fundamentals of protein structure and function

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Fundamentals Of Protein Structure And Function

Author : Engelbert Buxbaum
ISBN : 9783319199207
Genre : Science
File Size : 66. 66 MB
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This book serves as an introduction to protein structure and function. Starting with their makeup from simple building blocks, called amino acids, the 3-dimensional structure of proteins is explained. This leads to a discussion how misfolding of proteins causes diseases like cancer, various encephalopathies, or diabetes. Enzymology and modern concepts of enzyme kinetics are then introduced, taking into account the physiological, pharmacological and medical significance of this often neglected topic. This is followed by thorough coverage of hæmoglobin and myoglobin, immunoproteins, motor proteins and movement, cell-cell interactions, molecular chaperones and chaperonins, transport of proteins to various cell compartments and solute transport across biological membranes. Proteins in the laboratory are also covered, including a detailed description of the purification and determination of proteins, as well as their characterisation for size and shape, structure and molecular interactions. The book emphasises the link between protein structure, physiological function and medical significance. This book can be used for graduate and advanced undergraduate classes covering protein structure and function and as an introductory text for researchers in protein biochemistry, molecular and cell biology, chemistry, biophysics, biomedicine and related courses. About the author: Dr. Buxbaum is a biochemist with interest in enzymology and protein science. He has been working on the biochemistry of membrane transport proteins for nearly thirty years and has taught courses in biochemistry and biomedicine at several universities.

Structural Bioinformatics

Author : Jenny Gu
ISBN : 9781118210567
Genre : Science
File Size : 61. 82 MB
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Structural Bioinformatics was the first major effort to show the application of the principles and basic knowledge of the larger field of bioinformatics to questions focusing on macromolecular structure, such as the prediction of protein structure and how proteins carry out cellular functions, and how the application of bioinformatics to these life science issues can improve healthcare by accelerating drug discovery and development. Designed primarily as a reference, the first edition nevertheless saw widespread use as a textbook in graduate and undergraduate university courses dealing with the theories and associated algorithms, resources, and tools used in the analysis, prediction, and theoretical underpinnings of DNA, RNA, and proteins. This new edition contains not only thorough updates of the advances in structural bioinformatics since publication of the first edition, but also features eleven new chapters dealing with frontier areas of high scientific impact, including: sampling and search techniques; use of mass spectrometry; genome functional annotation; and much more. Offering detailed coverage for practitioners while remaining accessible to the novice, Structural Bioinformatics, Second Edition is a valuable resource and an excellent textbook for a range of readers in the bioinformatics and advanced biology fields. Praise for the previous edition: "This book is a gold mine of fundamental and practical information in an area not previously well represented in book form." —Biochemistry and Molecular Education "... destined to become a classic reference work for workers at all levels in structural bioinformatics...recommended with great enthusiasm for educators, researchers, and graduate students." —BAMBED "...a useful and timely summary of a rapidly expanding field." —Nature Structural Biology "...a terrific job in this timely creation of a compilation of articles that appropriately addresses this issue." —Briefings in Bioinformatics

Fundamentals Of Protein Nmr Spectroscopy

Author : Gordon S. Rule
ISBN : 9781402035005
Genre : Science
File Size : 20. 1 MB
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NMR spectroscopy has proven to be a powerful technique to study the structure and dynamics of biological macromolecules. Fundamentals of Protein NMR Spectroscopy is a comprehensive textbook that guides the reader from a basic understanding of the phenomenological properties of magnetic resonance to the application and interpretation of modern multi-dimensional NMR experiments on 15N/13C-labeled proteins. Beginning with elementary quantum mechanics, a set of practical rules is presented and used to describe many commonly employed multi-dimensional, multi-nuclear NMR pulse sequences. A modular analysis of NMR pulse sequence building blocks also provides a basis for understanding and developing novel pulse programs. This text not only covers topics from chemical shift assignment to protein structure refinement, as well as the analysis of protein dynamics and chemical kinetics, but also provides a practical guide to many aspects of modern spectrometer hardware, sample preparation, experimental set-up, and data processing. End of chapter exercises are included to emphasize important concepts. Fundamentals of Protein NMR Spectroscopy not only offer students a systematic, in-depth, understanding of modern NMR spectroscopy and its application to biomolecular systems, but will also be a useful reference for the experienced investigator.

Fundamentals Of Protein Biotechnology

Author : Stein
ISBN : 9781351446358
Genre : Medical
File Size : 56. 63 MB
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Fills a gap between the existing studies of proteins, which tend to be highly technical and geared toward the practicing protein chemist, and biochemistry textbooks, which focus on general principles. Scientists cover a dozen topics by presenting fundamental principles, an overview, and the practica

Pharmaceutical Biotechnology

Author : Gary Walsh
ISBN : 9781118685754
Genre : Science
File Size : 71. 28 MB
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Pharmaceutical Biotechnology offers students taking Pharmacy and related Medical and Pharmaceutical courses a comprehensive introduction to the fast-moving area of biopharmaceuticals. With a particular focus on the subject taken from a pharmaceutical perspective, initial chapters offer a broad introduction to protein science and recombinant DNA technology- key areas that underpin the whole subject. Subsequent chapters focus upon the development, production and analysis of these substances. Finally the book moves on to explore the science, biotechnology and medical applications of specific biotech products categories. These include not only protein-based substances but also nucleic acid and cell-based products. introduces essential principles underlining modern biotechnology- recombinant DNA technology and protein science an invaluable introduction to this fast-moving subject aimed specifically at pharmacy and medical students includes specific ‘product category chapters’ focusing on the pharmaceutical, medical and therapeutic properties of numerous biopharmaceutical products. entire chapter devoted to the principles of genetic engineering and how these drugs are developed. includes numerous relevant case studies to enhance student understanding no prior knowledge of protein structure is assumed

Prionen Und Prionkrankheiten

Author : Detlev Riesner
ISBN : 3110163616
Genre : Science
File Size : 35. 94 MB
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Ein Fachbuch im besten Sinne des Wortes. Fuhrende Wissenschaftler, darunter Stanley B. Prusiner, Nobelpreistrager des Jahres 1997, vermitteln einen aktuellen und umfassenden Uberblick uber die durch einen neuartigen Erregertyp verursachten Prionkrankheiten. Die Beschreibung der Krankheiten (z.B. Creutzfeld-Jakob, Kuru, BSE und Scapie) und der Geschichte ihrer Erforschung, die Darstellung ihrer Biochemie, Molekularbiologie und Genetikm und die ausfuhrliche Abhandlung klinisch-medizinischer und epidemiologischer Aspekte wird durch eine Diskussion praventiver Massnahmen abgerundet. Mit Sorgfalt editiert, bietet das Werk einen stringent angelegten, einer klaren Darstellung des aktuellen Wissensstandes verpflichteten Zugang zu diesem sowohl die Fachwelt als auch die offentliche Diskussion gleichermassen bewegenden Thema."

Nutrient Requirements Of Fish And Shrimp

Author : National Research Council
ISBN : 9780309216197
Genre : Technology & Engineering
File Size : 72. 91 MB
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Aquaculture now supplies half of the seafood and fisheries products consumed worldwide and is gaining international significance as a source of food and income. Future demands for seafood and fisheries products can only be met by expanded aquaculture production. Such production will likely become more intensive and will depend increasingly on nutritious and efficient aquaculture feeds containing ingredients from sustainable sources. To meet this challenge, Nutrient Requirements of Fish and Shrimp provides a comprehensive summary of current knowledge about nutrient requirements of fish and shrimp and supporting nutritional science. This edition incorporates new material and significant updates to information in the 1993 edition. It also examines the practical aspects of feeding of fish and shrimp. Nutrient Requirements of Fish and Shrimp will be a key resource for everyone involved in aquaculture and for others responsible for the feeding and care of fish and shrimp. It will also aid scientists in developing new and improved approaches to satisfy the demands of the growing aquaculture industry.

Dipolar Correlation Spectroscopy

Author : Bettina Basel
ISBN : 9783658091910
Genre : Science
File Size : 50. 61 MB
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Bettina Basel presents experimental conditions which allow to extract the three-spin contribution precisely from experimental multi-spin double electron-electron resonance (DEER) signals. The theory and concepts behind the used techniques, which are among others broadband chirp pump pulses, over coupling of microwave resonators and echo reduction measurements, are discussed and explained in detail. Moreover the setup and results of DEER experiments with newly introduced double chirp pump pulses consisting of two separate chirps are shown. Particular attention is paid to the phenomenon of orientation selection and the concept of orthogonal spin labeling.

Molekularbiologie Der Zelle

Author : Bruce Alberts
ISBN : 9783527323845
Genre : Cells
File Size : 60. 99 MB
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Seit einem Vierteljahrhundert ist 'Molekularbiologie der Zelle' das führende Lehrbuch im Bereich Zellbiologie. Diese erfolgreiche Tradition wird nun mit der fünften Auflage fortgesetzt, die vollständig überarbeitet und aktualisiert wurde. Mit zahlreichen inhaltlichen Neuerungen stellt sie unser aktuelles, sich rasch weiterentwickelndes Wissens zum zentralen Gegenstand der Biologie dar - der Zelle.

Stryer Biochemie

Author : Jeremy M. Berg
ISBN : 9783827429896
Genre : Science
File Size : 29. 40 MB
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Der Klassiker unter den Biochemie-Lehrbüchern – seit Jahrzehnten international bewährt, von Lehrenden und Lernenden hoch geschätzt und jetzt wieder auf dem neuesten Stand Diese vollständig überarbeitete Neuauflage weist all die innovativen konzeptionell-didaktischen und herausragenden gestalterischen Eigenschaften auf, die schon die früheren Auflagen zu Bestsellern gemacht haben – die außerordentlich klare und präzise Art der Darstellung, die Aktualität, die ausgefeilte Didaktik, die Verständlichkeit. In gewohnt verständlicher Form greift das Buch auch jüngste Fortschritte auf dem Gebiet der Biochemie auf. Es veranschaulicht den „Kern“ der Biochemie – die Schlüsselkonzepte und Grundprinzipien –, schlägt Brücken zwischen verschiedenen Befunden und Untersuchungsansätzen und offenbart damit letztlich sowohl die molekulare Logik des Lebendigen als auch die Bedeutung der Biochemie für die Medizin. Studierende und Lehrende werden unter anderem folgende Neuerungen und Verbesserungen in der 7. Auflage zu schätzen wissen: - erweiterte Darstellung der Genregulation bei Prokaryoten (Kapitel 31) und Eukaryoten (Kapitel 32) mit zahlreichen neuen Abschnitten, etwa zum quorum sensing, zur Induktion pluripotenter Stammzellen und zur Funktion der Mikro-RNAs - Integration neuer Forschungsergebnisse zum Zusammenhang zwischen Stoffwechsel, Ernährung und Fettleibigkeit sowie zur Bedeutung der Leptine - Berücksichtigung zahlreicher wissenschaftlicher Fortschritte zu DNA-Sequenzierung, Myosin, Glykomik, Vogelgrippe, Endocytose, Cholesterin, Helikasen,, Riboswitches u. v. m. - erweiterte Darstellung wichtiger Labormethoden - neue Beispiele für medizinische Zusammenhänge und klinische Anwendungen - deutlich mehr Übungsaufgaben an den Kapitelenden - zusätzliche Informationen, Materialien und Lernhilfen, etwa interaktive Molekülmodelle und Animationen, im Internet (englischsprachig) - die Abbildungen des Buches in elektronischer Form für den Einsatz in der Lehre

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