ion channels and disease quantitative finance

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Ion Channels And Disease

Author : Frances M. Ashcroft
ISBN : 9780080535210
Genre : Science
File Size : 52. 11 MB
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Ion channels are membrane proteins that act as gated pathways for the movement of ions across cell membranes. They play essential roles in the physiology of all cells. In recent years, an ever-increasing number of human and animal diseases have been found to result from defects in ion channel function. Most of these diseases arise from mutations in the genes encoding ion channel proteins, and they are now referred to as the channelopathies. Ion Channels and Disease provides an informative and up-to-date account of our present understanding of ion channels and the molecular basis of ion channel diseases. It includes a basic introduction to the relevant aspects of molecular biology and biophysics and a brief description of the principal methods used to study channelopathies. For each channel, the relationship between its molecular structure and its functional properties is discussed and ways in which genetic mutations produce the disease phenotype are considered. This book is intended for research workers and clinicians, as well as graduates and advanced undergraduates. The text is clear and lively and assumes little knowledge, yet it takes the reader to frontiers of what is currently known about this most exciting and medically important area of physiology. Key Features * Introduces the relevant aspects of molecular biology and biophysics * Describes the principal methods used to study channelopathies * Considers single classes of ion channels with summaries of the physiological role, subunit composition, molecular structure and chromosomal location, plus the relationship between channel structure and function * Looks at those diseases associated with defective channel structures and regulation, including mutations affecting channel function and to what extent this change in channel function can account for the clinical phenotype

The Spark Of Life Electricity In The Human Body

Author : Frances Ashcroft
ISBN : 9780393089547
Genre : Science
File Size : 64. 15 MB
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“A gem that sparkles.”—William Bynum, Wall Street Journal What happens during a heart attack? Can someone really die of fright? What is death, anyway? How does electroshock treatment affect the brain? What is consciousness? The answers to these questions lie in the electrical signals constantly traveling through our bodies, driving our thoughts, our movements, and even the beating of our hearts. The history of how scientists discovered the role of electricity in the human body is a colorful one, filled with extraordinary personalities, fierce debates, and brilliant experiments. Moreover, present-day research on electricity and ion channels has created one of the most exciting fields in science, shedding light on conditions ranging from diabetes and allergies to cystic fibrosis, migraines, and male infertility. With inimitable wit and a clear, fresh voice, award-winning researcher Frances Ashcroft weaves together compelling real-life stories with the latest scientific findings, giving us a spectacular account of the body electric.

Handbook Of Ion Channels

Author : Jie Zheng
ISBN : 9781466551428
Genre : Medical
File Size : 86. 77 MB
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The New Benchmark for Understanding the Latest Developments of Ion Channels Ion channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of cells. In nonexcitable tissues, they also help regulate basic salt balance critical for homeostasis. All of these features make ion channels important targets for pharmaceuticals. Handbook of Ion Channels illustrates the fundamental importance of these membrane proteins to human health and disease. Renowned researchers from around the world introduce the technical aspects of ion channel research, provide a modern guide to the properties of major ion channels, and present powerful methods for modeling ion channel diseases and performing clinical trials for ion channel drugs. Conveniently divided into five parts, the handbook first describes the basic concepts of permeation and gating mechanisms, balancing classic theories and the latest developments. The second part covers the principles and practical issues of both traditional and new ion channel techniques and their applications to channel research. The third part organizes the material to follow the superfamilies of ion channels. This part focuses on the classification, properties, gating mechanisms, function, and pharmacology of established and novel channel types. The fourth part addresses ion channel regulation as well as trafficking and distribution. The final part examines several ion channel-related diseases, discussing genetics, mechanisms, and pharmaceutical advances.

Quantitative Proteome Analysis

Author : Kazuhiro Imai
ISBN : 9789814316514
Genre : Science
File Size : 47. 16 MB
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This book focuses on the advantages and disadvantages of each of the commonly used quantitative proteomic methods in terms of accuracy, sensitivity, and reproducibility. It also concentrates on the effective applications of these methods that resulted in many discoveries of the role of the proteins expressed in living cells and biological fluids. The first part of the book focuses on the description of advantages and disadvantages of each of the commonly used quantitative proteomic methods in terms of accuracy, sensitivity, and, especially, reproducibility. The second part of the book focuses on providing concise descriptions of the effective applications of these methods to demonstrate how they have resulted in many important discoveries of the roles of the proteins expressed in living cells.

Handbook Of Pharmacogenomics And Stratified Medicine

Author :
ISBN : 9780123868831
Genre : Science
File Size : 73. 34 MB
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Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics

Handbook Of Quantitative Science And Technology Research

Author : Henk F. Moed
ISBN : 1402027559
Genre : Computers
File Size : 40. 44 MB
Format : PDF
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This handbook offers a state-of-the-art overview of quantitative science and technology research. It focuses on the development and application of indicators derived from data on scientific or scholarly publications and patents. It comprises 34 chapters written by leading specialists in the various sub-domains. These chapters deal with theoretical and methodological issues, illustrate applications, and highlight their policy context and relevance. Authors present a survey of the research topics they address, and show their most recent achievements. The 34 chapters are arranged into 5 parts: Disciplinary Approaches; General Methodology; The Science System; The Technology System; and The Science–Technology Interface. The Editor’s Introduction provides a further specification of the handbook’s scope and of the main topics addressed in its chapters. This handbook aims at four distinct groups of readers: – practitioners in the field of science and technology studies; – research students in this field; – scientists, scholars and technicians who are interested in a systematic, thorough analysis of their activities; – policy makers and administrators who wish to be informed about the potentialities and limitations of the various approaches and about their results.

Financing Social Protection

Author : Michael Cichon
ISBN : 9221151220
Genre : Political Science
File Size : 53. 43 MB
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This publication considers the range of financing options available for the design of cost-effective and equitable social welfare systems, giving a thorough analysis of their advantages and disadvantages and their financial and economic implications. Written by practitioners for practitioners, the book discusses the design and maintenance of national social protection systems that seek to ensure effective and efficient use of available resources at the community, national and international levels while supporting long-term economic development. The book explores theoretical and practical policy questions, as well as looking at the policy process that determines the affordable levels of and scope of social protection in a given country.

Cell Function And Disease

Author : L. Canedo
ISBN : 9781461308133
Genre : Medical
File Size : 57. 91 MB
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The new experimental tools and approaches of modern biology have allowed us to better understand many fundamental properties of the eukaryotic cells. These significant discoveries have drastically changed the diagnostic and therapeutic approaches of modern clinical practice. On April 18-22, 1988, an International Symposium on Cell Function and Disease was held in Monterrey, Nuevo Leon, Mexico, aimed at reviewing some of the most recent advances made in the following five areas: Genes and Human Diseases; Cellular and Molecular Pathology; Infectious Diseases; Brain Transplants and the New Approaches and Techniques with Potential Application to Cell Function and Disease. This book is based on the contributed papers of the symposium. To underline the importance of the clinical approach to the study of cell function and disease a section on this subject was added at the end of the book. The chapters in this volume include contributions by some of the leading scientists of the international scientific community and Mexico. During the course of this international conference, numerous discussions were held by the local and international representatives of the scientific community concerning the creation of an International Center of Molecular Medicine aimed at stimulating further interaction between molecular biologists, biochemists, biophyscists and clinicians. Such ideas received the endorsement and support of the Director General of the united Nations Educational and Scientific Organization (UNESCO), Federico Mayor, the Governor of the State of Nuevo Leon, Jorge Trevino, and the Secretary of Health of Mexico, Guillermo Soberon.

Neuromuscular Disorders In Clinical Practice

Author : Bashar Katirji
ISBN : 9781461465676
Genre : Medical
File Size : 83. 91 MB
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Comprehensive, thoroughly updated, and expanded, Neuromuscular Disorders in Clinical Practice, Second Edition encompasses all disorders of the peripheral nervous system, covering all aspects of neuromuscular diseases from diagnosis to treatment. Mirroring the first book, this two-volume edition is divided into two parts. Part one discusses the approach to neuromuscular disorders, covering principles and basics, neuromuscular investigations, and assessment and treatment of neurological disorders. Part two then addresses the complete range of specific neuromuscular diseases: neuronopathies, peripheral neuropathies, neuromuscular junction disorders, muscle ion channel disorders, myopathies, and miscellaneous neuromuscular disorders and syndromes. Neuromuscular Disorders in Clinical Practice, Second Edition is intended to serve as a comprehensive text for both novice and experienced practitioners. General neurologists as well as specialists in neuromuscular medicine and trainees in neuromuscular medicine, clinical neurophysiology and electromyography should find this book inclusive, comprehensive, practical and highly clinically focused. Additionally, specialists in physical medicine and rehabilitation, rheumatology, neurosurgery, and orthopedics will find the book of great value in their practice.

Ion Channels In Health And Disease

Author : Geoffrey S. Pitt
ISBN : 9780128020173
Genre : Science
File Size : 55. 84 MB
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Ion Channels in Health and Disease provides key insight to allow researchers to generate discoveries across disease states. A single resource that integrates disparate areas of biology and disease ion channel biology, this publication includes cross-referencing for disease, channels, and tissues. Offers a broad view of research of interest to early and experienced researchers across biological and biomedical research. Provides an overview of fundamental concepts in ion channels research to link defects in human disease Written in an accessible manner, without jargon Provides a helpful, easy cross-reference for diseases, channels, and tissues

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