evolutionary biology of aging

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Evolutionary Biology Of Aging

Author : Michael R. Rose
ISBN : 0198022727
Genre : Science
File Size : 60. 33 MB
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This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes. The basis for this approach lies in the fact that natural selection, as a powerful determining force, tends to decline in importance with age. Many of the characteristics we associate with aging, the author argues, are more the result of this decline than any mechanical imperative contained within organic structures. This theory in turn yields the most fruitful avenues for seeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research. The author ably surveys the vast literature on aging, presenting mathematical, experimental, and comparative findings to illustrate and support the central thesis. The result is the first complete synthesis of this vital field. Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account.

Darwin S Spectre

Author : Michael R. Rose
ISBN : 1400822637
Genre : Science
File Size : 22. 14 MB
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Extending the human life-span past 120 years. The "green" revolution. Evolution and human psychology. These subjects make today's newspaper headlines. Yet much of the science underlying these topics stems from a book published nearly 140 years ago--Charles Darwin's On the Origin of Species. Far from an antique idea restricted to the nineteenth century, the theory of evolution is one of the most potent concepts in all of modern science. In Darwin's Spectre, Michael Rose provides the general reader with an introduction to the theory of evolution: its beginning with Darwin, its key concepts, and how it may affect us in the future. First comes a brief biographical sketch of Darwin. Next, Rose gives a primer on the three most important concepts in evolutionary theory--variation, selection, and adaptation. With a firm grasp of these concepts, the reader is ready to look at modern applications of evolutionary theory. Discussing agriculture, Rose shows how even before Darwin farmers and ranchers unknowingly experimented with evolution. Medical research, however, has ignored Darwin's lessons until recently, with potentially grave consequences. Finally, evolution supplies important new vantage points on human nature. If humans weren't created by deities, then our nature may be determined more by evolution than we have understood. Or it may not be. In this question, as in many others, the Darwinian perspective is one of the most important for understanding human affairs in the modern world. Darwin's Spectre explains how evolutionary biology has been used to support both valuable applied research, particularly in agriculture, and truly frightening objectives, such as Nazi eugenics. Darwin's legacy has been a comfort and a scourge. But it has never been irrelevant.

Does Aging Stop

Author : Laurence D. Mueller
ISBN : 9780199754229
Genre : Health & Fitness
File Size : 25. 42 MB
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Does Aging Stop? shatters the conventional beliefs on which aging research has been based for the last fifty years.

The Long Tomorrow

Author : Michael R. Rose
ISBN : 0198039867
Genre : Science
File Size : 48. 80 MB
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The conquest of aging is now within our grasp. It hasn't arrived yet, writes Michael R. Rose, but a scientific juggernaut has started rolling and is picking up speed. A long tomorrow is coming. In The Long Tomorrow, Rose offers us a delightfully written account of the modern science of aging, spiced with intriguing stories of his own career and leavened with the author's engaging sense of humor and rare ability to make contemporary research understandable to nonscientists. The book ranges from Rose's first experiments while a graduate student--counting a million fruit fly eggs, which took 3,000 hours over the course of a year--to some of his key scientific discoveries. We see how some of his earliest experiments helped demonstrate that "the force of natural selection" was key to understanding the aging process--a major breakthrough. Rose describes how he created the well-known Methuselah Flies, fruit flies that live far longer than average. Equally important, Rose surveys the entire field, offering colorful portraits of many leading scientists and shedding light on research findings from around the world. We learn that rodents given fifteen to forty percent fewer calories live about that much longer, and that volunteers in Biosphere II, who lived on reduced caloric intake for two years, all had improved vital signs. Perhaps most interesting, we discover that aging hits a plateau and stops. Popular accounts of Rose's work have appeared in The New Yorker, Time magazine, and Scientific American, but The Long Tomorrow is the first full account of this exciting new science written for the general reader. "Among his peers, Rose is considered a brilliantly innovative scientist, who has almost single-handedly brought the evolutionary theory of aging from an abstract notion to one of the most exciting topics in science."--Malcolm Gladwell, The New Yorker

Handbook Of The Biology Of Aging

Author : Matt Kaeberlein
ISBN : 9780124116207
Genre : Medical
File Size : 68. 58 MB
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Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Methuselah Flies

Author : Michael R Rose
ISBN : 9789814483353
Genre : Science
File Size : 68. 90 MB
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Methuselah Flies presents a trailblazing project on the biology of aging. It describes research on the first organisms to have their lifespan increased, and their aging slowed, by hereditary manipulation. These organisms are fruit flies from the species Drosophila melanogaster, the great workhorse of genetics. Michael Rose and his colleagues have been able to double the lifespan of these insects, and improved their health in numerous respects as well. The study of these flies with postponed aging is one of the best means we have of understanding, and ultimately achieving, the postponement of aging in humans. As such, the carefully presented detail of this book will be of value to research devoted to the understanding and control of aging. Methuselah Flies: • is a tightly edited distillation of twenty years of work by many scientists • contains the original publications regarding the longer-lived fruit flies • offers commentaries on each of the topics covered — new, short essays that put the individual research papers in a wider context • gives full access to the original data • captures the scientific significance of postponed aging for a wide academic audience Contents: Creation and Long-term Evolution of Methuselah FliesStress, Resistance, Physiology, and AgingReproduction, Nutrition, and AgingGenetics and Molecular Biology of Methuselah FliesReverse Evolution of Methuselah FliesAging, Development, and Crowding Readership: Biologists and doctors interested in the study of aging. Keywords:Aging;Evolution;Drosophila;Postponed Senescence;Fruit Flies

Molecular Biology Of Aging

Author : Leonard Guarente
ISBN : 9780879698249
Genre : Medical
File Size : 61. 6 MB
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This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.

Handbook Of The Biology Of Aging

Author : Edward J. Masoro
ISBN : 9780080491400
Genre : Social Science
File Size : 61. 17 MB
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The Handbook of the Biology of Aging, Sixth Edition, provides a comprehensive overview of the latest research findings in the biology of aging. Intended as a summary for researchers, it is also adopted as a high level textbook for graduate and upper level undergraduate courses. The Sixth Edition is 20% larger than the Fifth Edition, with 21 chapters summarizing the latest findings in research on the biology of aging. The content of the work is virtually 100% new. Though a selected few topics are similar to the Fifth Edition, these chapters are authored by new contributors with new information. The majority of the chapters are completely new in both content and authorship. The Sixth Edition places greater emphasis and coverage on competing and complementary theories of aging, broadening the discussion of conceptual issues. Greater coverage of techniques used to study biological issues of aging include computer modeling, gene profiling, and demographic analyses. Coverage of research on Drosophilia is expanded from one chapter to four. New chapters on mammalian models discuss aging in relation to skeletal muscles, body fat and carbohydrate metabolism, growth hormone, and the human female reproductive system. Additional new chapters summarize exciting research on stem cells and cancer, dietary restriction, and whether age related diseases are an integral part of aging. The Handbook of the Biology of Aging, Sixth Edition is part of the Handbooks on Aging series, including Handbook of the Psychology of Aging and Handbook of Aging and the Social Sciences, also in their 6th editions.

Biology Of Aging

Author : Robert Arking
ISBN : 0199727627
Genre : Science
File Size : 67. 81 MB
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Robert Arking's Biology of Aging, 3rd edition, is an introductory text to the biology of aging which gives advanced undergraduate and graduate students a thorough review of the entire field. His prior two editions have also served admirably as a reference text for clinicians and scientists. This new edition captures the extraordinary recent advances in our knowledge of the ultimate and proximal mechanisms underlying the phenomenon of aging. As a result, six important conceptual changes are included here: ? Clarified distinctions between the biological mechanisms involved in longevity determination and those involved in senescent processes. ? A new conceptual framework around which we can organize all the new facts about aging. This will assist readers to make sense of the information and use the data to form their own ideas. ? Increased knowledge of aging cells has lead to new ideas on how a cell transits from a healthy state to a senescent state, while still allowing for high levels of intra- and inter-specific variability. ? Discussion of senescent mechanisms assists the reader to understand that aging is a non-programmatic loss of function, likely arising from the loss of regulatory signals, and so is modifiable in the laboratory. ? Because the standard evolutionary story does not fully explain the evolution of social organisms, this edition also includes recent work dealing with intergenerational resource transfers. ? Lastly, if aging mechanisms are plastic, then the demand to move these anti-aging interventions into the human arena will inevitably grow. A discussion of the biological and ethical arguments on both sides of the question frames the question in an appropriate manner. The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. The last two chapters integrate all this material into a coherent view of how the relevant biological processes change over the life span. This view is expressed in two non-technical figures (you might say that the whole book exists to fully support Figs 9-4 & 14-9), whose meanings are elucidated as the reader progresses through the book.

Longevity Senescence And The Genome

Author : Caleb E. Finch
ISBN : 0226248895
Genre : Science
File Size : 72. 37 MB
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Featuring extensive references, updated for this paperback edition, Longevity, Senescence, and the Genome constitutes a landmark contribution to biomedicine and the evolutionary biology of aging. To enhance gerontology's focus on human age-related dysfunctions, Caleb E. Finch provides a comparative review of all the phyla of organisms, broadening gerontology to intersect with behavioral, developmental, evolutionary, and molecular biology. By comparing species that have different developmental and life spans, Finch proposes an original typology of senescence from rapid to gradual to negligible, and he provides the first multiphyletic calculations of mortality rate constants.

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