : Michael R. Rose
ISBN : 0198022727
Genre : Science
File Size : 39. 75 MB
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This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes. The basis for this approach lies in the fact that natural selection, as a powerful determining force, tends to decline in importance with age. Many of the characteristics we associate with aging, the author argues, are more the result of this decline than any mechanical imperative contained within organic structures. This theory in turn yields the most fruitful avenues for seeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research. The author ably surveys the vast literature on aging, presenting mathematical, experimental, and comparative findings to illustrate and support the central thesis. The result is the first complete synthesis of this vital field. Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account.

Evolutionary Biology Of Aging

Author : Michael R. Rose
ISBN : 9780195095302
Genre : Family & Relationships
File Size : 33. 17 MB
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In this provocative book on the process of growing old, Michael Rose goes right to the heart of the fundamental "unsolved problem" of biology. Why do we grow old? The proposed theory is that to understand aging we must understand its evolution; only then do its taxonomic distribution and its genetic and physiological mechanisms become intelligible. Evidence is produced from the fields of cell biology, physiology, and gerontology.

Evolutionary Biology Of Aging

Author : Michael R. Rose
ISBN : 9780190282578
Genre : Science
File Size : 53. 44 MB
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This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes. The basis for this approach lies in the fact that natural selection, as a powerful determining force, tends to decline in importance with age. Many of the characteristics we associate with aging, the author argues, are more the result of this decline than any mechanical imperative contained within organic structures. This theory in turn yields the most fruitful avenues for seeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research. The author ably surveys the vast literature on aging, presenting mathematical, experimental, and comparative findings to illustrate and support the central thesis. The result is the first complete synthesis of this vital field. Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account.

Does Aging Stop

Author : Laurence D. Mueller
ISBN : 9780199754229
Genre : Health & Fitness
File Size : 78. 16 MB
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Does Aging Stop? shatters the conventional beliefs on which aging research has been based for the last fifty years.

Darwin S Spectre

Author : Michael R. Rose
ISBN : 1400822637
Genre : Science
File Size : 66. 15 MB
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Extending the human life-span past 120 years. The "green" revolution. Evolution and human psychology. These subjects make today's newspaper headlines. Yet much of the science underlying these topics stems from a book published nearly 140 years ago--Charles Darwin's On the Origin of Species. Far from an antique idea restricted to the nineteenth century, the theory of evolution is one of the most potent concepts in all of modern science. In Darwin's Spectre, Michael Rose provides the general reader with an introduction to the theory of evolution: its beginning with Darwin, its key concepts, and how it may affect us in the future. First comes a brief biographical sketch of Darwin. Next, Rose gives a primer on the three most important concepts in evolutionary theory--variation, selection, and adaptation. With a firm grasp of these concepts, the reader is ready to look at modern applications of evolutionary theory. Discussing agriculture, Rose shows how even before Darwin farmers and ranchers unknowingly experimented with evolution. Medical research, however, has ignored Darwin's lessons until recently, with potentially grave consequences. Finally, evolution supplies important new vantage points on human nature. If humans weren't created by deities, then our nature may be determined more by evolution than we have understood. Or it may not be. In this question, as in many others, the Darwinian perspective is one of the most important for understanding human affairs in the modern world. Darwin's Spectre explains how evolutionary biology has been used to support both valuable applied research, particularly in agriculture, and truly frightening objectives, such as Nazi eugenics. Darwin's legacy has been a comfort and a scourge. But it has never been irrelevant.

Handbook Of The Biology Of Aging

Author : Matt Kaeberlein
ISBN : 9780124116207
Genre : Medical
File Size : 59. 98 MB
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Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

The Biology Of Human Longevity

Author : Caleb E. Finch
ISBN : 0080545947
Genre : Medical
File Size : 87. 29 MB
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Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle. Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists Provides a novel synthesis of existing ideas about the biology of longevity and aging Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition

How Men Age

Author : Richard G. Bribiescas
ISBN : 9781400883264
Genre : Science
File Size : 31. 18 MB
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While the health of aging men has been a focus of biomedical research for years, evolutionary biology has not been part of the conversation—until now. How Men Age is the first book to explore how natural selection has shaped male aging, how evolutionary theory can inform our understanding of male health and well-being, and how older men may have contributed to the evolution of some of the very traits that make us human. In this informative and entertaining book, renowned biological anthropologist Richard Bribiescas looks at all aspects of male aging through an evolutionary lens. He describes how the challenges males faced in their evolutionary past influenced how they age today, and shows how this unique evolutionary history helps explain common aspects of male aging such as prostate disease, loss of muscle mass, changes in testosterone levels, increases in fat, erectile dysfunction, baldness, and shorter life spans than women. Bribiescas reveals how many of the physical and behavioral changes that we negatively associate with male aging may have actually facilitated the emergence of positive traits that have helped make humans so successful as a species, including parenting, long life spans, and high fertility. Popular science at its most compelling, How Men Age provides new perspectives on the aging process in men and how we became human, and also explores future challenges for human evolution—and the important role older men might play in them.

Methuselah Flies

Author : Hardip Brar Passananti
ISBN : 9812567224
Genre : Aging
File Size : 90. 20 MB
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Methuselah Flies presents a trailblazing project on the biology of aging. It describes research on the first organisms to have their lifespan increased, and their aging slowed, by hereditary manipulation. These organisms are fruit flies from the species Drosophila melanogaster, the great workhorse of genetics. Michael Rose and his colleagues have been able to double the lifespan of these insects, and improved their health in numerous respects as well. The study of these flies with postponed aging is one of the best means we have of understanding, and ultimately achieving, the postponement of aging in humans. As such, the carefully presented detail of this book will be of value to research devoted to the understanding and control of aging. Methuselah Flies: is a tightly edited distillation of twenty years of work by many scientists; contains the original publications regarding the longer-lived fruit flies; offers commentaries on each of the topics covered - new, short essays that put the individual research papers in a wider context; gives full access to the original data; captures the scientific significance of postponed aging for a wide academic audience.

The Evolution Of Aging

Author : Theodore C. Goldsmith
ISBN : 9780978870904
Genre : Family & Relationships
File Size : 67. 99 MB
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Goldsmith provides a historical review of biological aging theories including underlying evolution and genetics issues and describes exciting recent discoveries and new theories that are causing renewed interest in aging-by-design.

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