methods in pain research frontiers in neuroscience

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Translational Pain Research

Author : Lawrence Kruger
ISBN : 1439812098
Genre : Health & Fitness
File Size : 72. 49 MB
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One of the Most Rapidly Advancing Fields in Modern Neuroscience The success of molecular biology and the new tools derived from molecular genetics have revolutionized pain research and its translation to therapeutic effectiveness. Bringing together recent advances in modern neuroscience regarding genetic studies in mice and humans and the practicality of clinical trials, Translational Pain Research: From Mouse to Man effectively bridges the gap between basic research and patient care by humanely examining rodent models for pain associated with bone cancer, osteoarthritis, fibromyalgia, and cardiac episodes. Distinguished Team of International Contributors In addition to addressing the groundbreaking technical advances in tract tracing, endocannabinoids, cannabis, gene therapy, siRNA gene studies, and the role of glia, cytokines, P2X receptors and ATP, this book also presents cutting-edge information on: Nociceptor sensitization Muscle nociceptors and metabolite detection Visceral afferents in disease Innovative rodent model for bone cancer pain Highly specific receptor cloning Modular molecular mechanisms relevant to painful neuropathies This sharply focused work also discusses unexpected discoveries derived from brain-imaging studies related to thalamic pain. Translational Pain Research covers the progress made toward bringing laboratory science (much of it at the molecular level) to our understanding of pain phenomena in humans, with the ultimate goal of reducing the suffering that often accompanies pain and its indirect consequences.

Body Space And Pain

Author : Camila Valenzuela-Moguillansky
ISBN : 9782889192915
Genre :
File Size : 22. 63 MB
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Getting Grounded In Social Psychology

Author : Todd D Nelson
ISBN : 9781351694674
Genre :
File Size : 23. 62 MB
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This volume provides a fast and efficient way for undergraduate and graduate students to gain a solid understanding of the social psychology literature. Each chapter reviews a major subsection of research in the field, written by a leading social psychology researcher in that area. Coverage includes all the major empirical, theoretical and methodological developments in its subfield of social psychology. Beginning social psychologists, as well as those who may have emerged from their formal training with a less-than-solid grounding in the research literature, will find this volume invaluable. It is the book all social psychologists wished they had access to when they were getting grounded in the research literature!

Frontiers In Neurology And Neuroscience Research 1974

Author : University of Toronto. Ṉeuroscience Institute
ISBN : UCAL:B4514023
Genre : Medical
File Size : 67. 1 MB
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Mindfulness And Education

Author : Tamara Ditrich
ISBN : 9781443878609
Genre : Education
File Size : 22. 54 MB
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With mindfulness initiatives currently highly topical in a range of academic, therapeutic and other domains, new applications of mindfulness have begun to appear in educational settings. This accumulation of twelve research-focused papers contributes to the nascent field of mindfulness in education by exploring practical implementations, as well as theoretical concerns within a range of educational contexts. The contributions in this volume reflect and capture the diversity of approaches to research-linked mindfulness programmes being implemented in contemporary education at primary, secondary and tertiary levels. Ranging across a number of disciplines, the chapters contribute to work on mindfulness in psychology, education theory, and Buddhist studies. From the evidence provided here, it is shown that the implementation of mindfulness in educational settings is certainly worthwhile, while appropriately rigorous research methods are still being developed.

The Development Of Deep Brain Stimulation For Neurological And Psychiatric Disorders Clinical Societal And Ethical Issues

Author : Thomas E. Schlaepfer
ISBN : 9782889190409
Genre :
File Size : 56. 99 MB
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To date more than eighty thousand patients worldwide have received deep brain stimulation (DBS), mainly in order to alleviate symptoms of treatment-resistant disorders such as tremor associated with Parkinson’s disease, essential tremor, chronic pain, epilepsy, obsessive compulsive disorder, major depression and Tourette syndrome. The number of indications for neurological and psychiatric conditions using this technology is rapidly increasing, raising important societal and ethical issues that cannot be dealt with by scientists and clinicians on their own, but need discussions among all possible stakeholders on questions such as: what are the comprehensive risks and benefits of this technology? what is the real impact on patients’ life, in terms of health, quality of life and personal identity? This Research Topic provides an overview of potentials and limitations of deep brain stimulation as used to treat neurological and psychiatric conditions, bringing together Mini Reviews, Perspectives and Opinion papers from key stakeholders interested in the development and social impact of this technology. It is also a continuation of the debate that started among scientists, clinicians, patients, sociologists, journalists, philosophers and other experts during the “brains in dialogue on deep brain stimulation” workshop that was organized in September 2010 in Warsaw, Poland, by the FP7 project bid – brains in dialogue (www.neuromedia.eu) coordinated by the Interdisciplinary Laboratory of SISSA (Trieste, Italy).

Glycinergic Transmission Physiological Developmental And Pathological Implications

Author : Robert J. Harvey
ISBN : 9782889190218
Genre :
File Size : 57. 86 MB
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Inhibitory glycine receptors (GlyRs) containing the alpha1 and beta subunits are well known for their involvement in an inherited motor disorder (hyperekplexia) characterised by neonatal hypertonia and an exaggerated startle reflex. However, it has recently emerged that other GlyR subtypes (e.g. those containing the alpha2, alpha3 and alpha4 subunits) may play more diverse biological roles. New animal models of glycinergic dysfunction have been reported in zebrafish (bandoneon, shocked), mice (cincinatti, Nmf11) and cows (CMD2). In addition, key studies on neurotransmitter transporters for glycine (GlyT1, GlyT2, VIAAT) have also revealed key roles for these presynaptic and glial proteins in health and disease. Molecular modelling and structure/function studies have also provided key insights into allosteric signal transduction mechanisms and the diverse pharmacology of glycine receptors. This Research Topic aims to bring together experts in the field of glycinergic transmission, and invite research articles or topical reviews to provide an up-to-date perspective on the insights into receptor, transporter and synaptic function that can be gained by the study of glycinergic transmission.

Investigating The Human Brainstem With Structural And Functional Mri

Author : Florian Beissner
ISBN : 9782889192472
Genre :
File Size : 65. 96 MB
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The brainstem is one of the least understood parts of the human brain despite its prime importance for the maintenance of basic vital functions. Owing to its role as a relay station between spinal cord, cerebellum and neocortex, the brainstem contains vital nodes of all functional systems in the central nervous system, including the visual, auditory, gustatory, vestibular, somatic and visceral senses, and the somatomotor as well as autonomic nervous systems. While the brainstem has been extensively studied in animals using invasive methods, human studies remain scarce. Magnetic resonance imaging (MRI) as a non-invasive and widely available method is one possibility to access the brainstem in humans and measure its structure as well as function. The close vicinity of the brainstem to large arteries and ventricles and the small size of the anatomical structures, however, place high demands on imaging as well as data analysis methods. Nevertheless, the field of brainstem-(f)MRI has significantly advanced in the past few years, largely due to the development of several new tools that facilitate studying this critical part of the human brain. Within this scope, the goal of this Research Topic is to compile work representing the state of the art in functional and structural MRI of the human brainstem.

Zeitschriften Deutschland Sterreich Schweiz

Author :
ISBN : UOM:39015079683812
Genre : Periodicals
File Size : 40. 27 MB
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Current Catalog

Author :
ISBN : UOM:39015020584267
Genre : Medicine
File Size : 28. 71 MB
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First multi-year cumulation covers six years: 1965-70.

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