human longevity omega 3 fatty acids bioenergetics molecular biology and evolution

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Human Longevity

Author : Raymond C. Valentine
ISBN : 9781466594876
Genre : Medical
File Size : 25. 76 MB
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More than 7 billion people inhabit the earth and all of them are subject to aging. This book is aimed at persons interested in a molecular explanation of how our cells age. Human Longevity: Omega-3 Fatty Acids, Bioenergetics, Molecular Biology, and Evolution is built on the proposition that we age as our mitochondria age. It suggests a revised version of Harman’s famous hypothesis featuring mitochondrial oxidative and energy stresses as the root causes of aging. Human cells are protected from the ravages of aging by a battery of defensive systems including some novel mechanisms against membrane oxidation introduced in this book. This concept is consistent with recent discoveries showing that mitochondria-targeted antioxidants prevent Huntington’s disease, Parkinson’s disease, and traumatic brain disease in animal models of neurodegeneration. This book explores a unified theory of aging based on bioenergetics. It covers a variety of topics including an introduction to the science of human aging, the Darwinian selection of membranes enabling longevity, a revised mitochondrial membrane hypothesis of aging, and various mechanisms that protect human mitochondrial membranes, thereby enabling longevity.

Fett Das Handbuch F R Einen Optimierten Stoffwechsel

Author : Anja Leitz
ISBN : 9783959714358
Genre : Health & Fitness
File Size : 38. 18 MB
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Welche Fette wir konsumieren und die Zusammensetzung unseres Körperfetts entscheiden unser Leben lang über die Entwicklung und Funktionsfähigkeit diverser Organe, zelluläre Abläufe und die Effektivität des gesamten Stoffwechsels. Eine optimale Balance der Fettsäuren führt zu optimaler Gehirnfunktion, erhöhtem IQ, mehr emotionaler Stabilität, hormonellem Gleichgewicht und körperlicher Fitness. Umgekehrt können fehlende Balance, andauernd schlechte Licht- und Lebensstilbedingungen eine Vielzahl degenerativer Erkrankungen auslösen. Mit einer klugen Auswahl der Nahrungsfette und einer Verbesserung unseres Lebensstils können wir selbst dafür sorgen, dass der Zellstoffwechsel auf Hochtouren läuft. Unterschiedliche Organe, wie das Gehirn oder das Herz, brauchen unterschiedliche Fettsäuren, um optimal funktionieren zu können. In diesem fundierten Fachbuch erklärt Anja Leitz, wie man sich mit dem richtigen Cocktail an Fettsäuren und den passenden Mikronährstoffen in Höchstform bringen kann. Sie erläutert die Vielfalt und Eigenheiten aller für uns wichtigen Fettsäuren und zeigt, wie diese Fette im Körper wirken. Sie hilft, saisonale Lebensmittel auszuwählen, die eine optimale Versorgung gewährleisten, und erklärt, warum Umweltbedingungen wie Licht- und Temperaturverhältnisse oder die Jahreszeiten und klimatischen Zonen von großer Bedeutung für unsere Versorgung mit lebenswichtigen Fettsäuren sind. Eine Auswahl an schmackhaften Gerichten und Snacks, die optimale Fette enthalten, – vom Frühstückscrumble bis zur Sommerpizza – lässt sich anhand der bebilderten Rezepte zu Hause nachkochen.

Omega 3 Fatty Acids In Brain And Neurological Health

Author : Ronald Ross Watson
ISBN : 9780124105478
Genre : Technology & Engineering
File Size : 60. 56 MB
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Research has clearly established a link between omega-3 fatty acids and general health, particularly cardiovascular health. Omega-3 Fatty Acids in Brain and Neurological Health is the first book to focus exclusively on the role of omega-3 fatty acids on general brain health. The articles in this collection illustrate omega-3 fatty acids' importance in longevity, cognitive impairment, and structure and function of the brain's neurons. Research has established links between omega-3 fatty acids and the developing brain, aging, dementia, Alzheimer's disease and multiple sclerosis. This book encompasses some of the most recent research, including the role of omega-3 fatty acid supplements on hippocampal neurogenesis, substantia nigra modulation, migraine headaches, the developing brain in animals, sleep, and neurodegenerative diseases. This collection helps to push research forward toward a complete understanding of omega-3 fatty acids' relationship to brain and neurological health. The first book-length collection of original research on the connection between omega-3 fatty acids and the brain Provides a comprehensive introduction to the state of research on omega-3 fatty acids and the brain and directions for future research A foundational collection for neuroscience, neurology, and nutrition research

Neurons And The Dha Principle

Author : Raymond C. Valentine
ISBN : 9781439874868
Genre : Medical
File Size : 34. 96 MB
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Studies with bacteria and other systems suggest that the omega-3 fatty acid DHA confers great benefits to neurons in maximizing both speed of neural impulses and energy efficiency. Unfortunately, studies also show that DHA’s ease of oxidation damages membrane integrity. Exploring this duality, Neurons and the DHA Principle proposes a new model for the causes of neurodegeneration, in which DHA-enriched membranes of neurons become dysfunctional and energetically wasteful, triggering the premature death of neurons. The challenge of this book is to digest how DHA acts as an essential building block of neurons while also conspiring for their assassination during aging. As the book reviews the extraordinary properties of DHA in life forms from deep-sea bacteria to human neurons, it asks: Is there a trade-off between speed and efficiency of brain function enabled by DHA versus longevity or life span? Has modern medicine advanced significantly in the treatment of the body but not necessarily of the brain? What are the molecular explanations for the decline in brain health during the age of longevity? A full accounting of the roles of DHA in neurons requires balancing the enormous benefits of these molecules against the risks. Introducing the dual chemical personalities of DHA from an evolutionary perspective, Neurons and the DHA Principle explores DHA from the standpoint of benefit–risk analysis, opening new perspectives for understanding how DHA functions in neurons.

The Future Of Aging

Author :
ISBN : 9789048139996
Genre : Medical
File Size : 71. 10 MB
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Just as the health costs of aging threaten to bankrupt developed countries, this book makes the scientific case that a biological "bailout" could be on the way, and that human aging can be different in the future than it is today. Here 40 authors argue how our improving understanding of the biology of aging and selected technologies should enable the successful use of many different and complementary methods for ameliorating aging, and why such interventions are appropriate based on our current historical, anthropological, philosophical, ethical, evolutionary, and biological context. Challenging concepts are presented together with in-depth reviews and paradigm-breaking proposals that collectively illustrate the potential for changing aging as never before. The proposals extend from today to a future many decades from now in which the control of aging may become effectively complete. Examples include sirtuin-modulating pills, new concepts for attacking cardiovascular disease and cancer, mitochondrial rejuvenation, stem cell therapies and regeneration, tissue reconstruction, telomere maintenance, prevention of immunosenescence, extracellular rejuvenation, artificial DNA repair, and full deployment of nanotechnology. The Future of Aging will make you think about aging differently and is a challenge to all of us to open our eyes to the future therapeutic potential of biogerontology.

Concepts Of Biology

Author : Samantha Fowler
ISBN : 9888407457
Genre : Science
File Size : 80. 64 MB
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Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.

Annual Plant Reviews Biology Of The Plant Cuticle

Author : Markus Riederer
ISBN : 9781405171571
Genre : Science
File Size : 72. 44 MB
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Annual Plant Reviews, Volume 23 A much clearer picture is now emerging of the fine structure of the plant cuticle and its surface, the composition of cuticular waxes and the biosynthetic pathways leading to them. Studies assessing the impact of UV radiation on plant life have emphasized the role of the cuticle and underlying epidermis as optical filters for solar radiation. The field concerned with the diffusive transport of lipophilic organic non-electrolytes across the plant cuticle has reached a state of maturity. A new paradigm has recently been proposed for the diffusion of polar compounds and water across the cuticle. In the context of plant ecophysiology, cuticular transpiration can now be placed in the perspective of whole-leaf water relations. New and unexpected roles have been assigned to the cuticle in plant development and pollen-stigma interactions. Finally, much progress has been made in understanding the cuticle as a specific and extraordinary substrate for the interactions of the plant with microorganisms, fungi and insects. This volume details the major developments of recent years in this important interdisciplinary area. It is directed at researchers and professionals in plant biochemistry, plant physiology, plant ecology, phytopathology and environmental microbiology, in both the academic and industrial sectors.

Molecular Basis Of Nutrition And Aging

Author : Marco Malavolta
ISBN : 9780128018279
Genre : Medical
File Size : 43. 83 MB
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Molecular Basis of Nutrition and Aging: A Volume in the Molecular Nutrition Series focuses on the nutritional issues associated with aging and the important metabolic consequences of diet, nutrition, and health. The book is subdivided into four parts that reflect the impact of nutrition from a biomolecular level to individual health. In Part One, chapters explore the general aspects of aging, aging phenotypes, and relevant aspects of nutrition related to the elderly and healthy aging. Part Two includes molecular and cellular targets of nutrition in aging, with chapters exploring lipid peroxidation, inflammaging, anabolic and catabolic signaling, epigenetics, DNA damage and repair, redox homeostasis, and insulin sensitivity, among others. Part Three looks at system-level and organ targets of nutrition in aging, including a variety of tissues, systems, and diseases, such as immune function, the cardiovascular system, the brain and dementia, muscle, bone, lung, and many others. Finally, Part Four focuses on the health effects of specific dietary compounds and dietary interventions in aging, including vitamin D, retinol, curcumin, folate, iron, potassium, calcium, magnesium, zinc, copper, selenium, iodine, vitamin B, fish oil, vitamin E, resveratrol, polyphenols, vegetables, and fruit, as well as the current nutritional recommendations. Offers updated information and a perspectives on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of aging Explores how nutritional factors are involved in the pathogenesis of aging across body systems Investigates the molecular and genetic basis of aging and cellular senescence through the lens of the rapidly evolving field of molecular nutrition

The Evolution Of Hominin Diets

Author : Jean-Jacques Hublin
ISBN : 1402096992
Genre : Social Science
File Size : 71. 58 MB
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Michael P. Richards and Jean-Jacques Hublin The study of hominin diets, and especially how they have (primates, modern humans), (2) faunal and plant studies, (3) evolved throughout time, has long been a core research archaeology and paleoanthropology, and (4) isotopic studies. area in archaeology and paleoanthropology, but it is also This volume therefore presents research articles by most of becoming an important research area in other fields such as these participants that are mainly based on their presentations primatology, nutrition science, and evolutionary medicine. at the symposium. As can hopefully be seen in the volume, Although this is a fundamental research topic, much of the these papers provide important reviews of the current research research continues to be undertaken by specialists and there in these areas, as well as often present new research on dietary is, with some notable exceptions (e. g. , Stanford and Bunn, evolution. 2001; Ungar and Teaford, 2002; Ungar, 2007) relatively lit- In the section on modern studies Hohmann provides a tle interaction with other researchers in other fields. This is review of the diets of non-human primates, including an unfortunate, as recently it has appeared that different lines interesting discussion of the role of food-sharing amongst of evidence are causing similar conclusions about the major these primates. Snodgrass, Leonard, and Roberston provide issues of hominid dietary evolution (i. e.

Handbook Of Dietary And Nutritional Aspects Of Human Breast Milk

Author : Sherma Zibadi
ISBN : 9789086862092
Genre : Medical
File Size : 81. 93 MB
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Breast feeding has a great impact on the growth of infants both physically and psychologically. Human breast milk is beneficial to infant health because it contains the necessary macro- and micro-nutrients for tissue accretion, repair and behavioural developments. The production of milk is a complex biological process and its composition and volume is dependent upon a variety of factors such as the health and dietary status of the mother. Moreover, it is influenced by the different stages and duration of breast feeding. Environmental factors, both global and local, may also alter lactation, milk composition and nutritional value. This handbook provides a unique and complete insight into the dietary and nutritional aspects of human breast milk. For a general understanding an overview is given of breast structure and function and lactation. Nutritional aspects are highlighted in a section on the composition of breast milk, including recent research results on breast milk and growth factors, vitamins, proteins and antigens, amongst others. Finally an analysis of both the beneficial and adverse factors relating to lactation and composition of breast milk are discussed.

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