genomes and what to make of them

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Genomes And What To Make Of Them

Author : Barry Barnes
ISBN : 9781459605930
Genre : Genomes
File Size : 67. 3 MB
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The announcement in 2003 that the Human Genome Project had completed its map of the entire human genome was heralded as a stunning scientific breakthrough: our first full picture of the basic building blocks of human life. Since then, boasts about the benefits - and warnings of the dangers - of genomics have remained front-page news, with everyone agreeing that genomics has the potential to radically alter life as we know it. For the nonscientist, the claims and counterclaims are dizzying - what does it really mean to understand the genome? Barry Barnes and John Dupr offer an answer to that question and much more in Genomes and What to Make of Them, a clear and lively account of the genomic revolution and its promise. The book opens with a brief history of the science of genetics and genomics, from Mendel to Watson and Crick and all the way up to Craig Venter; from there the authors delve into the use of genomics in determining evolutionary paths - and what it can tell us, for example, about how far we really have come from our ape ancestors. Barnes and Dupr then consider both the power and risks of genetics, from the economic potential of plant genomes to overblown claims that certain human genes can be directly tied to such traits as intelligence or homosexuality. Ultimately, the authors argue, we are now living with a new knowledge as powerful in its way as nuclear physics, and the stark choices that face us - between biological warfare and gene therapy, a new eugenics or a new agricultural revolution - will demand the full engagement of both scientists and citizens. Written in straightforward language but without denying the complexity of the issues, Genomes and What to Make of Them is both an up-to-date primer and a blueprint for the future.

Genomes 3

Author : Terence A. Brown
ISBN : 9780815341383
Genre : Science
File Size : 44. 38 MB
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The VitalBook e-book version of Genomes 3 is only available in the US and Canada at the present time. To purchase or rent please visit http://store.vitalsource.com/show/9780815341383 Covering molecular genetics from the basics through to genome expression and molecular phylogenetics, Genomes 3is the latest edition of this pioneering textbook. Updated to incorporate the recent major advances, Genomes 3 is an invaluable companion for any undergraduate throughout their studies in molecular genetics. Genomes 3 builds on the achievements of the previous two editions by putting genomes, rather than genes, at the centre of molecular genetics teaching. Recognizing that molecular biology research was being driven more by genome sequencing and functional analysis than by research into genes, this approach has gathered momentum in recent years.

Introduction To Genomics

Author : Arthur Lesk
ISBN : 9780199564354
Genre : Medical
File Size : 29. 25 MB
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Introduction to Genomics is a fascinating insight into what can be revealed from the study of genomes: how organisms differ or match; how different organisms evolved; how the genome is constructed and how it operates; and what our understanding of genome structure and function means in terms of our future health and wellbeing.

Foundations Of Comparative Genomics

Author : Arcady R. Mushegian
ISBN : 0080546099
Genre : Science
File Size : 74. 29 MB
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This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics. Presents an historic overview of genome biology and its achievements Includes topics not covered in other books such as minimal and ancestral genomes Discusses the evolutionary resilience of protein-coding genes and frequent functional convergence at the molecular level Critically reviews horizontal gene transfer and other contentious issues Covers comparative virology as a somewhat overlooked foundation of modern genome science

The Age Of Genomes

Author : Steven Monroe Lipkin
ISBN : 9780807074589
Genre : Science
File Size : 50. 76 MB
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A leading geneticist explores what promises to be one of the most transformative advances in health and medicine in history Almost every week, another exciting headline appears about new advances in the field of genetics. Genetic testing is experiencing the kind of exponential growth once seen with the birth of the Internet, while the plummeting cost of DNA sequencing makes it increasingly accessible for individuals and families. Steven Lipkin and Jon Luoma posit that today’s genomics is like the last century’s nuclear physics: a powerful tool for good if used correctly, but potentially dangerous nonetheless. DNA testing is likely the most exciting advance in a long time for treating serious disease, but sequencing errors, complex biology, and problems properly interpreting genetic data can also cause life-threatening misdiagnoses of patients with debilitating and fatal genetic diseases. DNA testing can also lead to unnecessary procedures and significantly higher health-care costs. And just around the corner is the ability to cure genetic diseases using powerful gene-editing technologies that are already being used in human embryo research. Welcome to the Age of Genomes! The Age of Genomes immerses readers in true stories of patients on the frontier of genomic medicine and explores both the transformative potential and risks of genetic technology. It will inform anxious parents increasingly bombarded by offers of costly new prenatal testing products, and demonstrate how genetic technology, when deployed properly, can significantly improve the lives of patients who have devastating neurological diseases, cancer, and other maladies. Dr. Lipkin explains the science in depth, but in terms a layperson can follow.

The Evolution Of The Genome

Author : T. Ryan Gregory
ISBN : 0080470521
Genre : Science
File Size : 88. 5 MB
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The Evolution of the Genome provides a much needed overview of genomic study through clear, detailed, expert-authored discussions of the key areas in genome biology. This includes the evolution of genome size, genomic parasites, gene and ancient genome duplications, polypoidy, comparative genomics, and the implications of these genome-level phenomena for evolutionary theory. In addition to reviewing the current state of knowledge of these fields in an accessible way, the various chapters also provide historical and conceptual background information, highlight the ways in which the critical questions are actually being studied, indicate some important areas for future research, and build bridges across traditional professional and taxonomic boundaries. The Evolution of the Genome will serve as a critical resource for graduate students, postdoctoral fellows, and established scientists alike who are interested in the issue of genome evolution in the broadest sense. Provides detailed, clearly written chapters authored by leading researchers in their respective fields Presents a much-needed overview of the historical and theoretical context of the various areas of genomic study Creates important links between topics in order to promote integration across subdisciplines, including descriptions of how each subject is actually studied Provides information specifically designed to be accessible to established researchers, postdoctoral fellows, and graduate students alike

Exploring Personal Genomics

Author : Joel T. Dudley
ISBN : 9780199644483
Genre : Medical
File Size : 33. 27 MB
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This book provides a novel inquiry-based approach to understanding and interpreting the practical, medical, and societal aspects of personal genomic information. It opens with an introduction to genomics and the issues surrounding the use of genomic data, and then discusses the potential applications of this data using real examples and data sets.

Genome

Author : A. G. Riddle
ISBN : 1788541316
Genre :
File Size : 72. 70 MB
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The X1 pandemic ravaged the world. Billions were infected, 30 million died. It was not an act of nature. X1 was man-made, a deadly plague deliberately released for one reason only: to force people to take the cure. But the cure is worse than the disease, a sophisticated nanotechnology that has the potential to enslave all humanity unless Dr Peyton Shaw can stop it. Dr Shaw's search for the culprits and a countermeasure starts at the ends of the Earth, on a sunken submarine beneath the Arctic ice. It will take her deep into humanity's past, towards an ancient secret encoded in our DNA, and a revelation that will rewrite history... The final thrilling installment of the Extinction Files will change your very understanding of what it means to be human, blending meticulous scientific research with the heart-pounding fiction that has made A.G. RIDDLE a global phenomenon.

Neanderthal Man

Author : Svante PŠŠbo
ISBN : 9780465020836
Genre : Science
File Size : 30. 22 MB
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An influential geneticist traces his investigation into the genes of humanity's closest evolutionary relatives, explaining what his sequencing of the Neanderthal genome has revealed about their extinction and the origins of modern humans.

The New Science Of Metagenomics

Author : Committee on Metagenomics: Challenges and Functional Applications
ISBN : 9780309106764
Genre : Science
File Size : 81. 57 MB
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Although we can't usually see them, microbes are essential for every part of human life -- indeed all life on Earth. The emerging field of metagenomics offers a new way of exploring the microbial world that will transform modern microbiology and lead to practical applications in medicine, agriculture, alternative energy, environmental remediation, and many others areas. Metagenomics allows researchers to look at the genomes of all of the microbes in an environment at once, providing a "meta" view of the whole microbial community and the complex interactions within it. It's a quantum leap beyond traditional research techniques that rely on studying -- one at a time -- the few microbes that can be grown in the laboratory. At the request of the National Science Foundation, five Institutes of the National Institutes of Health, and the Department of Energy, the National Research Council organized a committee to address the current state of metagenomics and identify obstacles current researchers are facing in order to determine how to best support the field and encourage its success. The New Science of Metagenomics recommends the establishment of a "Global Metagenomics Initiative" comprising a small number of large-scale metagenomics projects as well as many medium- and small-scale projects to advance the technology and develop the standard practices needed to advance the field. The report also addresses database needs, methodological challenges, and the importance of interdisciplinary collaboration in supporting this new field.

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