medicinal organometallic chemistry 32 topics in organometallic chemistry

Download Book Medicinal Organometallic Chemistry 32 Topics In Organometallic Chemistry in PDF format. You can Read Online Medicinal Organometallic Chemistry 32 Topics In Organometallic Chemistry here in PDF, EPUB, Mobi or Docx formats.

Medicinal Organometallic Chemistry

Author : Gérard Jaouen
ISBN : 9783642131844
Genre : Science
File Size : 81. 38 MB
Format : PDF, ePub, Docs
Download : 191
Read : 745

Get This Book


Contents: Gérard Jaouen, Nils Metzler-Nolte : Introduction ; Stéphane GIBAUD and Gérard JAOUEN: Arsenic - based drugs: from Fowler’s solution to modern anticancer chemotherapy; Ana M. Pizarro, Abraha Habtemariam and Peter J. Sadler : Activation Mechanisms for Organometallic Anticancer Complexes; Angela Casini, Christian G. Hartinger, Alexey A. Nazarov, Paul J. Dyson : Organometallic antitumour agents with alternative modes of action; Elizabeth A. Hillard, Anne Vessières, Gerard Jaouen : Ferrocene functionalized endocrine modulators for the treatment of cancer; Megan Hogan and Matthias Tacke : Titanocenes – Cytotoxic and Anti-Angiogenic Chemotherapy Against Advanced Renal-Cell Cancer; Seann P. Mulcahy and Eric Meggers : Organometallics as Structural Scaffolds for Enzyme Inhibitor Design; Christophe Biot and Daniel Dive : Bioorganometallic Chemistry and Malaria; Nils Metzler-Nolte : Biomedical applications of organometal-peptide conjugates; Roger Alberto : Organometallic Radiopharmaceuticals; Brian E. Mann : Carbon Monoxide – an essential signaling molecule.

Synthesis And Application Of Organoboron Compounds

Author : Elena Fernández
ISBN : 9783319130545
Genre : Science
File Size : 72. 75 MB
Format : PDF, ePub
Download : 381
Read : 833

Get This Book


The series Topics in Organometallic Chemistry presents critical overviews of research results in organometallic chemistry. As our understanding of organometallic structure, properties and mechanisms increases, new ways are opened for the design of organometallic compounds and reactions tailored to the needs of such diverse areas as organic synthesis, medical research, biology and materials science. Thus the scope of coverage includes a broad range of topics in pure and applied organometallic chemistry, where new breakthroughs are being achieved that are of significance to a larger scientific audience. The individual volumes of Topics in Organometallic Chemistry are thematic. Review articles are generally invited by the volume editors.

An Introduction To Medicinal Chemistry

Author : Graham Patrick
ISBN : 9780198749691
Genre : Pharmaceutical chemistry
File Size : 82. 79 MB
Format : PDF, ePub, Docs
Download : 464
Read : 1123

Get This Book


For many people, taking some form of medication is part of everyday life, whether for mild or severe illness, acute or chronic disease, to target infection or to relieve pain. However for most it remains a mystery as to what happens once the drug has been taken into the body: how do the drugs actually work? Furthermore, by what processes are new drugs discovered and brought to market?An Introduction to Medicinal Chemistry, sixthedition, provides an accessible and comprehensive account of this fascinating multidisciplinary field. Assuming little prior knowledge, the text is ideal for those studying the subject for the first time. Inaddition to covering the key principles of drug design and drug action, the text also discusses important current topics in medicinal chemistry. The subject is brought to life throughout by engaging case studies highlighting particular classes of drugs, and the stories behind their discovery and development.

Catalytic Carbonylation Reactions

Author : Matthias Beller
ISBN : 9783540330028
Genre : Science
File Size : 83. 55 MB
Format : PDF, Kindle
Download : 342
Read : 503

Get This Book


Carbonylation reactions are of major importance in both organic and industrial chemistry. Due to the availability, price and reactivity pattern, carbon monoxide is becoming a more and more important building block for fine and bulk chemicals. The major reaction types of carbon monoxide are comprehensively discussed by leading experts from academia and industry. The authors highlight important carbonylation reactions such as hydroformylation, alkoxy-carbonylations, co/olefin-copolymerization, Pauson-Khand reactions and others. They illustrate applications in organic synthesis and give industrial examples. This volume is designed to provide graduate students and researchers with essential information on the use of carbon monoxide in organic synthesis. Therefore, the reader will get a balanced view of this developing and complex subject.

Green Techniques For Organic Synthesis And Medicinal Chemistry

Author : Wei Zhang
ISBN : 9780470711514
Genre : Medical
File Size : 52. 87 MB
Format : PDF, ePub, Mobi
Download : 757
Read : 1119

Get This Book


Green chemistry is a new way of looking at organic synthesis and the design of drug molecules, offering important environmental and economic advantages over traditional synthetic processes. Pharmaceutical companies are increasingly turning to the principles of green chemistry in an effort to reduce waste, reduce costs and develop environmentally benign processes. Green Techniques for Organic Synthesis and Medicinal Chemistry presents an overview of the established and emerging techniques in green organic chemistry, highlighting their applications in medicinal chemistry. The book is divided into four parts: Introduction: Introduces the reader to the toxicology of organic chemicals,their environmental impact, and the concept of green chemistry. Green Catalysis: Covers a variety of green catalytic techniques including organocatalysis, supported catalysis, biocatalysis, fluorous catalysis, and catalytic direct C-H bond activation reactions. Green Synthetic Techniques: Presents a series of new techniques, assessing the green chemistry aspects and limitations (i.e. cost, equipment, expertise). Techniques include reactions in alternative solvents, atom economic multicomponent reactions, microwave and ultrasonic reactions, solid-supported synthesis, fluorous and ionic liquid-based recycling techniques, and flow reactors. Green Techniques in Pharmaceutical Industry: Covers applications of green chemistry concepts and special techniques for medicinal chemistry, including synthesis, analysis, separation, formulation, , and drug delivery. Process and business case studies are included to illustrate the applications in the pharmaceutical industry. Green Techniques for Organic Synthesis and Medicinal Chemistry is an essential resource on green chemistry technologies for academic researchers, R&D professionals and students working in organic chemistry and medicinal chemistry.

Advances In Organometallic Chemistry And Catalysis

Author : Armando J. L. Pombeiro
ISBN : 9781118742891
Genre : Science
File Size : 50. 5 MB
Format : PDF, ePub, Docs
Download : 174
Read : 949

Get This Book


A contemporary compilation of recent achievements in organometallic chemistry The prestigious International Conference on Organometallic Chemistry (ICOMC) was launched in 1963, providing a forum for researchers from around the world to share their findings and explore new paths to advance our knowledge and application of organometallic chemistry. The 25th ICOMC, held in Lisbon in 2012, gathered more than 1,200 participants from 54 countries. This volume celebrates the 25th Silver Edition and the 50th Gold Year of the ICOMC. Featuring contributions from invited 25th ICOMC speakers, Advances in Organometallic Chemistry and Catalysis highlights recent achievements and new and emerging areas of research in the field. Its seven sections cover: Activation and Functionalization of Carbon Single Bonds and Small Molecules Organometallic Synthesis and Catalysis Organometallic Polymerization Catalysis Organometallic Polymers and Materials Organometallic Chemistry and Sustainable Energy Bioorganometallic Chemistry Organometallic Electrochemistry Chapters discuss fundamental underlying concepts, offer illustrative examples and cases, and explore future avenues for continued research. Readers will discover basic principles and properties of organometallic compounds, reaction mechanisms, and detailed descriptions of current applications. Collectively, these chapters underscore the versatility, richness, and potential of modern organometallic chemistry, including its interrelationships with other scientific disciplines. All the contributions are extensively referenced, providing a gateway to the most important original research papers and reviews in organometallic chemistry. Presenting a contemporary understanding of organometallic chemistry and its many applications, Advances in Organometallic Chemistry and Catalysis is recommended for all researchers in the field, from students to advanced investigators.

Arrow Pushing In Organic Chemistry

Author : Daniel E. Levy
ISBN : 9781118991343
Genre : Science
File Size : 35. 49 MB
Format : PDF, ePub
Download : 132
Read : 979

Get This Book


Organic chemistry is required coursework for degrees in life, food, and medical sciences. To help the students discouraged by the belief that this topic cannot be mastered without significant memorization, Arrow Pushing in Organic Chemistry serves as a handy supplement for understanding the subject. • Includes new chapters, an expanded index, and additional problem sets complete with detailed solutions • Focuses on understanding the mechanics and logic of organic reaction mechanisms • Introduces ionic and non-ionic reactive species and reaction mechanisms • Teaches strategies to predict reactive species, sites of reactions, and reaction products • Provides a solid foundation upon which organic chemistry students can advance with confidence

Computational Organic Chemistry

Author : Steven M. Bachrach
ISBN : 9781118671221
Genre : Science
File Size : 52. 94 MB
Format : PDF, ePub, Mobi
Download : 245
Read : 1263

Get This Book


The Second Edition demonstrates how computational chemistry continues to shed new light on organic chemistry The Second Edition of author Steven Bachrach’s highly acclaimed Computational Organic Chemistry reflects the tremendous advances in computational methods since the publication of the First Edition, explaining how these advances have shaped our current understanding of organic chemistry. Readers familiar with the First Edition will discover new and revised material in all chapters, including new case studies and examples. There’s also a new chapter dedicated to computational enzymology that demonstrates how principles of quantum mechanics applied to organic reactions can be extended to biological systems. Computational Organic Chemistry covers a broad range of problems and challenges in organic chemistry where computational chemistry has played a significant role in developing new theories or where it has provided additional evidence to support experimentally derived insights. Readers do not have to be experts in quantum mechanics. The first chapter of the book introduces all of the major theoretical concepts and definitions of quantum mechanics followed by a chapter dedicated to computed spectral properties and structure identification. Next, the book covers: Fundamentals of organic chemistry Pericyclic reactions Diradicals and carbenes Organic reactions of anions Solution-phase organic chemistry Organic reaction dynamics The final chapter offers new computational approaches to understand enzymes. The book features interviews with preeminent computational chemists, underscoring the role of collaboration in developing new science. Three of these interviews are new to this edition. Readers interested in exploring individual topics in greater depth should turn to the book’s ancillary website www.comporgchem.com, which offers updates and supporting information. Plus, every cited article that is available in electronic form is listed with a link to the article.

The Organic Chemistry Of Drug Design And Drug Action

Author : Richard B. Silverman
ISBN : 9780123820310
Genre : Medical
File Size : 20. 14 MB
Format : PDF
Download : 255
Read : 1054

Get This Book


The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries. Updates to all chapters, including new examples and references Chapter 1 (Introduction): Completely rewritten and expanded as an overview of topics discussed in detail throughout the book Chapter 2 (Lead Discovery and Lead Modification): Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit-to-lead and scaffold hopping; expanded sections on sources of lead compounds, fragment-based lead discovery, and molecular graphics; and deemphasized solid-phase synthesis and combinatorial chemistry Chapter 3 (Receptors): Drug-receptor interactions, cation-π and halogen bonding; atropisomers; case history of the insomnia drug suvorexant Chapter 4 (Enzymes): Expanded sections on enzyme catalysis in drug discovery and enzyme synthesis Chapter 5 (Enzyme Inhibition and Inactivation): New case histories: for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinib for transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe-ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazid for slow, tight-binding inhibition, the dipeptidyl peptidase-4 inhibitor, saxagliptin Chapter 7 (Drug Resistance and Drug Synergism): This new chapter includes topics taken from two chapters in the previous edition, with many new examples Chapter 8 (Drug Metabolism): Discussions of toxicophores and reactive metabolites Chapter 9 (Prodrugs and Drug Delivery Systems): Discussion of antibody–drug conjugates

The Chemistry Of Plants

Author : Margareta Sequin
ISBN : 9781782625568
Genre : Science
File Size : 78. 48 MB
Format : PDF, ePub
Download : 609
Read : 482

Get This Book


This book is an introduction to organic chemistry and its compounds as related to plants. Chemistry tends to be seen as a field that is hard to comprehend and that has few connections with the living world. This book fills a gap as it eases access to organic chemistry by connecting it with plants and includes numerous photos and other illustrations. The book is a combination of organic chemistry with the living world of plants and is an introduction to organic plant compounds for the non-chemist. It starts with a review of basic concepts of chemistry as they relate to plant life, followed by an introduction to structures of organic compounds, which prepares the reader for the following chapters on primary metabolites and on plant fragrances, pigments, and plant defensive compounds. The final chapter relates plant compounds to human life, with subchapters on foods from plants, medicines, psychoactives, fibers, and dyes. Historic discoveries of plant compounds and their developments to contemporary uses, like modern pharmaceuticals, and a section on genetically modified plants, connect with topics of recent interest. The book leads the serious reader from chemistry basics to complex plant substances and their human uses and plant photos and stories accompany chemistry topics and chemical structures to aid understanding. The author, an organic chemist and plant enthusiast, has taught popular undergraduate college level courses on plant chemistry to non-chemistry majors and numerous field seminars to the general public for more than fifteen years. The book's topics and contents have been taught for many years and have proved successful in providing an understanding of plant compounds, organic compounds, and their importance. The book provides a basis for a better understanding of chemistry and its connections to the world of plants, the natural world in general, and to daily life. It is aimed at non-chemistry undergraduate students and to people in general who are interested in plants and who would like to learn more about them. It addresses an audience with little previous chemistry knowledge, yet, leads the serious reader to an understanding of sometimes complex plant compounds, by providing an introduction to chemistry basics, combining the chemistry with pictures and stories, and using simple, clear language. The book can be used both as a text to introduce organic chemistry as it relates to plants and as a text of reference for more advanced readers.

Top Download:

Best Books