molecular biology of cancer mechanisms targets and therapeutics

Download Book Molecular Biology Of Cancer Mechanisms Targets And Therapeutics in PDF format. You can Read Online Molecular Biology Of Cancer Mechanisms Targets And Therapeutics here in PDF, EPUB, Mobi or Docx formats.

Molecular Biology Of Cancer

Author : Lauren Pecorino
ISBN : 9780199577170
Genre : Medical
File Size : 48. 3 MB
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The third edition of The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer, by showing how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents.

Molecular Biology Of Cancer

Author : Principal Lecturer in Cancer Biology Lauren Pecorino
ISBN : 0198717342
Genre :
File Size : 31. 52 MB
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Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers an accessible, engaging, and optimistic account of cancer biology for undergraduate and graduate students. Using the hallmarks of cancer as a starting point, the book looks at the cellular and molecular mechanisms underpinning the transformation of cells into cancer cells. After discussing the theory, each chapter then demonstrates how this knowledge can be directly applied to the development of new targeted therapies, giving the reader a clear appreciation of how the theory translates to tackling the disease. Drawing on the latest research in this dynamic field, the author makes cutting edge science readily accessible. The book features a variety of learning features--'Pause and think', 'How do we know that?', self-tests and activities--to help students engage with, and master, the concepts presented. The emphasis is not on exhaustive coverage of the subject to the point of overwhelming with detail, but on acquiring a solid understanding of the essentials and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit. Online Resource Centre The Online Resource Centre features: For registered adopters of the book: - Figures from the book, ready to download. - A test bank of multiple choice questions, with feedback linked to the book. For students: - Web links to a range of additional cancer biology resources on the internet.

Molecular Biology Of Cancer

Author : Lauren Pecorino
ISBN : 0199211485
Genre : Medical
File Size : 47. 29 MB
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The second edition of The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics gives a fresh approach to the study of the molecular basis of cancer, by showing how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents. Opening with an overview of the key hallmarks of cancer as a disease state, the book then leads us through the principal components of the regulatory machinery through which cell division is controlled, and explains how the failure of these components can lead to the onset of cancer. Uniquely, within each chapter, students are shown how this molecular knowledge is being applied to develop new targeted therapeutic strategies. Written with the student learner in mind, the book features a variety of learning features to help students engage with, and master, the concepts presented. The emphasis is not on exhaustive coverage of the field, but on acquiring a solid understanding of the essentials of the subject - and an appreciation of how a theoretical understanding can be transformed into therapeutic benefit. The Molecular Biology of Cancer is an invaluable resource for any student wishing to gain an insight into the molecular basis of the disease, and possible solutions for its effective control.

Molecular Biology Of Cancer

Author : Lauren Pecorino
ISBN : 0199264724
Genre : Medical
File Size : 64. 75 MB
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Demonstrating how the malfunction of normal molecular pathways and components can lead to cancer, this text explores how our understanding of these defective mechanisms can be harnessed to develop new targeted therapeutic agents.

The Biology Of Cancer Second Edition

Author : Robert Weinberg
ISBN : 9781317963462
Genre : Science
File Size : 68. 40 MB
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Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, The Biology of Cancer, Second Edition, maintains all of its hallmark features admired by students, instructors, researchers, and clinicians around the world. The Biology of Cancer is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology.

Introduction To Cancer Biology

Author : Robin Hesketh
ISBN : 9781107013988
Genre : Medical
File Size : 21. 88 MB
Format : PDF
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A concise overview of the fundamental concepts of cancer biology, ideal for those with little or no background in the field. From cancer epidemiology and the underlying mechanisms, through to tumour detection and treatment, the comprehensive picture revealed will enable students to move into the cancer field with confidence.

Molecular Oncology

Author : Edward P. Gelmann
ISBN : 9780521876629
Genre : Medical
File Size : 39. 98 MB
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Reviews the origins of molecular oncology, including technologies for cancer analysis, key pathways in human malignancies, and available pharmacologic therapies.

Cell And Molecular Biology Of Breast Cancer

Author : Heide Schatten
ISBN : 9781627036344
Genre : Science
File Size : 38. 90 MB
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Highlighting recent advances in our understanding of breast cancer, this book is intended for a wide audience as a reference book. Included are reviews of genetics, epigenetics, various aspects of cell and molecular biology, and several other areas of breast cancer that are aimed at determining new intervention sites for treatments and cures of the disease. The chapters are written by internationally recognized experts and include reviews of key topics in breast cancer research. Each chapter highlights the new aspects of specific research topics and the various impacts of designing new strategies as well as identifies new targets for therapeutic intervention. The topics addressed are selected to be of interest to patients, scientists, students, teachers, and anyone else interested in expanding their knowledge of breast cancer imaging, diagnostics, therapeutics, or basic biomedical research on breast cancer.

Cancer Genomics

Author : Graham Dellaire
ISBN : 9780123972743
Genre : Medical
File Size : 77. 54 MB
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Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics. Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.

Dna Repair In Cancer Therapy

Author : Mark R. Kelley
ISBN : 9780128035993
Genre : Medical
File Size : 41. 3 MB
Format : PDF
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DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors. Provides a comprehensive overview of the basic and translational research in DNA repair as a cancer therapeutic target Includes timely updates from the earlier edition, including Fanconi Anemia cross-link repair, translesion DNA polymerases, chemotherapy induced peripheral neuropathy, and many other new areas within DNA repair and cancer therapy Saves academic, medical, and pharma researchers time by allowing them to quickly access the very latest details on DNA repair and cancer therapy Assists researchers and research clinicians in understanding the importance of the breakthroughs that are contributing to advances in disease-specific research

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