handbook of pharmacogenomics and stratified medicine

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Handbook Of Pharmacogenomics And Stratified Medicine

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ISBN : 9780123868831
Genre : Science
File Size : 25. 22 MB
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Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics

Textbook Of Cultural Psychiatry

Author : Dinesh Bhugra
ISBN : 9781108683166
Genre : Medical
File Size : 30. 50 MB
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Cultural psychiatry deals with the impact of culture on causation, perpetuation and treatment of patients suffering with mental illness. The role of culture in mental illness is increasingly being recognised, and the misconceptions that can occur as a result of cultural differences can lead to misdiagnoses, under or over-diagnosis. This second edition of the Textbook of Cultural Psychiatry has been completely updated with additional new chapters on globalisation and mental health, social media and tele-psychiatry. Written by world-leading experts in the field, this new edition provides a framework for the provision of mental health care in an increasingly globalised world. The first edition of the Textbook of Cultural Psychiatry was commended in the BMA Book Awards in 2008 and was the recipient of the 2012 Creative Scholarship Award from the Society for the Study of Psychiatry and Culture.

High Throughput Screening Methods

Author : Joshua A Bittker
ISBN : 9781782626770
Genre : Science
File Size : 63. 95 MB
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High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions. This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.

Omics For Personalized Medicine

Author : Debmalya Barh
ISBN : 9788132211846
Genre : Medical
File Size : 76. 66 MB
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“Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

Textbook Of Anxiety Disorders

Author : Dan J. Stein
ISBN : 9781585629008
Genre : Medical
File Size : 50. 98 MB
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Acclaimed as "a tremendous contribution to the field of psychiatry" (Doody's Health Science Book Review Journal), the Textbook of Anxiety Disorders is now available in an expanded second edition. The new edition continues to offer both clinicians and researchers a single-volume resource that covers not only progress in clinical interventions but also the latest advances in theoretical knowledge. Following a comprehensive overview of anxiety disorders, the book provides detailed coverage of seven specific DSM-IV-TR diagnoses: generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD), mixed anxiety-depression, panic disorder, social phobia, specific phobias, and posttraumatic stress disorder (PTSD). Each section covers the latest thinking on symptomatology and pathogenesis, then provides evidence-based clinical recommendations for pharmacotherapy and psychotherapy. All chapters have been expanded and fully updated with new research findings. Many chapters have been entirely rewritten by new authors to provide fresh insight into such topics as integrated treatment of anxiety disorders; pharmacotherapy for GAD, OCD, and panic disorder; psychotherapy for OCD and PTSD; anxiety disorders in the elderly; anxiety accompanying substance abuse; and the economic and social costs of anxiety. In addition, new chapters on anxious traits and temperaments, the neuropsychology of anxiety disorders, and anxiety and insomnia enhance this comprehensive edition. Each chapter now includes a concise summary of key clinical points that helps readers put findings into practice -- as well as recommended readings that provide access to essential reports. Standing at the cutting edge of anxiety disorder research and clinical practice, this authoritative volume deserves a place on the reference shelf of any busy clinician, researcher, or educator. It will be invaluable to all mental health care professionals interested in the latest developments in understanding and treating these complex and costly disorders.

Handbook Of Pharmacogenetics

Author : Sean Boyd
ISBN : 1632422115
Genre : Medical
File Size : 34. 86 MB
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This book offers expertly selected information to the readers regarding the field of Pharmacogenetics. The main purpose of the fast developing field of Pharmacogenetics is to identify the genetic factors responsible for the inter-individual variation of drug reaction. These factors make it convenient to classify the patients according to their treatment needs and hence, catalyze drug development and encourage customized, secure and effective treatments. This book provides a wide range of examples discussing various drugs for distinct diseases which reflect different stages of assessment and application. This book is comprehensive and a great source of information to scientists, professionals, practitioners and students alike, since it discusses not just the fundamentals of pharmacogenetics but also focuses on the applications of pharmacogenetics and latest developments in this field along with discussion on its limitations and proposal of ideas to overcome them.

Handbook Of Psoriasis And Psoriatic Arthritis

Author : Richard Warren
ISBN : 9783319182278
Genre : Medical
File Size : 67. 23 MB
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This concise handbook looks at psoriasis and psoriatic arthritis as separate but often related conditions, focusing on a background around the indications, such as disease overview and epidemiology; going on to look at the etiology and immunopathogenesis of each indication; looking at the clinical presentation and diagnosis; before focusing on the current and emerging treatment options, including a brief section on the issues of quality of life and comorbidities associated with these indications. ​

Applying Pharmacogenomics In Therapeutics

Author : Xiaodong Feng
ISBN : 9781466582682
Genre : Medical
File Size : 41. 18 MB
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Recent advances in high-throughput gene sequencing and other omics biotechnologies have served as a springboard for the field of pharmacogenomics. Pharmacogenomics is now generally accepted as the major determinant of variable drug safety, efficacy, and cost-effectiveness. Therefore, widespread use of pharmacogenomics for patient care has become a critical requirement. There is an unprecedented urgency for aspiring and practicing clinicians to become trained on how to interpret data from pharmacogenomic testing in preparation for the future of healthcare—i.e., personalized medicine. Applying Pharmacogenomics in Therapeutics provides timely coverage of the principles, practice, and potential of pharmacogenomics and personalized medicine. Comprised of chapters contributed by well-established pharmacologists and scientists from US and Chinese academia and industry, this authoritative text: Demonstrates how to apply the principles of pharmacogenomics and its biotechnologies in patient care Depicts the use of genetic biomarkers in drug discovery and development, laboratory medicine, and clinical services Describes the practice of pharmacogenomics in the treatment of cancers, cardiovascular diseases, neurologic and psychiatric disorders, and pulmonary diseases Discusses the merging of pharmacogenomics and alternative medicine, as well as the integration of pharmacogenomics into pharmacoeconomics Each chapter begins with the key concepts, followed by in-depth explorations of case reports or critical evaluations of genetic variants/biomarkers, and concludes with questions for self-examination.

Preventive And Predictive Genetics Towards Personalised Medicine

Author : Godfrey Grech
ISBN : 9783319153445
Genre : Science
File Size : 74. 94 MB
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Pharmacogenomics supports personalized medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalized medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.

Handbook Of Practical Immunohistochemistry

Author : Fan Lin
ISBN : 9781493915781
Genre : Medical
File Size : 24. 77 MB
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In a conceptually current, quick-reference, Question & Answer format, the second edition of Handbook of Practical Immunohistochemistry: Frequently Asked Questions continues to provide a comprehensive and yet concise state-of-the-art overview of the major issues specific to the field of immunohistochemistry. With links to the authors Immunohistochemical Laboratory website, this volume creates a current and up-to-date information system on immunohistochemistry. This includes access to tissue microarrays (TMA) of over 10,000 tumors and normal tissue to validate common diagnostic panels and provide the best reproducible data for diagnostic purposes. Fully revised and updated from the first edition, the new features of the second edition include over 200 additional questions or revised questions with an IHC panel to answer each question; over 250 new color photos and illustrations; over 20 new useful biomarkers; hundreds of new references; several new chapters to cover phosphoproteins, rabbit monoclonal antibodies, multiplex IHC stains, overview of predictive biomarkers, and integration of IHC into molecular pathology; many new coauthors who are international experts in a related field; many updated IHC panels using Geisinger IHC data collected from over 10,000 tumors and normal tissues; and updated appendices containing detailed antibody information for both manual and automated staining procedures. Comprehensive yet practical and concise, the Handbook of Practical Immunohistochemistry: Frequently Asked Questions, Second Edition will be of great value for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.

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