modeling the psychopathological dimensions of schizophrenia from molecules to behavior handbook of behavioral neuroscience

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Modeling The Psychopathological Dimensions Of Schizophrenia

Author : Mikhail Pletnikov
ISBN : 9780128011843
Genre : Medical
File Size : 51. 97 MB
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Modeling the Psychopathological Dimensions of Schizophrenia: From Molecules to Behavior is the first book to offer a comprehensive review of the new theoretical, clinical, and basic research framework that considers psychotic illness as a group of dimensional representations of psychopathology rather than as traditional distinct categorical diagnoses. Psychotic illness, typified by schizophrenia, is a devastating condition increasingly recognized as a disorder of abnormal brain development and dysconnectivity. Its complex etiology involves both genetic and environmental factors, as well as the interplay among them. This book describes the current understanding of the clinical and pathological features of schizophrenia, with a particular focus on the evolving conceptualization of schizophrenia and related diagnostic categories of psychotic illness as combinations of dimensional abnormalities. It provides an overview of modern strategies for generating cellular and whole animal models of schizophrenia as well as detailed reviews of the specific experimental preparations and paradigms aimed at molecular, developmental, and brain-network mechanisms that are the underlying aspects of abnormal behavior and various aspects of schizophrenia. This groundbreaking book is an authoritative overview of the translational impact of emerging clinical insights on basic research approaches in schizophrenia that will advance the reader’s understanding of the five major dimensions of psychopathology in schizophrenia and related psychoses and resolve the genetic and neurobiological underpinnings of these dimensions. Includes reviews of animal models that capture the most recent insights into the etiology and pathogenetic mechanisms of schizophrenia, with an emphasis on the translational potential of these models Contains a series of reviews of recently available cellular models for analysis of signaling pathways and gene expression, which complement behavioral neuroscience research in schizophrenia Edited and authored by leading researchers in the field of schizophrenia and related psychoses

Encyclopedia Of Behavioral Neuroscience

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ISBN : 9780080453965
Genre : Psychology
File Size : 67. 64 MB
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Behavioral Neuroscientists study the behavior of animals and humans and the neurobiological and physiological processes that control it. Behavior is the ultimate function of the nervous system, and the study of it is very multidisciplinary. Disorders of behavior in humans touch millions of people’s lives significantly, and it is of paramount importance to understand pathological conditions such as addictions, anxiety, depression, schizophrenia, autism among others, in order to be able to develop new treatment possibilities. Encyclopedia of Behavioral Neuroscience is the first and only multi-volume reference to comprehensively cover the foundation knowledge in the field. This three volume work is edited by world renowned behavioral neuroscientists George F. Koob, The Scripps Research Institute, Michel Le Moal, Université Bordeaux, and Richard F. Thompson, University of Southern California and written by a premier selection of the leading scientists in their respective fields. Each section is edited by a specialist in the relevant area. The important research in all areas of Behavioral Neuroscience is covered in a total of 210 chapters on topics ranging from neuroethology and learning and memory, to behavioral disorders and psychiatric diseases. The only comprehensive Encyclopedia of Behavioral Neuroscience on the market Addresses all recent advances in the field Written and edited by an international group of leading researchers, truly representative of the behavioral neuroscience community Includes many entries on the advances in our knowledge of the neurobiological basis of complex behavioral, psychiatric, and neurological disorders Richly illustrated in full color Extensively cross referenced to serve as the go-to reference for students and researchers alike The online version features full searching, navigation, and linking functionality An essential resource for libraries serving neuroscientists, psychologists, neuropharmacologists, and psychiatrists

Handbook Of Basal Ganglia Structure And Function

Author : Heinz Steiner
ISBN : 9780128025260
Genre : Science
File Size : 54. 98 MB
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Handbook of Basal Ganglia Structure and Function, Second Edition, offers an integrated overview of the structural and functional aspects of the basal ganglia, highlighting clinical relevance. The basal ganglia, a group of forebrain nuclei interconnected with the cerebral cortex, thalamus, and brainstem, are involved in numerous brain functions, such as motor control and learning, sensorimotor integration, reward, and cognition. These nuclei are essential for normal brain function and behavior, and their importance is further emphasized by the numerous and diverse disorders associated with basal ganglia dysfunction, including Parkinson’s disease, Tourette’s syndrome, Huntington’s disease, obsessive-compulsive disorder, dystonia, and psychostimulant addiction. This updated edition has been thoroughly revised to provide the most up-to-date account of this critical brain structure. Edited and authored by internationally acclaimed basal ganglia researchers, the new edition contains ten entirely new chapters that offer expanded coverage of anatomy and physiology, detailed accounts of recent advances in cellular/molecular mechanisms and cellular/physiological mechanisms, and critical, deeper insights into the behavioral and clinical aspects of basal ganglia function and dysfunction. Synthesizes widely dispersed information on the behavioral neurobiology of the basal ganglia, including advances in the understanding of anatomy, cellular/molecular and cellular/physiological mechanisms, and behavioral and clinical aspects of function and dysfunction Written by international authors who are preeminent researchers in the field Explores, in full, the clinically relevant impact of the basal ganglia on various psychiatric and neurological diseases

The Neurobiology Of Schizophrenia

Author : Ted Abel
ISBN : 9780128018774
Genre : Science
File Size : 32. 32 MB
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The Neurobiology of Schizophrenia begins with an overview of the various facets and levels of schizophrenia pathophysiology, ranging systematically from its genetic basis over changes in neurochemistry and electrophysiology to a systemic neural circuits level. When possible, the editors point out connections between the various systems. The editors also depict methods and research strategies used in the respective field. The individual backgrounds of the two editors promote a synthesis between basic neuroscience and clinical relevance. Provides a comprehensive overview of neurobiological aspects of schizophrenia Discusses schizophrenia at behavioral, cognitive, clinical, electrophysiological, molecular, and genetic levels Edited by a translational researcher and a psychiatrist to promote synthesis between basic neuroscience and clinical relevance Elucidates connections between the various systems depicted, when possible

The Neuropsychopathology Of Schizophrenia

Author : Ming Li
ISBN : 9783319305967
Genre : Psychology
File Size : 41. 6 MB
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One of the first major theoretical reviews of schizophrenia since the publication of the 5th edition of the APA’s Diagnostic and Statistical Manual, the DSM-5, this volume is a landmark in the history of schizophrenia research. It assembles recent groundbreaking developments in research on schizophrenia and reaffirms its central place in the mental health research agenda. Significantly, this volume reflects the paradigmatic shift in schizophrenia research applied in parallel to new approaches in psychiatric diagnosis. New models and findings from across disciplines in recent years reflect a new and greater understanding of the workings of the brain, which, in turn, helps develop our knowledge of the neuro and psychological processes in schizophrenia. Consequently, this volume illustrates a historical convergence of psychology, psychopathology and the neurosciences in schizophrenia. World-renowned leaders of the schizophrenia research community in fields such as neuroscience, psychiatry, neuropsychology, and clinical psychology offer clear suggestions for further advances in psychological and medical interventions, assessment, prevention strategies, and research. And in keeping with other titles in the Nebraska Symposium on Motivation series, these papers are noteworthy for their depth of detail, scientific rigor, and clinical relevance. Included among the topics: Cognitive organization as a dimension of individual differences and psychopathology. Neurodevelopmental genomic strategies in the study of the psychosis spectrum. Multimodal brain and behavior indices of psychosis risk. The NIMH Research Domain Criteria Project: new approaches to classifying psychotic spectrum disorders. The Neuropsychopathology of Schizophrenia is one of the most forward-thinking and engaging treatments of the field in recent years, and is an indispensable text for all researchers, academics, and clinicians who treat or study mental illness, especially psychiatrists, psychologists, mental health practitioners, and neuroscientists specializing in schizophrenia.

Systems Neuroscience In Depression

Author : Thomas Frodl
ISBN : 9780128026281
Genre : Medical
File Size : 76. 32 MB
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Systems Neuroscience in Depression provides a comprehensive overview of the normal and depressed brain processes as studied from a systems neuroscience perspective. Systems neuroscience uses a wide variety of approaches to study how networks of neurons form the bases of higher brain function. A broad overview is discussed starting with a background from neurodevelopment and neural understanding as well as novel treatment approaches for depression. This book covers basic developmental aspects and depressive psychopathology, as well as the basic scientific background from animal models and experimental research. Current advances in systems neuroscience are highlighted in studies from child and adolescent psychiatry. Integrated approaches are presented with regards to genetics, neuroimaging and neuroinflammation as well as neuroendocrinology. The field of systems and network neuroscience is evolving rapidly and this book provides a greatly needed resource for researchers and practitioners in systems neuroscience and psychiatry. Knowledge covering the whole life span from early to later life Comprehensively written chapters developing from molecules via epigenetics and neural circuits to clinical neuroscience Understanding the neurobiology of major depressive disorder Integrating stress and environmental factors with molecular underpinnings More than 25 illustrations and tables

Behavioral Neuroscience Of Motivation

Author : Eleanor H. Simpson
ISBN : 9783319269351
Genre : Medical
File Size : 82. 53 MB
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This volume covers the current status of research in the neurobiology of motivated behaviors in humans and other animals in healthy condition. This includes consideration of the psychological processes that drive motivated behavior and the anatomical, electrophysiological and neurochemical mechanisms which drive these processes and regulate behavioural output. The volume also includes chapters on pathological disturbances in motivation including apathy, or motivational deficit as well as addictions, the pathological misdirection of motivated behavior. As with the chapters on healthy motivational processes, the chapters on disease provide a comprehensive up to date review of the neurobiological abnormalities that underlie motivation, as determined by studies of patient populations as well as animal models of disease. The book closes with a section on recent developments in treatments for motivational disorders.

Animal Models Of Behavior Genetics

Author : Jonathan Gewirtz
ISBN : 9781493937776
Genre : Medical
File Size : 71. 3 MB
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This stimulating analysis reviews the broad potential of animal models to foster a deeper understanding of human pathology, strengthen connections between genetic and behavioral studies, and develop more effective treatments for mental disorders. Widely-studied and lesser-used species are examined in models that capture features along the continuum of normative and pathological behavior. The models highlight genetic causes of core features, or endophenotypes, of developmental, internalizing, and externalizing disorders, as well as dementia. Expert contributors address questions ranging from how suitable species are chosen for study to the costs and benefits of using inbred versus outbred strains, and the effects of housing environment on subject animals. Larger issues addressed include how to evaluate the applicability of animal behavioral models to the human condition and how these models can harness emerging molecular technologies to further our understanding of the genetic basis of mental illness. Included in the coverage: Mating and fighting in Drosophila. Attachment and social bonding. Impulsivity in rodents and humans. Animal models of cognitive decline. Animal models of social cognition. Future directions for animal models in behavioral genetics. A detailed map of where this evolving field is headed, Animal Models of Behavior Genetics shows geneticists, molecular biologists, and cognitive neuroscientists paths beyond established concepts toward a more knowledgeable and collaborative future.

Handbook Of Reward And Decision Making

Author : Jean-Claude Dreher
ISBN : 0080923488
Genre : Psychology
File Size : 56. 51 MB
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This book addresses a fundamental question about the nature of behavior: how does the brain process reward and makes decisions when facing multiple options? The book presents the most recent and compelling lesion, neuroimaging, electrophysiological and computational studies, in combination with hormonal and genetic studies, which have led to a clearer understanding of neural mechanisms behind reward and decision making. The neural bases of reward and decision making processes are of great interest to scientists because of the fundamental role of reward in a number of behavioral processes (such as motivation, learning and cognition) and because of their theoretical and clinical implications for understanding dysfunctions of the dopaminergic system in several neurological and psychiatric disorders (schizophrenia, Parkinson's disease, drug addiction, pathological gambling, ...). Comprehensive coverage of approaches to studying reward and decision making, including primate neurophysiology and brain imaging studies in healthy humans and in various disorders, genetic and hormonal influences on the reward system and computational models. Covers clinical implications of process dysfunction (e.g., schizophrenia, Parkinson's disease, eating disorders, drug addiction, pathological gambling) Uses multiple levels of analysis, from molecular mechanisms to neural systems dynamics and computational models. " This is a very interesting and authoritative handbook by some of the most outstanding investigators in the field of reward and decision making ", Professor Edmund T. Rolls, Oxford Center for Computational Neuroscience, UK

The Cambridge Handbook Of The Neuroscience Of Creativity

Author : Rex E. Jung
ISBN : 9781108340458
Genre : Psychology
File Size : 64. 88 MB
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Historically, the brain bases of creativity have been of great interest to scholars and the public alike. However, recent technological innovations in the neurosciences, coupled with theoretical and methodological advances in creativity assessment, have enabled humans to gain unprecedented insights into the contributions of the brain to creative thought. This unique volume brings together contributions by the very best scholars to offer a comprehensive overview of cutting edge research on this important and fascinating topic. The chapters discuss creativity's relationship with intelligence, motivation, psychopathology and pharmacology, as well as the contributions of general psychological processes to creativity, such as attention, memory, imagination, and language. This book also includes specific and novel approaches to understanding creativity involving musicians, polymaths, animal models, and psychedelic experiences. The chapters are meant to give the reader a solid grasp of the diversity of approaches currently at play in this active and rapidly growing field of inquiry.

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