insights into enzyme mechanisms and functions from experimental and computational methods advances in protein chemistry and structural biology

Download Book Insights Into Enzyme Mechanisms And Functions From Experimental And Computational Methods Advances In Protein Chemistry And Structural Biology in PDF format. You can Read Online Insights Into Enzyme Mechanisms And Functions From Experimental And Computational Methods Advances In Protein Chemistry And Structural Biology here in PDF, EPUB, Mobi or Docx formats.

Insights Into Enzyme Mechanisms And Functions From Experimental And Computational Methods

Author :
ISBN : 9780128052419
Genre : Science
File Size : 84. 32 MB
Format : PDF, ePub
Download : 395
Read : 1312

Get This Book


Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Written by authorities in their respective fields Targeted to a wide audience of researchers, specialists, and students

Structural And Mechanistic Enzymology

Author :
ISBN : 9780123983183
Genre : Science
File Size : 82. 61 MB
Format : PDF, Docs
Download : 880
Read : 599

Get This Book


Both strategies for investigation (computational and experimental) in structural and mechanistic Enzymology have developed to some extent independently. However, over the last few years a trend has emerged for strengthening their integration. This combination not only brings together computations and experiments focused on the same enzymatic problems, but also provides complementary insights into the investigated properties and has a powerful synergy effect. This thematic volume of Advances in Protein Chemistry and Structural Biology focuses on the recent success in structural and mechanistic enzymology and has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches. The selected contributions demonstrate how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design. Focuses on the recent success in structural and mechanistic enzymology Has its main emphasis on explaining the enzyme phenomena by using both the experimental and computational approaches Demonstrates how the application of a variety of experimental techniques and modeling methods helps further the understanding of enzyme dynamics, mechanism, inhibition, and drug design

Comprehensive Medicinal Chemistry Iii

Author :
ISBN : 9780128032015
Genre : Science
File Size : 88. 93 MB
Format : PDF, ePub, Docs
Download : 267
Read : 411

Get This Book


Comprehensive Medicinal Chemistry III provides a contemporary and forward-looking critical analysis and summary of recent developments, emerging trends, and recently identified new areas where medicinal chemistry is having an impact. The discipline of medicinal chemistry continues to evolve as it adapts to new opportunities and strives to solve new challenges. These include drug targeting, biomolecular therapeutics, development of chemical biology tools, data collection and analysis, in silico models as predictors for biological properties, identification and validation of new targets, approaches to quantify target engagement, new methods for synthesis of drug candidates such as green chemistry, development of novel scaffolds for drug discovery, and the role of regulatory agencies in drug discovery. Reviews the strategies, technologies, principles, and applications of modern medicinal chemistry Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Computational Approaches To Protein Dynamics

Author : Monika Fuxreiter
ISBN : 9781482297867
Genre : Science
File Size : 54. 83 MB
Format : PDF, ePub, Docs
Download : 886
Read : 952

Get This Book


The Latest Developments on the Role of Dynamics in Protein Functions Computational Approaches to Protein Dynamics: From Quantum to Coarse-Grained Methods presents modern biomolecular computational techniques that address protein flexibility/dynamics at all levels of theory. An international contingent of leading researchers in chemistry, physics, and biology show how these advanced methods provide insights into dynamic aspects of biochemical processes. A particular focus is on intrinsically disordered proteins (IDPs), which lack a well-defined three-dimensional structure and function as dynamic ensembles. The book covers a wide spectrum of dynamics, from electronic structure-based to coarse-grained techniques via multiscaling at different levels. After an introduction to dynamics and historical overview of basic methodologies, the book addresses the following issues: Is there a quantitative relationship between enzymatic catalysis and protein dynamics? Which are the functionally relevant motions of proteins? How can structural properties and partner recognition mechanisms of IDPs be simulated? How can we speed up molecular dynamics? How can we describe conformational ensembles by the synergistic effort of computations and experiments? While dynamics is now considered essential for interpreting protein action, it is not yet an integral component in establishing structure–function relationships of proteins. Helping to reshape this classical view in biochemistry, this groundbreaking book explores advances in computational methodology and contributes to the new, ensemble way of studying proteins.

Computational Approaches For Studying Enzyme Mechanism

Author :
ISBN : 9780128111086
Genre : Medical
File Size : 35. 91 MB
Format : PDF
Download : 617
Read : 728

Get This Book


Computational Approaches for Studying Enzyme Mechanism, Part B is the first of two volumes in the Methods in Enzymology series that focuses on computational approaches for studying enzyme mechanism. The serial achieves the critically acclaimed gold standard of laboratory practices and remains one of the most highly respected publications in the molecular biosciences. Each volume is eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 550 volumes, the series remains a prominent and essential publication for researchers in all fields of the life sciences and biotechnology, including biochemistry, chemical biology, microbiology, synthetic biology, cancer research, genetics, and other fields of study. Focuses on computational approaches for studying enzyme mechanism Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in intermediate filament associated proteins, and contains sections on such topics as lamin-associated proteins, intermediate filament-associated proteins and plakin, and other cytoskeletal cross-linkers

Advances In Protein Chemistry And Structural Biology

Author : Alexander McPherson
ISBN : 012381264X
Genre : Medical
File Size : 55. 48 MB
Format : PDF, ePub, Mobi
Download : 343
Read : 1082

Get This Book


Structural genomics is the systematic determination of 3-dimensional structures of proteins representative of the range of protein structure and function found in nature. The goal is to build a body of structural information that will predict the structure and potential function for almost any protein from knowledge of its coding sequence. This is essential information for understanding the functioning of the human proteome, the ensemble of tens of thousands of proteins specified by the human genome. While most structural biologists pursue structures of individual proteins or protein groups, specialists in structural genomics pursue structures of proteins on a genome wide scale. This implies large scale cloning, expression and purification. One main advantage of this approach is economy of scale. Key Features *Examines the three dimensional structure of all proteins of a given organism, by experimental methods such as X-ray crystallography and NMR spectroscopy * Looks at structural genomics as a foundation of drug discovery as discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission

Scientific Report

Author : Scripps Research Institute
ISBN : UOM:39015045484543
Genre : Medicine
File Size : 64. 32 MB
Format : PDF, Kindle
Download : 990
Read : 892

Get This Book



Handbook Of Computational Chemistry

Author : Jerzy Leszczynski
ISBN : 9789400707115
Genre : Computers
File Size : 76. 22 MB
Format : PDF, ePub, Mobi
Download : 669
Read : 177

Get This Book


This handbook is a guide to current methods of computational chemistry, explaining their limitations and advantages and providing examples of their applications. The first part outlines methods, the balance of volumes present numerous important applications.

Introduction To Protein Structure

Author : Carl-Ivar Brändén
ISBN : 9780815323051
Genre : Medical
File Size : 66. 13 MB
Format : PDF, ePub
Download : 692
Read : 1206

Get This Book


This new edition gives an up-to-date account of the principles of protein structure, with examples of key proteins in their biological context, illustrated in colour to illuminate the structural principles described in the text.

Scientific Report

Author :
ISBN : NWU:35558004475766
Genre : Medicine
File Size : 20. 17 MB
Format : PDF, Kindle
Download : 453
Read : 1016

Get This Book



Top Download:

Best Books