handbook of pharmacogenomics and stratified medicine

Download Book Handbook Of Pharmacogenomics And Stratified Medicine in PDF format. You can Read Online Handbook Of Pharmacogenomics And Stratified Medicine here in PDF, EPUB, Mobi or Docx formats.

Handbook Of Pharmacogenomics And Stratified Medicine

Author :
ISBN : 9780123868831
Genre : Science
File Size : 21. 18 MB
Format : PDF, Mobi
Download : 428
Read : 1173

Get This Book


Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics

Textbook Of Cultural Psychiatry

Author : Dinesh Bhugra
ISBN : 9781108683166
Genre : Medical
File Size : 77. 22 MB
Format : PDF, ePub, Docs
Download : 233
Read : 262

Get This Book


Cultural psychiatry deals with the impact of culture on causation, perpetuation and treatment of patients suffering with mental illness. The role of culture in mental illness is increasingly being recognised, and the misconceptions that can occur as a result of cultural differences can lead to misdiagnoses, under or over-diagnosis. This second edition of the Textbook of Cultural Psychiatry has been completely updated with additional new chapters on globalisation and mental health, social media and tele-psychiatry. Written by world-leading experts in the field, this new edition provides a framework for the provision of mental health care in an increasingly globalised world. The first edition of the Textbook of Cultural Psychiatry was commended in the BMA Book Awards in 2008 and was the recipient of the 2012 Creative Scholarship Award from the Society for the Study of Psychiatry and Culture.

Omics For Personalized Medicine

Author : Debmalya Barh
ISBN : 9788132211846
Genre : Medical
File Size : 76. 90 MB
Format : PDF, Mobi
Download : 823
Read : 345

Get This Book


“Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

Clinical Trials

Author : Tom Brody
ISBN : 9780128042588
Genre : Medical
File Size : 55. 56 MB
Format : PDF, Docs
Download : 835
Read : 963

Get This Book


Clinical Trials, Second Edition, offers those engaged in clinical trial design a valuable and practical guide. This book takes an integrated approach to incorporate biomedical science, laboratory data of human study, endpoint specification, legal and regulatory aspects and much more with the fundamentals of clinical trial design. It provides an overview of the design options along with the specific details of trial design and offers guidance on how to make appropriate choices. Full of numerous examples and now containing actual decisions from FDA reviewers to better inform trial design, the 2nd edition of Clinical Trials is a must-have resource for early and mid-career researchers and clinicians who design and conduct clinical trials. Contains new and fully revised material on key topics such as biostatistics, biomarkers, orphan drugs, biosimilars, drug regulations in Europe, drug safety, regulatory approval and more Extensively covers the "study schema" and related features of study design Incorporates laboratory data from studies on human patients to provide a concrete tool for understanding the concepts in the design and conduct of clinical trials Includes decisions made by FDA reviewers when granting approval of a drug as real world learning examples for readers

Textbook Of Anxiety Disorders

Author : Dan J. Stein
ISBN : 9781585629008
Genre : Medical
File Size : 52. 58 MB
Format : PDF, ePub
Download : 562
Read : 924

Get This Book


Acclaimed as "a tremendous contribution to the field of psychiatry" (Doody's Health Science Book Review Journal), the Textbook of Anxiety Disorders is now available in an expanded second edition. The new edition continues to offer both clinicians and researchers a single-volume resource that covers not only progress in clinical interventions but also the latest advances in theoretical knowledge. Following a comprehensive overview of anxiety disorders, the book provides detailed coverage of seven specific DSM-IV-TR diagnoses: generalized anxiety disorder (GAD), obsessive-compulsive disorder (OCD), mixed anxiety-depression, panic disorder, social phobia, specific phobias, and posttraumatic stress disorder (PTSD). Each section covers the latest thinking on symptomatology and pathogenesis, then provides evidence-based clinical recommendations for pharmacotherapy and psychotherapy. All chapters have been expanded and fully updated with new research findings. Many chapters have been entirely rewritten by new authors to provide fresh insight into such topics as integrated treatment of anxiety disorders; pharmacotherapy for GAD, OCD, and panic disorder; psychotherapy for OCD and PTSD; anxiety disorders in the elderly; anxiety accompanying substance abuse; and the economic and social costs of anxiety. In addition, new chapters on anxious traits and temperaments, the neuropsychology of anxiety disorders, and anxiety and insomnia enhance this comprehensive edition. Each chapter now includes a concise summary of key clinical points that helps readers put findings into practice -- as well as recommended readings that provide access to essential reports. Standing at the cutting edge of anxiety disorder research and clinical practice, this authoritative volume deserves a place on the reference shelf of any busy clinician, researcher, or educator. It will be invaluable to all mental health care professionals interested in the latest developments in understanding and treating these complex and costly disorders.

Handbook Of Pharmacogenetics

Author : Sean Boyd
ISBN : 1632422115
Genre : Medical
File Size : 23. 69 MB
Format : PDF, Kindle
Download : 335
Read : 1067

Get This Book


This book offers expertly selected information to the readers regarding the field of Pharmacogenetics. The main purpose of the fast developing field of Pharmacogenetics is to identify the genetic factors responsible for the inter-individual variation of drug reaction. These factors make it convenient to classify the patients according to their treatment needs and hence, catalyze drug development and encourage customized, secure and effective treatments. This book provides a wide range of examples discussing various drugs for distinct diseases which reflect different stages of assessment and application. This book is comprehensive and a great source of information to scientists, professionals, practitioners and students alike, since it discusses not just the fundamentals of pharmacogenetics but also focuses on the applications of pharmacogenetics and latest developments in this field along with discussion on its limitations and proposal of ideas to overcome them.

Routledge Handbook Of Medical Law And Ethics

Author : Yann Joly
ISBN : 9781134448654
Genre : Law
File Size : 81. 36 MB
Format : PDF, Kindle
Download : 261
Read : 1134

Get This Book


This book explores the scope, application and role of medical law, regulatory norms and ethics, and addresses key challenges introduced by contemporary advances in biomedical research and healthcare. While mindful of national developments, the handbook supports a global perspective in its approach to medical law. Contributors include leading scholars in both medical law and ethics, who have developed specially commissioned pieces in order to present a critical overview and analysis of the current state of medical law and ethics. Each chapter offers comprehensive coverage of longstanding and traditional topics in medical law and ethics, and provides dynamic insights into contemporary and emerging issues in this heavily debated field. Topics covered include: Bioethics, health and human rights Medical liability Law and emerging health technologies Public health law Personalized medicine The law and ethics of access to medicines in developing countries Medical research in the genome era Emerging legal and ethical issues in reproductive technologies This advanced level reference work will prove invaluable to legal practitioners, scholars, students and researchers in the disciplines of law, medicine, genetics, dentistry, theology, and medical ethics.

Preventive And Predictive Genetics Towards Personalised Medicine

Author : Godfrey Grech
ISBN : 9783319153445
Genre : Science
File Size : 25. 99 MB
Format : PDF
Download : 235
Read : 873

Get This Book


Pharmacogenomics supports personalized medicine by translating genome-based knowledge into clinical practice, offering enhanced benefit for patients and health-care systems at large. Current routine practice for diagnosing and treating patients is conducted by correlating parameters such as age, gender and weight with risks and expected treatment outcomes. In the new era of personalized medicine the healthcare provider is equipped with improved ability to prevent, diagnose, treat and predict outcomes on the basis of complex information sources, including genetic and genomic data. Targeted therapy and reliable prediction of expected outcomes offer patients access to better healthcare management, by way of identifying the therapies effective for the relevant patient group, avoiding prescription of unnecessary treatment and reducing the likelihood of developing adverse drug reactions.

Personal Genomics And Personalized Medicine

Author : Hamid Bolouri
ISBN : 1848165641
Genre : Medical
File Size : 75. 87 MB
Format : PDF, Mobi
Download : 403
Read : 628

Get This Book


Current research in genomics and pharmacogenomics is increasingly highlighting the need to move towards stratified disease descriptions and individualized treatment plans. This book explains how a confluence of recent biological, technological and methodological developments is making it possible to provide personalized diagnoses and treatments. By virtue of treating each person's condition as unique, personal genomics and personalized medicine require health professionals to understand the nature of the data, its health implications, and its limitations. This book provides a detailed scientific treatment of the emerging disciplines of personal genomics and personalized medicine. It also includes a comprehensive treatment of both the promises and challenges of personal genomics and medicine from technological, societal and medical perspectives. It offers a wide-ranging review of the state of the art across all aspects of a highly multi-disciplinary subject. This book will be immensely useful for practicing health professionals and researchers, as well as senior undergraduates and graduate students in biomedical sciences.

Handbook Of Genomics And The Family

Author : Kenneth P. Tercyak
ISBN : 1441958002
Genre : Medical
File Size : 65. 8 MB
Format : PDF, Mobi
Download : 917
Read : 1160

Get This Book


This book introduces readers to the study of how genes, singly and in combination with each other and the environment, affect health and behavior. It provides family-focused perspectives relating to genetic counseling and education.

Top Download:

Best Books