intercellular signaling in development and disease cell signaling collection

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Intercellular Signaling In Development And Disease

Author : Edward A. Dennis
ISBN : 9780123822154
Genre : Science
File Size : 89. 16 MB
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"Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.

Transduction Mechanisms In Cellular Signaling

Author : Edward A. Dennis
ISBN : 9780123838636
Genre : Science
File Size : 73. 8 MB
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Cytosol, the liquid found inside cells, is the site for multiple cell processes, including signaling from the cell membrane to sites within the cell. Cytosolic signaling mechanisms are researched and studied in graduate programs in cell biology, molecular biology, biochemistry, pharmacology, molecular and cellular physiology, pharmacy, and biomedical sciences. Articles written and edited by experts in the field Thematic volume covering material needed for young professionals joining the field of research and graduate students taking survey courses Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

Regulation Of Organelle And Cell Compartment Signaling

Author : Ralph A. Bradshaw
ISBN : 9780123822147
Genre : Science
File Size : 86. 36 MB
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This must-have cell signaling title will appeal to researchers across molecular biology, biochemistry, cell biology and genetics. The articles are written and edited by experts in the field and emphasize signaling to and from intracellular compartments including transcriptional responses to cytoplasmic and nuclear signaling events, chromatin remodeling and stress responses, the regulation of endoplasmic reticulum function, control of cell cycle progression and apoptosis and the modulation of the activities of mitochondria and other organelles. Articles written and edited by experts in the field Thematic volume covering regulation of endoplasmic reticulum function, regulation of cell cycle progression, and quality control and assurance in mitochondrion events Up-to-date research on events in membrane proteins and proteins of intracellular matrix

Functioning Of Transmembrane Receptors In Signaling Mechanisms

Author : Ralph A. Bradshaw
ISBN : 9780123822123
Genre : Science
File Size : 60. 93 MB
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A primary component of cell signaling research, this title covers the principal membrane-bound receptor families, including their structural organization. Written and edited by experts in the field, this book provides up-to-date research on transmembrane signaling entities and their initiating responses following extracellular stimulation. Articles written and edited by experts in the field Thematic volume covering effectors, cytosolic events, nuclear, and cytoplasmic events Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease

Nuclear Factor B

Author : R. Beyaert
ISBN : 1402014341
Genre : Medical
File Size : 55. 91 MB
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Seventeen years after its initial description, nuclear factor-KB (NF-KB) endures as one of the most studied transcription factors. NF-KB has attracted widespread interest based on the variety of stimuli that activate it, the diverse genes and bio logical responses that it controls, the striking evolutionary conservation of struc ture and function among species, and its involvement in a variety of human diseases. The biochemical basis by which several stimuli converge to activate NF-KB has been largely elucidated during recent years. While first discovered as a key regulatory factor of the immune system, NF-KB is now recognized as an important player in the functioning of many organs and cell types. The ongoing examination of NF-KB signaling has revealed its ever expanding role in immune and inflammatory responses, but also in cancer and development. For this reason, numerous efforts are underway to develop safe inhibitors of NF-KB to be used in the treatment of both chronic and acute disease situations. The present book is the first to review and synthesize our knowledge of this interesting transcription factor. As such, the choice of subjects to review was daunting. To set the stage, an introductory chapter on activators and target genes, as well as the role they play in several responses, has been included.

Adhesion Molecules In Health And Disease

Author : Paul
ISBN : 0824798244
Genre : Science
File Size : 25. 72 MB
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Provides an overview of the structure, transcription regulation and binding characteristics of cellular adhesion molecules and their ligands in the maintenance of function, immunological reactions and inflammatory processes with organ systems. The text examines the role of adhesion molecules in biological processes such as morphogenesis, blood coagulation, tumour metastasis, bone tissue remodelling and transplant rejection.

Spinal Cord Medicine Second Edition

Author : Diana D. Cardenas, MD, MHA
ISBN : 1935281771
Genre : Medical
File Size : 76. 39 MB
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A Doody's Core Title 2012 The thoroughly revised Second Edition of this authoritative reference continues to define the standard of care for the field of spinal cord medicine. Encompassing all of the diseases and disorders that may a!ect the proper functioning of the spinal cord or spinal nerves, this comprehensive volume provides a state of the art review of the principles of care and best practices for restoring function and quality of life to patients with spinal cord injuries. Expert contributors from multiple disciplines cover topics ranging from acute medical and surgical management of specific problems to cutting-edge research, bladder, bowel and sexual dysfunction, neurologic and musculoskeletal issues, advanced rehabilitation techniques and technologies, functional outcomes, and psychosocial care. While comprehensive in scope, Spinal Cord Medicine offers practical guidance for physicians and other health care professionals involved in the management of individuals with SCI, multiple sclerosis, and other spinal cord disorders. The Second Edition has been completely updated to fully reflect current science and practice. Each section has been re-ordered to better present information and the Second Edition brings in many new authors and topics, more diagrams, illustrations, and tables to solidify concepts, and contains 18 entirely new chapters. Spinal Cord Medicine: Principles and Practice, Second Edition, reflects the breadth and depth of this multi-faceted specialty. Involving over 150 authors from more than 20 fields of medicine, it is a trusted reference for anyone who works with spinal cord patients and strives to deliver superior clinical care and improve outcomes.

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