genomics circuits and pathways in clinical neuropsychiatry

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Genomics Circuits And Pathways In Clinical Neuropsychiatry

Author : Thomas Lehner
ISBN : 9780128005309
Genre : Science
File Size : 90. 68 MB
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This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment

Developing Therapeutics For Alzheimer S Disease

Author : Michael S. Wolfe
ISBN : 9780128021644
Genre : Medical
File Size : 59. 62 MB
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Developing Therapeutics for Alzheimer's Disease: Progress and Challenges provides a thorough overview of the latest advances toward the development of therapeutics for Alzheimer’s disease, along with the major hurdles that still must be overcome and potential solutions to these problems. Despite the lack of progress toward developing therapeutics that can slow or stop the progression of this disease, important discoveries have been made and many promising approaches are advancing in preclinical studies and clinical trials. This book outlines the special challenges related to specific targets and approaches, while presenting a realistic, comprehensive and balanced view of drug discovery and development in this area. Written by international leaders in the field, the book assesses prospects for the emergence of effective agents and allows readers to better understand the challenges, failures, and future potential for research in Alzheimer’s disease. This book is a valuable resource to academic scientists carrying out translational research in Alzheimer’s disease, industrial scientists engaged in Alzheimer's drug discovery, executives in biopharmaceutical companies making strategic decisions regarding the direction of internal research and potential outside partnerships, and graduate-level students pursuing courses on Alzheimer's therapeutics. Provides a realistic but promising assessment of the potential of various therapeutic approaches to Alzheimer’s disease Focuses primarily on neuroprotective agents and cognitive enhancers, as well as approaches to targeting the amyloid B-peptide, tau and Apolipoprotein E Discusses alternative approaches, preclinical and clinical development issues, related biomarkers and diagnostics, and prevention and nonpharmacological approaches

Functional Neuromarkers For Psychiatry

Author : Juri D. Kropotov
ISBN : 9780124105201
Genre : Medical
File Size : 88. 26 MB
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Functional Neuromarkers for Psychiatry explores recent advances in neuroscience that have allowed scientists to discover functional neuromarkers of psychiatric disorders. These neuromarkers include brain activation patterns seen via fMRI, PET, qEEG, and ERPs. The book examines these neuromarkers in detail—what to look for, how to use them in clinical practice, and the promise they provide toward early detection, prevention, and personalized treatment of mental disorders. The neuromarkers identified in this book have a diagnostic sensitivity and specificity higher than 80%. They are reliable, reproducible, inexpensive to measure, noninvasive, and have been confirmed by at least two independent studies. The book focuses primarily on the analysis of EEG and ERPs. It elucidates the neuronal mechanisms that generate EEG spontaneous rhythms and explores the functional meaning of ERP components in cognitive tasks. The functional neuromarkers for ADHD, schizophrenia, and obsessive-compulsive disorder are reviewed in detail. The book highlights how to use these functional neuromarkers for diagnosis, personalized neurotherapy, and monitoring treatment results. Identifies specific brain activation patterns that are neuromarkers for psychiatric disorders Includes neuromarkers as seen via fMRI, PET, qEEG, and ERPs Addresses neuromarkers for ADHD, schizophrenia, and OCD in detail Provides information on using neuromarkers for diagnosis and/or personalized treatment

The Behavioral Neurology Of Dementia

Author : Bruce L. Miller
ISBN : 9781316688106
Genre : Medical
File Size : 40. 51 MB
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This new edition of The Behavioral Neurology of Dementia provides clinicians and researchers with the latest research findings written by the leading dementia experts. With chapters ranging from cognitive evaluation to imaging, and genetics and pathology to treatment, the detailed clinical descriptions of diseases and symptoms serve not only as an educational tool for trainees, but also as an opportunity for experienced clinicians to deepen their knowledge and better serve their patients. After years of little progress, the pace of discovery has been speeding up in the last decade, and the authors distil the most valuable discoveries into clear, insightful chapters with applicable information. All the chapters from the first edition have been refreshed with new text and figures. There are new chapters on autoimmune antibody-associated encephalopathy; chronic traumatic encephalopathy; and sleep issues in dementia.

The Fundamentals Of Clinical Neuropsychiatry

Author : Michael Alan Taylor
ISBN : 0198029934
Genre : Medical
File Size : 22. 56 MB
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Increasingly, psychiatrists make little distinction between psychiatric and neurologic disorders, considering them all as dysfunctions of the central nervous system. This is a practical how to book intended primarily for trainees and practicing clinicians unfamiliar with the relatively new field of neuropsychiatry. It is written as the author might teach the material during clinical rounds and in small group seminars. In a clear and engaging style, he explains what to do and how to do it, giving the rationale for each step, and synthesizing neuropsychiatric principles with practical guidelines for diagnosis and management of adult patients. Many tables are included for quick reference and to help the reader to quickly see the big picture of a given topic. The book covers personality and personality disorders, depression, bipolar disorder, psychiatric disorders, alcohol and substance abuse, epilepsy, traumatic brain injury and stroke, anxiety disorders, obsessive compulsive disorders, headache and violence. It can be used as an introductory text for psychiatric residents, medical students, and others who care for persons with behavioral disorders. It can also be used as a clinical manual or reference by practitioners in psychiatry and neurology.

The Clinical Neuropsychiatry Of Stroke

Author : Robert G. Robinson
ISBN : 9781139447713
Genre : Medical
File Size : 70. 53 MB
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This second edition, published in 2006, covers the range of neuropsychiatric syndromes associated with stroke, including cognitive, emotional and behavioural disorders such as depression, anxiety and psychosis. There is growing recognition among a wide range of clinicians and allied healthcare staff that post-stroke neuropsychiatric syndromes are common and serious. Such complications can have a negative impact on recovery and even survival; however, there is now evidence suggesting that pre-emptive therapeutic intervention in high-risk patient groups can prevent the initial onset of the conditions. This opportunity for primary prevention marks a huge advance in the management of this patient population.

The Clinical Neuropsychiatry Of Multiple Sclerosis

Author : Anthony Feinstein
ISBN : 9781139463904
Genre : Medical
File Size : 28. 85 MB
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Multiple sclerosis is the most common cause of neurological disability in young and middle-aged adults. This fully updated and revised new edition provides a detailed account of the many neuropsychiatric disorders associated with MS and is relevant to both the research and the clinical setting. Using the latest brain imaging findings and results from treatment trials, the symptoms, assessment, diagnosis, and treatment of depression in MS are covered, as are psychosocial factors and the link between depression and MRI abnormalities. Subsequent chapters focus on cognitive dysfunction in MS, including the natural history of cognitive change, the use of screening instruments and neuropsychological batteries, brain imaging correlations and management strategies. The book concludes with a survey of the behavioral benefits and risks associated with disease-modifying drugs. It will be valuable to all mental health professionals, neurologists, and others caring for those affected by MS.

Fundamental Neuroscience

Author : Larry R. Squire
ISBN : 9780123858702
Genre : Medical
File Size : 48. 2 MB
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Fundamental Neuroscience, 3rd Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts. A companion web site contains test questions, and an imagebank of the figures for ready use in presentations, slides, and handouts. Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers! New to this edition: * 30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and Consciousness * Companion website with figures, web links to additional material, and test questions * Additional text boxes describing key experiments, disorders, methods, and concepts * Multiple model system coverage beyond rats, mice, and monkeys * Extensively expanded index for easier referencing

Exercise Genomics

Author : Linda S. Pescatello
ISBN : 1607613557
Genre : Medical
File Size : 26. 42 MB
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Exercise Genomics encompasses the translation of exercise genomics into preventive medicine by presenting a broad overview of the rapidly expanding research examining the role of genetics and genomics within the areas of exercise performance and health-related physical activity. Leading researchers from a number of the key exercise genomics research groups around the world have been brought together to provide updates and analysis on the key discoveries of the past decade, as well as lend insights and opinion about the future of exercise genomics, especially within the contexts of translational and personalized medicine. Clinicians, researchers and health/fitness professionals will gain up-to-date background on the key findings and critical unanswered questions across several areas of exercise genomics, including performance, body composition, metabolism, and cardiovascular disease risk factors. Importantly, basic information on genomics, research methods, and statistics are presented within the context of exercise science to provide students and professionals with the foundation from which to fully engage with the more detailed chapters covering specific traits. Exercise Genomics will be of great value to health/fitness professionals and graduate students in kinesiology, public health and sports medicine desiring to learn more about the translation of exercise genomics into preventive medicine.

The Autisms

Author : Mary Coleman
ISBN : 9780199732128
Genre : Medical
File Size : 59. 51 MB
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Rev. ed. of: Biology of the autistic syndromes / Christopher Gillberg, Mary Coleman. 3rd ed. 2000.

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