introduction to macromolecular crystallography

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Introduction To Macromolecular Crystallography

Author : Alexander McPherson
ISBN : 9781118210635
Genre : Science
File Size : 53. 37 MB
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A comprehensive and approachable introduction to crystallography— now updated in a valuable new edition The Second Edition of this well-received book continues to offerthe most concise, authoritative, and easy-to-follow introduction tothe field of crystallography. Dedicated to providing a complete,basic presentation of the subject that does not assume a backgroundin physics or math, the book's content flows logically from basicprinciples to methods, such as those for solving phase problems,interpretation of Patterson maps and the difference Fourier method,the fundamental theory of diffraction and the properties ofcrystals, and applications in determining macromolecularstructure. This new edition includes a vast amount of carefully updatedmaterials, as well as two completely new chapters on recording andcompiling X-ray data and growing crystals of proteins and othermacromolecules. Richly illustrated throughout to clarify difficult concepts,this book takes a non-technical approach to crystallography that isideal for professionals and graduate students in structuralbiology, biophysics, biochemistry, and molecular biology who arestudying the subject for the first time.

Macromolecular Crystallography Protocols

Author : Sylvie Doublié
ISBN : 9781597452663
Genre : Science
File Size : 80. 96 MB
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In the decade since publication of the first edition this book, the field has seen several major developments. These developments have both accelerated the pace of structure determination and made crystallography accessible to a broader range of investigators. Volume I is dedicated to crystallization and ways to increase the odds of obtaining crystals in macromolecules. Volume 2 covers both computational methods for characterizing crystals and solving structures.

Macromolecular Crystallography With Synchrotron Radiation

Author : John R. Helliwell
ISBN : 0521544041
Genre : Science
File Size : 51. 7 MB
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This highly illustrated monograph provides a comprehensive study of the structure and function of proteins, nucleic acids and viruses using synchrotron radiation and crystallography. Synchrotron radiation is intense, polychromatic and finely collimated, and is highly effective for probing the structure of macromolecules. This is a fast-expanding field, and this timely monograph gives a complete introduction to the technique and its uses. Beginning with chapters on the fundamentals of macromolecular crystallography and macromolecular structure, the book goes on to review the sources and properties of synchrotron radiation, instrumentation and data collection. There are chapters on the Laue method, on diffuse X-ray scattering and on variable wavelength dispersion methods. The book concludes with a description and survey of applications including studies at high resolution, the use of small crystals, the study of large unit cells, and time-resolved crystallography (particularly of enzymes). Appendices are provided which present essential information for the synchrotron user as well as information about synchrotron facilities currently available. A detailed bibliography and reference section completes the volume. Many tables, diagrams and photographs are included.

Direct Methods Macromolecular Crystallography And Crystallographic Statistics Proceedings Of Winter School

Author : Schenk H
ISBN : 9789813201774
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Vasopressin is a hormone which has an increasingly important profile. Not only does it play a physiologically significant role in renal water regulation but it also has other renal actions and plays a role in overall cardiovascular control. Even more interesting is the recent growing interest in its potential effects on the brain, notably its influence on specific behaviours.This monograph about the polypeptide vasopressin covers all aspects relating to the production, control of release, and actions of this molecule within the body, including its roles as a hormone and as a central neurotransmitter. A consideration of the evolution of the molecule across the species and a brief historical perspective are also included. Clinical conditions associated with hypo- and hyper-production states are considered together with aspects of treatment, in addition to other clinical correlates./a

Einf Hrung In Die Kristallographie

Author : Will Kleber
ISBN : 9783486598858
Genre : Science
File Size : 53. 31 MB
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Das dynamische Fachgebiet wird in seiner gesamten Bandbreite dargestellt, wodurch sich das Buch auch den Studierenden verwandter Fachrichtungen wie z.B. Physik, Chemie und Werkstoffwissenschaft als eines der besten deutschsprachigen Lehrwerke empfiehlt.

Kristallstrukturbestimmung

Author : Werner Massa
ISBN : 9783658094126
Genre : Science
File Size : 38. 52 MB
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In anschaulicher Form – unterstützt durch zahlreiche Abbildungen – wird in diesem aktualisierten Lehrbuch in die Methode der Kristallstrukturbestimmung eingeführt. Die kristallographischen Grundlagen und einzelne praktische Schritte der modernen Kristallstrukturbestimmung werden verständlich und nachvollziehbar erklärt.

Macromolecular Crystallography

Author : Mark R. Sanderson
ISBN : 9780191523427
Genre : Science
File Size : 50. 36 MB
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Macromolecular Crystallography is the study of macromolecules (proteins and nucleic acids) using X-ray crystallographic techniques in order to determine their molecular structure. The knowledge of accurate molecular structures is a pre-requisite for rational drug design, and for structure-based function studies to aid the development of effective therapeutic agents and drugs. The successful determination of the complete genome (genetic sequence) of several species (including humans) has recently directed scientific attention towards identifying the structure and function of the complete complement of proteins that make up that species; a new and rapidly growing field of study called 'structural genomics'. There are now several important and well-funded global initiatives in operation to identify all of the proteins of key model species. One of the main requirements for these initiatives is a high-throughput crystallization facility to speed-up the protein identification process. The extent to which these technologies have advanced, calls for an updated review of current crystallographic theory and practice. This practical reference book features the latest conventional and high-throughput methods, and includes contributions from a team of internationally recognized leaders and experts. It will be of relevance and use to graduate students, research scientists and professionals currently working in the field of conventional and high-throughput macromolecular crystallography.

Comprehensive Natural Products Ii Chemistry And Biology

Author :
ISBN : 9780080453828
Genre : Science
File Size : 51. 9 MB
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This work presents a definitive interpretation of the current status of and future trends in natural products—a dynamic field at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids, and enzymes. With more than 1,800 color figures, Comprehensive Natural Products II features 100% new material and complements rather than replaces the original work (©1999). Reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine Stimulates new ideas among the established natural products research community—which includes chemists, biochemists, biologists, botanists, and pharmacologists Informs and inspires students and newcomers to the field with accessible content in a range of delivery formats Includes 100% new content, with more than 6,000 figures (1/3 of these in color) and 40,000 references to the primary literature, for a thorough examination of the field Highlights new research and innovations concerning living organisms and their distinctive role in our understanding and improvement of human health, genomics, ecology/environment, and more Adds to the rich body of work that is the first edition, which will be available for the first time in a convenient online format giving researchers complete access to authoritative Natural Products content

Macromolecular Crystallography

Author : Maria Armenia Carrondo
ISBN : 9789400725294
Genre : Science
File Size : 81. 29 MB
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This volume is a collection of the contributions presented at the 42nd Erice Crystallographic Course whose main objective was to train the younger generation on advanced methods and techniques for examining structural and dynamic aspects of biological macromolecules. The papers review the techniques used to study protein assemblies and their dynamics, including X-ray diffraction and scattering, electron cryo-electron microscopy, electro nanospray mass spectrometry, NMR, protein docking and molecular dynamics. A key theme throughout the book is the dependence of modern structural science on multiple experimental and computational techniques, and it is the development of these techniques and their integration that will take us forward in the future.

Synchrotron Based Macromolecular Crystallography Module For An Undergraduate Biochemistry Laboratory Course

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ISBN : OCLC:1016885967
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Abstract : A 2 week module on macromolecular crystallography was introduced into an undergraduate biochemistry class, including the use of remote data collection at a synchrotron X‐ray source. Abstract : This paper describes the introduction of synchrotron‐based macromolecular crystallography (MX) into an undergraduate laboratory class. An introductory 2 week experimental module on MX, consisting of four laboratory sessions and two classroom lectures, was incorporated into a senior‐level biochemistry class focused on a survey of biochemical techniques, including the experimental characterization of proteins. Students purified recombinant protein samples, set up crystallization plates and flash‐cooled crystals for shipping to a synchrotron. Students then collected X‐ray diffraction data sets from their crystals via the remote interface of the Molecular Biology Consortium beamline (4.2.2) at the Advanced Light Source in Berkeley, CA, USA. Processed diffraction data sets were transferred back to the laboratory and used in conjunction with partial protein models provided to the students for refinement and model building. The laboratory component was supplemented by up to 2 h of lectures by faculty with expertise in MX. This module can be easily adapted for implementation into other similar undergraduate classes, assuming the availability of local crystallographic expertise and access to remote data collection at a synchrotron source.

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