methodological issues and strategies in clinical research third edition

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Methodological Issues And Strategies In Clinical Research

Author : Alan E. Kazdin
ISBN : 1433820919
Genre : Psychology
File Size : 43. 73 MB
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This fourth edition of Alan E. Kazdin's classic Methodological Issues and Strategies in Clinical Research is intended to help students and professionals alike master a wide range of methodological approaches with which to scientifically examine clinical issues and phenomena.

Designing Clinical Research

Author : Stephen B. Hulley
ISBN : 9781469840543
Genre : Medical
File Size : 85. 25 MB
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Designing Clinical Research sets the standard for providing a practical guide to planning, tabulating, formulating, and implementing clinical research, with an easy-to-read, uncomplicated presentation. This product incorporates current research methodology--including molecular and genetic clinical research--and offers an updated syllabus for conducting a clinical research workshop. Emphasis is on common sense as the main ingredient of good science. The book explains how to choose well-focused research questions and details the steps through all the elements of study design, data collection, quality assurance, and basic grant-writing.

Design And Analysis Of Clinical Trials

Author : Shein-Chung Chow
ISBN : 9780471473299
Genre : Mathematics
File Size : 42. 69 MB
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Clinical Trials

Author : Steven Piantadosi
ISBN : 9781118959213
Genre : Mathematics
File Size : 89. 92 MB
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Presents elements of clinical trial methods that are essential in planning, designing, conducting, analyzing, and interpreting clinical trials with the goal of improving the evidence derived from these important studies This Third Edition builds on the text’s reputation as a straightforward, detailed, and authoritative presentation of quantitative methods for clinical trials. Readers will encounter the principles of design for various types of clinical trials, and are then skillfully guided through the complete process of planning the experiment, assembling a study cohort, assessing data, and reporting results. Throughout the process, the author alerts readers to problems that may arise during the course of the trial and provides common sense solutions. All stages of therapeutic development are discussed in detail, and the methods are not restricted to a single clinical application area. The authors bases current revisions and updates on his own experience, classroom instruction, and feedback from teachers and medical and statistical professionals involved in clinical trials. The Third Edition greatly expands its coverage, ranging from statistical principles to new and provocative topics, including alternative medicine and ethics, middle development, comparative studies, and adaptive designs. At the same time, it offers more pragmatic advice for issues such as selecting outcomes, sample size, analysis, reporting, and handling allegations of misconduct. Readers familiar with the First and Second Editions will discover revamped exercise sets; an updated and extensive reference section; new material on endpoints and the developmental pipeline, among others; and revisions of numerous sections. In addition, this book: • Features accessible and broad coverage of statistical design methods—the crucial building blocks of clinical trials and medical research -- now complete with new chapters on overall development, middle development, comparative studies, and adaptive designs • Teaches readers to design clinical trials that produce valid qualitative results backed by rigorous statistical methods • Contains an introduction and summary in each chapter to reinforce key points • Includes discussion questions to stimulate critical thinking and help readers understand how they can apply their newfound knowledge • Provides extensive references to direct readers to the most recent literature, and there are numerous new or revised exercises throughout the book Clinical Trials: A Methodologic Perspective, Third Edition is a textbook accessible to advanced undergraduate students in the quantitative sciences, graduate students in public health and the life sciences, physicians training in clinical research methods, and biostatisticians and epidemiologists. Steven Piantadosi, MD, PhD, is the Phase One Foundation Distinguished Chair and Director of the Samuel Oschin Cancer Institute, and Professor of Medicine at Cedars-Sinai Medical Center in Los Angeles, California. Dr. Piantadosi is one of the world’s leading experts in the design and analysis of clinical trials for cancer research. He has taught clinical trials methods extensively in formal courses and short venues. He has advised numerous academic programs and collaborations nationally regarding clinical trial design and conduct, and has served on external advisory boards for the National Institutes of Health and other prominent cancer programs and centers. The author of more than 260 peer-reviewed scientific articles, Dr. Piantadosi has published extensively on research results, clinical applications, and trial methodology. While his papers have contributed to many areas of oncology, he has also collaborated on diverse studies outside oncology including lung disease and degenerative neurological disease.

Clinical Trials In Oncology Third Edition

Author : Stephanie Green
ISBN : 9781439814482
Genre : Mathematics
File Size : 46. 38 MB
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The third edition of the bestselling Clinical Trials in Oncology provides a concise, nontechnical, and thoroughly up-to-date review of methods and issues related to cancer clinical trials. The authors emphasize the importance of proper study design, analysis, and data management and identify the pitfalls inherent in these processes. In addition, the book has been restructured to have separate chapters and expanded discussions on general clinical trials issues, and issues specific to Phases I, II, and III. New sections cover innovations in Phase I designs, randomized Phase II designs, and overcoming the challenges of array data. Although this book focuses on cancer trials, the same issues and concepts are important in any clinical setting. As always, the authors use clear, lucid prose and a multitude of real-world examples to convey the principles of successful trials without the need for a strong statistics or mathematics background. Armed with Clinical Trials in Oncology, Third Edition, clinicians and statisticians can avoid the many hazards that can jeopardize the success of a trial.

Acupuncture Research

Author : Hugh MacPherson
ISBN : 9780443100291
Genre : Medical
File Size : 29. 75 MB
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This is the first book to set out a full range of research strategies for evaluating the clinical practice of acupuncture. Leading acupuncturists and researchers with international reputations share their expertise. They illustrate their descriptions with practical examples of what has worked and what has not. It outlines many of the key challenges in the field. These challenges relate to the nature of acupuncture and the gap between current research evidence and the actual experiences of acupuncturists in the field. By focusing the chapters on key research questions, rather than methods, the book has a user-friendly feel. Each chapter is easily accessible with brief explanations of research designs as well as vignettes of relevant past research. The book is based on a deep understanding of acupuncture, with its inherent complexity in practice, whether based on traditional principles or more modern concepts. By incorporating a more sophisticated understanding of the field, this book details a range of strategies aiming to develop the evidence base with the utmost rigour. It is the first book on acupuncture research to take this unique view, integrating the very best of evidence-based medicine with a genuine sensitivity to the discipline of acupuncture, from its traditional and holistic roots to its more modern interpretations.

Cognitive Therapy With Children And Adolescents Third Edition

Author : Philip C. Kendall
ISBN : 9781462528233
Genre : Medical
File Size : 26. 65 MB
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"Subject Areas/Keywords: adolescents, assessments, behavioral, casebooks, cases, CBT, childhood, children, cognitive-behavioral therapy, diagnosis, emotional, evidence-based practice, externalizing, families, family-based, internalizing, interventions, problems, programs, psychological disorders, psychopathology, psychotherapies, psychotherapy, treatment manuals, treatments DESCRIPTION Thousands of clinicians and students have turned to this casebook--now completely revised with 90% new material--to see what cognitive-behavioral therapy (CBT) looks like in action with the most frequently encountered child and adolescent disorders. Concise and accessible, the book is designed for optimal clinical utility. Leading scientist-practitioners provide a brief overview of each clinical problem and its assessment and management. Chapters are organized around one or more detailed case examples that demonstrate how to build rapport with children and families; plan effective, age-appropriate treatment; and deliver evidence-based interventions using a variety of therapeutic strategies and materials. (Prior edition editors: Mark A. Reinecke, Frank M. Dattilio, and Arthur Freeman.)"--

Analysis Of Clinical Trials Using Sas

Author : Alex Dmitrienko
ISBN : 9781635261448
Genre : Computers
File Size : 61. 16 MB
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Analysis of Clinical Trials Using SAS®: A Practical Guide, Second Edition bridges the gap between modern statistical methodology and real-world clinical trial applications. Tutorial material and step-by-step instructions illustrated with examples from actual trials serve to define relevant statistical approaches, describe their clinical trial applications, and implement the approaches rapidly and efficiently using the power of SAS. Topics reflect the International Conference on Harmonization (ICH) guidelines for the pharmaceutical industry and address important statistical problems encountered in clinical trials. Commonly used methods are covered, including dose-escalation and dose-finding methods that are applied in Phase I and Phase II clinical trials, as well as important trial designs and analysis strategies that are employed in Phase II and Phase III clinical trials, such as multiplicity adjustment, data monitoring, and methods for handling incomplete data. This book also features recommendations from clinical trial experts and a discussion of relevant regulatory guidelines. This new edition includes more examples and case studies, new approaches for addressing statistical problems, and the following new technological updates: SAS procedures used in group sequential trials (PROC SEQDESIGN and PROC SEQTEST) SAS procedures used in repeated measures analysis (PROC GLIMMIX and PROC GEE) macros for implementing a broad range of randomization-based methods in clinical trials, performing complex multiplicity adjustments, and investigating the design and analysis of early phase trials (Phase I dose-escalation trials and Phase II dose-finding trials) Clinical statisticians, research scientists, and graduate students in biostatistics will greatly benefit from the decades of clinical research experience and the ready-to-use SAS macros compiled in this book.

Corporate Finance Decisions In Volatile Economic Times

Author : Giampiero Favato
ISBN : 9780595524136
Genre : Business & Economics
File Size : 51. 84 MB
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Troubled economic times are putting an extraordinary pressure on corporate managers, who have to make investment decisions under unprecedented uncertainty and risk. The aim of this book is to help managers to reflect upon the critical assumptions underlying the most relevant tools for valuation of corporate investments under uncertainty. It offers a wide range of working papers, journal articles and case studies which are the fruit of our recent experience in teaching, consulting and research. This book is ideally suited to both managers and MBA students who seek to improve their critical ability to make value decisions based on an array of relevant investment valuation tools.

Principles And Methods Of Social Research

Author : William D. Crano
ISBN : 9781317666066
Genre : Psychology
File Size : 85. 8 MB
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Used to train generations of social scientists, this thoroughly updated classic text covers the latest research techniques and designs. Applauded for its comprehensive coverage, the breadth and depth of content is unparalleled. Through a multi-methodology approach, the text guides readers toward the design and conduct of social research from the ground up. Explained with applied examples useful to the social, behavioral, educational, and organizational sciences, the methods described are intended to be relevant to contemporary researchers. The underlying logic and mechanics of experimental, quasi-experimental, and non-experimental research strategies are discussed in detail. Introductory chapters covering topics such as validity and reliability furnish readers with a firm understanding of foundational concepts. Chapters dedicated to sampling, interviewing, questionnaire design, stimulus scaling, observational methods, content analysis, implicit measures, dyadic and group methods, and meta-analysis provide coverage of these essential methodologies. The book is noted for its: -Emphasis on understanding the principles that govern the use of a method to facilitate the researcher’s choice of the best technique for a given situation. - Use of the laboratory experiment as a touchstone to describe and evaluate field experiments, correlational designs, quasi experiments, evaluation studies, and survey designs. -Coverage of the ethics of social research including the power a researcher wields and tips on how to use it responsibly. The new edition features: -A new co-author, Andrew Lac, instrumental in fine tuning the book’s accessible approach and highlighting the most recent developments at the intersection of design and statistics. -More learning tools including more explanation of the basic concepts, more research examples, tables, and figures, and the addition of bold faced terms, chapter conclusions, discussion questions, and a glossary. -Extensive revision of chapter (3) on measurement reliability theory that examines test theory, latent factors, factor analysis, and item response theory. -Expanded coverage of cutting-edge methodologies including mediation and moderation, reliability and validity, missing data, and more physiological approaches such as neuroimaging and fMRIs. -A new web based resource package that features Power Points and discussion and exam questions for each chapter and for students chapter outlines and summaries, key terms, and suggested readings. Intended as a text for graduate or advanced undergraduate courses in research methods (design) in psychology, communication, sociology, education, public health, and marketing, an introductory undergraduate course on research methods is recommended.

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