genetic models of immune and inflammatory diseases serono symposia usa

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Genetic Models Of Immune And Inflammatory Diseases

Author : Abul K. Abbas
ISBN : 9781461223764
Genre : Medical
File Size : 78. 16 MB
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This book contains the proceedings of the Serono Symposia USA interna tional symposium on Genetic Models of Immune and Inflammatory Dis eases held on October 20 to 23, 1994, in Savannah, Georgia. The advent of methods for introducing genes into the germlines of mice, and for targeted disruption of particular genes by homologous recombination, has provided scientists in many disciplines with an extraordinarily powerful set of analyti cal tools. Some of the most informative applications of transgenic and gene knockout technology have been in studies of lymphocyte development and activation. The goal of this symposium was to bring together investigators using these genetic approaches for analyzing the immune system, with a view to defining common themes and novel directions. Transgenic mice have a wide variety of important applications in immu nology. Defined proteins can be expressed in selected tissues throughout development, thus acquiring the essential characteristic of "self" antigens. Such models have been used to study how immune responses to these artificially created "self" antigens are controlled. Antigen receptors of lym phocytes have been expressed as transgenes, and because lymphocytes are endowed with the unique property of allelic exclusion, such transgenic mice become essentially monospecific. Immunomodulatory agents have been expressed in defined tissues or throughout the body, providing tools for studying the functional consequences of dysregulated expression of biologi cal response modifiers.

Inhibin Activin And Follistatin

Author : Toshihiro Aono
ISBN : 9781461218746
Genre : Health & Fitness
File Size : 34. 10 MB
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This volume is the proceedings of the International Conference on Inhibin, Activin: Recent Advances and Future Views held in Tokushima, Japan from November 9-10, 1996. The Internationally recognized faculty present the latest research in the exploration of inhibin, activin and follistatin mechanisms of action.


Author : Rogerio A. Lobo
ISBN : 9781461222880
Genre : Medical
File Size : 73. 37 MB
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Here, the editor, Rogerio Lobo, has assembled an internationally recognized group of reproductive endocrinologists to address perimenopause -- the time both before and after the last menses -- and its attendant decline in ovarian function, as well as the clinical issues and therapeutic options for women during this period.

Polycystic Ovary Syndrome

Author : R. Jeffrey Chang
ISBN : 9781461384830
Genre : Medical
File Size : 83. 19 MB
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The term polycystic ovary syndrome (peOS) is meant to describe a clinical endocrinopathy characterized by menstrual irregularity and evidence of hyperandrogenism. While recognized since the 1800s, a clinical composite was not constructed until 1935 when Stein and Leventhal reported their findings of seven women with infertility, menstrual dysfunction, hirsutism, and enlarged ovaries. Notably, the ovaries contained numerous multiple cysts and the ovarian capsule was thickened. At the time, this preciseness of definition was sufficient to entitle the entity Stein-Leventhal syndrome. Subsequently, over the intervening years as investigators attempted to un ravel the pathophysiology and genesis of this disorder and the number of reported studies increased, there ensued a gradual and distinct terminologic conversion to polycystic ovary syndrome, which, whether intentional or not, connoted a less well-defined condition. Perhaps this is appropriately so, given the seemingly broadening spectrum of clinical presentations and the continuing debate over what constitutes peos. The expansive new knowledge about peos was discussed to a significant degree at an international symposium organized by Serono Symposia USA and held in Boston in the late spring of 1995. Ovarian physiology, including the fate of the follicular unit, was a central focus with several presentations on the genesis, growth, and death of ovarian cellular components. A discus sion of the regulation of ovarian cell function was also highlighted and comprised a major portion of the program.

Subject Guide To Books In Print

Author :
ISBN : STANFORD:36105025888558
Genre : American literature
File Size : 44. 80 MB
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Biennial Scientific Report

Author : Howard Hughes Medical Institute
ISBN : UOM:39015046940733
Genre : Cytology
File Size : 77. 56 MB
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Germ Cell Development Division Disruption And Death

Author : B. R. Zirkin
ISBN : UOM:39015040377908
Genre : Medical
File Size : 47. 74 MB
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An exploration of germ cell development, division, disruption and death, designed for reproductive endocrinologists, microbiologists and physiologists. Topics covered include: cloning and characterization of genes expressed in germ cell lines; spermatological transplantation; and testicular ageing.

The Endocrine Society Annual Meeting Program And Abstracts

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ISBN : UOM:39015072142410
Genre : Endocrinology
File Size : 60. 28 MB
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The Cumulative Book Index

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ISBN : UOM:39015058373732
Genre : American literature
File Size : 42. 99 MB
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Interdok Directory Of Published Proceedings

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ISBN : UVA:X006051065
Genre : Science
File Size : 83. 10 MB
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