introduction to enzyme and coenzyme chemistry

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Introduction To Enzyme And Coenzyme Chemistry

Author : T. D. H. Bugg
ISBN : 9781118348994
Genre : Science
File Size : 87. 96 MB
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Enzymes are giant macromolecules which catalyse biochemical reactions. They are remarkable in many ways. Their three-dimensional structures are highly complex, yet they are formed by spontaneous folding of a linear polypeptide chain. Their catalytic properties are far more impressive than synthetic catalysts which operate under more extreme conditions. Each enzyme catalyses a single chemical reaction on a particular chemical substrate with very high enantioselectivity and enantiospecificity at rates which approach “catalytic perfection”. Living cells are capable of carrying out a huge repertoire of enzyme-catalysed chemical reactions, some of which have little or no precedent in organic chemistry. The popular textbook Introduction to Enzyme and Coenzyme Chemistry has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action, with additional recent examples from the literature used to illustrate key points. A major new feature is the inclusion of two-colour figures, and the addition of over 40 new figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. This new edition provides a concise but comprehensive account from the perspective of organic chemistry, what enzymes are, how they work, and how they catalyse many of the major classes of enzymatic reactions, and will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry, chemical biology, biochemistry and biotechnology.

Introduction To Enzyme And Coenzyme Chemistry

Author : T. D. H. Bugg
ISBN : 9781405148009
Genre : Science
File Size : 63. 18 MB
Format : PDF
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Enzyme catalysis is a topic of fundamental importance in organic, bio-organic and medicinal chemistry. This new edition of a very popular textbook provides a concise introduction to the underlying principles and mechanisms of enzyme and coenzyme action from a chemical perspective. Whilst retaining the overall structure of the first edition – preliminary chapters describe the basic principles of enzyme structure and catalysis moving through to detailed discussions of the major classes of enzyme processes in the later chapters – the book has been thoroughly updated to include information on the most recent advances in our understanding of enzyme action. A major feature of the second edition is the inclusion of two-colour figures of the active sites of enzymes discussed in the text, in order to illustrate the interplay between enzyme structure and function. Problems, with outline answers, at the end of each chapter give the student the chance to the check their understanding of the material. As a concise but comprehensive account, Introduction to Enzyme and Coenzyme Chemistry will continue to prove invaluable to both undergraduate and postgraduate students of organic, bio-organic and medicinal chemistry. Tim Bugg is professor of biological chemistry in the Department of Chemistry, University of Warwick, UK.

Introduction To Enzyme And Coenzyme Chemistry

Author : Tim Bugg
ISBN : 9781119995944
Genre : Science
File Size : 28. 91 MB
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Looking at enzymes from an organic chemistry perspective, this updated reference includes information on recent advances in our understanding of enzyme action; topical examples to illustrate key points; two-color figures of the active sites of enzymes discussed in the text to illustrate the interplay between enzyme structure and function; and end-of-chapter problems to allow readers to check their understanding of the material. This concise but comprehensive guide is essential for undergraduate and postgraduate students of organic, bio-organic, and medicinal chemistry, chemical biology, biochemistry, and biotechnology.

The Biological Chemistry Of Nickel

Author : Deborah Zamble
ISBN : 9781788010580
Genre : Science
File Size : 78. 44 MB
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Nickel is an essential element in many biochemical processes and there has been significant research into understanding in great depth the role that this transition element plays. This book provides a comprehensive review of the latest findings in nickel biology, covering the function, biochemistry, toxicology and medical applications of nickel systems. Chapters discuss a range of topics in this field including the coordination chemistry of nickel-containing biomolecules, current theories on nickel-containing enzymes and the transport, storage and transcriptional regulation of nickel in biological systems. Issues such as the key role of nickel in pathogens, nickel toxicity in humans and the potential medical applications are also examined. Written by internationally leading experts in nickel biology and chemistry research, this book is an essential reference for bioinorganic chemists, biochemists, biologists and medicinal chemists.

Introduction To Enzyme And Coenzyme Chemistry

Author : Ronald Lewis (ed)
ISBN : 1680952781
Genre :
File Size : 37. 79 MB
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Bioorganic Chemistry

Author : Hermann Dugas
ISBN : UCAL:B4489331
Genre : Science
File Size : 51. 21 MB
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Introduction to bioorganic chemistry; Bioorganic chemistry of the amino acids; Bioorganic chemistry of the phosphates; Enzyme chemistry; Enzyme models; Metal ions; Coenzyme chemistry.

The Pyridine Nucleotide Coenzymes

Author : Johannes Everse
ISBN : 9780323150842
Genre : Science
File Size : 64. 31 MB
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The Pyridine Nucleotide Coenzymes provides a comprehensive discussion of the evolution, properties, and reactions of pyridine nucleotide coenzymes. The pyridine nucleotide coenzymes, NAD and NADP, appear to be among the most versatile of molecules with respect to their biological functions. In addition to their well-documented roles in a large number of oxidation-reduction reactions, these coenzymes are involved in many aspects of metabolic regulation. The book begins by tracing the evolution of coenzymes and pyridine nucleotide coenzymes. This is followed by separate chapters that deal with the static and dynamic properties of the pyridine nucleotide coenzymes; chemistry and solution conformation of the pyridine coenzymes; pyridine nucleotide analogs; and the three-dimensional structures of pyridine nucleotide binding enzymes. Subsequent chapters cover the synthesis and characterization of immobilized coenzymes and derivatives and their applications in affinity chromatography and enzyme reactors; the pathways to quinolinate, a major precursor of pyridine nucleotides; the role of pyridine nucleotides in phagocytosis; and non-oxidation-reduction reactions of pyridine nucleotides.

Nucleic Acids In Chemistry And Biology

Author : G Michael Blackburn
ISBN : 9781782625773
Genre : Science
File Size : 87. 74 MB
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The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

Heme Peroxidases

Author : Emma Raven
ISBN : 9781849739115
Genre : Electronic books
File Size : 50. 9 MB
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This book will provide an up to date handbook that is unique in its combination of both the general aspects of heme protein structure and the function in a single volume.

Introduction To Enzymology

Author : Alan H. Mehler
ISBN : 9781483258478
Genre : Science
File Size : 59. 62 MB
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Introduction to Enzymology focuses on the processes, methodologies, reactions, and approaches involved in enzyme chemistry. The book first offers information on the hydrolysis of peptides and proteins and fermentation and oxidation of major metabolic fuels. Discussions focus on oxidation of fatty acids, alternative pathways of carbohydrate metabolism, Krebs citric acid cycle, free energy and the concept of bond energy, pyruvate oxidation and acetyl coenzyme A formation, and glycolysis. The text then elaborates on the transfer of oxygen, hydrogen, and electrons and sugars and sugar derivatives. The publication takes a look at polynucleotides and their components, amino acids, and acids and acid derivatives. Topics include carbonic anhydrase, mechanism of action of pyridoxal phosphate enzymes, aromatic ring biosynthesis and metabolism of phenylalanine and tyrosine, metabolism of sulfur-containing amino acids, and oxidation of amino acids. The book is a valuable reference for chemists and researchers interested in enzymology.

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