molecular photofitting predicting ancestry and phenotype using dna

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Molecular Photofitting

Author : Tony Frudakis, Ph.D.
ISBN : 0080551378
Genre : Social Science
File Size : 20. 45 MB
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In the field of forensics, there is a critical need for genetic tests that can function in a predictive or inferential sense, before suspects have been identified, and/or for crimes for which DNA evidence exists but eye-witnesses do not. Molecular Photofitting fills this need by describing the process of generating a physical description of an individual from the analysis of his or her DNA. The molecular photofitting process has been used to assist with the identification of remains and to guide criminal investigations toward certain individuals within the sphere of prior suspects. Molecular Photofitting provides an accessible roadmap for both the forensic scientist hoping to make use of the new tests becoming available, and for the human genetic researcher working to discover the panels of markers that comprise these tests. By implementing population structure as a practical forensics and clinical genomics tool, Molecular Photofitting serves to redefine the way science and history look at ancestry and genetics, and shows how these tools can be used to maximize the efficacy of our criminal justice system. Explains how physical descriptions of individuals can be generated using only their DNA Contains case studies that show how this new forensic technology is used in practical application Includes over 100 diagrams, tables, and photos to illustrate and outline complex concepts

Fundamentals Of Forensic Dna Typing

Author : John M. Butler
ISBN : 0080961762
Genre : Law
File Size : 78. 79 MB
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Fundamentals of Forensic DNA Typing is written with a broad viewpoint. It examines the methods of current forensic DNA typing, focusing on short tandem repeats (STRs). It encompasses current forensic DNA analysis methods, as well as biology, technology and genetic interpretation. This book reviews the methods of forensic DNA testing used in the first two decades since early 1980’s, and it offers perspectives on future trends in this field, including new genetic markers and new technologies. Furthermore, it explains the process of DNA testing from collection of samples through DNA extraction, DNA quantitation, DNA amplification, and statistical interpretation. The book also discusses DNA databases, which play an important role in law enforcement investigations. In addition, there is a discussion about ethical concerns in retaining DNA profiles and the issues involved when people use a database to search for close relatives. Students of forensic DNA analysis, forensic scientists, and members of the law enforcement and legal professions who want to know more about STR typing will find this book invaluable. Includes a glossary with over 400 terms for quick reference of unfamiliar terms as well as an acronym guide to decipher the DNA dialect Continues in the style of Forensic DNA Typing, 2e, with high-profile cases addressed in D.N.A.Boxes-- "Data, Notes & Applications" sections throughout Ancillaries include: instructor manual Web site, with tailored set of 1000+ PowerPoint slides (including figures), links to online training websites and a test bank with key

Genetics And The Unsettled Past

Author : Keith Wailoo
ISBN : 9780813553368
Genre : Medical
File Size : 51. 56 MB
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Our genetic markers have come to be regarded as portals to the past. Analysis of these markers is increasingly used to tell the story of human migration; to investigate and judge issues of social membership and kinship; to rewrite history and collective memory; to right past wrongs and to arbitrate legal claims and human rights controversies; and to open new thinking about health and well-being. At the same time, in many societies genetic evidence is being called upon to perform a kind of racially charged cultural work: to repair the racial past and to transform scholarly and popular opinion about the “nature” of identity in the present. Genetics and the Unsettled Past considers the alignment of genetic science with commercial genealogy, with legal and forensic developments, and with pharmaceutical innovation to examine how these trends lend renewed authority to biological understandings of race and history. This unique collection brings together scholars from a wide range of disciplines—biology, history, cultural studies, law, medicine, anthropology, ethnic studies, sociology—to explore the emerging and often contested connections among race, DNA, and history. Written for a general audience, the book’s essays touch upon a variety of topics, including the rise and implications of DNA in genealogy, law, and other fields; the cultural and political uses and misuses of genetic information; the way in which DNA testing is reshaping understandings of group identity for French Canadians, Native Americans, South Africans, and many others within and across cultural and national boundaries; and the sweeping implications of genetics for society today.

Ancestors And Relatives

Author : Eviatar Zerubavel
ISBN : 9780199773954
Genre : Reference
File Size : 64. 28 MB
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Noted social scientist Eviatar Zerubavel casts a critical eye on how we trace our past-individually and collectively arguing that rather than simply find out who our ancestors are from genetics or history, we actually create the stories that make them our ancestors.

Race And The Genetic Revolution

Author : Sheldon Krimsky
ISBN : 9780231527699
Genre : Science
File Size : 22. 60 MB
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Do advances in genomic biology create a scientific rationale for long-discredited racial categories? Leading scholars in law, medicine, biology, sociology, history, anthropology, and psychology examine the impact of modern genetics on the concept of race. Contributors trace the interplay between genetics and race in forensic DNA databanks, the biology of intelligence, DNA ancestry markers, and racialized medicine. Each essay explores commonly held and unexamined assumptions and misperceptions about race in science and popular culture. This collection begins with the historical origins and current uses of the concept of "race" in science. It follows with an analysis of the role of race in DNA databanks and racial disparities in the criminal justice system. Essays then consider the rise of recreational genetics in the form of for-profit testing of genetic ancestry and the introduction of racialized medicine, specifically through an FDA-approved heart drug called BiDil, marketed to African American men. Concluding sections discuss the contradictions between our scientific and cultural understandings of race and the continuing significance of race in educational and criminal justice policy.

A Good Man

Author : Mark Shriver
ISBN : 9780805095326
Genre : Biography & Autobiography
File Size : 39. 36 MB
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In this intimate portrait of an extraordinary father-son relationship, Mark K. Shriver discovers the moral principles that guided his legendary father and applies them to his own life When Sargent "Sarge" Shriver—founder of the Peace Corps and architect of President Johnson's War on Poverty—died in 2011 after a valiant fight with Alzheimer's, thousands of tributes poured in from friends and strangers worldwide. These tributes, which extolled the daily kindness and humanity of "a good man," moved his son Mark far more than those who lauded Sarge for his big-stage, headline-making accomplishments. After a lifetime searching for the path to his father's success in the public arena, Mark instead turns to a search for the secret of his father's joy, his devotion to others, and his sense of purpose. Mark discovers notes and letters from Sarge; hears personal stories from friends and family that zero in on the three guiding principles of Sarge's life—faith, hope, and love—and recounts moments with Sarge that now take on new value and poignancy. In the process, Mark discovers much about himself, as a father, as a husband, and as a social justice advocate. A Good Man is an inspirational and deeply personal story about a son discovering the true meaning of his father's legacy.

A Genetic Assay For Estimating Scalp Hair Pigmentation From Forensic Specimens

Author : Sara Lynn Jubelirer
ISBN : MSU:31293030635522
Genre : DNA
File Size : 44. 13 MB
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Pilgrimage

Author : Mark K. Shriver
ISBN : 9780812987553
Genre : Biography & Autobiography
File Size : 52. 20 MB
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When Jorge Mario Bergoglio became Pope Francis on March 13, 2013, Mark Shriver found himself fascinated with this humble, charismatic, and authentic leader. What led this Argentine to become a priest? What struggles had shaped him? And what could his past tell us about his plans for the future of the Catholic Church? Mark Shriver was brought up as a Catholic-both his father, Sargent Shriver, and his mother, Eunice Kennedy, were faithful Catholics-but he had long since grown disillusioned with the Church. Watching Pope Francis, though, Shriver was intrigued. Would this pope put the Catholic Church on a new path? What would that mean for Catholics around the world? Sparked by a renewed sense of faith (as well as personal curiosity), Shriver traveled to Buenos Aires, where Bergoglio was born, to meet with the men and women who remembered him as a child, as a young man and Jesuit priest, and later as a Bishop. Shriver visits the confessional where Bergoglio first felt called to religion and a faith-based life, hears about Bergoglio's early job as a clerk at a hosiery factory, and learns about the female biochemist-who co-founded the Mothers of the Plaza del Mayo before she was tragically odisappearedo-whom he credits with shaping his work ethic and spirit of dedication. He also visits Bergoglio's first, incredibly humble parish- a church that was a converted vegetable shed deep in the barrios-or slums-of Buenos Aires and speaks with the men and women who still remember Bergoglio with great fondness.

The Enculturated Gene

Author : Duana Fullwiley
ISBN : 9781400840410
Genre : Social Science
File Size : 73. 30 MB
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In the 1980s, a research team led by Parisian scientists identified several unique DNA sequences, or haplotypes, linked to sickle cell anemia in African populations. After casual observations of how patients managed this painful blood disorder, the researchers in question postulated that the Senegalese type was less severe. The Enculturated Gene traces how this genetic discourse has blotted from view the roles that Senegalese patients and doctors have played in making sickle cell "mild" in a social setting where public health priorities and economic austerity programs have forced people to improvise informal strategies of care. Duana Fullwiley shows how geneticists, who were fixated on population differences, never investigated the various modalities of self-care that people developed in this context of biomedical scarcity, and how local doctors, confronted with dire cuts in Senegal's health sector, wittingly accepted the genetic prognosis of better-than-expected health outcomes. Unlike most genetic determinisms that highlight the absoluteness of disease, DNA haplotypes for sickle cell in Senegal did the opposite. As Fullwiley demonstrates, they allowed the condition to remain officially invisible, never to materialize as a health priority. At the same time, scientists' attribution of a less severe form of Senegalese sickle cell to isolated DNA sequences closed off other explanations of this population's measured biological success. The Enculturated Gene reveals how the notion of an advantageous form of sickle cell in this part of West Africa has defined--and obscured--the nature of this illness in Senegal today. Some images inside the book are unavailable due to digital copyright restrictions.

Microbial Forensics

Author : Bruce Budowle
ISBN : 0123820073
Genre : Law
File Size : 49. 50 MB
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Microbial Forensics is a rapidly evolving scientific discipline. In the last decade, and particularly due to the anthrax letter attacks in the United States, microbial forensics has become more formalized and has played an increasingly greater role in crime investigations. This has brought renewed interest, development and application of new technologies, and new rules of forensic and policy engagement. It has many applications ranging from biodefense, criminal investigations, providing intelligence information, making society more secure, and helping protect precious resources, particularly human life. A combination of diverse areas is investigated, including the major disciplines of biology, microbiology, medicine, chemistry, physics, statistics, population genetics, and computer science. Microbial Forensics, Second Edition is fully revised and updated and serves as a complete reference of the discipline. It describes the advances, as well as the challenges and opportunities ahead, and will be integral in applying science to help solve future biocrimes. A collection of microbiology, virology, toxicology and mycology as it relates to forensics, in one reference New and expanded content to include statistical analysis of forensic data and legal admissibility and the standards of evidence, to name a few Includes research information and application of that research to crime scene analysis, which will allow practitioners to understand and apply the knowledge to their practice with ease

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