genetic association studies background conduct analysis interpretation

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Genetic Association Studies Background Conduct Analysis Interpretation

Author : Mehmet Tevfik Dorak
ISBN : 9781351806435
Genre : Science
File Size : 73. 72 MB
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Genetic Association Studies is designed for students of public health, epidemiology, and the health sciecnes, covering the main principles of molecular genetics, population genetics, medical genetics, epidemiology and statistics. It presents a balanced view of genetic associations with coverage of candidate gene studies as well as genome-wide association studies. All aspects of a genetic association study are included, from the lab to analysis and interpretation of results, but also bioinformatics approaches to causality assessment. The role of the environment in genetic disease is also highlighted. Genetic Association Studies will enable readers to understand and critique genetic association studies and set them on the way to designing, executing, analyzing, interpreting, and reporting their own.

Principles Of Evolution Systems Species And The History Of Life

Author : Jonathan Bard
ISBN : 9781351854771
Genre : Science
File Size : 62. 92 MB
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Principles of Evolution considers evolution in the context of systems biology, a contemporary approach for handling biological complexity. Evolution needs this systems perspective for three reasons. First, most activity in living organisms is driven by complex networks of proteins and this has direct implications, particularly for understanding evo-devo and for seeing how variation is initiated. Second, it provides the natural language for discussing phylogenetic trees. Third, evolutionary change involves events at levels ranging from the genome to the ecosystem and systems biology provides a context for integrating material of this complexity. Understanding evolution means, on the one hand, describing the history of life and, on the other, making sense of the principles that drove that history. The solution adopted here is to make the science of evolution the primary focus of the book and place the various parts of the history of life in the context of the research that unpicks it. This means that the history is widely distributed across the text. This concise textbook assumes that the reader has a fair amount of biological knowledge and gives equal weight to all the major themes of evolution: the fossil record, phylogenetics, evodevo, and speciation. Principles of Evolution will therefore be an interesting and thought-provoking read for honors-level undergraduates, and graduates working in the biological sciences.

Design Analysis And Interpretation Of Genome Wide Association Scans

Author : Daniel O. Stram
ISBN : 9781461494430
Genre : Medical
File Size : 49. 86 MB
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This book presents the statistical aspects of designing, analyzing and interpreting the results of genome-wide association scans (GWAS studies) for genetic causes of disease using unrelated subjects. Particular detail is given to the practical aspects of employing the bioinformatics and data handling methods necessary to prepare data for statistical analysis. The goal in writing this book is to give statisticians, epidemiologists, and students in these fields the tools to design a powerful genome-wide study based on current technology. The other part of this is showing readers how to conduct analysis of the created study. Design and Analysis of Genome-Wide Association Studies provides a compendium of well-established statistical methods based upon single SNP associations. It also provides an introduction to more advanced statistical methods and issues. Knowing that technology, for instance large scale SNP arrays, is quickly changing, this text has significant lessons for future use with sequencing data. Emphasis on statistical concepts that apply to the problem of finding disease associations irrespective of the technology ensures its future applications. The author includes current bioinformatics tools while outlining the tools that will be required for use with extensive databases from future large scale sequencing projects. The author includes current bioinformatics tools while outlining additional issues and needs arising from the extensive databases from future large scale sequencing projects.

Clinical And Translational Science

Author : David Robertson
ISBN : 9780128021118
Genre : Science
File Size : 56. 55 MB
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Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Analysis Of Genetic Association Studies

Author : Gang Zheng
ISBN : 9781461422440
Genre : Mathematics
File Size : 63. 46 MB
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Analysis of Genetic Association Studies is both a graduate level textbook in statistical genetics and genetic epidemiology, and a reference book for the analysis of genetic association studies. Students, researchers, and professionals will find the topics introduced in Analysis of Genetic Association Studies particularly relevant. The book is applicable to the study of statistics, biostatistics, genetics and genetic epidemiology. In addition to providing derivations, the book uses real examples and simulations to illustrate step-by-step applications. Introductory chapters on probability and genetic epidemiology terminology provide the reader with necessary background knowledge. The organization of this work allows for both casual reference and close study.

Systematic Approaches To A Successful Literature Review

Author : Andrew Booth
ISBN : 9781446289440
Genre : Reference
File Size : 62. 6 MB
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Reviewing the literature is an essential part of every research project. This book takes you step-by-step through the process of approaching your literature review systematically, applying systematic principles to a wide range of literature review types. Through numerous examples, case studies and exercises, the book covers often neglected areas of literature review such as concept analysis, scoping and mapping. The book includes practical tools for supporting the various stages of the review process, including; - managing your literature review - searching the literature - assessing the quality of the literature - synthesising qualitative and/or quantitative data - writing up and presenting data Systematic Approaches to a Successful Literature Review is essential reading for any student or researcher looking to approach their literature review in a systematic way.

Middleton S Allergy

Author : N. Franklin Adkinson, Jr.
ISBN : 9780323085939
Genre : Medical
File Size : 55. 16 MB
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Boasting a worldwide reputation as the leading text in allergy and immunology, Middleton's Allergy continues its steadfast tradition of providing comprehensive coverage of state-of-the-art basic science, as well as authoritative guidance on the clinical concepts of day-to-day diagnosis and management of allergic disorders. Offering timely information that's suited for clinicians and researchers alike, Middleton's is a user-friendly and versatile source for the knowledge you need to provide optimal care to your patients! Stay on top of continuous new developments in clinical allergy and immunology through online access to the Expert Consult site, which will feature regular updates as well as the fully searchable contents.Find all of the information you need quickly and easily with a glossary of allergy and immunology terms; highlighted key points for each chapter; hundreds of crystal-clear images with a full-color format, and access to relevant websites. Apply the latest scientific knowledge and clinical applications with new chapters on Innate and Adaptive Immunity, Immune Tolerance, Immunobiology of IgE and Its Receptors, Resolution of Allergic Inflammation, and Particulate and Allergen Interactions, plus sweeping updates throughout.Take full advantage of the major advances in asthma pathogenesis and management with significant updates on diagnosis, treatment, and special aspects of asthma.Obtain the best results from the newest therapeutics for allergic and immunologic diseases through an expanded discussion of immunotherapy that includes new chapters on Sublingual Immunotherapy, Biologics and Immunosuppressives in Asthma, and Alternative and Complementary Therapies.

Applied Statistical Genetics With R

Author : Andrea S. Foulkes
ISBN : 9780387895543
Genre : Science
File Size : 82. 81 MB
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Statistical genetics has become a core course in many graduate programs in public health and medicine. This book presents fundamental concepts and principles in this emerging field at a level that is accessible to students and researchers with a first course in biostatistics. Extensive examples are provided using publicly available data and the open source, statistical computing environment, R.

Probabilistic Graphical Models For Genetics Genomics And Postgenomics

Author : Raphaël Mourad
ISBN : 9780191019203
Genre : Mathematics
File Size : 64. 95 MB
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Nowadays bioinformaticians and geneticists are faced with myriad high-throughput data usually presenting the characteristics of uncertainty, high dimensionality and large complexity. These data will only allow insights into this wealth of so-called 'omics' data if represented by flexible and scalable models, prior to any further analysis. At the interface between statistics and machine learning, probabilistic graphical models (PGMs) represent a powerful formalism to discover complex networks of relations. These models are also amenable to incorporating a priori biological information. Network reconstruction from gene expression data represents perhaps the most emblematic area of research where PGMs have been successfully applied. However these models have also created renewed interest in genetics in the broad sense, in particular regarding association genetics, causality discovery, prediction of outcomes, detection of copy number variations, and epigenetics. This book provides an overview of the applications of PGMs to genetics, genomics and postgenomics to meet this increased interest. A salient feature of bioinformatics, interdisciplinarity, reaches its limit when an intricate cooperation between domain specialists is requested. Currently, few people are specialists in the design of advanced methods using probabilistic graphical models for postgenomics or genetics. This book deciphers such models so that their perceived difficulty no longer hinders their use and focuses on fifteen illustrations showing the mechanisms behind the models. Probabilistic Graphical Models for Genetics, Genomics and Postgenomics covers six main themes: (1) Gene network inference (2) Causality discovery (3) Association genetics (4) Epigenetics (5) Detection of copy number variations (6) Prediction of outcomes from high-dimensional genomic data. Written by leading international experts, this is a collection of the most advanced work at the crossroads of probabilistic graphical models and genetics, genomics, and postgenomics. The self-contained chapters provide an enlightened account of the pros and cons of applying these powerful techniques.

Electrophysiological Disorders Of The Heart E Book

Author : Sanjeev Saksena
ISBN : 9781437709711
Genre : Medical
File Size : 33. 70 MB
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The new edition of Electrophysiological Disorders of the Heart helps you diagnose and treat a full range of heart rhythm disorders using today’s latest technologies and therapies. It provides practical, hands-on coverage of hot topics such as pediatric EP, imaging, echocardiography-guided EP procedures, regenerative therapies, cardiac pacing, and more. Now available in a new full-color format, the title also includes easy online access at www.expertconsult.com. Discover new ways to treat and manage the full range of heart rhythm disorders with content focused on common clinical features, diagnosis, and management. Review expert management strategies to help you handle complex patient problems. Stay current with the latest molecular and technical advances as well as new treatment options implemented over the last few years. Use the latest technologies and devices to accurately diagnose and manage heart rhythm disorders. Consult new and expanded coverage of regenerative therapies, echo-guided procedures, cardiac pacing, and CRT, as well as a new section on pediatric electrophysiology and imaging. Enjoy improved visual guidance with many new full-color images. Log on to www.expertconsult.com to easily search the complete contents online and access a downloadable image library.

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