frontiers in clinical drug research alzheimer disorders

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Frontiers In Clinical Drug Research Alzheimer Disorders

Author : Atta-ur-Rahman
ISBN : 9781681083391
Genre : Science
File Size : 24. 43 MB
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Frontiers in Clinical Drug Research - Alzheimer Disorders is a book series concerned with Alzheimer's disease (AD) that causes dementia, or loss of brain function. The disease affects the parts of the brain that deal with memory, thought, and language. Chapters in each volume focus on (Alzheimer Disorders) drug research with special emphasis on clinical trials, research on drugs in advanced stages of development and cure for Alzheimer’s disease and related disorders. Frontiers in Clinical Drug Research - Alzheimer Disorders will be of particular interest to readers interested in drug therapy of this specific neurodegenerative condition and related brain disorders as the series provides relevant reviews written by experts in field of Alzheimer’s disease research.

Frontiers In Clinical Drug Research Cns And Neurological Disorders

Author : Atta-ur-Rahman
ISBN : 9781608059263
Genre : Science
File Size : 55. 37 MB
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Frontiers in Clinical Drug Research - CNS and Neurological Disorders is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the eBook series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. The third volume of this series features six chapters that cover a variety of topics including: -the role of Potassium transport channels in neuroprotection against tetrahydroprotoberberines -cannabinoids in cell therapy for CNS disorders -AMPA Receptor Antagonists -therapeutic intervention in polyglutamine ataxias -nutritional therapies in neurology practice

Drug Design And Discovery In Alzheimer S Disease

Author : Atta-ur-Rahman
ISBN : 9780128039601
Genre : Science
File Size : 42. 96 MB
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Drug Design and Discovery in Alzheimer’s Disease includes expert reviews of recent developments in Alzheimer's disease (AD) and neurodegenerative disease research. Originally published by Bentham as Frontiers in Drug Design and Discovery, Volume 6and now distributed by Elsevier, this compilation of the sixteen articles, written by leading global researchers, focuses on key developments in the understanding of the disease at molecular levels, identification and validation of molecular targets, as well as innovative approaches towards drug discovery, development, and delivery. Beginning with an overview of AD pharmacotherapy and existing blockbuster drugs, the reviews cover the potential of both natural and synthetic small molecules; the role of cholinesterases in the on-set and progression of AD and their inhibition; the role of beta-site APP clearing enzyme-1 (BACE-1) in the production of ß-amyloid proteins, one of the key reasons of the progression of AD; and other targets identified for AD drug discovery. Edited and written by leading experts in Alzheimer’s disease (AD) and other neurodegenerative disease drug development Describes existing drugs for AD and current molecular understanding of the condition Reviews recent advances in the field, including coverage of cholinesterases, BACE-1, and other drug development targets

Frontiers In Nanomedicine

Author : Maria Luisa Bondì Bondì
ISBN : 9781681080468
Genre : Science
File Size : 23. 46 MB
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Frontiers in Nanomedicine offers an up-to-date understanding of nanomaterials to readers having clinical or biomolecular research interests. Scientists, both aspiring and experienced, will find, in each volume, a comprehensive overview of current molecular strategies for using nanoscale materials in medicine. This volume explains the use of nanotechnology in medicine to improve the diagnosis of disease and the role of nanoparticles in targeted drug delivery systems for theranostic applications. This volume also covers the applications of nanoparticles in breast cancer research, liver disease therapy and Alzheimer’s disease treatment.

Reducing Risks For Mental Disorders

Author : Committee on Prevention of Mental Disorders
ISBN : 9780309568661
Genre : Medical
File Size : 84. 61 MB
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The understanding of how to reduce risk factors for mental disorders has expanded remarkably as a result of recent scientific advances. This study, mandated by Congress, reviews those advances in the context of current research and provides a targeted definition of prevention and a conceptual framework that emphasizes risk reduction. Highlighting opportunities for and barriers to interventions, the book draws on successful models for the prevention of cardiovascular disease, injuries, and smoking. In addition, it reviews the risk factors associated with Alzheimer's disease, schizophrenia, alcohol abuse and dependence, depressive disorders, and conduct disorders and evaluates current illustrative prevention programs. The models and examination provide a framework for the design, application, and evaluation of interventions intended to prevent mental disorders and the transfer of knowledge about prevention from research to clinical practice. The book presents a focused research agenda, with recommendations on how to develop effective intervention programs, create a cadre of prevention researchers, and improve coordination among federal agencies.

Drug Repositioning

Author : Joel Dudley
ISBN : 9781315356211
Genre : Medical
File Size : 54. 89 MB
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Nervous system diseases represent a major health concern worldwide. Although important financial and professional investment, their etiology and pathophysiology still remain mostly elusive. Moreover, the clinical need of disease-modifying therapies is still unmet. In the last decades, traditional R&D has failed in identifying new effective therapies in many medical areas and drug repositioning has recently emerged as a promising alternative strategy to de novo drug discovery to improve and accelerate therapeutic development. For the first time, Drug Repositioning: Approaches and Applications for Neurotherapeutics reviews history and advances in drug repositioning, with a special focus on therapeutics for nervous system diseases. International experts from Academia, Industry and Non-profit organisations will provide different views on drug repositioning advantages, challenges and specific applications, which will be covered for nervous system diseases including Alzheimer's, Parkinson's, Huntington's diseases, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, ischemic stroke, and psychiatric disorders. This book provides a balanced overview and synthesis of drug repositioning concept, methods and applications for neurotherapeutics. It represents a valuable resource for students, scientists and clinicians working in academic settings, industry and government agencies within the fields of neuroscience, pharmacology, neurology, pharmaceutical sciences, drug discovery and development.

100 Simple Things You Can Do To Prevent Alzheimer S And Age Related Memory Loss

Author : Jean Carper
ISBN : 0316121606
Genre : Health & Fitness
File Size : 49. 64 MB
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Most people think there is little or nothing you can do to avoid Alzheimer's. But scientists know this is no longer true. In fact, prominent researchers now say that our best and perhaps only hope of defeating Alzheimer's is to prevent it. After best-selling author Jean Carper discovered that she had the major susceptibility gene for Alzheimer's, she was determined to find all the latest scientific evidence on how to escape it. She discovered 100 surprisingly simple scientifically tested ways to radically cut the odds of Alzheimer's, memory decline, and other forms of dementia. Did you know that vitamin B 12 helps keep your brain from shrinking? Apple juice mimics a common Alzheimer's drug? Surfing the internet strengthens aging brain cells? Exercise is like Miracle-Gro for your brain? Even a few preventive actions could dramatically change your future. 100 Simple Things You Can Do to Prevent Alzheimer's will change the way you look at Alzheimer's and provide exciting new answers from the frontiers of brain research to help keep you and your family free of this heartbreaking disease.

Epigenetic Regulation In The Nervous System

Author : J. David Sweatt
ISBN : 9780123944054
Genre : Science
File Size : 66. 44 MB
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Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics

Neurodegenerative Diseases

Author : Jagan A Pillai PhD
ISBN : 9780190233570
Genre : Medical
File Size : 85. 10 MB
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As the global population ages the impact of neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are significant forces in shaping human health and quality of life in the 21st century. Insights into understanding these diseases, and knowing how to treat them are major frontiers of scientific research. Neurodegenerative Diseases: Unifying Principles is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction and its consequences over time. Providing an overview of this conceptual change is the main theme for the book. Conventional approach emphasize the differences among neurodegenerative disorders, here Drs. Cummings and Pillai compile the increasingly compelling evidence that these disorders share many features and that insights in one may be rapidly translated into advances in another. The goal is to accelerate understanding by showing linkages among biological, pathological, can clinical aspects of this class of diseases. This collection of 19, inter-related chapters, articulates and broadens our view of the unifying features that initiate and drive disease progression across a variety of neurodegenerative diseases over time. This book will serve as an outstanding sourcebook of insights from experts that have played key roles in this story.

Handbook Of Nanobiomedical Research Fundamentals Applications And Recent Developments In 4 Volumes

Author : Torchilin Vladimir P
ISBN : 9789814520669
Genre : Technology & Engineering
File Size : 39. 53 MB
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This book consists of 4 volumes containing about 70 chapters covering all the major aspects of the growing area of nanomedicine. Leading scientists from 15 countries cover all major areas of nanobiomedical research — materials for nanomedicine, application of nanomedicine in therapy of various diseases, use of nanomedicines for diagnostic purposes, technology of nanomedicines, and new trends in nanobiomedical research.This is the first detailed handbook specifically addressing various aspects of nanobiomedicine. Readers are treated to cutting-edge research and the newest data from leading researchers in this area.

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