modeling the psychopathological dimensions of schizophrenia from molecules to behavior handbook of behavioral neuroscience

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Modeling The Psychopathological Dimensions Of Schizophrenia

Author : Mikhail Pletnikov
ISBN : 9780128011843
Genre : Medical
File Size : 76. 42 MB
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Modeling the Psychopathological Dimensions of Schizophrenia: From Molecules to Behavior is the first book to offer a comprehensive review of the new theoretical, clinical, and basic research framework that considers psychotic illness as a group of dimensional representations of psychopathology rather than as traditional distinct categorical diagnoses. Psychotic illness, typified by schizophrenia, is a devastating condition increasingly recognized as a disorder of abnormal brain development and dysconnectivity. Its complex etiology involves both genetic and environmental factors, as well as the interplay among them. This book describes the current understanding of the clinical and pathological features of schizophrenia, with a particular focus on the evolving conceptualization of schizophrenia and related diagnostic categories of psychotic illness as combinations of dimensional abnormalities. It provides an overview of modern strategies for generating cellular and whole animal models of schizophrenia as well as detailed reviews of the specific experimental preparations and paradigms aimed at molecular, developmental, and brain-network mechanisms that are the underlying aspects of abnormal behavior and various aspects of schizophrenia. This groundbreaking book is an authoritative overview of the translational impact of emerging clinical insights on basic research approaches in schizophrenia that will advance the reader’s understanding of the five major dimensions of psychopathology in schizophrenia and related psychoses and resolve the genetic and neurobiological underpinnings of these dimensions. Includes reviews of animal models that capture the most recent insights into the etiology and pathogenetic mechanisms of schizophrenia, with an emphasis on the translational potential of these models Contains a series of reviews of recently available cellular models for analysis of signaling pathways and gene expression, which complement behavioral neuroscience research in schizophrenia Edited and authored by leading researchers in the field of schizophrenia and related psychoses

Modeling The Psychopathological Dimensions Of Schizophrenia From Molecules To Behavior Handbook Of Behavioral Neuroscience V 23 Interloan 339607

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ISBN : OCLC:981871962
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The Neuropsychopathology Of Schizophrenia

Author : Ming Li
ISBN : 9783319305967
Genre : Psychology
File Size : 58. 58 MB
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One of the first major theoretical reviews of schizophrenia since the publication of the 5th edition of the APA’s Diagnostic and Statistical Manual, the DSM-5, this volume is a landmark in the history of schizophrenia research. It assembles recent groundbreaking developments in research on schizophrenia and reaffirms its central place in the mental health research agenda. Significantly, this volume reflects the paradigmatic shift in schizophrenia research applied in parallel to new approaches in psychiatric diagnosis. New models and findings from across disciplines in recent years reflect a new and greater understanding of the workings of the brain, which, in turn, helps develop our knowledge of the neuro and psychological processes in schizophrenia. Consequently, this volume illustrates a historical convergence of psychology, psychopathology and the neurosciences in schizophrenia. World-renowned leaders of the schizophrenia research community in fields such as neuroscience, psychiatry, neuropsychology, and clinical psychology offer clear suggestions for further advances in psychological and medical interventions, assessment, prevention strategies, and research. And in keeping with other titles in the Nebraska Symposium on Motivation series, these papers are noteworthy for their depth of detail, scientific rigor, and clinical relevance. Included among the topics: Cognitive organization as a dimension of individual differences and psychopathology. Neurodevelopmental genomic strategies in the study of the psychosis spectrum. Multimodal brain and behavior indices of psychosis risk. The NIMH Research Domain Criteria Project: new approaches to classifying psychotic spectrum disorders. The Neuropsychopathology of Schizophrenia is one of the most forward-thinking and engaging treatments of the field in recent years, and is an indispensable text for all researchers, academics, and clinicians who treat or study mental illness, especially psychiatrists, psychologists, mental health practitioners, and neuroscientists specializing in schizophrenia.

Developmental Psychopathology Developmental Neuroscience

Author : Donald J. Cohen
ISBN : 9780470048191
Genre : Psychology
File Size : 29. 79 MB
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This volume applies multiple levels of analysis to neurobiological developmental organization, and functioning in normality and psychopathology. It also covers topics central to a developmental perspective on neuroscience.

Animal Models Of Behavior Genetics

Author : Jonathan Gewirtz
ISBN : 9781493937776
Genre : Medical
File Size : 57. 73 MB
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This stimulating analysis reviews the broad potential of animal models to foster a deeper understanding of human pathology, strengthen connections between genetic and behavioral studies, and develop more effective treatments for mental disorders. Widely-studied and lesser-used species are examined in models that capture features along the continuum of normative and pathological behavior. The models highlight genetic causes of core features, or endophenotypes, of developmental, internalizing, and externalizing disorders, as well as dementia. Expert contributors address questions ranging from how suitable species are chosen for study to the costs and benefits of using inbred versus outbred strains, and the effects of housing environment on subject animals. Larger issues addressed include how to evaluate the applicability of animal behavioral models to the human condition and how these models can harness emerging molecular technologies to further our understanding of the genetic basis of mental illness. Included in the coverage: Mating and fighting in Drosophila. Attachment and social bonding. Impulsivity in rodents and humans. Animal models of cognitive decline. Animal models of social cognition. Future directions for animal models in behavioral genetics. A detailed map of where this evolving field is headed, Animal Models of Behavior Genetics shows geneticists, molecular biologists, and cognitive neuroscientists paths beyond established concepts toward a more knowledgeable and collaborative future.

Handbook Of Medical Psychiatry

Author : Jair C. Soares
ISBN : 9780203912485
Genre : Medical
File Size : 37. 67 MB
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This volume examines attempts to identify genetic risk factors and environmental components contributing to the development of psychiatric disorders. It explores the symptoms, courses, outcomes, treatment responses and aetiologies of a range of psychiatric illnesses to improve disease classification schemes.

Handbook Of Schizophrenia Spectrum Disorders Volume I

Author : Michael S Ritsner
ISBN : 9400708378
Genre : Medical
File Size : 72. 67 MB
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A few disorders have some of the same symptoms as schizophrenia including schizoaffective disorders, schizophreniform disorder, schizotypal and schizoid personality disorders, delusional disorder, and autism (schizophrenia spectrum disorders). Since the 2000 there has been significant progress in our understanding of the early presentations, assessment, suspected neuropathology, and treatment of these disorders. Recent technological breakthroughs in basic sciences hold promise for advancing our understanding of the pathophysiology of schizophrenia spectrum disorders. This collective monograph reviewers recent researches regarding the origins, onset, course, and outcome of schizophrenia spectrum disorders. In particular, this book will be illustrate new developments in terms of conceptual models, and research methodology, genetics and genomics, brain imaging and neurochemical studies, neurophysiology and information processing in schizophrenia spectrum disorders patients. Also will be highlighted new developments in our understanding of the childhood psychosis, prodromal and first-episode states, in treatment and rehabilitation. Thus, the purpose of this book is to provide up-to-date overview of the rapid advances made in the clinical and basic science studies supporting our understanding of the relationship between cerebral processes and clinical, cognitive and other presentations of the schizophrenia spectrum disorders. In addition, this book aims to monitor important research developments, which may be relevant to treatment, and rehabilitation of patients.

Handbook Of Psychopathy Second Edition

Author : Christopher J. Patrick
ISBN : 9781462535170
Genre : Psychology
File Size : 45. 3 MB
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Widely considered the go-to reference--and now extensively revised with over 65% new material--this authoritative handbook surveys the landscape of current knowledge on psychopathy and addresses essential clinical and applied topics. Leading researchers explore major theoretical models; symptomatology and diagnostic subtypes; assessment methods; developmental pathways; and causal influences, from genes and neurobiology to environmental factors. The volume examines manifestations of psychopathy in specific populations as well as connections to antisocial behavior and recidivism. It presents contemporary perspectives on prevention and treatment and discusses special considerations in clinical and forensic practice. New to This Edition *Extensively revised with more than a decade's theoretical, empirical, and clinical advances. *Many new authors and topics. *Expanded coverage of phenotypic facets, with chapters on behavioral disinhibition, callous–unemotional traits, and boldness. *Chapters on DSM-5, clinical interviewing, cognitive and emotional processing, and serial murder. *Significantly updated coverage of etiology, assessment methods, neuroimaging research, and adult and juvenile treatment approaches.

Comprehensive Handbook Of Psychopathology

Author : Patricia B. Sutker
ISBN : 0306441691
Genre : Mental illness
File Size : 90. 16 MB
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The third edition of Comprehensive Handbook of Psychopathology provides in-depth coverage of theoretical, research, and clinical positions in psychopathology. Extensively revised and updated, this new edition Outlines a highly improved classification scheme based on the DSM IV; Includes two new chapters on schizophrenia that reflect renewed interest in this topic; Puts new emphasis on cultural and developmental issues; Contains increased coverage of the overlap of medicine and abnormal behavior.?/LIST?? Furnishing both empirical and research data useful to graduate students and practicing clinicians in the mental health profession, particularly clinical psychology, psychiatry, psychiatric nursing, and social work, this handbook is an ideal reference source.

Handbook Of Reward And Decision Making

Author : Jean-Claude Dreher
ISBN : 0080923488
Genre : Psychology
File Size : 87. 24 MB
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This book addresses a fundamental question about the nature of behavior: how does the brain process reward and makes decisions when facing multiple options? The book presents the most recent and compelling lesion, neuroimaging, electrophysiological and computational studies, in combination with hormonal and genetic studies, which have led to a clearer understanding of neural mechanisms behind reward and decision making. The neural bases of reward and decision making processes are of great interest to scientists because of the fundamental role of reward in a number of behavioral processes (such as motivation, learning and cognition) and because of their theoretical and clinical implications for understanding dysfunctions of the dopaminergic system in several neurological and psychiatric disorders (schizophrenia, Parkinson's disease, drug addiction, pathological gambling, ...). Comprehensive coverage of approaches to studying reward and decision making, including primate neurophysiology and brain imaging studies in healthy humans and in various disorders, genetic and hormonal influences on the reward system and computational models. Covers clinical implications of process dysfunction (e.g., schizophrenia, Parkinson's disease, eating disorders, drug addiction, pathological gambling) Uses multiple levels of analysis, from molecular mechanisms to neural systems dynamics and computational models. " This is a very interesting and authoritative handbook by some of the most outstanding investigators in the field of reward and decision making ", Professor Edmund T. Rolls, Oxford Center for Computational Neuroscience, UK

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