high content screening science techniques and applications

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High Content Screening

Author : Steven A. Haney
ISBN : 0470229853
Genre : Medical
File Size : 68. 21 MB
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The authoritative reference on High Content Screening (HCS) in biological and pharmaceutical research, this guide covers: the basics of HCS: examples of HCS used in biological applications and early drug discovery, emphasizing oncology and neuroscience; the use of HCS across the drug development pipeline; and data management, data analysis, and systems biology, with guidelines for using large datasets. With an accompanying CD-ROM, this is the premier reference on HCS for researchers, lab managers, and graduate students.

An Introduction To High Content Screening

Author : Steven A. Haney
ISBN : 9780470624562
Genre : Science
File Size : 57. 19 MB
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Using a collaborative and interdisciplinary author base with experience in the pharmaceutical industry and academia, this book is a practical resource for high content (HC) techniques. Instructs readers on the fundamentals of high content screening (HCS) techniques Focuses on practical and widely–used techniques like image processing and multiparametric assays Breaks down HCS into individual modules for training and connects them at the end Includes a tutorial chapter that works through sample HCS assays, glossary, and detailed appendices

Chemical Genomics

Author : Haian Fu
ISBN : 9780521889483
Genre : Medical
File Size : 39. 95 MB
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This text covers new techniques and applications in chemical genomics for researchers, professionals and graduates in biology, biomedicine and chemistry.

High Content Screening

Author : D. Lansing Taylor
ISBN : 9781597452175
Genre : Computers
File Size : 29. 98 MB
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This book assists both existing users of High Content Screening (HCS), as well as investigators considering the addition of a discovery-driven platform to their R&D activities. The chapters have been organized into sections that highlight the importance of integrating instrumentation, application software, reagents and informatics. In addition, there is a combination of pure review chapters on key topics and specific methods chapters.

High Throughput Lead Optimization In Drug Discovery

Author : Tushar Kshirsagar
ISBN : 1420006967
Genre : Medical
File Size : 20. 14 MB
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A Single Source on Parallel Synthesis for Lead Optimization The end of the previous millennium saw an explosion in the application of parallel synthesis techniques for making compounds for high-throughput screening. Over time, it became clear that more thought in the design phase of library development is necessary to generate high quality hits. More recently, the use of parallel synthesis techniques has shifted to applications beyond screening collections. Exploring the nuances of this technology, High-Throughput Lead Optimization in Drug Discovery describes the application of parallel synthesis to lead optimization and the design and synthesis of targeted libraries. Examine Case Studies that Cover a Range of Different Biological Targets Featuring real-world examples and contributions from well-known scientists, the book explores the shift to conducting parallel lead optimization in-house while outsourcing most of the screening libraries synthesis. It includes more than 15 case studies that encompass a range of biological targets for application in different therapeutic areas. The text contains examples of solid and solution-phase techniques for the synthesis of directed libraries. The chapter authors explain the design principles they used to direct the choice of templates and diversity elements. Speed Up Drug Discovery and the Hit-to-Lead Process Focusing on the application of combinatorial chemistry to medicinal chemistry, this volume compiles a series of optimization projects that give you a snapshot of successes and challenges in the use of parallel synthesis for lead optimization. It explores how this technology, when applied to library design, can speed up drug discovery.

Bioengineering In Cell And Tissue Research

Author : Gerhard M. Artmann
ISBN : 3540754091
Genre : Technology & Engineering
File Size : 67. 64 MB
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Cutting edge research in cell and tissue research abounds in this review of the latest technological developments in the area. The chapters are written by excellent scientists on advanced, frontier technology and address scientific questions that require considerable engineering brainpower. The aim is to provide students and scientists working in academia and industry new information on bioengineering in cell and tissue research to enhance their understanding and innovation.

Biologically Inspired Approaches To Advanced Information Technology

Author : Auke Jan Ijspeert
ISBN : 9783540233398
Genre : Computers
File Size : 20. 67 MB
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The evolution of the Internet has led us to the new era of the information infrastructure. As the information systems operating on the Internet are getting larger and more complicated, it is clear that the traditional approaches based on centralized mechanisms are no longer meaningful. One typical example can be found in the recent growing interest in a P2P (peer-to-peer) computing paradigm. It is quite different from the Web-based client-server systems, which adopt essentially centralized management mechanisms. The P2P computing environment has the potential to overcome bottlenecks in Web computing paradigm, but it introduces another difficulty, a scalability problem in terms of information found, if we use a brute-force flooding mechanism. As such, conventional information systems have been designed in a centralized fashion. As the Internet is deployed on a world scale, however, the information systems have been growing, and it becomes more and more difficult to ensure fau- free operation. This has long been a fundamental research topic in the field. A complex information system is becoming more than we can manage. For these reasons, there has recently been a significant increase in interest in biologically inspired approaches to designing future information systems that can be managed efficiently and correctly.

High Throughput Screening

Author : John P. Devlin
ISBN : 0824700678
Genre : Science
File Size : 40. 41 MB
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Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high throughput screening (HTS) systems and provides a solid foundation for the implementation and development of HTS in bio-based industries and associated academic environments.

Integrated Drug Discovery Technologies

Author : Houng-Yau Mei
ISBN : 9780824744731
Genre : Science
File Size : 63. 90 MB
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Integrated Drug Discovery Technologies provides a global overview of emerging drug development technologies by presenting and integrating new techniques from the disciplines of chemistry, biology, and computational sciences. It combines integration of contemporary mechanization with strategies in drug delivery. Topics include: functional genomics, microfabrication techniqes, integrated proteomics technologies, high throughput screening, and fluorescence correlation spectroscopy methods.

Protein Purification

Author : Jan-Christer Janson
ISBN : 9781118002193
Genre : Science
File Size : 31. 95 MB
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The authoritative guide on protein purification—now completely updated and revised Since the Second Edition of Protein Purification was published in 1998, the sequencing of the human genome and other developments in bioscience have dramatically changed the landscape of protein research. This new edition addresses these developments, featuring a wealth of new topics and several chapters rewritten from scratch. Leading experts in the field cover all major biochemical separation methods for proteins in use today, providing professionals in biochemistry, organic chemistry, and analytical chemistry with quick access to the latest techniques. Entirely new or thoroughly revised content includes: High-resolution reversed-phase liquid chromatography Electrophoresis in gels Conventional isoelectric focusing in gel slabs and capillaries and immobilized pH gradients Affinity ligands from chemical and biological combinatorial libraries Membrane separations Refolding of inclusion body proteins from E. coli Purification of PEGylated proteins High throughput screening techniques in protein purification The history of protein chromatography

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