measuring immunity basic science and clinical practice

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Measuring Immunity

Author : Michael T. Lotze
ISBN : 0080479332
Genre : Medical
File Size : 73. 79 MB
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Most of the diseases of modern mankind involve either acute or chronic inflammation. Measuring Immunity integrates the current information available on biomarkers and surrogate assays into a single handbook. It highlights the principles behind various applications, gives a brief summary on how they are conducted and provides detailed and critical analyses of murine models of immunity, clinical trials, and tests to predict utility and benefit. Measuring Immunity is indispensable for scientists and clinicians interested in the clinical applications of modern immunobiology. * Defines which assays of immune function are helpful in the assessment of clinical disorders involving inflammation and immunity * Assesses the dynamics of cellular and soluble factors in the peripheral blood using modern techniques * Includes basic science foundations as well as the approaches currently applied

Measuring Immunity Basic Science And Clinical Practice

Author : Michael T. Lotze
ISBN : OCLC:904752859
Genre :
File Size : 70. 73 MB
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Handbook Of Anticancer Pharmacokinetics And Pharmacodynamics

Author : Michelle A. Rudek
ISBN : 9781461491354
Genre : Medical
File Size : 61. 84 MB
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There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development

Inflammation And Immunity In Depression

Author : Bernhard Baune
ISBN : 9780128110744
Genre : Medical
File Size : 77. 19 MB
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Inflammation and Immunity in Depression: Basic Science and Clinical Applications is the first book to move beyond the established theory of cytokine-induced depression and explore the broader role the immune system plays in this devastating mood disorder. The book fully explores the most recent lines of research into this rapidly advancing field, including alterations of T-cells, the neurobiological implications of neuroinflammation and immune alterations for brain development and function, and the genetic components of neuroinflammation in depression, including the relationships between stress and inflammation that are revealing gene-environment interactions in the disorder. Combining contributions from researchers worldwide, this book provides the most comprehensive discussion available today on the involvement of the innate immune and adaptive immune systems in depressive disorder. Chapters span neuroscience, psychology, clinical applications and future directions, making this book an invaluable resource for advanced students, researchers and practitioners who need to understand the complex and varied role of inflammation and immune responses in depression. Synthesizes current knowledge of inflammation and immunity in depression, ranging from basic neuroscience research, to clinical applications in psychiatry Expands on the long-established theory of cytokine-induced depression to discuss broader involvement of the immune system Explores translational potential of targeting immune dysfunction for clinical interventions

Inflammatory Bowel Disease

Author : Stephan R. Targan
ISBN : 9781444359114
Genre : Medical
File Size : 63. 40 MB
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This is the state-of–the-art book on inflammatory bowel disease you have been waiting for Written and edited by international experts in gastroenterology this up-to-date volume provides a complete review of the basic science behind inflammatory bowel disease (IBD), as well as evidence-based clinical guidance on diagnosis, treatment and long-term management of IBD. In 50 chapters the authors cover the latest and most promising treatment modalities and the science behind them. There are chapters which cover the advances in the medical and surgical treatment of conditions such as Crohn's disease and ulcerative colitis, as well as chapters focusing on nutrition, imaging and complementary medicine. This is an invaluable information resource for all those in the medical team treating patients with IBD. Whether you are a gastroenterologist, gastrointestinal surgeon or GI nurse specialist this book deserves a place in your library.

Jama The Journal Of The American Medical Association

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ISBN :
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File Size : 62. 92 MB
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An Introduction To Biomedical Science In Professional And Clinical Practice

Author : Sarah Jane Pitt
ISBN : 9781118687710
Genre : Science
File Size : 81. 34 MB
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Biomedical Science in Professional and Clinical Practice isessential reading for all trainee biomedical scientists looking foran introduction to the biomedical science profession whether theyare undergraduates following an accredited biomedical sciences BSc,graduate trainees or experienced staff with overseasqualifications. This book guides trainees through the subjects,which they need to understand to meet the standards required by theHealth Professions Council for state registration. These includeprofessional topics, laws and guidelines governing clinicalpathology, basic laboratory techniques and an overview of eachpathology discipline. It helps trainees at any stage of trainingand in any pathology discipline(s) to think creatively about how togather evidence of their understanding and professional competence.By referring to specialist sources of information in each area, ithelps students to explore particular topics in more depth and tokeep up to date with professional and legalchanges. It is also of value to any Training Officers whoare looking for ideas while planning a programme of training for atrainee biomedical scientist. The book includes basic principles of working in the pathologylaboratory including laws and regulations, which must be observed,such as health and safety, data protection and equal opportunitieslaws and guidelines. Practical exercises are included throughoutthe book with examples of coursework, suggestions for furtherexercises and self -assessment. Summary boxes of key facts areclearly set out in each chapter and ideas for group/tutorialdiscussions are also provided to enhance studentunderstanding.

Annual Report

Author :
ISBN : OSU:32436011255732
Genre : Surgery
File Size : 89. 51 MB
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Hyperthermic Oncology From Bench To Bedside

Author : Satoshi Kokura
ISBN : 9789811007194
Genre : Medical
File Size : 48. 8 MB
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This comprehensive work broadens readers' understanding of the rudimentary mechanism of the anti-cancer effect of hyperthermia. It also presents state-of-the-art clinical outcomes by hyperthermia treatment of cancer. In the past few decades, basic and clinical research have shown through in vitro experiments that hyperthermia inhibits epithelial-mesenchymal transition (EMT), resulting in the prevention of metastasis. It also has been learned that hyperthermia shows its superior benefit when applied in combination with radiation therapy, chemotherapy, or various immunotherapies as treatments of several types of carcinoma. The chapters here from expert contributors describe the details of their research for each type of cancer. This book provides not only an overview and the current status of hyperthermia but also its future perspectives. Therefore this volume will greatly benefit oncologists, radiologists and radiology technologists, and chemotherapists who are involved in immunotherapy for all kinds of cancer.

Surgery

Author : Jeffrey Norton
ISBN : 0387681132
Genre : Medical
File Size : 58. 60 MB
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Much anticipated, the Second Edition of Surgery: Basic Science and Clinical Evidence features fully revised and updated information on the evidence-based practice of surgery, including significant new sections on trauma and critical care and the often challenging surgical care of unique populations, including elderly, pediatric, immunocompromised, and obese patients as well as timely new chapters on the pre- and post-operative care of the cardiac surgery patient, intestinal transplantation, surgical infections, the fundamentals of cancer genetics and proteomics. Also new to this edition are discussions of electrosurgical instruments, robotics, imaging modalities, and other emerging technologies influencing the modern practice of surgery. Clinically focused sections in gastrointestinal, vascular, cardiothoracic, transplant, and cancer surgery enable the surgeon to make decisions based upon the most relevant data in modern surgical practice. The text is enhanced by more than 1,000 illustrations and hundreds of the signature evidence-based tables that made the first edition of SURGERY an instant classic.

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