genes environment and alzheimer s disease

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Genes Environment And Alzheimer S Disease

Author : Orly Lazarov
ISBN : 9780128028858
Genre : Medical
File Size : 78. 51 MB
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Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease. Provides the first volume to link genetic and environmental risk factors for Alzheimer’s disease and dementia Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer’s disease and cognitive decline Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists

Environmental Factors In Neurodevelopmental And Neurodegenerative Disorders

Author : Michael Aschner
ISBN : 9780128004074
Genre : Technology & Engineering
File Size : 39. 35 MB
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Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders presents a state-of-the-art review of the effects of environmental contaminants on the development and degeneration of the human nervous system, brought together by world-leading experts in the field. Part One describes the adverse effects that the environment can have on neurological development, and how these effects may exhibit. Specific contaminants and their possible consequences of exposure are addressed (lead, methylmercury, alcohol), as well as specific disorders and the environmental factors associated with them, such as the effect of diet on attention deficit and hyperactivity disorders. Part Two tackles neurodegenerative disorders, specifically addressing their potential neurotoxic origins, and discussing the increasing interest in the effects that early exposure may have in later life. Environmental Factors in Neurodevelopmental and Neurodegenerative Disorders is an invaluable reference for those professionals working in the fields of toxicology, environmental health and neuroscience. Provides, for the first time, the cutting-edge theory of environmental impacts on both neurodegenerative and neurodevelopmental disorders Written by an international selection of the world’s foremost experts in the field of neurotoxicology Full-colour throughout, providing accurate and illustrative examples of neurotoxic effects in action An invaluable reference for those professionals working in the fields of toxicology, environmental health, and neuroscience

Environmental Causes And Prevention Measures For Alzheimer S Disease

Author : George J. Brewer
ISBN : 9780128111635
Genre : Medical
File Size : 44. 71 MB
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Environmental Causes and Prevention Measures for Alzheimer’s Disease examines the increased incidence of the disease in developed countries and aims to educate neuroscientists, medical practitioners and other educated individuals on new insights into environmental causation, primarily metals. This book looks into the web of evidence around the hypothesis of copper toxicity and the additional role that a high fat diet plays in disease progression and cognition loss. The data and its implications are discussed, along with potential prevention measures. This book will generate excitement and interest among neuroscientists, medical practitioners and other biomedical researchers. Emphasizes the history and epidemiology of Alzheimer’s disease, highlighting its epidemic proportions in developed countries Discusses data on new environmental factors in developed countries Provides prevention measures to potentially reduce Alzheimer’s rates through diet

Genetic Analysis Of Complex Disease

Author : Jonathan L. Haines
ISBN : 9780471781134
Genre : Science
File Size : 63. 43 MB
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Second Edition features the latest tools for uncovering the genetic basis of human disease The Second Edition of this landmark publication brings together a team of leading experts in the field to thoroughly update the publication. Readers will discover the tremendous advances made in human genetics in the seven years that have elapsed since the First Edition. Once again, the editors have assembled a comprehensive introduction to the strategies, designs, and methods of analysis for the discovery of genes in common and genetically complex traits. The growing social, legal, and ethical issues surrounding the field are thoroughly examined as well. Rather than focusing on technical details or particular methodologies, the editors take a broader approach that emphasizes concepts and experimental design. Readers familiar with the First Edition will find new and cutting-edge material incorporated into the text: Updated presentations of bioinformatics, multiple comparisons, sample size requirements, parametric linkage analysis, case-control and family-based approaches, and genomic screening New methods for analysis of gene-gene and gene-environment interactions A completely rewritten and updated chapter on determining genetic components of disease New chapters covering molecular genomic approaches such as microarray and SAGE analyses using single nucleotide polymorphism (SNP) and cDNA expression data, as well as quantitative trait loci (QTL) mapping The editors, two of the world's leading genetic epidemiologists, have ensured that each chapter adheres to a consistent and high standard. Each one includes all-new discussion questions and practical examples. Chapter summaries highlight key points, and a list of references for each chapter opens the door to further investigation of specific topics. Molecular biologists, human geneticists, genetic epidemiologists, and clinical and pharmaceutical researchers will find the Second Edition a helpful guide to understanding the genetic basis of human disease, with its new tools for detecting risk factors and discovering treatment strategies.

Investigating The Human Genome

Author : Moyra Smith
ISBN : 0132172844
Genre : Medical
File Size : 47. 10 MB
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Leading medical genetics scholar Moyra Smith reviews current and recent work in genetics and genomics to assess progress in understanding human variation and the pathogenesis of common and rare diseases in which genetics plays a role. Smith provides an exceptional overview of the most important biomedical progress arising from the greatly increased genetic information base generated by gene mapping and the sequencing of the complete Human Genome. This book addresses into a wide spectrum of topics associated with human genetics and genomics, including: Human origins; migrations and human population diversity gained though genomic analyses. The complexities of psychiatric diseases that are influenced by genetics. The pathogenesis of late-onset neurological diseases such as Alzheimer’s, Parkinsonism, and ALS. Key aspects of protein misfolding. Gene-environment interactions in DNA damage and repair and DNA instability. Micro RNAs and mRNA translation. Epigenetics. New functions for old enzymes in cancer.

Gene Environment Interactions

Author : Lucio G. Costa
ISBN : 9780471758037
Genre : Science
File Size : 80. 29 MB
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Understanding the play between heredity and environment, and relating it to disease causation, is the task of ecogenetics. Gene-Environment Interactions: Fundamentals of Ecogenetics presents the first comprehensive survey of this discipline, reflecting its relationship with toxicology, epidemiology, pharmacology, public health, and other medical and biological fields. Divided into four sections, the text elucidates key basic and advanced topics: * Section 1 covers fundamentals, including the history of the discipline, a discussion of the molecular laboratory tools currently available to assess genotypes, using such measurements in molecular epidemiology studies, and the statistical issues involved in their analysis. * Section 2 focuses on a number of key genetic polymorphisms relevant for ecogenetics, including enzymes of phase I and phase II metabolism, enzymes involved in DNA repair, as well as receptors and ion channels. This highlights characteristics of selected, widely studied genotypic/phenotypic differences, and allows discussion of how given genetic variations can influence responses to exogenous chemicals. * Section 3 examines gene-environment interactions through a disease-based approach, addressing how genetic polymorphisms can influence susceptibility to various diseases. Chapters cover important disease conditions such as various types of cancer, neurodegenerative diseases, cardiovascular disease, chronic pulmonary diseases, infectious diseases, diabetes, and obesity. * The final section discusses the ethical, legal, and social issues that arise when investigating and evaluating genetic polymorphisms in human populations, as well as the impact of ecogenetics on risk assessment, regulatory policies, and medicine and public health. Packed with clear examples illustrating concepts, as well as numerous tables and figures, Gene-Environment Interactions: Fundamentals of Ecogenetics is a unique resource for a wide range of physicians, students, and other specialists.

Alzheimer S Disease A Century Of Scientific And Clinical Research

Author : G. Perry
ISBN : 9781607501756
Genre : Medical
File Size : 74. 23 MB
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This publication is a landmark work commemorating the centennial of Alois Alzheimer's discovery of what would be known as Alzheimer's disease (AD). The centennial of Alois Alzheimer’s original description of the disease that would come to bear his name offers a vantage point from which to commemorate the seminal discoveries in the field. It traces how the true importance of AD as the major cause of late life dementia ultimately came to light and narrates the evolution of the concepts related to AD throughout the years and its recognition as a major public health problem, with an estimated 30-40 million people affected by AD today. To identify the breakthroughs, the editors have used citation analysis, landmark papers identified by current researchers, and drew upon their own experience and insights. This process took into account the perspectives of individuals who recall the impact of findings at the time they were made, as well as of scientists today who have the advantage of hindsight in weighing the lasting influence of these findings. Because modern AD research was triggered by the seminal work of Tomlinson, Blessed, and Roth some four decades ago, it is particularly fortunate that the vast majority of these milestone authors are still with us.

Alzheimer S Disease

Author : Evelyn B. Kelly
ISBN : 9781438118116
Genre : Alzheimer's disease
File Size : 69. 57 MB
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First documented at the turn of the century by German neurologist Alois Alzheimer, Alzheimer's disease is the most common dementia in older adults, robbing them of their minds and dignity. With the aging of the world's population, incidences of this degenerative brain disease are set to dramatically increase by 2010. However, there may be hope. Research at the genetic level is uncovering secrets of what makes up the disease and how it works. Presenting a history of Alzheimer's disease, this title looks at the human genome and explores how the pieces of the Alzheimer's puzzle are beginning to fit together. Alzheimer's Disease is an adventure into the exciting world of the search for a cure.

Cognitive Enhancement

Author : Shira Knafo
ISBN : 9780124171251
Genre : Psychology
File Size : 39. 45 MB
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Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors addresses the gap that exists in research on the topic, gathering multidisciplinary knowledge and tools that help the reader understand the basics of cognitive enhancement. It also provides assistance in designing procedures and pharmacological approaches to further the use of novel cognitive enhancers, a field that offers potential benefit to a variety of populations, including those with neurologic and psychiatric disorders, mild aging-related cognitive impairment, and those who want to improve intellectual performance. The text builds on our knowledge of the molecular/cellular basis of cognitive function, offering the technological developments that may soon enhance cognition. Separate sections cover enhancement drugs, environmental conditions, and genetic factors in terms of both human and animal studies, including both healthy/young and aging/diseased individuals. Provides a multidisciplinary knowledge, enabling a further understanding of cognitive enhancement Offers coverage of the pharmacologic, environmental, and genetic factors relevant to the topic Discusses cognitive enhancement from the perspective of both healthy and diseased or aging populations Topics are discussed in terms of both human and animal studies

Developing Therapeutics For Alzheimer S Disease

Author : Michael S. Wolfe
ISBN : 9780128021644
Genre : Medical
File Size : 77. 33 MB
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Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics. Provides a realistic but promising assessment of the potential of various therapeutic approaches to Alzheimer’s disease Focuses primarily on neuroprotective agents and cognitive enhancers, as well as approaches to targeting the amyloid B-peptide, tau and Apolipoprotein E Discusses alternative approaches, preclinical and clinical development issues, related biomarkers and diagnostics, and prevention and nonpharmacological approaches

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