general and molecular pharmacology principles of drug action

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General And Molecular Pharmacology

Author : Francesco Clementi
ISBN : 9781118768594
Genre : Medical
File Size : 80. 60 MB
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With a focus on functional relationships between drugs and theirtargets, this book covers basic and general pharmacology, from acellular and molecular perspective, with particular attention to the mechanisms of drug action – the fundamental basis forproper clinical use- without neglecting clinical application,toxicology and pharmacokinetics. • Covers cell and molecular pharmacology,bringing together current research on regulation of drug targets,at a level appropriate for advanced undergrad and graduatestudents • Discusses the relevance ofpharmacokinetics and drug development for the clinical applicationof drugs • Presents material from the perspective ofdrug targets and interaction, the theoretical basis of drug actionanalysis, and drug properties • Focuses on structure-functionrelationships of drug targets – informing about theirbiochemical and physiologic functions and experimental and clinicalpathways for drug discovery and development • Has a companion website that offers ahost of resources: short additional chapters about methodology,topics at the forefront of research, all figures and tables fromthe book, and Power Point slides

Basic Pharmacology

Author : Maria A. Hernandez, Ph.D.
ISBN : 9781351988650
Genre : Medical
File Size : 75. 12 MB
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Intended for use in an introductory pharmacology course, Basic Pharmacology: Understanding Drug Actions and Reactions provides an in-depth discussion of how to apply the chemical and molecular pharmacology concepts, a discussion students need for more advanced study. The textbook introduces the principles of chemistry and biology necessary to understand drug interactions at the cellular level. The authors highlight chemical and physical properties of drugs, drug absorption and distribution, drug interactions with cellular receptors, and drug metabolism and elimination. The book begins with a review of chemical principles as they apply to drug molecules, focusing mainly on those for commonly prescribed drugs. The authors use drug structures to illustrate the chemical concepts learned in general and organic chemistry courses. They cover the dynamics of receptors in mediating the pharmacological effects of drugs. They clarify theories, drawn from the scientific literature, which explain drug-receptor interactions and the quantitative relationship between drug binding and its effects at the cellular level. The authors’ extensive use of drug structures for teaching chemical and molecular pharmacology principles, and their emphasis on the relevance of these principles in future professional life makes this book unique. It provides the framework for better understanding of advanced pharmacology and therapeutics topics. Blending medicinal chemistry and pharmacodynamics aspects, this textbook clearly elucidates the essential concepts that form the cornerstone for further work in pharmacology.

Encyclopedia Of Molecular Pharmacology

Author : Stefan Offermanns
ISBN : 9783540389163
Genre : Medical
File Size : 37. 82 MB
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An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.


Author : R.R. Levine
ISBN : 185070497X
Genre : Medical
File Size : 50. 74 MB
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This is an updated, expanded new edition of Dr. Ruth Levine's renowned Pharmacology: Drug Actions and Reactions. It covers basic pharmacological principles and the general concepts of chemical-biological interactions and now includes important new material on molecular biology, updated clinical information, and added coverage of the newer drugs. For the sixth edition of this landmark book Dr. Levine is joined by co-authors Dr. Carol T. Walsh and Dr. Rochelle D. Schwartz-Bloom. Acclaimed for its exceptionally thorough coverage, superb presentation, and intelligent organization, the book guides you through the most elementary aspects of pharmacology to a sophisticated understanding of drug mechanisms. Each chapter contains a series of thought-provoking essay-type questions designed to test comprehension of the material in the chapter. In addition, a sufficient number of important, specific examples are included to illustrate the application of the principles. With the background provided by Pharmacology: Drug Actions and Reactions, Sixth Edition, you will be prepared to understand the actions of most individual drugs.

Foundations Of Molecular Pharmacology

Author : J. B. Stenlake
ISBN : 0485111721
Genre : Medical
File Size : 83. 51 MB
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Molecular Pharmacology V3

Author : E.J. Ariens
ISBN : 9780323147149
Genre : Medical
File Size : 42. 24 MB
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Molecular Pharmacology: The Model of Action of Biologically Active Compounds, Volume 1 discusses the mode of action of bioactive compounds on a molecular level. This book reviews the processes that control the uptake of drugs, their diffusion through tissues, as well as their metabolism and excretion. Comprised of three sections, this volume starts with an overview of the different aspects of drug distribution and metabolism. This text then examines the totality of intermolecular processes or reactions between drug and receptor molecules, which is known as drug-receptor interaction. Other chapters explore the actions of various pharmacodynamic agents, including hormones and substances with selective toxicity, auxins, and odorants. This book discusses as well the ways in which the actions of drugs combine with the tissues and act upon themselves. The final chapter deals with the complicated types of relations between stimulus and effect. Pharmacologists and researchers will find this book useful.

Encyclopedic Reference Of Molecular Pharmacology

Author : Stefan Offermanns
ISBN : UOM:39015052659656
Genre : Medical
File Size : 40. 77 MB
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Presents current information on the molecular mechanisms of drug action. Provides 159 essays describing groups of drugs and drug targets. Several essays deal with general principles of pharmacology, such as drug tolerance, drug addiction, or drug metabolism.

Smith And Williams Introduction To The Principles Of Drug Design And Action

Author : H. John Smith
ISBN : 0203304152
Genre : Medical
File Size : 86. 6 MB
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Advances in knowledge and technology have revolutionized the process of drug development, making it possible to design drugs for a given target or disease. Building on the foundation laid by the previous three editions, Smith and Williams’ Introduction to the Principles of Drug Design and Action, Fourth Edition includes the latest information on topics such as gene therapy, computer-aided design, and molecular techniques including proteomics. Using real-world examples that illustrate the principles of drug design, the author explores the discovery of lead compounds and their manipulation in the production of non-toxic, metabolically stable drug candidates that will interact with target receptors in a predicted fashion. See what’s new in the Fourth Edition: Fully updates and expands the contents Coverage of agonists and antagonists of neuro-transmitters Information on the design of stable peptide-like drugs The human genome and its impact on drug discovery and development Advances in therapy and pharmacokinetics Adopting a from-the-bench-to-the-marketplace approach, the book provides a thorough grounding in rational drug design. It emphasizes principles and elucidates a framework for basic drug design into which current and, more importantly, future drugs will fit.

Cardiovascular Diseases

Author : Y. Robert Li
ISBN : 9780470915370
Genre : Medical
File Size : 76. 25 MB
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Even though there has been improvement in treatment and significant reduction in mortality rate, cardiovascular disease remains one of the leading causes of death around the world. Drug therapy continues to rank high as a way to manage heart disease – making cardiovascular pharmacology a key part of medical education and drug development research. This book addresses the needs of these students and researchers by systematically integrating essentials, advances, and clinical correlations for cardiovascular drugs. The author, who has over two decades of experience teaching this topic, covers both the fundamentals and most recent advances in the pharmacology of cardiovascular drugs, as well as their integrated applications in the management of individual cardiovascular diseases. In addition, the text presents evidence-based pharmacotherapeutics in the management of common cardiovascular diseases and conditions that include dyslipidemias, hypertension, ischemic heart disease, heart failure, cardiac arrhythmias, and ischemic stroke. Written in an accessible style and consistent format, the book covers both the fundamentals and advances in the pharmacology of cardiovascular drugs, as well as their integrated applications in the management of individual cardiovascular diseases. • Blends basic and clinical sciences needed to effectively understand and treat cardiovascular diseases • Facilitates understanding of drug action and mechanism by covering physiology / pathophysiology and pharmacology • Includes guidelines and algorithms for pharmacotherapeutic management of cardiovascular diseases • Uses case presentations and study questions to enhance understanding of the material • Serves as a resource for pharmaceutical and medical students and researchers interested in cardiovascular issues

Basic And Clinical Pharmacology 11th Edition

Author : Bertram G. Katzung
ISBN : 9780071604062
Genre : Medical
File Size : 66. 35 MB
Format : PDF, Kindle
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The most trusted and up-to-date pharmacology text in medicine -- completely redesigned to make the learning process even more interesting and efficient 5 Star Doody's Review! "This is the most widely used textbook for teaching pharmacology to health professionals. This 11th edition is far superior to any previous editions....The authors' goals are to provide a complete, authoritative, current, and readable textbook of pharmacology for students in health sciences. Testimony to their success is the widespread use of this work as required textbook for pharmacology courses around the world. This book is used extensively by thousands of medical, pharmacy, podiatry, nursing, and other health professions students to study pharmacology. Likewise, it remains a valuable resource for residents and practicing physicians....I continue to use this book as a required resource for all courses that I teach to medical, nursing, and allied health students. It is authoritative, readable, and supported by numerous learning tools."--Doody's Review Service Organized to reflect the syllabi in Pharmacology courses, Basic & Clinical Pharmacology covers all the important concepts students need to know about the science of pharmacology and its application to clinical practice. It is acknowledged worldwide as the field’s most current, authoritative, and comprehensive textbook. To be as clinically relevant as possible, the book features a strong focus on the choice and use of drugs in patients and the monitoring of their effects. Coverage that spans every important aspect of medical pharmacology: Basic Principles Autonomic Drugs Cardiovascular-Renal Drugs Drugs with Important Actions on Smooth Muscle Drugs that Act in the Central Nervous System Drugs Used to Treat Diseases of the Blood, Inflammation, and Gout Endocrine Drugs Chemotherapeutic Drugs Toxicology NEW to this edition: Full-color presentation, including 300+ illustrations Case studies introduce clinical problems in many chapters Drug summary tables for key information in comparative context Descriptions of important newly released drugs, including new immunopharmacologic agents Expanded coverage of general concepts relating to newly discovered receptors, receptor mechanisms, and drug transporters

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