mitochondrial signaling in health and disease oxidative stress and disease

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Mitochondrial Signaling In Health And Disease

Author : Sten Orrenius
ISBN : 9781439880029
Genre : Medical
File Size : 73. 8 MB
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Mitochondria have traditionally been associated with metabolic functions; however recent research has uncovered a central role for these organelles in cell signaling, cell survival, and cell death. Mitochondrial dysfunction is a factor in a myriad of pathophysiological conditions, including age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. Mitochondrial Signaling in Health and Disease examines themes essential for the maintenance of the mitochondrial redox (reduction-oxidation) energy axis. With contributions from an impressive cadre of internationally recognized scientists, the book discusses coordinated mitochondrial functions that regulate cell function by discrete signaling pathways. Topics discussed include: Electron transport and energy production Mitochondrial biogenesis and dynamics Mitochondrial signaling Apoptosis and autophagy Pharmacology signaling Epigenetic signaling: mitochondrial methylation and acetylation reactions An essential resource for life and health scientists as well as pharmaceutical industry professionals, this volume highlights the importance of mitochondrial signaling and its role in establishing a harmonized communication between several cellular compartments. The information in this volume is critical to those developing mitochondrion-targeted therapies aimed at assuaging mitochondrial dysfunction or the specific factors contributing to its dysfunction.

Mitochondrial Function In Lung Health And Disease

Author : Viswanathan Natarajan
ISBN : 9781493908295
Genre : Medical
File Size : 53. 30 MB
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Mitochondria, often referred to as the “powerhouses” of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.

Oxidative Phosphorylation In Health And Disease

Author : Jan A.M. Smeitink
ISBN : 0306482320
Genre : Medical
File Size : 70. 65 MB
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Mitochondrial diseases are often hard to diagnose. From the time they were first researched without animal models, patients of mitochondrial diseases were of equal interest to both clinical and basic scientists. With the new research done, this book includes updates on the normal structure, function, and molecular biology of the mitochondrial respiratory chain, information on traditional diagnostical methodologies, and an overview of the diagnostic promise of new technologies. The hypermetabolism of Luft disease, although only seen twice, is also studied. There are critical reviews of symptoms and signs associated with syndromes, as well as updates on the genetic defects of either the mitochondrial or the nuclear genome responsible for many disorders.

Redox Genome Interactions In Health And Disease

Author : Jürgen Fuchs
ISBN : 020391287X
Genre : Medical
File Size : 88. 68 MB
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At the nexus of advances in molecular genetics and findings in redox biology, this volume elaborates on the dynamics governing cellular redox states and aggregates the body of evidence linking oxidative stress and redox modulation with a host of monogenetic and polygenetic diseases.

Mitochondria In Health And Disease

Author : Carolyn D. Berdanier
ISBN : 9781420028843
Genre : Medical
File Size : 63. 47 MB
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It was once assumed that mitochondrial diseases were rare and that few people were affected. As knowledge has grown about these organelles and their function, it became clear that mitochondrial malfunction could be linked to several chronic diseases. Diabetes has been associated with DNA mutation and can cause mutation itself. This text discusses findings involving the effects of disease on mitochondrial number, mitogenesis, and the base sequence of mitochondrial DNA. Experts discuss their study of mitochondria and what happens when it malfunctions. This book also explores the idea that mutated mitochondrial DNA can result in disease, and vice versa.

Lipid Oxidation In Health And Disease

Author : Corinne M. Spickett
ISBN : 9781482202861
Genre : Medical
File Size : 50. 5 MB
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Oxidative modification of lipids and phospholipids—including radical damage, halogenation, and nitration—result in significant changes to the chemical properties of the molecules, which in turn have a major effect on their biochemical functions. Lipid oxidation has long been regarded as a deleterious process responsible for lipid rancidity, loss of function, and generation of toxic products. However in recent years, research has also focused on the non-detrimental physiological and pathological effects of these chemical reactions. Lipid Oxidation in Health and Disease provides an up-to-date review of the role of oxidized lipid products in physiological and pathophysiological processes. Covering the diverse topics that contribute to research in this important field, this book explores: The mechanisms of lipid oxidation, both enzymatic and non-enzymatic Antioxidant defenses and lipid oxidation Lipid oxidation products and cell signaling The roles of oxidized lipids in specific diseases—including cardiovascular, neurodegenerative, and metabolic disorders, as well as in cancer Drug targeting and the therapeutic potential of oxidized lipids Accurate measurement of the formation of lipid oxidation products and investigation of their biological effects and roles in disease are critical to biomedical science and new targeted therapeutics. Written by acknowledged experts in the field, this book provides a broad survey of both established knowledge and recent findings on the action of oxidized lipid products on cell signaling and gene expression in health and disease.

Stress In Health And Disease An Issue Of Psychiatric Clinics Of North America

Author : Daniel L. Kirsch
ISBN : 9780323326773
Genre : Medical
File Size : 72. 18 MB
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Stress in the DSM is referred to only in the sense of post traumatic stress disorder (PTSD). However, some research studies estimate up to two thirds of illnesses seen by general practitioners are ‘stress related’–GI problems, sleep disturbance, mental concentration, headaches, fatigue, shortness of breath, high blood pressure, dermatitis, illnesses from lowered immune system, and vague aches and pains – all can be symptoms and outcomes of the elusive stress factor. This issue of Psychiatric Clinics of North America discusses the scientific medical facets of stress, written by mental health and medical practitioners. It looks at the brain-body connection of stress – what the body does to result in stress and varying results stress has on the body. This fascinating cross-discipline look at stress is intended for psychiatrists, general practitioners, cardiologists, GI specialists, neurologists, sleep medicine specialists, respiratory specialists, and others who diagnose and treat patients with stress suspected as part of the illness equation or with self-reported stress. Topics include: Measurement of stress; Anxiety and stress-how they work together; Relationship between genetics and stress; Role of glia in stress; Sleep and stress; Diet and stress; Supplements and stress; Effect of severe stress on early brain development, attachment, and emotions; Role of stress and fear on the development of psychopathology; Expressions of stress in psychiatric illness; Dermatologic manifestations of stress in normal and psychiatric populations; Humor and the psychological buffers of stress; Stress expression in children and adolescents; Stress in service members; Stress in the geriatric population.

Signal Transduction In The Cardiovascular System In Health And Disease

Author : Ashok K. Srivastava
ISBN : 9780387095523
Genre : Medical
File Size : 51. 17 MB
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Signal Transduction in Cardiovascular System Health and Disease highlights the major contributions of different signaling systems in modulating normal cardiovascular functions and how a perturbation in these signaling events leads to abnormal cell functions and cardiovascular disorders. This title is volume 3 in the new Springer series, Advances in Biochemistry in Health and Disease.

Insulin Like Growth Factors In Health And Disease An Issue Of Endocrinology And Metabolism Clinics E Book

Author : Claire M. Perks
ISBN : 9781455742776
Genre : Medical
File Size : 71. 77 MB
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This issue of Endocrinology Clinics, authored by experts worldwide, provides essential updates about insulin-like growth factors (IGFs). The physiology is examined, including the latest in what we have learned from animal models as well as humans. The issue also covers IGFs and IGF system in the following: growth disorders; adipogenesis and obesity; muscle function and disease; bone; cancer; cardiac function and disease; normal and diseased kidney; peripheral nervous systems; gastrointestinal diseases; diabetes and metabolism; and IGF-1 central/degenerative diseases.

Flavonoids In Health And Disease Second Edition

Author : Catherine A. Rice-Evans
ISBN : 9780824755249
Genre : Medical
File Size : 64. 65 MB
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Revised and expanded throughout, this blue-ribbon reference emphasizes the latest developments in the identification, utilization, and analysis of flavonoids for the prevention of disease and maintenance of good health-examining the processes involved in the absorption, metabolism, distribution, and excretion of these compounds and the impact of biotransformation on flavonoid function.

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