exposure science

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Exposure Science

Author : Paul Lioy
ISBN : 9780124202382
Genre : Technology & Engineering
File Size : 54. 51 MB
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Exposure Science: Basic Principles and Applications provides a concise overview of the field of exposure science, from its origins in sanitation and occupational health, to its exciting involvement with emerging scientific concepts. Written by world-leading experts in the field of exposure science, this book provides all the basic understanding you need to employ the best tools and methods for measurement, analysis, and modeling of exposure. Exposure Science: Basic Principles and Applications is an invaluable introduction to exposure science for anyone working in the fields of environmental health, risk assessment, toxicology, or epidemiology. Focuses on and highlights the basic fundamentals, scientific goals, theories and tools of exposure science Examines the use of the exposome and eco-exposome concepts within the field of exposure science

Exposure Science In The 21st Century

Author : Committee on Human and Environmental Exposure Science in the 21st Century
ISBN : 9780309264686
Genre : Medical
File Size : 83. 18 MB
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From the use of personal products to our consumption of food, water, and air, people are exposed to a wide array of agents each day--many with the potential to affect health. Exposure Science in the 21st Century: A Vision and A Strategy investigates the contact of humans or other organisms with those agents (that is, chemical, physical, and biologic stressors) and their fate in living systems. The concept of exposure science has been instrumental in helping us understand how stressors affect human and ecosystem health, and in efforts to prevent or reduce contact with harmful stressors. In this way exposure science has played an integral role in many areas of environmental health, and can help meet growing needs in environmental regulation, urban and ecosystem planning, and disaster management. Exposure Science in the 21st Century: A Vision and A Strategy explains that there are increasing demands for exposure science information, for example to meet needs for data on the thousands of chemicals introduced into the market each year, and to better understand the health effects of prolonged low-level exposure to stressors. Recent advances in tools and technologies--including sensor systems, analytic methods, molecular technologies, computational tools, and bioinformatics--have provided the potential for more accurate and comprehensive exposure science data than ever before. This report also provides a roadmap to take advantage of the technologic innovations and strategic collaborations to move exposure science into the future.

Completing The Link Between Exposure Science And Toxicology For Improved Environmental Health Decision Making

Author :
ISBN : OCLC:971476531
Genre :
File Size : 47. 8 MB
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Here, driven by major scientific advances in analytical methods, biomonitoring, computation, and a newly articulated vision for a greater impact in public health, the field of exposure science is undergoing a rapid transition from a field of observation to a field of prediction. Deployment of an organizational and predictive framework for exposure science analogous to the "systems approaches" used in the biological sciences is a necessary step in this evolution. Here we propose the aggregate exposure pathway (AEP) concept as the natural and complementary companion in the exposure sciences to the adverse outcome pathway (AOP) concept in the toxicological sciences. Aggregate exposure pathways offer an intuitive framework to organize exposure data within individual units of prediction common to the field, setting the stage for exposure forecasting. Looking farther ahead, we envision direct linkages between aggregate exposure pathways and adverse outcome pathways, completing the source to outcome continuum for more meaningful integration of exposure assessment and hazard identification. Together, the two frameworks form and inform a decision-making framework with the flexibility for risk-based, hazard-based, or exposure-based decision making.

Journal Of Exposure Science Environmental Epidemiology

Author :
ISBN : STANFORD:36105122660496
Genre : Environmental health
File Size : 32. 86 MB
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Using 21st Century Science To Improve Risk Related Evaluations

Author : National Academies of Sciences, Engineering, and Medicine
ISBN : 9780309453486
Genre : Nature
File Size : 24. 1 MB
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Over the last decade, several large-scale United States and international programs have been initiated to incorporate advances in molecular and cellular biology, -omics technologies, analytical methods, bioinformatics, and computational tools and methods into the field of toxicology. Similar efforts are being pursued in the field of exposure science with the goals of obtaining more accurate and complete exposure data on individuals and populations for thousands of chemicals over the lifespan; predicting exposures from use data and chemical-property information; and translating exposures between test systems and humans. Using 21st Century Science to Improve Risk-Related Evaluations makes recommendations for integrating new scientific approaches into risk-based evaluations. This study considers the scientific advances that have occurred following the publication of the NRC reports Toxicity Testing in the 21st Century: A Vision and a Strategy and Exposure Science in the 21st Century: A Vision and a Strategy. Given the various ongoing lines of investigation and new data streams that have emerged, this publication proposes how best to integrate and use the emerging results in evaluating chemical risk. Using 21st Century Science to Improve Risk-Related Evaluations considers whether a new paradigm is needed for data validation, how to integrate the divergent data streams, how uncertainty might need to be characterized, and how best to communicate the new approaches so that they are understandable to various stakeholders.

Exposure Analysis

Author : Wayne R. Ott
ISBN : 9781420012637
Genre : Science
File Size : 44. 13 MB
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Written by experts, Exposure Analysis is the first complete resource in the emerging scientific discipline of exposure analysis. A comprehensive source on the environmental pollutants that affect human health, the book discusses human exposure through pathways including air, food, water, dermal absorption, and, for children, non-food ingestion. The book summarizes existing definitions of exposure, dose, and related concepts and provides the mathematical framework at the heart of these conceptual definitions. Using secondhand smoke as an example, the book illustrates how exposure analysis studies can change human behavior and improve public health. An extensive section on air pollutants considers volatile organic compounds (VOCs), carbon monoxide (CO), fine and ultrafine particles, and the latest personal air quality monitors for measuring individual exposure. Another detailed section examines exposures to pesticides, metals such as lead, and dioxin that may occur through multiple routes such as air, food, and dust ingestion. The book explores important aspects of dermal exposure such as the absorption of volatile organic compounds while showering or bathing and exposure through multiple carrier media. The authors describe quantitative methods that have been validated for predicting the concentrations in enclosed everyday locations, such as automobiles and rooms of the home. They also discuss existing laws and examine the relationship between exposure and national policies. Defining the new field of exposure analysis, this book provides the basic tools needed to identify sources, understand causes, measure exposures, and develop strategies for improving public health.

Handbook Of Exposure Therapies

Author : David C.S. Richard
ISBN : 9780080467818
Genre : Psychology
File Size : 52. 71 MB
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Exposure Therapy refers to any clinical intervention in which a client directly confronts a source of fear. Since high levels of anxiety can not be maintained indefinitely, repeated exposure leads to decreased anxiety. This type of treatment is effective with phobias, post traumatic stress disorder, obsessive compulsive disorders, panic, generalized anxiety, and several other disorders. It's also been found to be effective in helping to treat substance abuse. Although exposure-based treatments have been extensively researched and reported in the literature, there is no single comprehensive treatment of exposure therapies. Writings tend to be limited to larger pieces on treating specific disorders or types of patients. A comprehensive book on the use of these treatments across patient disorders will be of great use to practitioners. The book is divided into three sections: Foundation, Applications, and Issues. Foundation chapters considers theoretical and assessment issues. Applications chapters will discuss research literature on each disorder having been proven to be successfully treated with exposure therapy. Issue chapters will discuss liability issues, false memory syndrome, and the use of computers and virtual reality in exposure therapy. *Covers the broad range of exposure therapies in one comprehensive source *Provides an integrated look at exposure therapy across a variety of disorders *Each such chapter will include a case study *Blends literature review and practice guidelines

Adverse Effects Of Engineered Nanomaterials

Author : Bengt Fadeel
ISBN : 9780128094907
Genre : Medical
File Size : 44. 59 MB
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Adverse Effects of Engineered Nanomaterials: Exposure, Toxicology, and Impact on Human Health, Second Edition, provides a systematic evaluation of representative engineered nanomaterials (ENM) of high volume production and their high economic importance. Each class of nanomaterials discussed includes information on what scientists, industry, regulatory agencies, and the general public need to know about nanosafety. Written by leading international experts in nanotoxicology and nanomedicine, this book gives a comprehensive view of the health impact of ENM, focusing on their potential adverse effects in exposed workers, consumers, and patients. All chapters have been updated with new sections on the endocrine system and other organ systems. In addition, other newly added sections include introductory chapters on the physio-chemical characterization of nanomaterials and interactions between nanomaterials and biological systems, as well as a new chapter that explores risk assessment and management of nanomaterials. This book fills an important need in terms of bridging the gap between experimental findings and human exposure to ENM, also detailing the clinical and pathological consequences of such exposure in the human population. Uses a schematic, non-exhaustive approach to summarizes the most important research data in this field Discusses the health implications of experimental data in nanotoxicology Presents a completely revised edition that focuses on the human health impacts of engineered nanomaterials, including many organ-specific chapters

The Exposome

Author : Gary W Miller
ISBN : 9780124172180
Genre : Science
File Size : 49. 87 MB
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The Exposome: A Primer is the first book dedicated to exposomics, detailing the purpose and scope of this emerging field of study, its practical applications and how it complements a broad range of disciplines. Genetic causes account for up to a third of all complex diseases. (As genomic approaches improve, this is likely to rise.) Environmental factors also influence human disease but, unlike with genetics, there is no standard or systematic way to measure the influence of environmental exposures. The exposome is an emerging concept that hopes to address this, measuring the effects of life-long environmental exposures on health and how these exposures can influence disease. This systematic introduction considers topics of managing and integrating exposome data (including maps, models, computation, and systems biology), "-omics"-based technologies, and more. Both students and scientists in disciplines including toxicology, environmental health, epidemiology, and public health will benefit from this rigorous yet readable overview.

Environmental Mycology In Public Health

Author : Carla Viegas
ISBN : 9780124115354
Genre : Science
File Size : 85. 40 MB
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Environmental Mycology in Public Health: Fungi and Mycotoxins Risk Assessment and Management provides the most updated information on fungi, an essential element in the survival of our global ecology that can also pose a significant threat to the health of occupants when they are present in buildings. As the exposure to fungi in homes is a significant risk factor for a number of respiratory symptoms, including allergies and hypersensitivity pneumonitis, this book presents information on fungi and their disease agents, important aspects of exposure assessment, and their impacts on health. This book answers the hard questions, including, "How does one detect and measure the presence of indoor fungi?" and "What is an acceptable level of indoor fungi?" It then examines how we relate this information to human health problems. Provides unique new insights on fungi and their metabolites detection in the environmental and occupational settings Presents new information that is enriched by significant cases studies Multi-contributed work, edited by a proficient team in medical and environmental mycology with different individual expertise Guides the readers in the implementation of preventive and protective measures regarding exposure to fungi

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