karch s pathology of drug abuse fourth edition

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Karch S Pathology Of Drug Abuse Fourth Edition

Author : Steven B. Karch, MD
ISBN : 0849378818
Genre : Law
File Size : 20. 33 MB
Format : PDF
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Written for practitioners in the field, this critically acclaimed bestseller provides authoritative information focused on the investigation of drug-related deaths and practical approaches to the detection of drug abuse. Organized to provide forensic investigators and pathologists with ready access to the authoritative and comprehensive information they need, Karch’s Pathology of Drug Abuse, Fourth Edition includes— • 171 new color photos and microphotographs • 46 tables of comparative information • 2,000 new references to the literature Authored by a World-Renowned Forensic Pathologist Steven B. Karch is a fellow in several forensic and toxicological societies and has served many years as consultant to both the legal community and the pharmaceutical industry in the United States and the United Kingdom. His bestselling resources can be found on the bookshelves of forensic experts and pathologists across the world. They include the classic Drug Abuse Handbook, and A Brief History of Cocaine, both in their second editions, available from CRC Press.

Karch S Pathology Of Drug Abuse Fifth Edition

Author : Steven B. Karch, MD
ISBN : 9781439861479
Genre : Law
File Size : 60. 16 MB
Format : PDF
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Written in the same accessible manner as previous editions, the fifth edition of Karch’s Pathology of Drug Abuse is an essential guide to the pathology, toxicology, and pharmacology of commonly abused drugs. The book focuses on the investigation of drug-related deaths, practical approaches to the detection of drug abuse, and discussions of medical complications associated with each of the abused drugs. The Fifth Edition Now Features: Completely revised with hundreds of pages of wholly new coverage Extensive discussion of new synthetic cannabinoids and cathinone derivatives Expanded coverage of the functional and molecular pharmacology of cocaine and myocardial remodeling Expanded discussion of deaths related to prescription medications Detailed suggestions on the interpretation of postmortem drug measurements Many new high resolution full-color photomicrographs Additional, helpful new appendices on standard reference values Separate chapters are devoted to cocaine, naturally occurring stimulants, synthetic stimulants, hallucinogens, narcotics, anabolic steroids, disassociative anesthetics, solvent abuse, and marijuana. The book also offers detailed information on the origins, history, and production techniques used to make many of these drugs. Updated, revised, and newly illustrated, Karch’s Pathology of Drug Abuse, Fifth Edition is a must-have reference for research and practice related to drug abuse. Steven B. Karch also discusses the book in a video on the CRC Press YouTube channel.

Drug Abuse Handbook Second Edition

Author : Steven B. Karch, MD, FFFLM
ISBN : 9781420003468
Genre : Law
File Size : 80. 26 MB
Format : PDF, Kindle
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Following the well-received first edition, the Drug Abuse Handbook, Second Edition is a thorough compendium of the knowledge of the pharmacological, medical, and legal aspects of drugs. The book examines criminalistics, pathology, pharmacokinetics, neurochemistry, treatment, as well as drugs and drug testing in the workplace and in sports, and the ethical, legal, and practical issues involved. Dr. Karch gathers contributions from 80 leading experts in their respective fields to update and revise this second edition with more than 40 percent new material. New topics include genetic testing in drug death investigation, the neurochemistry of nicotine and designer amphetamines, genetic doping in sports, and the implications of the Daubert ruling on the admissibility of scientific evidence in federal court. Packed with the latest information in an easily accessible format, the book includes tables of all Scheduled Drugs, methods of Drug Quantitative Analysis, and a glossary of forensic toxicology terms. Vivid pictures and diagrams illustrate the pathological effects of drugs and the chemical make-up and breakdown of abused drugs. It includes more than 6000 references to the best sources in medicine, pharmacology, and the law. This book addresses specific problems in drug testing, drug-related medical emergencies, and the physical, neurochemical, and sociological phenomenon of addiction. With unparalleled detail and the highest level of authoritative information, The Drug Abuse Handbook, Second Edition is the definitive resource for drug related issues.

Pathology Toxicogenetics And Criminalistics Of Drug Abuse

Author : Steven B. Karch, MD, FFFLM
ISBN : 1420054562
Genre : Law
File Size : 74. 29 MB
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Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Pathology, Toxicogenetics, and Criminalistics of Drug Abuse presents a detailed introduction to the cutting-edge advances in this emerging field. Beginning with a definition and explanation of the scheduling of controlled substances, the book covers all illicit drugs, as well as several legitimate pharmaceutical preparations that are used illicitly, including steroids. It describes in detail the most common pathologic syndromes seen in the hearts, lungs, and central nervous systems of drug abusers and explains how inherited genetic defects and variations can alter drug effects. Written by leading investigators in the field, this useful volume describes the techniques most commonly used by forensic analysts including chemical confirmatory tests such as microcrystal identification and gas chromatography/mass spectrometry. The book reviews the basics of toxicogenetics, including the molecular changes in cardiac structure ("channelopathies") that may cause sudden death.

Addiction And The Medical Complications Of Drug Abuse

Author : Steven B. Karch, MD, FFFLM
ISBN : 1420054449
Genre : Medical
File Size : 68. 19 MB
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Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Addiction and the Medical Complications of Drug Abuse explores the physiological and psychological phenomenon of addiction including the nature of dependence, the dependence potential of drugs, and the importance of motivation. Contributions analyze the practice of substitute prescribing and detail the immediate and long term benefits of their use in maintenance or controlled withdrawal from opioids, stimulants, and benzodiazepines. It considers the use of methadone, buprenorphine, adrenergic agonists, and naltrexone for detoxification. Practitioners will benefit from the expert instruction on the management of common comorbidities, including diagnosis and pharmaceutical treatment of psychological disorders. Additional information covers the physiological effects of each drug and the emergency management of several drug related disorders such as psychosis, seizures, stroke, hyperthermia, and cardiac crisis. With 29 tables and figures, expert data and extensive references, this is an indispensable book for anyone in the field of addiction or emergency medicine.

Forensic Issues In Alcohol Testing

Author : Steven B. Karch, MD, FFFLM
ISBN : 1420054465
Genre : Law
File Size : 41. 49 MB
Format : PDF, ePub
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Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Forensic Issues in Alcohol Testing offers concise and focused information specific to the interests of forensic scientists and clinical and forensic toxicologists. It analyzes the acute effects of alcohol intoxication and the methods by which investigators can measure alcohol concentration in blood, urine, and breath. It considers extenuating circumstances affecting acute impairment by detailing the disposition and fate of alcohol in the body as well as the factors influencing absorption, distribution, and elimination. Specific chapters address difficulties in measuring and interpreting post-mortem alcohol concentrations due to poor quality of specimen, sampling site differences, and post-mortem diffusion or synthesis. Recent advances in biochemical testing make it possible to quantitate chronic alcohol ingestion, and the book analyzes the efficacy of these tests as evaluators of dependence or potential for dependence.

Neurochemistry Of Abused Drugs

Author : Steven B. Karch, MD, FFFLM
ISBN : 1420054422
Genre : Law
File Size : 75. 68 MB
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Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Beginning with a detailed look at individual drugs and their effects on the brain, Neurochemistry of Abused Drugs considers the changes in neurotransmitter levels and discusses the relationship of these changes to the nature and phenomenon of addiction. New studies highlight the addictive capacity of nicotine as well as introduce novel compounds that may aid in tobacco cessation. Chapters examine nicotine dependant neuroplasticity and the various neurochemical substrates that support and promote addiction including cholinergic, dopaminergic, and GABAergic adaptations. The book also offers detailed information on the neurochemical and neurobehavioral consequences of MDMA, methamphetamine, and cocaine use. Recent discoveries on the neurotransmitter systems involved in each of these drugs reveal new therapeutic targets for alleviating addiction including ibogaine, and GABA and glutamate receptors. Extensively referenced and citing numerous up-to-date studies, this book provides unparalleled insight into the action and potential inhibition of drugs of abuse.

Workplace Drug Testing

Author : Steven B. Karch, MD, FFFLM
ISBN : 142005449X
Genre : Law
File Size : 41. 88 MB
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Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Using sample protocols from the transportation and nuclear power industries, Workplace Drug Testing reviews current federal regulations and mandatory guidelines for federal workplace testing programs and demonstrates practical techniques for specimen collection and laboratory testing. The book compares workplace testing outside the US including protocols, attitude surveys, and legislation from Europe, Australia and South America. Chapters include analytical approaches for sample testing such as radioimmunoassay and enzyme immunoassay, as well as confirmatory testing via quality assurance, calibrators, and controls. The book also offers analytical information for biological matrices other than urine; details the procedures for using hair, oral fluid, and sweat; and examines the physiologic considerations when interpreting alternative matrix test results. Containing numerous tables and figures, expert data, and supported by extensive references, this is a crucial tool for those charged with maintaining a drug-free workplace.

Postmortem Toxicology Of Abused Drugs

Author : Steven B. Karch, MD, FFFLM
ISBN : 1420054546
Genre : Law
File Size : 29. 5 MB
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Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Postmortem Toxicology of Abused Drugs considers the role of toxicology in the investigation of homicide, suicide, accident, natural death, and overdose. It gives practical insights and case reviews on conducting toxicology tests and completing toxicology reports. It explains chain of custody; specimen collection and security; sampling of blood, urine, bile, and vitreous humor; and the selection of post-mortem specimens. Analyzing various testing procedures, the book covers simple chemical tests, microdiffusion tests, chromatography, spectroscopy, and more. It also discusses methods and strategies for analysis; and covers quality assurance protocols and controls. To help avoid common pitfalls, the text demonstrates the proper interpretation of postmortem drug levels based on knowledge of pharmacokinetics, metabolism, and pharmacogenetics; post-mortem redistribution and diffusion; and other considerations such as synergistic toxicity, and drug instability. Heavily referenced and containing several tables, figures, and useful appendices, this book is a handy reference for forensic scientists and medical examiners involved with death investigation.

Pharmacokinetics And Pharmacodynamics Of Abused Drugs

Author : Steven B. Karch, MD, FFFLM
ISBN : 1420054600
Genre : Law
File Size : 71. 67 MB
Format : PDF, ePub, Mobi
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Extracted from the Drug Abuse Handbook, 2nd edition, to give you just the information you need at an affordable price. Pharmacokinetics and Pharmacodynamics of Abused Drugs is a concise and focused volume devoted to the metabolism and measurable effects of drugs on the human body. Beginning with basic concepts and models designed to provide a fundamental understanding of the subject matter, the book details the specifics of absorption, distribution, and elimination pathways and rates of commonly abused drugs. It analyzes the effects of drug use on human performance including response time, memory and recall, logical and cognitive processes, as well as physiological changes. Packed with data and comparative studies, this handy volume considers the effects of marketed and prescription medications as well as illicit drugs including opioids, cannabis, cocaine, methamphetamine, MDMA, ketamine, nicotine, and LSD. Containing 29 figures and tables and extensive references, this is a must-have resource for the influence of drug use and abuse on human physiology and performance.

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