latent inhibition

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Latent Inhibition

Author : Robert Lubow
ISBN : 9781139488648
Genre : Medical
File Size : 67. 87 MB
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Latent inhibition is a phenomenon by which exposure to an irrelevant stimulus impedes the acquisition or expression of conditioned associations with that stimulus. Latent inhibition, an integral part of the learning process, is observed in many species. This comprehensive collection of studies of latent inhibition, from a variety of disciplines including behavioural/cognitive psychology, neuroscience and genetics, focuses on abnormal latent inhibition effects in schizophrenic patients and schizotypal normals. Amongst other things, the book addresses questions such as, is latent inhibition an acquisition or performance deficit? What is the relationship of latent inhibition to habituation, extinction, and learned irrelevance? Does reduced latent inhibition predict creativity? What are the neural substrates, pharmacology, and genetics of latent inhibition? What do latent inhibition research and theories tell us about schizophrenia? This book provides a single point of reference for neuroscience researchers, graduate students, and professionals, such as psychologists and psychiatrists.

Latent Inhibition And Conditioned Attention Theory

Author : R. E. Lubow
ISBN : 0521363071
Genre : Medical
File Size : 37. 45 MB
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Latent inhibition is an exquisitely simple, robust, and pervasive behavioural phenomenon - the reduced ability of an organism to learn new associations to previously inconsequential stimuli. It has been demonstrated in a variety of animals, including humans, across many different learning tasks.

Latent Inhibition Effects In Psychopaths

Author : David E. Warner
ISBN : WISC:89055507495
Genre :
File Size : 70. 40 MB
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Latent Inhibition And Its Neural Substrates

Author : Nestor Schmajuk
ISBN : 9781461508410
Genre : Psychology
File Size : 51. 75 MB
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Latent Inhibition and Its Neural Substrates describes a neural network model of attentional processes during associative learning, mainly latent inhibition, and shows how variables in the model can be mapped onto different brain regions and neurotransmitters. The result is a neurophysiological model capable of generating predictions and descriptions of numerous experimental results using latent inhibition, including the effects of brain lesions, drug administration, and the combination of both. The model also explains the absence of latent inhibition in acute schizophrenia and its reinstatement by the administration of psychotropic drugs.

The Effects Of Nmda Antagonists On Latent Inhibition Via Chronic Administration Of Mk 801

Author : Amanda S. Adams
ISBN : OCLC:876378556
Genre : Cognition
File Size : 20. 87 MB
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Evidence shows the N-methyl-D-aspartate (NMDA) receptor for the neurotransmitter glutamate plays an important role in regulating learning and behavior. These receptors are critically involved in the establishment of long-term potentiation (LTP). LTP is a widely studied cellular mechanism of learning and memory that has been observed in the Hippocampus and other areas of the brain. Researchers have investigated the role of LTP and NMDA receptors in many behavioral learning and memory tasks. One study showed the NMDA antagonist MK-801 ((+)-5-methyl-10, 11-dihydro-5H-dibenzo[a,d]cyclo- hepten-5,10-iminemaleate) produced deficits in place learning and spatial strategies in the Morris water maze (Robinson, Crooks, Shinkman, & Gallagher, 1989). Another hippocampal-dependent task that is commonly studied is called latent inhibition. There are many discrepancies in past literature regarding the nature of MK-801's effects on latent inhibition. The purpose of this study was to examine how the NMDA antagonist MK-801 affects a within-subjects, appetitive latent inhibition task. Long-Evans rats received subcutaneous injections of either a low (0.05 mg/kg) or high (0.1 mg/kg) dose of MK-801, or saline. The subjects received 1 day of magazine training, 4 days of non-reinforced exposure to either a clicker or a white noise, and 4 days of conditioning in which the preexposed stimulus and a novel stimulus were paired with the delivery of a food pellet. Conditioning days were recorded and scored for 6 different behaviors occurring just before and during each conditioned stimulus (CS) presentation. Results indicated that rats displayed significantly more conditioning behavior to the clicker CS than the white noise CS independent of which stimulus was preexposed. Evidence suggested the clicker could possibly have unconditioned aversive properties. Nevertheless, rats showed more rapid acquisition to the novel clicker when preexposed to the white noise, which signified a latent inhibition effect. MK-801 neither disrupted nor enhanced the latent inhibition effect; therefore, NMDA receptors were not critical for latent inhibition.

Latent Inhibition And Habituation During Sensory Preconditioning

Author : Pierre Mercier
ISBN : OCLC:61541779
Genre : Classical conditioning
File Size : 82. 4 MB
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"Eight experiments tested priming in short-term memory as a model for latent inhibition and habituation. The model postulates that the two phenomena result from reduced processing when a representation of the target stimulus is already active (primed) in short-term memory at the time of its presentation. Priming is assumed to depend on the integrity of an association formed between the contextual stimuli and the conditional stimulus (CS) during exposure. Using a procedure that should have overshadowed the context, Experiment 1 found that latent inhibition and habituation were nevertheless maintained when a second CS of either equal or shorter duration overlapped with the target during exposure. Experiment 2 found no support for the priming of a configural stimulus when simultaneous compounds were preexposed. Experiment 3 ruled out sensitization and/or pseudoconditioning as an alternative explanation of latent inhibition. Experiments 4, 5 and 6 showed that sensory preconditioning as well as habituation and latent inhibition were obtained with compound exposure, providing evidence that the added CS was indeed processed along with the target. In Experiment 7, sequential pairings produced as much latent inhibition as compounds but less sensory preconditioning. Experiment 8 showed that retardation of conditioned inhibition was not attenuated by compound exposure. These results are interpreted as consistent with a correlational approach to classical conditioning." --

Latent Inhibition And Extinction Rate Of The Conditioned Stimulus In Long Evans And Brattleboro Rats Using Conditioned Taste Aversion

Author : Elizabeth Vu Tran
ISBN : 1124727701
Genre :
File Size : 55. 54 MB
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Brattleboro rats, a Long Evans strain with a single gene mutation in vasopressin, have inherent cognitive deficits in memory, emotional reactivity, motivation, attention, and social recognition, which are abnormalities associated with schizophrenia. Latent inhibition (LI) refers to a decrease in conditioned learning that occurs when the subject being tested is preexposed to the to-be-conditioned stimulus without the paired unconditioned stimulus. The LI deficit in schizophrenics has been used as evidence of a selective attention deficit in schizophrenia. Given that the Brattleboro rats display several natural deficits that are also seen in schizophrenics, this experiment investigated whether Brattleboro rats also display deficient LI. We hypothesized that the Brattleboro rats will exhibit LI deficits compared to Long Evans rats. The conditioned taste aversion paradigm was used to test LI. Analysis of the data showed that both the Long Evans and Brattleboro rats displayed LI (p0.05), however, the Brattleboro rats showed reduced LI compared to the Long Evans rats (p

Latent Inhibition And Contextual Associations

Author : Martha Escobar
ISBN : OCLC:46707809
Genre : Conditioned response
File Size : 62. 15 MB
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The Behavioural And Pharmacological Evaluation Of Latent Inhibition And Prepulse Inhibition In C57bl6 J Mice

Author : De Li Tilly Chang
ISBN : OCLC:427962375
Genre :
File Size : 56. 69 MB
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Testing Predictions From Theories Of Latent Inhibition

Author : Amit Shahar
ISBN : OCLC:234110157
Genre :
File Size : 84. 42 MB
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