horizontal gene transfer in the evolution of pathogenesis advances in molecular and cellular microbiology

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Horizontal Gene Transfer In The Evolution Of Pathogenesis

Author : Michael Hensel
ISBN : 0521862973
Genre : Science
File Size : 64. 93 MB
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Horizontal gene transfer is a major driving force in the evolution of many bacterial pathogens. The development of high-throughput sequencing tools and more sophisticated genomic and proteomic techniques in recent years has resulted in a better understanding of this phenomenon. Written by leading experts in the field, this edited volume is aimed at graduate students and researchers and provides an overview of current knowledge relating to the evolution of microbial pathogenicity. This volume provides an overview of the mechanisms and biological consequences of the genome rearrangements resulting from horizontal gene transfer, in both prokaryotes and eukaryotes, as well as overviews of the key mobile genetic elements involved. Subsequent chapters focus on paradigms for the evolution of important bacterial pathogens, including Salmonella enterica, Streptococcus pneumoniae, and Staphylococcus aureus. The influence of socioeconomic parameters in the dissemination of transferable elements, such as antibiotic resistant genes in bacteria is also discussed.

Molecular Medical Microbiology

Author : Yi-Wei Tang
ISBN : 9780123977632
Genre : Science
File Size : 68. 14 MB
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The molecular age has brought about dramatic changes in medical microbiology, and great leaps in our understanding of the mechanisms of infectious disease. Molecular Medical Microbiology is the first book to synthesise the many new developments in both molecular and clinical research in a single comprehensive resource. This timely and authoritative three-volume work is an invaluable reference source of medical bacteriology. Comprising more than 100 chapters, organized into 17 major sections, the scope of this impressive work is wide-ranging. Written by experts in the field, chapters include cutting-edge information, and clinical overviews for each major bacterial group, in addition to the latest updates on vaccine development, molecular technology and diagnostic technology. Topics covered include bacterial structure, cell function, and genetics; mechanisms of pathogenesis and prevention; antibacterial agents; and infections ranging from gastrointestinal to urinary tract, centrtal nervous system, respiratory tract, and more. The first comprehensive and accessible reference on molecular medical microbiology Full color presentation througout In-depth discussion of individual pathogenic bacteria in a system-oriented approach Includes a clinical overview for each major bacterial group Presents the latest information on vaccine development, molecular technology, and diagnostic technology More than 100 chapters covering all major groups of bacteria Written by an international panel of authors who are experts in their respective disciplines

Horizontal Gene Transfer

Author : Michael Syvanen
ISBN : 0080534120
Genre : Science
File Size : 63. 6 MB
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The second edition of Horizontal Gene Transfer has been organized to provide a concise and up-to-date coverage of the most important discoveries in this fascinating field. Written by the most prominent gene transfer and genome analytical scientists, this book details experimental evidence for the phenomenon of horizontal gene transfer and discusses further evidence provided by the recent completion of genomic sequences from Archea, Bacteria, and Eucarya members. The relevance of horizontal gene transfer to plant and metazoan taxonomy, GM foods, antibiotic resistance, paleontology, and phylogenetic reconstruction is also explored. Horizontal Gene Transfer is essential for microbiologists, geneticists, biochemists, evolutionary biologists, infectious disease specialists, paleontologists, ecologists, and researchers working in plant/animal systematics and agriculture with an interest in gene transfer. This includes scientific researchers from government and industry concerned with the release of genetically modified organisms. Up-to-the-minute reviews, maps, conclusions, urls to relevant websites and colour figures Unique chapters, for example one written by paleontologists presents data for horizontal gene transfer from fingerprints form the fossil record

Molecular Phylogeny Of Microorganisms

Author : Aharon Oren
ISBN : 9781904455677
Genre : Science
File Size : 77. 17 MB
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An introduction to molecular phylogeny, this text provides an overview of the diversity, systematics and nomenclature of microbes in many branches of biological science.

Microbial Population Genetics

Author : Jianping Xu
ISBN : 9781904455592
Genre : Science
File Size : 32. 36 MB
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Microbial population genetics is a rapidly advancing field of investigation with relevance to many areas of science. The subject encompasses theoretical issues, such as the origins and evolution of species, sex, and recombination. Population genetics lays the foundations for tracking the origin and evolution of antibiotic resistance and deadly infectious pathogens and is also an essential tool in the utilization of beneficial microbes. This invaluable book, written by leading researchers in the field, details the current major advances in microbial population genetics and genomics. Distinguished international scientists introduce fundamental concepts, describe genetic tools, and comprehensively review recent data from SNP surveys, whole-genome DNA sequences, and microarray hybridizations. The chapters cover broad groups of microorganisms including viruses, bacteria, archaea, fungi, protozoa, and algae. A major focus is the application of molecular tools in the study of genetic variation. Topics covered include microbial systematics, comparative microbial genomics, horizontal gene transfer, pathogenic bacteria, nitrogen-fixing bacteria, cyanobacteria, microalgae, fungi, malaria parasites, viral pathogens, and metagenomics. Microbial Population Genetics is an essential volume for everyone interested in population genetics, and it is highly recommended reading for all microbiologists.

Plant Pathogenic Bacteria

Author : Robert W. Jackson
ISBN : 9781904455370
Genre : Science
File Size : 39. 60 MB
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Reviews the most important developments in the field providing an invaluable up-to-date summary. The first two chapters tackle bacterial evolution, diversity and taxonomy; topics that have been transformed by molecular biology and genomics analyses. The third chapter delves into the crucially understudied area of pathogen adaptation to the plant apoplast environment. This is followed by seven chapters focusing on specific plant pathogens: Agrobacterium, Leifsonia, Pectobacterium, Pseudomonas, Ralstonia, Xanthomonas, and Xylella. The next four chapters review specific, intensively studied areas of research in the plant pathogen field: microbe associated molecular patterns (MAMPs) and innate immunity; use of bacterial virulence factors to suppress plant defence; cyclic di-GMP signalling and the regulation of virulence; and plasmids and the spread of virulence. The final chapter covers the critical area of bioinformatics.

Applications Of Molecular Microbiological Methods

Author : Sean M. Caffrey Torben L. Skovhus
ISBN : 9781908230690
Genre : Science
File Size : 47. 63 MB
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Innovative, constructive and continually evolving technologies are propelling microbiology into an exciting new era. This new era will witness the harnessing and control of complex microbial communities in a huge variety of applications in the industrial, medical and environmental spheres. State-of-the-art tools are being developed and utilized to analyse the molecules that microorganisms possess and generate, including DNA, RNA, proteins, lipids and cellular metabolites. This book, written by international experts in the field, presents emerging molecular methods that allow the diversity of a microbial community to be surveyed and its functions to be investigated. The first part of the book provides examples of the application of molecular microbiological methods in various industrial applications. Part two deals with the identification of microorganisms in medical settings while the third part presents case studies that use molecular methods to assess the structure and function of microbial communities in natural environments. The fourth part of the book describes in greater detail the methods and technologies featured in the preceding case studies including metagenomics, stable isotope probing, fluorescence in situ hybridization, quantitative PCR, reverse transcription PCR and single cell methods. These detailed descriptions enable readers to evaluate the applicability of various tools for approaching questions and case studies of their own. This practical, authoritative and up-to-date volume is a valuable resource for anyone applying or developing molecular methods in any area of microbiology and is a recommended acquisition for all microbiology laboratories.

Campylobacter Ecology And Evolution

Author : Samuel K. Sheppard
ISBN : 9781908230980
Genre : Science
File Size : 37. 35 MB
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Members of the genus Campylobacter are commonly found in the gastrointestinal tract of mammals and birds, and can be commensal or pathogenic in nature. For example, Campylobacter jejuni can be a harmless commensal organism in poultry and other avian and animal hosts but in humans, it is pathogenic and the most common cause of bacterial gastroenteritis worldwide. In recent years, the application of DNA sequencing and 'omics' technologies to large numbers of isolates has allowed Campylobacter research to advance rapidly revealing fascinating new insights into the cellular biology and evolution of this highly variable group of bacteria. In this book, internationally recognised experts critically review and provide novel insights into important aspects Campylobacter research. The book is divided into four sections: Mechanisms of evolution; Adaptations to host colonisation; Molecular epidemiology; and Ecology in poultry. The topics covered range from the mechanisms of evolution through the processes of host colonisation and within host adaptation, and epidemiology to considerations of their broader biochemical and ecological properties. An important resource summarising our current knowledge of Campylobacter ecology and evolution, this book is essential reading for all researchers working with Campylobacter and related organisms.

Advances In Cell And Molecular Diagnostics

Author : Pongali Raghavendra
ISBN : 9780128136805
Genre : Medical
File Size : 61. 26 MB
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Advances in Cell and Molecular Diagnostics brings the scientific advances in the translation and validation of cellular and molecular discoveries in medicine into the clinical diagnostic setting. It enumerates the description and application of technological advances in the field of cellular and molecular diagnostic medicine, providing an overview of specialized fields, such as biomarker, genetic marker, screening, DNA-profiling, NGS, cytogenetics, transcriptome, cancer biomarkers, prostate specific antigen, and biomarker toxicologies. In addition, it presents novel discoveries and clinical pathologic correlations, including studies in oncology, infectious diseases, inherited diseases, predisposition to disease, and the description or polymorphisms linked to disease states. This book is a valuable resource for oncologists, practitioners and several members of the biomedical field who are interested in understanding how to apply cutting-edge technologies into diagnostics and healthcare. Encompasses the current scientific advances in the translation and validation of cellular and molecular discoveries into the clinical diagnostic setting Explains the application of cellular and molecular diagnostics methodologies in clinical trials Focuses on translating preclinical tests to the bedside in order to help readers apply the most recent technologies to healthcare

Molecular Oral Microbiology

Author : Anthony H. Rogers
ISBN : 9781904455240
Genre : Medical
File Size : 90. 15 MB
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In this book, a panel of experts discuss the molecular biology of micro-organisms involved in the two major dental diseases: caries and periodontal disease. Research has focused on factors which might modulate the interaction between the resident oral bacteria and the host. Chapters deal with the interactions of oral micro-organisms with one another and with the host; the innate defense mechanisms of the host; and the development of vaccines against oral diseases. Topics include oral microbial taxonomy, identification and typing, applied genomics, horizontal gene transfer, cell-cell communication, cariogenic bacteria, aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, treponema denticola, host-pathogen interaction, host defense mechanisms, and vaccination against oral infections. Essential reading for students and researchers in the field of oral biology and oral microbiology and a recommended book for all microbiology laboratories.ò

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