implantable biomedical microsystems design principles and applications micro and nano technologies

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Implantable Biomedical Microsystems

Author : Swarup Bhunia
ISBN : 9780323261906
Genre : Technology & Engineering
File Size : 57. 88 MB
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Research and innovation in areas such as circuits, microsystems, packaging, biocompatibility, miniaturization, power supplies, remote control, reliability, and lifespan are leading to a rapid increase in the range of devices and corresponding applications in the field of wearable and implantable biomedical microsystems, which are used for monitoring, diagnosing, and controlling the health conditions of the human body. This book provides comprehensive coverage of the fundamental design principles and validation for implantable microsystems, as well as several major application areas. Each component in an implantable device is described in details, and major case studies demonstrate how these systems can be optimized for specific design objectives. The case studies include applications of implantable neural signal processors, brain-machine interface (BMI) systems intended for both data recording and treatment, neural prosthesis, bladder pressure monitoring for treating urinary incontinence, implantable imaging devices for early detection and diagnosis of diseases as well as electrical conduction block of peripheral nerve for chronic pain management. Implantable Biomedical Microsystems is the first comprehensive coverage of bioimplantable system design providing an invaluable information source for researchers in Biomedical, Electrical, Computer, Systems, and Mechanical Engineering as well as engineers involved in design and development of wearable and implantable bioelectronic devices and, more generally, teams working on low-power microsystems and their corresponding wireless energy and data links. First time comprehensive coverage of system-level and component-level design and engineering aspects for implantable microsystems. Provides insight into a wide range of proven applications and application specific design trade-offs of bioimplantable systems, including several major case studies Enables Engineers involved in development of implantable electronic systems to optimize applications for specific design objectives.

Molecular Sensors And Nanodevices

Author : John X J Zhang
ISBN : 9781455776764
Genre : Science
File Size : 45. 53 MB
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With applications ranging from medical diagnostics to environmental monitoring, molecular sensors (also known as biosensors, chemical sensors, or chemosensors), along with emerging nanotechnologies offer not only valuable tools but also unlimited possibilities for engineers and scientists to explore the world. New generation of functional microsystems can be designed to provide a variety of small scale sensing, imaging and manipulation techniques to the fundamental building blocks of materials. This book provides comprehensive coverage of the current and emerging technologies of molecular sensing, explaining the principles of molecular sensor design and assessing the sensor types currently available. Having explained the basic sensor structures and sensing principles, the authors proceed to explain the role of nano/micro fabrication techniques in molecular sensors, including MEMS, BioMEMS, MicroTAS among others. The miniaturization of versatile molecular sensors opens up a new design paradigm and a range of novel biotechnologies, which is illustrated through case studies of groundbreaking applications in the life sciences and elsewhere. As well as the techniques and devices themselves, the authors also cover the critical issues of implantability, biocompatibility and the regulatory framework. The book is aimed at a broad audience of engineering professionals, life scientists and students working in the multidisciplinary area of biomedical engineering. It explains essential principles of electrical, chemical, optical and mechanical engineering as well as biomedical science, intended for readers with a variety of scientific backgrounds. In addition, it will be valuable for medical professionals and researchers. An online tutorial developed by the authors provides learning reinforcement for students and professionals alike. Reviews of state-of-the-art molecular sensors and nanotechnologies Explains principles of sensors and fundamental theories with homework problems at the end of each chapter to facilitate learning Demystifies the vertical integration from nanomaterials to devices design Covers practical applications the recent progress in state-of-the-art sensor technologies Includes case studies of important commercial products Covers the critical issues of implantability, biocompatibility and the regulatory framework

Microfluidic Cell Culture Systems

Author : Jeffrey T Borenstein
ISBN : 9780128136720
Genre : Science
File Size : 86. 9 MB
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Techniques for microfabricating intricate microfluidic structures that mimic the microenvironment of tissues and organs, combined with the development of biomaterials with carefully engineered surface properties, have enabled new paradigms in and cell culture-based models for human diseases. The dimensions of surface features and fluidic channels made accessible by these techniques are well-suited to the size scale of biological cells. Microfluidic Cell Culture Systems applies design and experimental techniques used in in microfluidics, and cell culture technologies to organ-on-chip systems. This book is intended to serve as a professional reference, providing a practical guide to design and fabrication of microfluidic systems and biomaterials for use in cell culture systems and human organ models. The book covers topics ranging from academic first principles of microfluidic design, to clinical translation strategies for cell culture protocols. The goal is to help professionals coming from an engineering background to adapt their expertise for use in cell culture and organ models applications, and likewise to help biologists to design and employ microfluidic technologies in their cell culture systems. This 2nd edition contains new material that strengthens the focus on in vitro models useful for drug discovery and development. One new chapter reviews liver organ models from an industry perspective, while others cover new technologies for scaling these models and for multi-organ systems. Other new chapters highlight the development of organ models and systems for specific applications in disease modeling and drug safety. Previous chapters have been revised to reflect the latest advances. Provides design and operation methodology for microfluidic and microfabricated materials and devices for organ-on-chip disease and safety models. This is a rapidly expanding field that will continue to grow along with advances in cell biology and microfluidics technologies. Comprehensively covers strategies and techniques ranging from academic first principles to industrial scale-up approaches. Readers will gain insight into cell-material interactions, microfluidic flow, and design principles. Offers three fundamental types of information: 1) design principles, 2) operation techniques, and 3) background information/perspectives. The book is carefully designed to strike a balance between these three areas, so it will be of use to a broad range of readers with different technical interests and educational levels.

Microsystems For Bioelectronics

Author : Victor V. Zhirnov
ISBN : 1437778410
Genre : Technology & Engineering
File Size : 37. 13 MB
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Microsystems for Bioelectronics is the ultimate guide in the biomedical application industry. It provides a physics-based assessment of the limitless potential of miniaturization technologies. This book goes far beyond the complete design of the final systems. It also discusses the developments of computation and communication subsystems. The future of this technology lies in understanding the scaling limits for the individual systems. This includes all of its components and the fundamental energy source that powers all autonomous microsystems. Rapid advances in microfabrication technologies are offering new opportunities and capabilities to develop systems for biomedical applications. These applications include the diagnostics community and those that are active in therapy services. Microsystems for Bioelectronics is one of the only books on the market today that goes into the comprehensive treatment of integrated microsystems. Discusses the diverse components that make up Microsystems Outlines the problems with miniaturization of energy sources Perfect reference for those in both the Engineering and Medical Profession

Biomedical Microsystems

Author : Ellis Meng
ISBN : 9781420051230
Genre : Medical
File Size : 21. 87 MB
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Poised to dramatically impact human health, biomedical microsystems (bioMEMS) technologies incorporate various aspects from materials science, biology, chemistry, physics, medicine, and engineering. Reflecting the highly interdisciplinary nature of this area, Biomedical Microsystems covers the fundamentals of miniaturization, biomaterials, microfabrication, and nanotechnology, along with relevant applications. Written by an active researcher who was recently named one of Technology Review’s Young Innovators Under 35, the book begins with an introduction to the benefits of miniaturization. It then introduces materials, fabrication technology, and the necessary components of all bioMEMS. The author also covers fundamental principles and building blocks, including microfluidic concepts, lab-on-a-chip systems, and sensing and detection methods. The final chapters explore several important applications of bioMEMS, such as microdialysis, catheter-based sensors, MEMS implants, neural probes, and tissue engineering. For readers with a limited background in MEMS and bioMEMS, this book provides a practical introduction to the technology used to make these devices, the principles that govern their operation, and examples of their application. It offers a starting point for understanding advanced topics and encourages readers to begin to formulate their own ideas about the design of novel bioMEMS. A solutions manual is available for instructors who want to convert this reference to classroom use.

Microsystems And Nanotechnology

Author : Zhaoying Zhou
ISBN : 9783642182938
Genre : Technology & Engineering
File Size : 65. 20 MB
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“Microsystems and Nanotechnology” presents the latest science and engineering research and achievements in the fields of microsystems and nanotechnology, bringing together contributions by authoritative experts from the United States, Germany, Great Britain, Japan and China to discuss the latest advances in microelectromechanical systems (MEMS) technology and micro/nanotechnology. The book is divided into five parts – the fundamentals of microsystems and nanotechnology, microsystems technology, nanotechnology, application issues, and the developments and prospects – and is a valuable reference for students, teachers and engineers working with the involved technologies. Professor Zhaoying Zhou is a professor at the Department of Precision Instruments & Mechanology , Tsinghua University , and the Chairman of the MEMS & NEMS Society of China. Dr. Zhonglin Wang is the Director of the Center for Nanostructure Characterization, Georgia Tech, USA. Dr. Liwei Lin is a Professor at the Department of Mechanical Engineering, University of California at Berkeley, USA.

Lab On A Chip

Author : Albert Berg
ISBN : 9780444511003
Genre : Science
File Size : 53. 73 MB
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In the past ten years there has been a rapid growth of the research and application area known as Lab-on-a-Chip. After an initial focus on electrokinetic separation techniques on chip, the scope of the field has widened to include topics like microfluidics, DNA analysis, cell analysis, microreactors and mass spectrometer interfacing. As well as the analytical chemistry community, synthetic chemists, chemical engineers, biochemists and biomedical engineers are now also becoming more and more interested in using new micro- and nanotechnological techniques. This first Lab-on-a-Chip book contains a broad collection of papers on microtechnology, microfluidics, analytical methods and applications. All contributions are written by leading researchers in their respective fields, and provide new scientists with an overview of the field, to make him/her aware of the enormous opportunities offered by modern technology. The work presented in this book will definitely stimulate readers to new ideas and concepts, and lead to further innovations in this area. - Provides a quick introduction into the different aspects of this field - Describes technology that has already revolutionized the world of chemical and biochemical analysis and synthesis - All contributions are written by leading researchers in their respective fields

Living Machines

Author : Tony J. Prescott
ISBN : 9780191662560
Genre : Science
File Size : 46. 73 MB
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Contemporary research in the field of robotics attempts to harness the versatility and sustainability of living organisms. By exploiting those natural principles, scientists hope to render a renewable, adaptable, and robust class of technology that can facilitate self-repairing, social, and moral—even conscious—machines. This is the realm of robotics that scientists call "the living machine". Living Machines can be divided into two entities-biomimetic systems, those that harness the principles discovered in nature and embody them in new artifacts, and biohybrid systems, which couple biological entities with synthetic ones. Living Machines: A handbook of research in biomimetic and biohybrid systems surveys this flourishing area of research. It captures the current state of play and points to the opportunities ahead, addressing such fields as self-organization and co-operativity, biologically-inspired active materials, self-assembly and self-repair, learning, memory, control architectures and self-regulation, locomotion in air, on land or in water, perception, cognition, control, and communication. In all of these areas, the potential of biomimetics is shown through the construction of a wide range of different biomimetic devices and animal-like robots. Biohybrid systems is a relatively new field, with exciting and largely unknown potential, but one that is likely to shape the future of humanity. Chapters outline current research in areas including brain-machine interfaces-where neurons are connected to microscopic sensors and actuators-and various forms of intelligent prostheses from sensory devices like artificial retinas, to life-like artificial limbs, brain implants, and virtual reality-based rehabilitation approaches. The handbook concludes by exploring the impact living machine technology will have on both society and the individual, by forcing human beings to question how we see and understand ourselves. With contributions from leading researchers drawing on ideas from science, engineering, and the humanities, this handbook will appeal to both undergraduate and postgraduate students of biomimetic and biohybrid technologies. Researchers in the areas of computational modeling and engineering, including artificial intelligence, machine learning, artificial life, biorobotics, neurorobotics, and human-machine interfaces, will find Living Machines an invaluable resource.

Phealth 2017

Author : B. Blobel
ISBN : 9781614997610
Genre : Medical
File Size : 75. 91 MB
Format : PDF
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Smart mobile systems such as microsystems, smart textiles, smart implants, sensor-controlled medical devices and innovative sensor techniques have become important enablers for telemedicine and next-generation health services, with social media and gamification adding further to personalized health (pHealth) as an eco-system. This book presents the proceedings of pHealth 2017, the 14th in a series of international conferences for personalized health held in Eindhoven, the Netherlands, in May 2017. The conference series, which began in 2003 as a dissemination activity in the framework of a European project on wearable micro and nano technologies for personalized health, presents advances in wearable or implantable micro-, nano- and bio-technologies for healthcare and wellness, and brings together expertise from medical, technological, political, administrative, and social domains, and even from philosophy and linguistics. The book contains keynotes and invited papers, as well as 16 oral presentations and 8 poster presentations. Encompassing diverse fields such as medical services, public health, prevention, social and elderly care, wellness and personal fitness, the book will be of interest to practitioners from various medical and health disciplines, as well as developers and administrators, provider institutions, and patient and citizens representatives.

4m 2006 Second International Conference On Multi Material Micro Manufacture

Author : Stefan Dimov
ISBN : 008046629X
Genre : Technology & Engineering
File Size : 88. 86 MB
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4M 2006 - Second International Conference on Multi-Material Micro Manufacture covers the latest state-of-the-art research results from leading European researchers in advanced micro technologies for batch processing of metals, polymers, and ceramics, and the development of new production platforms for micro systems-based products. These contributions are from leading authors at a platform endorsed and funded by the European Union R&D community, as well as leading universities, and independent research and corporate organizations. Contains authoritative papers that reflect the latest developments in micro technologies and micro systems-based products

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